{"id":16487,"date":"2020-10-21T15:49:39","date_gmt":"2020-10-21T19:49:39","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=16487"},"modified":"2020-10-21T15:49:39","modified_gmt":"2020-10-21T19:49:39","slug":"inmazeb-ebola-treatment","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/news\/inmazeb-ebola-treatment\/","title":{"rendered":"FDA approves first Ebola virus treatment"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">On Oct. 14, the U.S. Food and Drug Administration (FDA) approved its first Ebola treatment, Inmazeb. The treatment is approved for use in adults, children, and the newborns of mothers who have the virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThis approval was made possible because of our steadfast dedication to facilitate the development of safe and effective treatments for infectious diseases as part of our vital public health mission,\u201d said FDA Commissioner Stephen M. Hahn, MD, in an <\/span><a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-treatment-ebola-virus\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">FDA news release.<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">The treatment follows other recent positive news in the fight against Ebola with the FDA approving the first Ebola vaccine, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/ervebo-ebola-vaccine\/\"><span style=\"font-weight: 400;\">Ervebo<\/span><\/a><span style=\"font-weight: 400;\">, in December 2019.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What is the Ebola virus?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The Ebola virus is a very rare, but highly deadly, virus that is transmitted through direct contact with the blood, body fluids, and tissues of infected people or wild animals, as well as any surfaces or materials (bedding, clothing) containing contaminated fluids. The virus leads to widespread fever and inflammation in the body and causes blood clotting problems (causing internal bleeding) and tissue damage.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Most deaths from Ebola are caused by blood vessel damage that leads to leaking that can cause heavy bleeding, low blood pressure, and organ failure.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What is Inmazeb?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Manufactured by Regeneron Pharmaceuticals, Inc., Inmazeb is a cocktail of three lab-created monoclonal antibodies\u2014atoltivimab, maftivimab and odesivimab-ebgn\u2014that mimic the body\u2019s natural immune response to fighting Ebola. The antibodies work by binding the glycoprotein found on the surface of the Ebola virus to help prevent it from attaching to and entering a healthy human cell. Previously, Ebola treatments could only treat the symptoms of Ebola like replacing lost fluids.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A clinical trial of Inmazeb took place in 2018-2019 in the Democratic Republic of Congo during the world\u2019s second largest worst Ebola outbreak. The study found that 33.8% of patients who received Inmazeb died from the virus after 28 days versus 51% of those in the control group, according to an FDA news release. The <\/span><a href=\"https:\/\/www.who.int\/health-topics\/ebola\/#tab=tab_1\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">World Health Organization<\/span><\/a><span style=\"font-weight: 400;\"> reports that Ebola mortality rates can range from 25% to 90%, with an average of 50% depending on the outbreak.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common side effects experienced by patients in the trial included fever, chills, tachycardia (rapid heart rate), tachypnea (fast breathing), and vomiting. These also are common symptoms of Ebola virus infection. In rare instances, hypersensitivity reactions may occur, requiring discontinuation of the medication.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Next steps for the Ebola treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The FDA approval will make it easier for medical organizations to access stockpiles of Inmazeb. In July, Regeneron and the U.S. Biomedical Advanced Research and Development Authority (BARDA) also reached an agreement for Regeneron to deliver a set number of treatment doses to the national stockpile over the next six years. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>On Oct. 14, the U.S. Food and Drug Administration (FDA) approved its first Ebola treatment, Inmazeb. The treatment is approved for use in adults, children, and the newborns of mothers who have the virus. \u201cThis approval was made possible because of our steadfast dedication to facilitate the development of safe and effective treatments for infectious [&hellip;]<\/p>\n","protected":false},"author":85,"featured_media":6927,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589,4114],"tags":[4141],"coauthors":[10392],"class_list":["post-16487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","category-news","tag-fda-approvals","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ebola treatment approved by FDA: Inmazeb<\/title>\n<meta name=\"description\" content=\"On Oct. 14, the FDA 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