{"id":14827,"date":"2020-08-27T09:00:06","date_gmt":"2020-08-27T13:00:06","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=14827"},"modified":"2020-08-27T10:21:45","modified_gmt":"2020-08-27T14:21:45","slug":"biologics-for-psoriasis","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/biologics-for-psoriasis\/","title":{"rendered":"Everything you need to know about biologics for psoriasis"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">If you\u2019re dealing with dry, itchy skin patches that do not go away, you may need a dermatologist to determine if this inflammation is a rash, eczema, or psoriasis. August is National Psoriasis Awareness Month, a campaign to raise awareness about the skin disorder that affects more than 8 million Americans and 125 million people around the globe, according to the<\/span> <a href=\"https:\/\/www.psoriasis.org\/content\/statistics\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">National Psoriasis Foundation (NPF)<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What is psoriasis?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s a chronic<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/autoimmune-diseases-in-women\/\"><span style=\"font-weight: 400;\">autoimmune<\/span><\/a><span style=\"font-weight: 400;\"> skin disease that speeds up the growth cycle of skin cells, according to the <\/span><a href=\"https:\/\/www.cdc.gov\/psoriasis\/index.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Centers for Disease Control and Prevention (CDC)<\/span><\/a><span style=\"font-weight: 400;\">. Psoriasis causes thick, scaly, patches of either red or silver on white skin, and purple, gray, or dark brown patches on skin of color. It typically affects the elbows, knees, scalp, lower back, face, palms, and soles of the feet. Yet, it can also surface on the fingernails, toenails, and mouth.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common form of this skin disorder\u2014affecting between 80% and 90% of people diagnosed with psoriasis\u2014is plaque psoriasis, which is characterized by painful coin-sized raised patches (or plaques) that tend to crack and bleed, according to the<\/span> <a href=\"https:\/\/www.aad.org\/public\/diseases\/psoriasis\/what\/overview\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">American Academy of Dermatology (AAD)<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPsoriasis is thought to be caused by a genetic predisposition and abnormal immune system signaling that make skin cells grow too quickly, pile on top of one another, and lead to skin changes,\u201d says<\/span> <a href=\"https:\/\/www.mdcsnyc.com\/provider\/brendan-camp-md\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Brendan Camp, MD, FAAD<\/span><\/a><span style=\"font-weight: 400;\">, a double board-certified dermatologist and dermatopathology specialist who practices at Medical Dermatology &amp; Cosmetic Surgery in New York City.\u00a0<\/span><\/p>\n<p><b>Related:\u00a0<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/psoriasis-vs-eczema-vs-dry-skin\/\"><b>Is it just dry skin? Or could it be eczema? Or psoriasis?<\/b><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The<\/span> <a href=\"https:\/\/www.aad.org\/public\/diseases\/psoriasis\/what\/causes\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">AAD<\/span><\/a><span style=\"font-weight: 400;\"> states that while this skin disorder is not contagious, certain triggers can exacerbate symptoms and cause flare-ups, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Stress<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Skin injuries (for example, a deep cut or sunburn)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Certain prescription medications (for example, lithium and<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/prednisolone-vs-prednisone\/\"><span style=\"font-weight: 400;\">prednisone<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Weather (usually cold temperatures and dry conditions)<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Tobacco<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Alcohol\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Psoriasis can also lead to joint and back pain, stiffness, and swelling, a condition called psoriatic arthritis, says <\/span><a href=\"https:\/\/www.riverchasedermatology.com\/providers\/stacy-chimento-md\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Stacy Chimento, MD<\/span><\/a><span style=\"font-weight: 400;\">, a board-certified dermatologist who practices at Riverchase Dermatology in Miami. \u201cUnfortunately, psoriasis is a long-term, chronic condition with no known cure,\u201d she explains\u2014but there are ways to treat it.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Biologics for psoriasis<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Over the past 10 years, biologics have become a promising treatment option for plaque psoriasis. They are an alternative to traditional medications, like topical creams and light therapy.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What are biologics?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cBiologic drugs are manufactured in a living system (such as microorganisms, plant, or animal cells), whereas conventional medications are a combination of specific chemical ingredients,\u201d explains Dr. Chimento. \u201cMore specifically, biologics alter the immune system in a way that disrupts the disease cycle, unlike traditional drugs that work on your whole immune system.\u201d\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How do biologics work for psoriasis?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When it comes to the<\/span> <a href=\"https:\/\/www.singlecare.com\/conditions\/psoriasis-treatment-and-medications\"><span style=\"font-weight: 400;\">treatment of psoriasis<\/span><\/a><span style=\"font-weight: 400;\">, biologics are designed to block either the action of a specific immune cell (known as a T-cell) or proteins within the immune system, such as tumor necrosis factor-alpha (TNF-alpha), interleukin 17-A, or interleukins 12 and 23.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIn psoriasis, abnormal messaging by small proteins called cytokines stimulates skin cells to proliferate quickly,\u201d says Dr. Camp. \u201cBiologics block the messages from being received and quell the associated signs and symptoms of psoriasis.\u201d\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Why use biologics?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Healthcare providers will often prescribe biologics, a type of systemic medication, to patients with moderate to severe psoriasis\u2014those who are assessed with 3% to 10% percent (or more) of the body being affected by the disease, says Dr. Chimento. \u201cEven if psoriasis only affects a small part of your body, it can still be considered severe if it impacts your everyday life,\u201d she continues. A physician may also suggest biologics if traditional medicines (including topical creams, corticosteroids, cyclosporine, and retinoids) failed to manage the symptoms.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How long do you stay on biologics for psoriasis?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Biologic treatments are administered by intravenous (IV) infusion at a doctor\u2019s office or injection (either self-injection or given by your healthcare provider). \u201cSince psoriasis is a chronic condition, patients can typically stay on a biologic indefinitely to control it,\u201d says Dr. Camp. \u201cAlso, taking a biologic continuously is more effective than stopping and starting it as this may cause the medication to lose its efficacy.\u201d In the event where one biologic becomes less effective, a doctor would likely prescribe a different brand.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What are the risks of biologics?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both Dr. Camp and Dr. Chimento point out that because biologic medications suppress the immune system, patients may be more susceptible to serious infections. \u201cIn extremely rare cases, the adverse effects can be life-threatening, including bacterial infections such as tuberculosis, pneumonia, or staph and fungal infections,\u201d adds Dr. Chimento. In fact, it\u2019s imperative to be tested for tuberculosis prior to starting a biologic, and patients who take this class of drugs should not receive live vaccines, Dr. Camp says.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Popular biologic medications for psoriasis<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">These are a few of the popular FDA (Food and Drug Administration) approved biologics on the market today.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Administration route<\/b><\/td>\n<td><b>Standard dosage<\/b><\/td>\n<td><b>Common side effects<\/b><\/td>\n<td><b>Get coupon<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Cosentyx<\/span><span style=\"font-weight: 400;\"> (secukinumab)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">300 milligrams once a week for 4 weeks, then 1 injection every month. 150 milligrams may work for some patients.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cold symptoms, diarrhea, and upper respiratory infections<\/span><\/td>\n<td><span style=\"font-weight: 400;\"><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/cosentyx\">Get coupon<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Skyrizi<\/span><span style=\"font-weight: 400;\"> (risankizumab-rzaa)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">75 milligrams. Initially 2 doses over 4 weeks, then 1 dose every 12 weeks.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Upper respiratory infections, headache, fatigue, injection site reactions, and tinea infection<\/span><\/td>\n<td><span style=\"font-weight: 400;\"><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/skyrizi-150-mg-dose\">Get coupon<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ilumya<\/span><span style=\"font-weight: 400;\"> (tildrakizumab-asmn)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">100 milligrams. Initially 2 doses over 4 weeks, then 1 dose every 12 weeks.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Upper respiratory infections, injection site reactions, and diarrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\"><a class=\"cta-button\" href=\"https:\/\/www.ilumya.com\/\">Learn more<\/a><\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Orencia<\/span><span style=\"font-weight: 400;\"> (abatacept)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection (both prefilled syringe and autoinjector) and IV<\/span><\/td>\n<td><span style=\"font-weight: 400;\">IV Infusion: Weight based dose given every 2 weeks for 3 doses, then every 4 weeks thereafter (Adults weighing less than 60 kg: 500mg, 60 kg &#8211; 100 kg: 750 mg, greater than 100 mg: 1000mg)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Subcutaneous: 125 mg weekly, with or without IV loading dose.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Headache, upper respiratory tract infection, sore throat, and nausea\u00a0\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\"><a class=\"cta-button\" href=\"https:\/\/www.orencia.com\/\">Learn more<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span style=\"font-weight: 400;\">How fast do biologics work?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Patients can expect to notice improvements within 12 weeks with results lasting several months, says Dr. Chimento. \u201cWhile it varies from person to person, someone with a mild case of psoriasis may see symptoms reduced in as fast as one week.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">And the long-term results are impressive. \u201cFor many patients, taking a biologic has been life changing because it helped when other forms of therapy did not,\u201d states Dr. Camp. \u201cSome treatments can provide remission from psoriasis, in which the skin is clear or almost clear.\u201d<\/span><\/p>\n<p><b>RELATED:<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/living-with-psoriasis\/\"> <b>What it\u2019s really like living with psoriasis<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">How much do biologics for psoriasis cost?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">This class of immunosuppressive drugs are among the most expensive medications. \u201cWithout insurance, biologics can cost anywhere from $10,000 to $30,000 annually, depending on the drug and the dose,\u201d says Dr. Chimento. \u201cUnless your condition is severe, your insurance might not cover biologics until you&#8217;ve tried one or more systemic treatments, like methotrexate or retinoids.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Even if you have<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/how-to-get-health-insurance\/\"><span style=\"font-weight: 400;\">health insurance<\/span><\/a><span style=\"font-weight: 400;\">, Dr. Camp adds that numerous pharmaceutical companies offer financial assistance via co-pay assistance programs. SingleCare works with more than 35,000 pharmacies nationwide (including CVS, Target, Walgreens and Walmart) and offers free coupons for additional savings.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you\u2019re dealing with dry, itchy skin patches that do not go away, you may need a dermatologist to determine if this inflammation is a rash, eczema, or psoriasis. August is National Psoriasis Awareness Month, a campaign to raise awareness about the skin disorder that affects more than 8 million Americans and 125 million people [&hellip;]<\/p>\n","protected":false},"author":93,"featured_media":14894,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[790,15105],"coauthors":[9530],"class_list":["post-14827","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-chronic-disease","tag-skincare","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Biologics for psoriasis: Everything you need to know<\/title>\n<meta name=\"description\" content=\"Psoriasis is a chronic skin condition. 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