{"id":10105,"date":"2020-03-30T08:40:53","date_gmt":"2020-03-30T12:40:53","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=10105"},"modified":"2026-01-28T13:43:23","modified_gmt":"2026-01-28T18:43:23","slug":"lomotil-vs-imodium","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lomotil-vs-imodium\/","title":{"rendered":"Lomotil vs. Imodium: Key differences and how to choose the right treatment"},"content":{"rendered":"

Lomotil<\/span><\/a> (diphenoxylate\/atropine) and <\/span>Imodium<\/span><\/a> (loperamide) are two antidiarrheal medications that are used to treat diarrhea. These medications work in similar ways to decrease the number and frequency of bowel movements. Lomotil and Imodium are designed to be taken for short-term diarrhea, which usually resolves within a few days after taking the medication.<\/span><\/p>\n

Although an unpleasant experience, diarrhea is often mild and goes away on its own. The primary treatment for diarrhea is replacing fluids and electrolytes to prevent dehydration. However, medications like Lomotil and Imodium can be useful for acute diarrhea<\/span>. <\/span>Healthcare providers may also prescribe them for chronic diarrhea in certain situations.<\/span><\/p>\n

Despite their similarities in uses, Lomotil and Imodium have some differences to be mindful of. For example, these drugs contain different ingredients and have certain limitations. We\u2019ll explore their differences and similarities here.\u00a0<\/span><\/p>\n

What are the main differences between Lomotil and Imodium?<\/h2>\n

Lomotil<\/h3>\n

Lomotil<\/span><\/a> is a brand-name drug that can only be obtained with a prescription. It contains a combination of diphenoxylate (an opioid) and atropine (an anticholinergic drug).\u00a0<\/span><\/p>\n

Diphenoxylate is the primary ingredient that binds to opioid receptors in the gut to slow intestinal motility. Atropine is added to discourage drug abuse since diphenoxylate is a controlled substance on its own.\u00a0<\/span><\/p>\n

Imodium<\/h3>\n

Imodium<\/span><\/a>, also called Imodium A-D, is the brand name for loperamide. Unlike Lomotil, Imodium can be purchased over the counter (OTC). Therefore, it\u2019s more widely available.\u00a0<\/span><\/p>\n

Loperamide\u2019s chemical structure is similar to that of an opioid. It binds to opioid receptors in the intestinal wall to slow gut movement. It also blocks a chemical called acetylcholine and leads to decreased fluid and electrolyte loss. Because Imodium has minimal absorption in the central nervous system (CNS), it produces fewer CNS side effects than Lomotil, which has the opioid diphenoxylate as a primary ingredient.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between Lomotil and Imodium<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nLomotil<\/strong><\/td>\nImodium<\/strong><\/td>\n<\/tr>\n
Drug class<\/strong><\/td>\nAntidiarrheal<\/td>\nAntidiarrheal<\/td>\n<\/tr>\n
Brand\/generic status<\/strong><\/td>\nBrand and generic versions available<\/td>\nBrand and generic versions available<\/td>\n<\/tr>\n
What is the generic name?<\/strong><\/td>\nDiphenoxylate\/Atropine<\/td>\nLoperamide<\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/strong><\/td>\nOral tablet
\nLiquid solution<\/td>\n		Oral tablet
\nOral capsule
\nLiquid solution<\/td>\n<\/tr>\n
What is the standard dosage?<\/strong><\/td>\nAcute diarrhea:\u00a0<\/strong><\/p>\n

2 tablets (2.5 mg diphenoxylate\/0.025 mg atropine) four times daily until your diarrhea improves.<\/span><\/p>\n

Maximum daily dose: 20 mg of diphenoxylate<\/span><\/p>\n

Discontinue and consult a healthcare provider if symptoms do not improve within 10 days.\u00a0<\/span><\/p>\n

Chronic diarrhea:<\/strong> As directed by a healthcare provider<\/span><\/td>\n

When used OTC for diarrhea:<\/span><\/p>\n

4 mg after the first loose stool, and then 2 mg after each loose stool. <\/span>Maximum daily dose<\/span><\/a>: 8 mg<\/span><\/p>\n

Discontinue and consult a healthcare provider if your diarrhea doesn\u2019t improve within 2 days.\u00a0<\/span><\/p>\n

Healthcare providers may prescribe Imodium for chronic (ongoing) diarrhea in certain situations. The dosage for chronic diarrhea will be determined by your healthcare provider.\u00a0 <\/span><\/td>\n<\/tr>\n

How long is the typical treatment?<\/strong><\/td>\nShort-term diarrhea that resolves within 10 days. Long-term use may be needed for chronic diarrhea.<\/td>\nShort-term diarrhea that resolves within 10 days. Long-term use may be needed for chronic diarrhea.<\/td>\n<\/tr>\n
Who typically uses the medication?<\/strong><\/td>\nAdults and children 13 years of age and older<\/td>\nImodium oral solution and tablets:<\/strong> Adults and children ages 6 years and older. Children ages 2\u20135 years only if recommended by a healthcare provider<\/span><\/p>\n

Imodium capsules:<\/strong> Adults and children ages 12 years and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

Want the best price on Lomotil?<\/h3>\n

Sign up for Lomotil price alerts and find out when the price changes!<\/p>\n

Get price alerts<\/a><\/p>\n<\/div>\n

Conditions treated by Lomotil and Imodium<\/h2>\n

Lomotil is <\/span>FDA approved<\/span><\/a> as an adjunctive treatment for diarrhea. This means that Lomotil is recommended as additional therapy along with other diarrheal treatments.\u00a0<\/span><\/p>\n

Like Lomotil, Imodium is <\/span>FDA approved<\/span><\/a> to treat several types of diarrhea. Imodium can be used to treat <\/span>traveler\u2019s diarrhea<\/span><\/a> as well as diarrhea caused by medications such as those used for chemotherapy. Lomotil and Imodium can also treat chronic diarrhea caused by irritable bowel syndrome (IBS).\u00a0<\/span><\/p>\n

Diarrhea is typically defined as having loose stools three or more times in one day. Acute diarrhea is often mild and usually lasts no more than one or two days. <\/span>Food poisoning<\/span><\/a> is one of the most common causes of acute diarrhea.\u00a0<\/span><\/p>\n

Both drugs may also be used to treat <\/span>chronic diarrhea,<\/span><\/a> which is more severe and can last for more than four weeks at a time. <\/span><\/p>\n

Is Lomotil or Imodium more effective?<\/h2>\n

Lomotil and Imodium are the most commonly used antidiarrheal agents. They are both effective and work relatively quickly to relieve symptoms of diarrhea. The best drug for you will depend on your overall condition and medical history, which should be assessed by your healthcare provider.<\/span><\/p>\n

That being said, Imodium may be the more effective medication. Although there are no clinical trials that directly compare Lomotil and Imodium, some studies suggest that Imodium is a preferred option for treating diarrhea. One double-blind, <\/span>crossover study<\/span><\/a> found that loperamide was superior to diphenoxylate for treating chronic diarrhea, even at a 2.5-fold lower dose.\u00a0<\/span><\/p>\n

Another <\/span>crossover study<\/span><\/a> compared loperamide, diphenoxylate, and codeine for treating chronic diarrhea. The study found that loperamide and codeine were more effective than diphenoxylate for relief. Diphenoxylate was found to have the most side effects while loperamide was shown to have the least. <\/span><\/p>\n

Coverage and cost comparison of Lomotil vs. Imodium<\/h2>\n

Most Medicare and insurance plans do not cover brand-name Lomotil. However, many insurance plans cover the generic version of the drug. Medicare Part D plans should cover diphenoxylate\/atropine depending on your coverage. The average retail cost of generic Lomotil is around $130. Check with your pharmacy to see if you can use a discount savings card. <\/span>SingleCare Lomotil coupons<\/span><\/a> can lower the cost so that you pay around $14 at Kroger.\u00a0<\/span><\/p>\n

Imodium is an OTC drug that might not be covered by Medicare and insurance plans. Some plans may cover the generic form with a prescription. It\u2019s best to check your insurance plan\u2019s formulary to make sure. The average cost of loperamide is around $21. With a <\/span>SingleCare discount<\/span><\/a>, you can get generic loperamide tablets for about $11 at Kroger. In order to take advantage of OTC savings, you\u2019ll still have to get a <\/span>prescription from your healthcare provider<\/span><\/a>.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
\n

Compare coverage and cost of Lomotil vs. Imodium<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nLomotil<\/b><\/td>\nImodium<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/span><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare?<\/span><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Standard dosage<\/span><\/td>\n2.5 mg diphenoxylate\/0.025 mg atropine, quantity of 30 tablets<\/span><\/td>\n2 mg, quantity of 24 tablets<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\nSee latest prices<\/span><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of October 27, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/small><\/p>\n

Common side effects of Lomotil vs. Imodium<\/h2>\n

According to its prescribing information, side effects of Lomotil include drowsiness, dizziness, and nausea. Compared to Imodium, Lomotil may have more CNS side effects including headache, restlessness, and confusion.<\/span><\/p>\n

The most common side effect associated with Imodium is <\/span>constipation<\/span><\/a>. Other common side effects include dizziness, nausea, and abdominal cramps, <\/span>according to StatPearls<\/span><\/a>.\u00a0<\/span><\/p>\n

In higher doses, serious side effects of Lomotil could include severe drowsiness, hallucinations, lethargy, and slowed breathing (respiratory depression). Serious side effects of Imodium can include irregular heart rhythms, toxic megacolon, fainting, and severe skin reactions.<\/span><\/p>\n

Drug interactions of Lomotil vs. Imodium<\/h2>\n

Lomotil can interact with drugs like monoamine oxidase inhibitors (<\/span>MAOIs<\/span><\/a>) and CNS depressants. Taking an MAOI, like selegiline or phenelzine, with Lomotil may increase the risk of hypertensive crisis, or dangerously high blood pressure. The risk of adverse effects may also be increased while taking CNS depressant drugs like barbiturates, benzodiazepines, and <\/span>muscle relaxants<\/span><\/a>.\u00a0<\/span><\/p>\n

Imodium has many potential drug interactions. Unlike Lomotil, Imodium is broken down in the liver mostly by the CYP3A4 enzyme. Drugs that inhibit, or block, this enzyme, such as ketoconazole, atazanavir, verapamil, and clarithromycin, can increase the levels of Imodium in the blood. As a result, taking any of those drugs with Imodium can increase the risk of adverse side effects. Imodium may also interact with drugs such as amiodarone, carvedilol, and quinidine, according to StatPearls.<\/span><\/p>\n

Warnings of Lomotil and Imodium<\/h2>\n

Lomotil should not be used in children less than 6 years of age due to an increased risk of respiratory and CNS depression. Those with obstructive jaundice or known hypersensitivity to diphenoxylate or atropine should also avoid using Lomotil.<\/span><\/p>\n

Imodium has been reported to cause serious heart problems, such as <\/span>Torsade de Pointes<\/span><\/a> and cardiac arrest, and death when taken in higher than recommended doses. It\u2019s recommended to only take the minimum required dosage as instructed by your healthcare provider. Imodium should not be used in toddlers and infants less than 2 years of age due to the risk of respiratory and CNS depression.<\/span><\/p>\n

Lomotil and Imodium should not be used to treat diarrhea caused by bacterial infections or by organisms, such as <\/span>Clostridium difficile<\/span><\/i><\/a> and <\/span>Salmonella<\/span><\/i>.\u00a0<\/span><\/p>\n

Consult your healthcare provider if you have any medical conditions before taking these medications. It\u2019s recommended to take these medications with medical advice from your healthcare provider.\u00a0<\/span><\/p>\n

Frequently asked questions about Lomotil vs. Imodium<\/h2>\n

What is Lomotil?<\/span><\/h3>\n

Lomotil is a prescription medication used as adjunctive therapy for diarrhea. It is available in brand-name and generic versions. It can be taken for acute or chronic diarrhea in adults and children 13 years of age and older.<\/span><\/p>\n

What is Imodium?<\/span><\/h3>\n

Imodium is an OTC drug that is FDA approved to treat diarrhea. It is typically used to treat Traveler\u2019s diarrhea although it can also treat chronic diarrhea caused by IBS. Imodium can treat adults and children who are 2 years of age and older, however, children between 2 and 5 years of age should only take Imodium if recommended by a healthcare provider.\u00a0<\/span><\/p>\n

Are Lomotil and Imodium the same?<\/span><\/h3>\n

No. Lomotil and Imodium are not the same. Although they work in similar ways, Lomotil can only be obtained with a prescription and is a Schedule V controlled substance. Imodium can be purchased over the counter.<\/span><\/p>\n

Is Lomotil or Imodium better?<\/span><\/h3>\n

Lomotil and Imodium are both effective drugs for treating diarrhea. Some <\/span>research<\/span><\/a> has shown that there is no significant difference in effectiveness between the two. However, other <\/span>studies<\/span><\/a> have shown that Imodium is more effective and better tolerated. Consult your healthcare provider for the best treatment option that\u2019s right for you.\u00a0<\/span><\/p>\n

Can I use Lomotil or Imodium while pregnant?<\/span><\/h3>\n

Some healthcare providers may allow the use of Lomotil or Imodium during pregnancy only if it is necessary. Otherwise, Lomotil and Imodium are not generally recommended during pregnancy due to the possibility of fetal harm. Talk to your healthcare provider about antidiarrheal options while pregnant.\u00a0<\/span><\/p>\n

Can I use Lomotil or Imodium with alcohol?<\/span><\/h3>\n

It is not recommended to drink alcohol while using Lomotil or Imodium. Lomotil and Imodium may cause adverse effects such as drowsiness and dizziness. Drinking alcohol can increase these side effects.\u00a0<\/span><\/p>\n

Why is Lomotil banned?<\/span><\/h3>\n

Lomotil is not a banned drug. However, it is a Schedule V <\/span>controlled substance<\/span><\/a> as classified by the Drug Enforcement Administration. This means that there is a potential for misuse and abuse when using this drug. By itself, diphenoxylate, the main active ingredient of Lomotil, is a Schedule II substance with a higher potential for abuse.\u00a0<\/span><\/p>\n

Can you take Lomotil long-term?<\/span><\/h3>\n

Lomotil is not recommended to be used for more than 10 days for acute diarrhea. In some cases, Lomotil can be used for long-term use, especially for patients with chronic diarrhea. Long-term use of Lomotil should be monitored by a healthcare provider.\u00a0<\/span><\/p>\n

What happens if Imodium doesn’t stop diarrhea?<\/span><\/h3>\n

Imodium should relieve symptoms of mild diarrhea within 48 hours. If your diarrhea isn\u2019t improving after two days, stop taking Imodium and contact a healthcare provider. If you experience any of the following, you should call your healthcare provider immediately:<\/span><\/p>\n

    \n
  • Blood in the stool<\/span><\/li>\n
  • Fever or temperature above 101.3\u00b0F<\/span><\/li>\n
  • Severe abdominal pain<\/span><\/li>\n
  • Passing six or more loose stools per day\u00a0<\/span><\/li>\n
  • Diarrhea that lasts longer than 48 hours<\/span><\/li>\n
  • Symptoms such as severe lightheadedness, confusion, chest pain, or malaise\u00a0<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Lomotil (diphenoxylate\/atropine) and Imodium (loperamide) are two antidiarrheal medications that are used to treat diarrhea. These medications work in similar ways to decrease the number and frequency of bowel movements. Lomotil and Imodium are designed to be taken for short-term diarrhea, which usually resolves within a few days after taking the medication. Although an unpleasant […]<\/p>\n","protected":false},"author":87,"featured_media":10106,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[20948],"coauthors":[8669],"class_list":["post-10105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-diarrhea","wpautop"],"acf":[],"yoast_head":"\nComparing Lomotil & Imodium: Uses, effectiveness, and side effects<\/title>\n<meta name=\"description\" content=\"Learn the differences between Lomotil and Imodium, including their uses, side effects, and which antidiarrheal is best for you.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/lomotil-vs-imodium\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta 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