{"id":13271,"date":"2020-07-13T14:10:40","date_gmt":"2020-07-13T18:10:40","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=13271"},"modified":"2026-03-06T11:40:42","modified_gmt":"2026-03-06T16:40:42","slug":"allegra-vs-allegra-d","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/allegra-vs-allegra-d\/","title":{"rendered":"Allegra vs. Allegra-D: Differences, similarities, and which is better for you"},"content":{"rendered":"

Drug overview & main differences<\/a> | Conditions treated<\/a> | Efficacy<\/a> | Insurance coverage and cost comparison<\/a> | Side effects<\/a> | Drug interactions<\/a> | Warnings<\/a> | FAQ<\/a><\/p>\n

While shopping for allergy medicine at your local pharmacy, you may reach for Allegra (fexofenadine). Allegra relieves persistent allergy symptoms<\/a> like sneezing and itching. It\u2019s a popular over-the-counter (OTC) option if you\u2019re looking for quick relief. But, you might notice there are two different versions: Allegra and Allegra-D.<\/p>\n

Allegra, or fexofenadine<\/a>, is an FDA-approved antihistamine used to treat seasonal allergies. More specifically, fexofenadine is a second-generation antihistamine<\/a> that can relieve symptoms like sneezing, runny nose, and itchy, watery eyes. It works by blocking the chemical histamine from binding to histamine receptors, which hinders an allergic immune response.<\/p>\n

Read on to learn more about the differences and similarities between Allegra and Allegra-D.<\/p>\n

What are the main differences between Allegra and Allegra-D?<\/h2>\n

You might think they\u2019re practically the same since there\u2019s only a one-letter difference; however, although both versions of Allegra contain fexofenadine, they have an important distinction: Allegra-D<\/a> contains a decongestant called pseudoephedrine. Pseudoephedrine is often taken to relieve nasal congestion or a stuffy nose associated with allergies or the common cold.<\/p>\n

Allegra-D comes in a 12-hour and 24-hour tablet. The 12-hour formulation contains 60 mg of fexofenadine and 120 mg of pseudoephedrine, while the 24-hour formulation contains 180 mg of fexofenadine and 240 mg of pseudoephedrine. Allegra-D is only recommended for adults and children who are 12 years of age or older.<\/p>\n

Regular Allegra comes in an oral tablet, orally-disintegrating tablet, and liquid suspension. The 12-hour tablet contains 60 mg of fexofenadine, while the 24-hour tablet contains 180 mg of fexofenadine. Adults and children who are 12 years of age and older can take Allegra tablets, but there are lower-strength versions available to treat allergic rhinitis in children<\/a> aged 2 to 11 years old.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between Allegra and Allegra-D<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nAllegra<\/strong><\/td>\nAllegra-D<\/strong><\/td>\n<\/tr>\n
Drug class<\/strong><\/td>\nAntihistamine<\/td>\nAntihistamine<\/td>\n<\/tr>\n
Brand\/generic status<\/strong><\/td>\nBrand and generic available<\/td>\nBrand and generic available<\/td>\n<\/tr>\n
What is the generic name?<\/strong>
\n\u00a0<\/strong><\/td>\n		Fexofenadine<\/td>\nFexofenadine and pseudoephedrine<\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/strong><\/td>\nOral tablet
\nOrally disintegrating tablet
\nOral liquid<\/td>\n		Oral tablet, extended-release<\/td>\n<\/tr>\n
What is the standard dosage?<\/strong><\/td>\n30 mg tablet: One tablet by mouth twice daily<\/p>\n

60 mg tablet: One tablet by mouth twice daily<\/p>\n

180 mg tablet: One tablet by mouth once daily<\/td>\n

12-hour tablet: One tablet by mouth twice daily<\/p>\n

24-hour tablet: One tablet by mouth once daily<\/td>\n<\/tr>\n

How long is the typical treatment?<\/strong><\/td>\nShort-term<\/td>\nShort-term<\/td>\n<\/tr>\n
Who typically uses the medication?<\/strong><\/td>\nAdults and children 12 years and older<\/td>\nAdults and children 12 years and older<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by Allegra and Allegra-D<\/h2>\n

Allegra and Allegra-D are allergy medications<\/a> used to treat seasonal allergic rhinitis\u2014also known as hay fever\u2014in adults and children. They can be useful drugs if you experience symptoms after being exposed to allergens like pollen or dust mites.<\/p>\n

Allegra is also approved to treat hives, or urticaria. Many people break out in hives after experiencing an allergic reaction from certain foods or drugs. Allegra can treat chronic urticaria in children as young as 6 months old.<\/p>\n\n\n\n\n\n
Condition<\/strong><\/td>\nAllegra <\/strong><\/td>\nAllegra-D<\/strong><\/td>\n<\/tr>\n
Seasonal allergic rhinitis<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Hives<\/td>\nYes<\/td>\nNo<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Allegra or Allegra-D more effective?<\/h2>\n

Both Allegra and Allegra-D are effective medications for treating allergy symptoms. However, Allegra-D is more suitable for relieving congestion and sinus pressure because of the added pseudoephedrine. Currently, there are no head-to-head trials comparing Allegra and Allegra-D.<\/p>\n

Compared to first-generation antihistamines like Benadryl<\/a> (diphenhydramine<\/a>), Allegra has less sedating side effects. In this regard, Allegra can be considered safer<\/a> than older antihistamines.<\/p>\n

According to a review<\/a> of second-generation antihistamines, Allegra was found to be comparable to drugs like Zyrtec (cetirizine) and Claritin (loratadine) for treating allergic rhinitis. But, Zyrtec may be more effective<\/a> than Allegra for treating hives.<\/p>\n

The best seasonal allergy medicine<\/a> is the one that works best for you and your specific symptoms. Consult with your healthcare provider to find the most effective allergy drug for you. One drug may be better depending on your overall health and other drugs you may be taking.<\/p>\n

Coverage and cost comparison of Allegra vs. Allegra-D<\/h2>\n

Allegra and Allegra-D are over-the-counter (OTC) medicines that are not usually covered by Medicare and insurance plans. Allegra costs about $28 for 30, 180 mg tablets, while Allegra-D costs about $40 for 30, 180 mg 12-hour tablets. If you have a prescription, you can get generic <\/span>Allegra<\/span><\/a> or <\/span>Allegra-D<\/span><\/a> for around $4 and $22, respectively. Check the SingleCare search tool to find out how much you can save at your local pharmacy.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
\n

\u00a0 \u00a0 \u00a0 \u00a0Allegra vs. Allegra-D cost comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nAllegra\u00a0<\/b><\/td>\nAllegra-D<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nNo<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$4 for 30, 180 mg tablets at Walmart<\/span><\/a><\/td>\n$22 for 30, 180 mg 12-hour tablets at Publix<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of March 6, 2026. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/span><\/i><\/small><\/small><\/p>\n

Get the SingleCare prescription discount card<\/b><\/a><\/p>\n

Common side effects of Allegra vs. Allegra-D<\/h2>\n

The most common side effects of Allegra and Allegra-D include headache, nausea, drowsiness, indigestion, and upper respiratory infections. Allegra may also cause painful menstrual cramps (dysmenorrhea).<\/p>\n

Side effects specific to Allegra-D include insomnia, dry mouth, heart palpitations, and nervousness. These unique side effects are caused by the pseudoephedrine in Allegra-D.<\/p>\n

Serious side effects of Allegra are rare but generally involve sensitivity reactions to ingredients in the drug. The pseudoephedrine in Allegra-D may cause severe palpitations or high blood pressure, which may warrant medical attention in those who have preexisting cardiovascular problems.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/td>\nAllegra <\/strong><\/td>\nAllegra-D<\/strong><\/td>\n<\/tr>\n
Side effect<\/strong><\/td>\nApplicable?<\/strong><\/td>\nFrequency<\/strong><\/td>\nApplicable?<\/strong><\/td>\nFrequency<\/strong><\/td>\n<\/tr>\n
Headache<\/td>\nYes<\/td>\n10.6%<\/td>\nYes<\/td>\n13%<\/td>\n<\/tr>\n
Insomnia<\/td>\nNo<\/td>\n–<\/td>\nYes<\/td>\n13%<\/td>\n<\/tr>\n
Upper respiratory tract infection<\/td>\nYes<\/td>\n3.2%<\/td>\nYes<\/td>\n1.4%<\/td>\n<\/tr>\n
Nausea<\/td>\nYes<\/td>\n1.6%<\/td>\nYes<\/td>\n7.4%<\/td>\n<\/tr>\n
Dysmenorrhea<\/td>\nYes<\/td>\n1.5%<\/td>\nNo<\/td>\n–<\/td>\n<\/tr>\n
Drowsiness<\/td>\nYes<\/td>\n1.3%<\/td>\nYes<\/td>\n*<\/td>\n<\/tr>\n
Indigestion<\/td>\nYes<\/td>\n1.3%<\/td>\nYes<\/td>\n2.8%<\/td>\n<\/tr>\n
Dry mouth<\/td>\nNo<\/td>\n–<\/td>\nYes<\/td>\n2.8%<\/td>\n<\/tr>\n
Palpitations<\/td>\nNo<\/td>\n–<\/td>\nYes<\/td>\n1.9%<\/td>\n<\/tr>\n
Nervousness<\/td>\nNo<\/td>\n–<\/td>\nYes<\/td>\n1.4%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*<\/sup>not reported<\/p>\n

This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more about side effects. <\/em><\/p>\n

Source: DailyMed (Allegra<\/a>), DailyMed (Allegra-D<\/a>)<\/p>\n

Drug interactions of Allegra vs. Allegra-D<\/h2>\n

Antacids should be avoided within two hours before or after taking Allegra or Allegra-D. Antacids like Tums (calcium carbonate) or Alka-Seltzer (sodium bicarbonate) can decrease the absorption of fexofenadine and reduce its effectiveness. Grapefruit juice<\/a> has a similar effect on fexofenadine and should also be avoided while taking Allegra or Allegra-D.<\/p>\n

HIV drugs like cobicistat can increase blood concentrations of fexofenadine. Taking Allegra with cobicistat or antivirals may lead to increased side effects such as drowsiness or headache. Other antihistamines<\/a> should not be taken with Allegra since they can also lead to worsened side effects.<\/p>\n

Allegra-D should be avoided while taking tricyclic antidepressants or monoamine oxidase (MAO) inhibitors. The pseudoephedrine in Allegra-D can interact with these other drugs and lead to an increased risk of high blood pressure (hypertension)<\/a> or irregular heartbeat (arrhythmia).<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/strong><\/td>\nDrug class<\/strong><\/td>\nAllegra<\/strong><\/td>\nAllegra-D<\/strong><\/td>\n<\/tr>\n
Calcium carbonate
\nMagnesium hydroxide
\nSodium bicarbonate<\/td>\n		Antacid<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Carvedilol
\nLabetalol
\nNadolol<\/td>\n		Beta-blocker<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Cobicistat
\nDasabuvir
\nEtravirine
\nRitonavir<\/td>\n		Antiviral<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Desloratadine<\/td>\nAntihistamine<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Pioglitazone<\/td>\nAntidiabetic<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Grapefruit juice<\/td>\nFoods<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Rifampin<\/td>\nAntimycobacterial<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Ketoconazole
\nPosaconazole<\/td>\n		Antifungal<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
St. John\u2019s Wort<\/td>\nHerbal<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Amitriptyline
\nNortriptyline
\nClomipramine<\/td>\n		Tricyclic antidepressant<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n
Amlodipine
\nLisinopril
\nMethyldopa
\nReserpine<\/td>\n		Antihypertensive<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n
Selegiline
\nPhenelzine<\/td>\n		MAO inhibitor<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Consult a healthcare professional for other possible drug interactions.<\/em><\/p>\n

Warnings of Allegra and Allegra-D<\/h2>\n

Allegra and Allegra-D should be avoided in those with a known hypersensitivity to either drug\u2019s active ingredients. Otherwise, these drugs may cause an allergic reaction such as a severe rash or trouble breathing (anaphylaxis).<\/p>\n

Allegra and Allegra-D should be avoided in people with kidney disease<\/a>. Since fexofenadine is cleared from the body through the kidneys, altered kidney function may lead to an increased risk of toxicity and adverse effects.<\/p>\n

The use of Allegra-D may need to be avoided or monitored in those with high blood pressure and heart disease. Pseudoephedrine works by constricting blood vessels to reduce congestion. This effect may increase the risk of complications from cardiovascular disease.<\/p>\n

Consult your healthcare provider for other precautions to be aware of before taking Allegra or Allegra-D.<\/p>\n

Frequently asked questions about Allegra vs. Allegra-D<\/h2>\n

What is Allegra?<\/h3>\n

Allegra is the brand name of fexofenadine. It is used to treat hay fever (allergic rhinitis) and hives (urticaria) in adults and children. Allegra can be found over the counter and is available in tablet and liquid formulations.<\/p>\n

What is Allegra-D?<\/h3>\n

Allegra-D contains fexofenadine hydrochloride and pseudoephedrine. It can be purchased over the counter to help relieve allergy symptoms such as runny nose, watery eyes, and nasal congestion. Allegra-D is available as a 12-hour and 24-hour oral tablet.<\/p>\n

Are Allegra and Allegra-D the same?<\/h3>\n

Allegra and Allegra-D both contain fexofenadine HCl. However, they are not the same drug. Allegra-D contains another active ingredient called pseudoephedrine.<\/p>\n

Is Allegra or Allegra-D better?<\/h3>\n

Both Allegra and Allegra-D work for relieving general allergy symptoms. Since Allegra-D contains an added decongestant, it may be better for certain symptoms like congestion or stuffy nose.<\/p>\n

Can I use Allegra or Allegra-D while pregnant?<\/h3>\n

Allegra may be used during pregnancy if the benefits outweigh potential risks to the fetus. Therefore, these drugs should only be used with approval from your healthcare provider. Consult your doctor before using Allegra or Allegra-D during pregnancy.<\/p>\n

Can I use Allegra or Allegra-D with alcohol?<\/h3>\n

While occasional alcohol consumption may be fine while taking a second-generation antihistamine, it is not usually recommended. Alcohol may cause side effects such as dizziness or drowsiness, which can be intensified with an antihistamine<\/a>.<\/p>\n

Does Allegra-D make you sleepy?<\/h3>\n

Allegra-D contains fexofenadine, which has the potential to cause drowsiness. However, this drug also contains pseudoephedrine, which has stimulating effects on the central nervous system (CNS). Allegra-D may cause sleepiness or trouble sleeping, depending on your individual response to the medication. Compared to first-generation antihistamines, Allegra-D will cause less drowsiness.<\/p>\n

Is Allegra-D an over-the-counter drug?<\/h3>\n

Allegra-D is an over-the-counter drug that can be purchased without a prescription. According to federal law, Allegra-D is kept behind the counter at the pharmacy. You may need an ID to purchase it, and there will be a limit to how much you can purchase on a given day.<\/p>\n

Should I take Allegra at night or in the morning?<\/h3>\n

Allegra can be taken at night or in the morning, depending on which time of day you experience the worst symptoms. If you experience worse allergy symptoms at night or early in the morning, you can try taking Allegra in the evening. If you experience worse symptoms throughout the day, you can take it in the morning. Allegra comes in a 24-hour tablet that lasts for the whole day.<\/p>\n","protected":false},"excerpt":{"rendered":"

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ While shopping for allergy medicine at your local pharmacy, you may reach for Allegra (fexofenadine). Allegra relieves persistent allergy symptoms like sneezing and itching. It\u2019s a popular over-the-counter (OTC) […]<\/p>\n","protected":false},"author":87,"featured_media":13274,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[554,802],"coauthors":[8669],"class_list":["post-13271","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-allergies","tag-seasonal-allergies","wpautop"],"acf":[],"yoast_head":"\nAllegra vs Allegra-D: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Allegra and Allegra-D treat allergies but they work in different ways. 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