{"id":11025,"date":"2020-04-28T08:41:00","date_gmt":"2020-04-28T12:41:00","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=11025"},"modified":"2026-04-03T12:16:00","modified_gmt":"2026-04-03T16:16:00","slug":"robaxin-vs-flexeril","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/robaxin-vs-flexeril\/","title":{"rendered":"Robaxin vs. Flexeril: Differences, similarities, and which is better for you"},"content":{"rendered":"

Muscle relaxants are some of the most commonly prescribed medications to treat back pain and other strains or sprains. Robaxin (methocarbamol) and Flexeril (cyclobenzaprine) are examples of skeletal muscle relaxants (SMRs) that your healthcare provider may prescribe if you experience muscle pain.\u00a0<\/span><\/p>\n

Both Robaxin and Flexeril work in similar ways by acting on the central nervous system (CNS). Further classified as antispasmodic agents, Robaxin and Flexeril are effective for treating acute, painful musculoskeletal conditions that cause discomfort and muscle spasms. They also have similar side effects, such as drowsiness and dizziness. Healthcare providers will typically prescribe one of these prescription medications along with other measures such as rest and physical therapy, and sometimes other medication, such as prescription or over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs).<\/span><\/p>\n

What are the main differences between Robaxin and Flexeril?<\/span><\/h2>\n

Robaxin<\/span><\/h3>\n

Robaxin<\/span><\/a>, known by its generic name methocarbamol, was released on the market in the 1960s. While its exact mechanism of action is unknown, methocarbamol is believed to relieve discomfort through its sedative effects. It does not directly affect muscle contractions.<\/span><\/p>\n

Methocarbamol is available as a generic medication in 500 mg or 750 mg oral tablets. The brand name Robaxin is available in injection form but not in oral form.\u00a0<\/span><\/p>\n

Flexeril<\/span><\/h3>\n

The FDA initially approved Flexeril in the 1970s. It primarily works on the brain stem and spinal cord in the CNS, which helps reduce motor activity. Flexeril is also structurally similar to tricyclic antidepressants and has similar side effects, such as dry mouth and sedation.\u00a0\u00a0\u00a0<\/span><\/p>\n

Flexeril<\/a> is commonly known by its generic name, <\/span>cyclobenzaprine<\/span><\/a>. The brand name has been discontinued. However, cyclobenzaprine is available in another brand name, Amrix (extended-release capsules).\u00a0\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between Robaxin and Flexeril<\/span><\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nRobaxin<\/b><\/td>\nFlexeril<\/b><\/td>\n<\/tr>\n
Drug class<\/span><\/td>\nMuscle relaxant<\/span><\/p>\n

Antispasmodic agent<\/span><\/td>\n

Muscle relaxant<\/span><\/p>\n

Antispasmodic agent<\/span><\/td>\n<\/tr>\n

Brand\/generic status<\/span><\/td>\nGeneric oral form is available<\/span><\/td>\nGeneric available;\u00a0<\/span><\/p>\n

Brand-name Flexeril has been discontinued in the U.S.\u00a0<\/span><\/p>\n

Amrix is a brand-name,\u00a0 extended-release formulation of cyclobenzaprine.<\/span><\/td>\n<\/tr>\n

What is the generic name?<\/span><\/td>\nMethocarbamol<\/span><\/td>\nCyclobenzaprine<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/span><\/td>\nOral tablet<\/span><\/p>\n

Injection<\/span><\/td>\n

Oral tablet<\/span><\/p>\n

Oral extended-release capsule<\/span><\/td>\n<\/tr>\n

What is the standard dosage?<\/span><\/td>\nInitial dosage: 1500 mg 4 times daily<\/span><\/p>\n

Maintenance dosage: 1000 mg 4 times daily, 1500 mg 3 times daily, or 750 mg every 4 hours<\/span><\/td>\n

Immediate-release tablets: 5 mg three times daily. Dose may be increased to 10 mg 3 times daily.<\/span><\/p>\n

Extended-release capsules: 15 mg once daily. Dose may be increased to 30 mg once daily.<\/span><\/td>\n<\/tr>\n

How long is the typical treatment?<\/span><\/td>\nShort-term or long-term treatment as directed by your doctor<\/span><\/td>\nUp to 2 or 3 weeks<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/span><\/td>\nAdults and young adults ages 16 years or older<\/span><\/td>\nAdults and young adults ages 15 years or older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by Robaxin and Flexeril<\/span><\/h2>\n

Robaxin and Flexeril are both FDA-approved to relieve discomfort associated with acute, painful musculoskeletal conditions. They are generally prescribed along with other measures, such as rest and physical therapy. Methocarbamol can also be used in combination with other medicines to treat <\/span>tetanus<\/span><\/a>. Cyclobenzaprine is sometimes prescribed <\/span>off-label<\/span><\/a> (for a non-FDA-approved use) for fibromyalgia.\u00a0<\/span><\/p>\n

Robaxin<\/span><\/p>\n