{"id":14202,"date":"2020-07-22T10:06:13","date_gmt":"2020-07-22T14:06:13","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=14202"},"modified":"2026-01-28T13:45:31","modified_gmt":"2026-01-28T18:45:31","slug":"etodolac-vs-ibuprofen","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/etodolac-vs-ibuprofen\/","title":{"rendered":"Etodolac vs. ibuprofen: Differences, similarities, and which is better for you"},"content":{"rendered":"

Drug overview & main differences<\/a> | Conditions treated<\/a> | Efficacy<\/a> | Insurance coverage and cost comparison<\/a> | Side effects<\/a> | Drug interactions<\/a> | Warnings<\/a> | FAQ<\/a><\/p>\n

No one wants to live with discomfort or pain for extended periods of time, or at all<\/em> for that matter. Fortunately, prescription and over-the-counter pain relievers are accessible at your nearest drug store. While they\u2019re not as strong as opioid pain relievers, which require a more in-depth medical evaluation and prescription, NSAIDs like etodolac or ibuprofen are effective for treating mild to moderate pain.<\/p>\n

Otherwise known as nonsteroidal anti-inflammatory drugs, NSAIDs work by blocking the production of prostaglandins. Your body may respond to certain medical conditions by producing prostaglandins, which are the chemicals responsible for pain, inflammation, and fever. NSAIDs block prostaglandin-producing enzymes\u2014COX-1 and COX-2\u2014to control the body\u2019s inflammatory response and reduce pain.<\/p>\n

Etodolac and ibuprofen are classified as NSAIDs. However, they have some important differences.<\/p>\n

What are the main differences between etodolac and ibuprofen?<\/h2>\n

Etodolac is sometimes known by its (now discontinued) brand name, Lodine. It is available as a generic drug and can only be obtained with a doctor\u2019s prescription.<\/p>\n

Etodolac has a half-life of around six to seven hours and reaches peak concentrations in the blood one to two hours after ingesting it. It is usually taken two to three times daily for pain from arthritis<\/a>. There is also an etodolac extended-release tablet that has a longer half-life of around eight hours and can be taken once daily.<\/p>\n

Ibuprofen is a more common NSAID that is available over-the-counter (OTC). Higher strengths of ibuprofen are also available with a doctor\u2019s prescription. Popular brand names of ibuprofen include Advil, Motrin, and Midol.<\/p>\n

Ibuprofen reaches peak blood levels within one to two hours after taking it. However, unlike etodolac, ibuprofen has a shorter half-life of around two hours<\/a>. Prescription-strength ibuprofen comes in a tablet that\u2019s usually taken three to four times daily. The OTC version comes in oral tablets, capsules, and liquid suspensions.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between etodolac and ibuprofen<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nEtodolac<\/strong><\/td>\nIbuprofen<\/strong><\/td>\n<\/tr>\n
Drug class<\/strong><\/td>\nNonsteroidal anti-inflammatory drugs (NSAID)<\/td>\nNonsteroidal anti-inflammatory drugs (NSAID)<\/td>\n<\/tr>\n
Brand\/generic status<\/strong><\/td>\nGeneric available (brand discontinued)<\/td>\nBrand and generic available<\/td>\n<\/tr>\n
What is the brand name?<\/strong><\/td>\nLodine<\/td>\nAdvil, Motrin, Midol<\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/strong><\/td>\nOral capsule
\nOral tablet
\nOral tablet, extended-release<\/td>\n		Oral capsule
\nOral tablet
\nOral liquid
\nInjection (NeoProfen)<\/td>\n<\/tr>\n
What is the standard dosage?<\/strong><\/td>\nFor pain: 200 to 400 mg every 6 to 8 hours as needed. Do not exceed a maximum dose of 1200 mg per day.<\/p>\n

For osteoarthritis or rheumatoid arthritis: Immediate-release 300 mg two to three times daily or 400 to 500 mg twice daily. Extended-release 400 to 1000 mg once daily. Do not exceed a maximum dose of 1200 mg per day.<\/td>\n

For pain: 200 to 400 mg every 4 to 6 hours as needed. Do not exceed a maximum dose of 1200 mg per day unless directed by a physician.<\/p>\n

For osteoarthritis or rheumatoid arthritis: 400 to 800 mg three to four times daily. Do not exceed a maximum dose of 3200 mg per day.<\/td>\n<\/tr>\n

How long is the typical treatment?<\/strong><\/td>\nTreatment duration depends on health condition, severity of pain, and other factors. Treatment may be short-term or long-term.<\/td>\nTreatment duration depends on health condition, severity of pain, and other factors. Treatment may be short-term or long-term.<\/td>\n<\/tr>\n
Who typically uses the medication?<\/strong><\/td>\nAdults and children 6 years and older<\/td>\nAdults and children 6 months and older<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by etodolac and ibuprofen<\/h2>\n

Etodolac and ibuprofen are labeled to treat pain. They\u2019re commonly taken to treat mild to moderate acute pain from dental procedures, migraines<\/a>, or muscle aches (myalgia).<\/p>\n

Etodolac and ibuprofen are especially useful and FDA approved for treating pain and inflammation from osteoarthritis and rheumatoid arthritis. Higher strengths are usually needed to address more severe joint pain or bone pain associated with arthritis. In some cases, children above the recommended age limit can also be treated with these NSAIDs for juvenile idiopathic arthritis<\/a>.<\/p>\n

Over-the-counter ibuprofen is labeled to treat fever and menstrual cramps (primary dysmenorrhea). An injectable form of ibuprofen called NeoProfen is used to treat patent ductus arteriosus (PDA), a type of heart defect, in premature infants.<\/p>\n\n\n\n\n\n\n\n\n\n\n
Condition<\/strong><\/td>\nEtodolac<\/strong><\/td>\nIbuprofen<\/strong><\/td>\n<\/tr>\n
Pain<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Osteoarthritis<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Rheumatoid arthritis<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Juvenile idiopathic arthritis<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Fever<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n
Primary dysmenorrhea<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n
Patent ductus arteriosus<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is etodolac or ibuprofen more effective?<\/h2>\n

Both etodolac and ibuprofen are effective NSAIDs for pain relief. They both block cyclooxygenase (COX) enzymes to control inflammation and reduce pain in those with arthritis. However, the effects of etodolac last slightly longer. Therefore, some people may prefer etodolac for its lower-frequency dosing.<\/p>\n

In a double-blind study comparing etodolac and ibuprofen<\/a>, 1,446 patients with rheumatoid arthritis were given either 150 mg of etodolac twice daily, 500 mg of etodolac twice daily, or 600 mg of ibuprofen four times daily. Both dosages of etodolac were found to be similar in effectiveness to the ibuprofen dosage. In terms of side effects, those taking etodolac experienced less indigestion, rash, and stomach bleeding than those taking ibuprofen. However, this may be related to the amounts of drug patients were given.<\/p>\n

While no other clinical trials have directly compared etodolac and ibuprofen, different studies have compared other NSAIDs to etodolac or ibuprofen. One meta-analysis found that the maximum daily dose of diclofenac<\/a> is more effective than the maximum daily doses of ibuprofen, naproxen, and celecoxib (but the lowest effective dose of NSAIDs is always recommended). Another meta-analysis found that certain NSAIDs like piroxicam and azapropazone have a high risk of toxicity<\/a> while low-dose ibuprofen has a low risk of toxicity. Overall, it could be said that NSAIDs tend to differ more in safety rather than effectiveness.<\/p>\n

Because of the wide array of options for pain, it\u2019s important to consult a healthcare provider for the best treatment option. A doctor or healthcare provider can provide the appropriate medical advice for specific medical conditions.<\/p>\n

Coverage and cost comparison of etodolac vs. ibuprofen<\/h2>\n

Generic etodolac tablets are usually covered by Medicare and insurance plans. If you have medical conditions like arthritis, insurance plans will likely cover etodolac for pain. The average retail cost of etodolac can vary depending on the dose, but you can pay around $50 for etodolac<\/a> by using a SingleCare coupon at participating pharmacies.<\/p>\n

Since ibuprofen is available over-the-counter, some forms may not be covered by insurance plans. However, most Medicare Part D and insurance plans should cover prescription-strength ibuprofen tablets depending on the treatment regimen. In general, ibuprofen is more affordable than etodolac. Use a SingleCare coupon for ibuprofen<\/a> if you have a prescription from your healthcare provider.<\/p>\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/td>\nEtodolac<\/strong><\/td>\nIbuprofen<\/strong><\/td>\n<\/tr>\n
Typically covered by insurance?<\/strong><\/td>\nYes<\/td>\nYes (prescription-strength tablets)<\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/strong><\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Standard dosage<\/strong><\/td>\n300 mg 2 to 3 times daily<\/td>\n400 to 800 mg 3 to 4 times daily<\/td>\n<\/tr>\n
Typical Medicare copay<\/strong><\/td>\n$0\u2013$76<\/td>\n$0\u2013$22<\/td>\n<\/tr>\n
SingleCare cost<\/strong><\/td>\n$40\u2013$80<\/td>\n$4\u2013$24<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Common side effects of etodolac vs. ibuprofen<\/h2>\n

The most common side effects of NSAIDs, including etodolac and ibuprofen, are nausea, indigestion (dyspepsia), constipation, diarrhea, and abdominal or stomach pain. Other than gastrointestinal side effects, NSAIDs can also cause dizziness, swelling in the hands or feet (edema), headache, rash, and ringing in the ears (tinnitus). Most side effects of etodolac and ibuprofen are mild and go away on their own.<\/p>\n

Serious side effects of NSAIDs may include allergic reactions, such as severe rash or anaphylaxis, from active or inactive ingredients. Other serious side effects include gastrointestinal adverse effects such as stomach bleeding and peptic ulcers<\/a>. Consult your healthcare provider if you experience blood in the stool, weight loss, or severe abdominal pain.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/strong><\/td>\nEtodolac<\/strong><\/td>\nIbuprofen<\/strong><\/td>\n<\/tr>\n
Side effect<\/strong><\/td>\nApplicable?<\/strong><\/td>\nFrequency<\/strong><\/td>\nApplicable?<\/strong><\/td>\nFrequency<\/strong><\/td>\n<\/tr>\n
Nausea<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Abdominal pain<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Indigestion<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Constipation<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Diarrhea<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Dizziness<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Edema<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Headache<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Rash<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n
Tinnitus<\/td>\nYes<\/td>\n1%\u201310%<\/td>\nYes<\/td>\n1%\u20133%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.<\/em><\/p>\n

Source: DailyMed (Etodolac<\/a>), DailyMed (Ibuprofen<\/a>)<\/p>\n

Drug interactions of etodolac vs. ibuprofen<\/h2>\n

Because they block the COX-1 enzyme, which plays a role in platelet production and blood clots, NSAIDs can interfere with the effects of blood thinners. NSAIDs may increase the risk of bleeding from antiplatelet agents like aspirin and anticoagulants like warfarin.<\/p>\n

Etodolac and ibuprofen can cause the body to retain fluid and affect the function of the kidneys. As a result, these NSAIDs can increase blood pressure. If you\u2019re also taking high blood pressure (antihypertensive) medication<\/a>, such as lisinopril or losartan, your blood pressure may need to be monitored while taking an NSAID.<\/p>\n

Etodolac and ibuprofen can affect how cyclosporine, digoxin, or methotrexate are cleared from the body. Taking an NSAID could lead to an increased risk of cyclosporine, digoxin, or methotrexate toxicity.<\/p>\n

Find other possible drug interactions below.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/strong><\/td>\nDrug class<\/strong><\/td>\nEtodolac<\/strong><\/td>\nIbuprofen<\/strong><\/td>\n<\/tr>\n
Aspirin<\/td>\nAntiplatelet<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Warfarin<\/td>\nAnticoagulant<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Lisinopril
\nCaptopril
\nRamipril<\/td>\n		Angiotensin-converting enzyme (ACE) inhibitor<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Losartan
\nValsartan
\nOlmesartan<\/td>\n		Angiotensin receptor blocker (ARB)<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Furosemide
\nHydrochlorothiazide<\/td>\n		Diuretic<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Lithium<\/td>\nMood stabilizer<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Methotrexate
\nPemetrexed<\/td>\n		Antimetabolite<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Cyclosporine<\/td>\nImmunosuppressant<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Digoxin<\/td>\nCardiac glycoside<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Consult a healthcare professional for other possible drug interactions.<\/em><\/p>\n

Warnings of etodolac and ibuprofen<\/h2>\n

Etodolac and ibuprofen, like other NSAIDs, can increase the risk of serious cardiovascular thrombotic events such as heart attack and stroke. NSAID use should be avoided or monitored in people with cardiovascular problems<\/a> like heart failure, heart disease, and high blood pressure.<\/p>\n

The use of etodolac or ibuprofen can lead to an increased risk of serious gastrointestinal (GI) adverse events, such as stomach bleeding and peptic ulcers. Without proper treatment, inflammation, and bleeding in the GI tract can be fatal. Older people may have a higher risk of serious GI adverse events.<\/p>\n

NSAIDs should not be used right before or after a heart procedure called coronary artery bypass graft (CABG) surgery<\/a>.<\/p>\n

Those with kidney disease may be at an increased risk of further kidney problems while taking NSAIDs.<\/p>\n

Consult your healthcare provider for other precautions before taking an NSAID.<\/p>\n

Frequently asked questions about etodolac vs. ibuprofen<\/h2>\n

What is etodolac?<\/h3>\n

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. It is FDA approved to treat osteoarthritis and rheumatoid arthritis in adults. Generic etodolac can only be obtained with a prescription.<\/p>\n

What is ibuprofen?<\/h3>\n

Ibuprofen is commonly known by brand names such as Advil and Motrin. It is available over-the-counter to treat mild to moderate pain, fever, and menstrual cramps. Higher-strength ibuprofen can be obtained with a prescription to treat pain and inflammation from osteoarthritis and rheumatoid arthritis.<\/p>\n

Are etodolac and ibuprofen the same?<\/h3>\n

Etodolac and ibuprofen are not the same. While they\u2019re both NSAIDs, they have differences in dosing and how they\u2019re used. Etodolac is a prescription drug primarily used for adults with arthritis. Ibuprofen is more accessible as an over-the-counter drug for mild pain and fever.<\/p>\n

Is etodolac or ibuprofen better?<\/h3>\n

The better NSAID depends on the dose you take and what you\u2019re taking it for. Compared to ibuprofen, etodolac lasts longer in the body, and thus, it can be taken fewer times throughout the day. However, it may be more expensive than ibuprofen. Based on your overall condition, your doctor may recommend one over the other.<\/p>\n

Can I use etodolac or ibuprofen while pregnant?<\/h3>\n

Etodolac and ibuprofen are not generally recommended during pregnancy. The use of NSAIDs during pregnancy is associated with an increased risk of birth defects or miscarriage, especially during late pregnancy. Consult your healthcare provider if you are considering treatment options while pregnant<\/a>.<\/p>\n

Can I use etodolac or ibuprofen with alcohol?<\/h3>\n

Minimal alcohol consumption may be fine on occasion while taking an NSAID. However, drinking excessive amounts of alcohol can lead to an increased risk of gastrointestinal adverse effects with NSAIDs. Alcohol and NSAIDs<\/a> can irritate the stomach and intestinal lining, which could lead to ulcers or bleeding.<\/p>\n

Is etodolac a pain killer?<\/h3>\n

Etodolac is an effective pain killer. It is most effective for treating pain and inflammation caused by arthritis. It is also useful for treating acute pain after certain procedures such as dental surgery.<\/p>\n

Is etodolac stronger than naproxen?<\/h3>\n

The effectiveness of NSAIDs depends on the dose taken, among other factors. All things being equal, etodolac and naproxen are comparable in terms of effectiveness. According to double-blind studies, etodolac and naproxen are equally effective<\/a> for treating rheumatoid arthritis. Both drugs are also well tolerated in terms of side effects.<\/p>\n","protected":false},"excerpt":{"rendered":"

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ No one wants to live with discomfort or pain for extended periods of time, or at all for that matter. 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