{"id":11520,"date":"2020-05-13T15:47:41","date_gmt":"2020-05-13T19:47:41","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=11520"},"modified":"2026-01-28T13:49:30","modified_gmt":"2026-01-28T18:49:30","slug":"wellbutrin-vs-lexapro","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/wellbutrin-vs-lexapro\/","title":{"rendered":"Wellbutrin vs. Lexapro: Differences, similarities, and which is better for you"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\"><span style=\"font-weight: 400;\">Wellbutrin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> are two prescription medications that are used in the treatment of major depressive disorder, or MDD. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559078\/\"><span style=\"font-weight: 400;\">MDD<\/span><\/a><span style=\"font-weight: 400;\"> is characterized by a low mood for at least two weeks in most situations. People with MDD may exhibit a loss of interest in activities they normally enjoy, low energy, or pain without any known cause. For some, counseling or physical activity may effectively control symptoms of depression, but for many, medication may be needed in addition to those lifestyle changes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Several types of medications treat depression. Wellbutrin is an aminoketone antidepressant that works by increasing available dopamine and norepinephrine, while Lexapro is a selective serotonin reuptake inhibitor (SSRI) that increases available serotonin. While both drugs work to treat depression, they do so by acting on different neurotransmitters which affect mood. Learn more about the differences below.<\/span><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Main differences between Wellbutrin and Lexapro<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Wellbutrin<\/b><\/td>\n<td><b>Lexapro<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Drug class<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Aminoketone antidepressant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Selective serotonin reuptake inhibitor<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Brand\/generic status<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic available<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the generic name?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Bupropion<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Escitalopram<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What form(s) does the drug come in?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Immediate-release, sustained-release, and extended-release tablet<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet and oral solution<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">What is the standard dosage?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">150 mg once per day<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10 mg once per day<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">How long is the typical treatment?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term (months to years)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Long-term (months to years)<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Who typically uses the medication?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults (some off-label use in adolescents)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adolescents and adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"what-are-the-main-differences-between-wellbutrin-and-lexapro\"><span style=\"font-weight: 400;\">What are the main differences between Wellbutrin and Lexapro?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\/what-is\"><span style=\"font-weight: 400;\">Wellbutrin<\/span><\/a><span style=\"font-weight: 400;\"> (bupropion) is a prescription medication indicated in the treatment of MDD and seasonal affective disorder. The active ingredient, bupropion, is also approved for use in smoking cessation in its sustained-release formulation. This was previously marketed under the brand name Zyban. Wellbutrin works as a dopamine and norepinephrine reuptake inhibitor at the neuronal level. This leaves higher levels of each neurotransmitter freely available, and dopamine and norepinephrine levels play an important role in mood and affect.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin is available in immediate-release tablets in 75 mg and 100 mg. The sustained-release tablet indicated for every 12-hour dosing is available in 100 mg, 150 mg, and 200 mg. The extended-release tablet indicated for once every 24-hour dosing is available in 150 mg and 300 mg.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\/what-is\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> (escitalopram) is also a prescription medication indicated for the treatment of MDD. It belongs to the group of antidepressants known as SSRIs. Lexapro works by blocking the reuptake of serotonin at the neuronal membrane transport pump, effectively leaving more free serotonin in the neuron synapse. Other SSRIs you may be familiar with include Prozac, Zoloft, Celexa, or Paxil.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro is available as an oral tablet in strengths of 5 mg, 10 mg, and 20 mg and as an oral solution in a 5 mg\/5 ml concentration.<\/span><\/p>\n<h2 id=\"conditions-treated-by-wellbutrin-and-lexapro\"><span style=\"font-weight: 400;\">Conditions treated by Wellbutrin and Lexapro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Wellbutrin and Lexapro are both indicated in the treatment of major <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">. MDD is characterized by prolonged (2 weeks or more) feelings of low mood and decreased energy levels. It is possible that patients may not find joy in things they enjoyed previously.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro is also indicated in the treatment of generalized <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\"> disorder (GAD). GAD is characterized by prolonged and obsessive worrying about a variety of topics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Bupropion, the active ingredient in Wellbutrin, carries a unique indication for smoking cessation. Although the mechanism is not entirely understood, patients taking bupropion are more likely to be able to achieve smoking cessation. A <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32319681\"><span style=\"font-weight: 400;\">systematic review<\/span><\/a><span style=\"font-weight: 400;\"> of numerous studies with an overall large sample size supports this statement, though patients may experience more adverse events than with other smoking cessation interventions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin and Lexapro are both used off-label in a variety of psychological disorders that are closely related to depression. The following is not intended to be a complete listing of potential uses for Wellbutrin and Lexapro. Only your healthcare professional can diagnose your disorder and decide which treatment option is best for you.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Wellbutrin<\/b><\/td>\n<td><b>Lexapro<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Major depressive disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Seasonal affective disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Smoking cessation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Generalized anxiety disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Attention-deficit disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/conditions\/bipolar-disorder-treatment-and-medications\"><span style=\"font-weight: 400;\">Bipolar depression<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Augmentation of SSRI induced sexual dysfunction<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">ADHD<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Neuropathic pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cocaine dependence<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Amphetamine stimulant use disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Irritability in Autism<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Binge eating disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bulimia nervosa<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Obsessive-compulsive<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ocd-treatment-and-medications\"><span style=\"font-weight: 400;\"> Disorder<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Panic disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/conditions\/ptsd-treatment-and-medications\"><span style=\"font-weight: 400;\">Post-traumatic stress disorder<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Premenstrual dysphoric disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Premature ejaculation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Social anxiety disorder<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"is-wellbutrin-or-lexapro-more-effective\"><span style=\"font-weight: 400;\">Is Wellbutrin or Lexapro more effective?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Researchers have sought to compare Wellbutrin and Lexapro as singular therapies for MDD, and together as dual therapy. One <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16841623\"><span style=\"font-weight: 400;\">trial<\/span><\/a><span style=\"font-weight: 400;\"> evaluated the efficacy of Wellbutrin as a single therapy compared to Lexapro single therapy. This study also sought to compare the prevalence of negative sexual side effects. The results found that Wellbutrin and Lexapro produced similar improvements in depressive symptoms. However, Wellbutrin was significantly less likely to cause sexual dysfunction.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin and Lexapro affect different neurotransmitters and are oftentimes used together. The results of one <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2778329\/\"><span style=\"font-weight: 400;\">clinical trial<\/span><\/a><span style=\"font-weight: 400;\"> found that the use of both drugs together leads to significantly higher response and symptom remission rates as compared to typical monotherapy with SSRIs. While further studies may be warranted, this study suggests some value in dual therapy with both medications.<\/span><\/p>\n<h2 id=\"coverage-and-cost-comparison-of-wellbutrin-vs-lexapro\"><span style=\"font-weight: 400;\">Coverage and cost comparison of Wellbutrin vs. Lexapro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Wellbutrin is a prescription medication typically covered by commercial and Medicare drug plans. The out-of-pocket price for one month of Wellbutrin XL 150 mg can be more than $3,200, but with a coupon from SingleCare, you could get the generic for less than $10.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro is also a prescription medication typically covered by both commercial and Medicare drug plans. Similar to Wellbutrin, the out-of-pocket price for a 30-day supply of Lexapro 10 mg can be as much as $550. SingleCare offers a coupon for generic Lexapro, which lowers the price to $8.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Wellbutrin<\/b><\/td>\n<td><b>Lexapro<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by insurance?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typically covered by Medicare?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Standard dosage<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 150 mg XL tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">30, 10 mg tablets<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Typical Medicare copay<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Less than $10<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Less than $10<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">SingleCare cost<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$10-$27<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8-$21<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"common-side-effects-of-wellbutrin-vs-lexapro\"><span style=\"font-weight: 400;\">Common side effects of Wellbutrin vs. Lexapro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Wellbutrin and Lexapro affect the levels of different neurotransmitters. While their potential to cause certain side effects may be similar, there are some key differences.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro, like other SSRIs, has the potential to cause decreased libido or sex drive. Wellbutrin had no reported incidence of decreased libido. Some researchers estimate that up to <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7182464\/\"><span style=\"font-weight: 400;\">80% of the side effects<\/span><\/a><span style=\"font-weight: 400;\"> of SSRIs are related to sexual dysfunction. Compliance is an important factor in treating depression, so awareness of this side effect is important in managing a patient\u2019s therapy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin causes headaches in as many as a quarter of the patients who take it, while headaches were not reported with Lexapro. Both Wellbutrin and Lexapro may cause nausea, vomiting, sweating, and diarrhea.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following list is not intended to be a complete list of adverse events. Please consult a pharmacist, healthcare provider, or another medical professional for a complete list of possible side effects.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Wellbutrin<\/b><\/td>\n<td colspan=\"2\"><b>Lexapro<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Side effect<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Applicable?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Frequency<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Applicable?<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Frequency<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Asthenia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">13%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dry mouth<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">17%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Sweating<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vomiting<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/conditions\/diarrhea-treatment-and-medications\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8%<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/conditions\/constipation-treatment-and-medications\"><span style=\"font-weight: 400;\">Constipation<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dyspepsia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Somnolence<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Agitation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">26%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Decreased appetite<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Decreased libido<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight loss<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight gain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">n\/a<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Source: Wellbutrin (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a435da9d-f6e8-4ddc-897d-8cd2bf777b21\"><span style=\"font-weight: 400;\">DailyMed<\/span><\/a><span style=\"font-weight: 400;\">) Lexapro (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=13bb8267-1cab-43e5-acae-55a4d957630a\"><span style=\"font-weight: 400;\">DailyMed<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"drug-interactions-of-wellbutrin-vs-lexapro\"><span style=\"font-weight: 400;\">Drug interactions of Wellbutrin vs. Lexapro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Wellbutrin is a major substrate of CYP2B6 and a strong inhibitor of CYP2D6. If co-administration of Wellbutrin and a CYP2D6 substrate is needed, the dose of the 2D6 substrate may need to be decreased. Some examples of CYP2D6 substrates include fluoxetine, sertraline, haloperidol, risperidone, and metoprolol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lexapro is a major substrate of CYP2C19 and CYP3A4 and a weak inhibitor of CYP2D6.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The use of Lexapro with tricyclic antidepressants, such as amitriptyline, may increase the risk of QT prolongation and serotonin syndrome. In general, this combination should be avoided.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The following list is not intended to be a complete list of drug interactions. It is best to consult your provider or pharmacist for a complete list.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug Class<\/b><\/td>\n<td><b>Wellbutrin<\/b><\/td>\n<td><b>Lexapro<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acalabrutinib<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dabrafenib<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Erdafitinib<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gilteritinib<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Ibrutinib<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antineoplastics<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/almotriptan-malate\"><span style=\"font-weight: 400;\">Almotriptan<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/eletriptan-hydrobromide\"><span style=\"font-weight: 400;\">Eletriptan<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Oxitriptan<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5HT Agonist \/ Triptans (antimigraine agents)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/dexmethylphenidate-hcl\"><span style=\"font-weight: 400;\">Dexmethylphenidate<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/methylphenidate-hcl\"><span style=\"font-weight: 400;\">Methylphenidate<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Amphetamines<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/alosetron-hcl\"><span style=\"font-weight: 400;\">Alosetron<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ondansetron\"><span style=\"font-weight: 400;\">Ondansetron<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">Ramosetron<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5HT3 Antagonists<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(anti-nausea agents)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Apixaban<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Edoxaban<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antiplatelets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/aripiprazole\"><span style=\"font-weight: 400;\">Aripiprazole<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">Aspirin<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">Ibuprofen<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen\"><span style=\"font-weight: 400;\">Naproxen<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/diclofenac-sodium\"><span style=\"font-weight: 400;\">Diclofenac<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (NSAIDs)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/atomoxetine-hcl\"><span style=\"font-weight: 400;\">Atomoxetine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Selective norepinephrine reuptake inhibitor (SNRI)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Bemiparin<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/enoxaparin-sodium\"><span style=\"font-weight: 400;\">Enoxaparin<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/heparin-sodium-porcine\"><span style=\"font-weight: 400;\">Heparin<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Anticoagulants<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl\"><span style=\"font-weight: 400;\">Bupropion<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Dopamine\/ norepinephrine reuptake inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/buspirone-hcl\"><span style=\"font-weight: 400;\">Buspirone<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Antianxiety<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/carbamazepine\"><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Anticonvulsant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Enzalutamide<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Chemotherapy<\/span><\/p>\n<p><span style=\"font-weight: 400;\">agent<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/esomeprazole-sodium\"><span style=\"font-weight: 400;\">Esomeprazole<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole\"><span style=\"font-weight: 400;\">Omeprazole<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Proton pump inhibitor<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\"><span style=\"font-weight: 400;\">Fluconazole<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Antifungal<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl\"><span style=\"font-weight: 400;\">Fluoxetine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\"><span style=\"font-weight: 400;\">Duloxetine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/paroxetine-hcl\"><span style=\"font-weight: 400;\">Paroxetine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/sertraline-hcl\"><span style=\"font-weight: 400;\">Sertraline<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">SSRIs<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/hydroxychloroquine-sulfate\"><span style=\"font-weight: 400;\">Hydroxychloroquine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Aminoquinolone\/<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Antimalarial<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/linezolid\"><span style=\"font-weight: 400;\">Linezolid<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Antibiotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclobenzaprine-hcl\"><span style=\"font-weight: 400;\">Cyclobenzaprine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metaxalone\"><span style=\"font-weight: 400;\">Metaxalone<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Muscle relaxers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/pimozide\"><span style=\"font-weight: 400;\">Pimozide<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Antipsychotic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/selegiline-hcl\"><span style=\"font-weight: 400;\">Selegiline<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/phenelzine-sulfate\"><span style=\"font-weight: 400;\">Phenelzine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/rasagiline-mesylate\"><span style=\"font-weight: 400;\">Rasagiline<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Monoamine oxidase inhibitor (MAOI)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/st-johns-wort\"><span style=\"font-weight: 400;\">St. John\u2019s Wort<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Herbal supplement<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/hydrochlorothiazide\"><span style=\"font-weight: 400;\">Hydrochlorothiazide<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/chlorthalidone\"><span style=\"font-weight: 400;\">Chlorthalidone<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metolazone\"><span style=\"font-weight: 400;\">Metolazone<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Thiazide diuretics<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/tramadol-hcl\"><span style=\"font-weight: 400;\">Tramadol<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Opiate pain reliever<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\"><span style=\"font-weight: 400;\">Amitriptyline<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/clomipramine-hcl\"><span style=\"font-weight: 400;\">Clomipramine<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/doxepin-hcl\"><span style=\"font-weight: 400;\">Doxepin<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/nortriptyline-hcl\"><span style=\"font-weight: 400;\">Nortriptyline<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/venlafaxine-hcl\"><span style=\"font-weight: 400;\">Venlafaxine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Selective norepinephrine reuptake inhibitor (SNRI)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"warnings-of-wellbutrin-and-lexapro\"><span style=\"font-weight: 400;\">Warnings of Wellbutrin and Lexapro<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Patients with MDD may experience a worsening of depression or suicidal thoughts whether or not they are taking antidepressant medications. These conditions may worsen until remission is achieved. Wellbutrin and Lexapro therapy may increase suicidal ideation and thoughts among teens and young adults, especially in the early stages of treatment before any type of remission is achieved. These patients must be monitored closely if this treatment is deemed medically necessary. A therapy change may be necessary if symptoms suddenly arise or get worse.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients taking bupropion products for smoking cessation and who have no previous history of depression may experience mental changes when they initiate therapy. These can include mood changes, hallucinations, paranoia, delusions, aggression, and anxiety. If this occurs, speak with your healthcare provider immediately.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In the case of both Wellbutrin and Lexapro, depression symptoms do not start to resolve immediately. Typically, changes in symptoms take a minimum of two weeks to observe, with most patients needing at least four to six weeks to see if the drug impacts their symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Wellbutrin can increase the risk of seizure. This increased risk is dose-dependent, and the maximum total daily dose should not exceed 300 mg. Wellbutrin may also be responsible for increased cardiovascular events. Patients on Wellbutrin may experience increased blood pressure, leading to hypertension, even if they had no previous cardiovascular diagnoses.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Serotonin syndrome, though rare, has been reported with all SSRIs, including Lexapro. This is a condition related to abnormally high levels of serotonin and can result in the patient feeling agitated, dizzy, and having an increased heart rate. This can be brought on by the use of two serotonergic drugs together. It is important to refer to the manufacturer\u2019s information on drug interactions when prescribing these drugs.<\/span><\/p>\n<h2 id=\"frequently-asked-questions-about-wellbutrin-vs-lexapro\"><span style=\"font-weight: 400;\">Frequently asked questions about Wellbutrin vs. Lexapro<\/span><\/h2>\n<h3 id=\"are-wellbutrin-and-lexapro-the-same\"><span style=\"font-weight: 400;\">Are Wellbutrin and Lexapro the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While both Wellbutrin and Lexapro treat depression, they are not the same type of drug. Wellbutrin blocks the reuptake of dopamine and norepinephrine in the neuronal synapse, while Lexapro blocks serotonin reuptake. All of these neurotransmitters play a role in mood and affect.<\/span><\/p>\n<h3 id=\"is-wellbutrin-or-lexapro-better\"><span style=\"font-weight: 400;\">Is Wellbutrin or Lexapro better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In comparative studies, Wellbutrin and Lexapro provided similar improvement rates in depression measurement scales. Wellbutrin may have fewer side effects, specifically related to libido, and therefore, may be the better choice for some patients.<\/span><\/p>\n<h3 id=\"does-lexapro-or-wellbutrin-make-you-gain-weight\"><span style=\"font-weight: 400;\">Does Lexapro or Wellbutrin make you gain weight?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Antidepressant use has generally been related to some weight change with long-term use, though it can be hard to correlate the reason. Many patients experiencing depression experience weight changes before treatment, and this can include both weight loss and weight gain. For some, depression can lead to a loss of appetite and unhealthy weight loss, and by treating depressive symptoms, their appetite may return to normal levels. There is evidence to show that <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/1878922\"><span style=\"font-weight: 400;\">Wellbutrin is less likely to cause weight gain<\/span><\/a><span style=\"font-weight: 400;\"> than serotonergic antidepressants such as Lexapro. Weight management in depression involves many aspects of treatment, and you should discuss weight change concerns with your prescriber.<\/span><\/p>\n<h3 id=\"can-i-use-wellbutrin-or-lexapro-while-pregnant\"><span style=\"font-weight: 400;\">Can I use Wellbutrin or Lexapro while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Wellbutrin is categorized as pregnancy category B by the Food and Drug Administration (FDA), meaning it is generally considered safe during pregnancy. Bupropion and its metabolites do cross the human placenta. Lexapro is pregnancy category C, meaning there have not been adequate human studies to determine efficacy. Animal studies have shown teratogenic effects on the fetus, including cardiovascular effects, and it has been determined that Lexapro crosses the human placenta. For these reasons, the use of Wellbutrin or<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/lexapro-side-effects-in-women\/\"><span style=\"font-weight: 400;\"> Lexapro in pregnancy <\/span><\/a><span style=\"font-weight: 400;\">must be weighed against potential harm to the fetus.\u00a0<\/span><\/p>\n<h3 id=\"can-i-use-wellbutrin-or-lexapro-with-alcohol\"><span style=\"font-weight: 400;\">Can I use Wellbutrin or Lexapro with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol can increase the toxic effects of both Wellbutrin and Lexapro. Drinking alcohol while taking these drugs can cause significant psychomotor impairment, and for this reason, patients are advised to avoid alcohol if taking Wellbutrin or Lexapro. Alcohol specifically lowers the seizure threshold in patients taking Wellbutrin, and patients with a history of seizures should avoid this combination.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Wellbutrin and Lexapro are two prescription medications that are used in the treatment of major depressive disorder, or MDD. MDD is characterized by a low mood for at least two weeks in most situations. People with MDD may exhibit a loss of interest in activities they normally enjoy, low energy, or pain without any known [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":11521,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[9777,4343,451,450],"coauthors":[10437],"class_list":["post-11520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-anxiety","tag-brand-name-drugs","tag-depression","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Wellbutrin vs. Lexapro: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Wellbutrin and Lexapro treat depression, but they work in different ways. 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