{"id":16684,"date":"2020-11-10T13:00:48","date_gmt":"2020-11-10T18:00:48","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=16684"},"modified":"2024-05-28T15:49:06","modified_gmt":"2024-05-28T19:49:06","slug":"tretinoin-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tretinoin-side-effects\/","title":{"rendered":"Learn tretinoin side effects and interactions\u2014and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/tretinoin\"><span style=\"font-weight: 400;\">Tretinoin<\/span><\/a><span style=\"font-weight: 400;\"> is a vitamin A derivative (retinoid) topical cream used to treat skin conditions like acne and facial discoloration. Although it\u2019s mainly used topically on the skin, its oral form can be used with other chemotherapy drugs to treat acute promyelocytic leukemia. Tretinoin is only available by prescription because it\u2019s stronger and more aggressive than a traditional retinol cream. Let\u2019s take a deeper look at tretinoin to understand what it does, its side effects, warnings, and drug interactions.\u00a0\u00a0<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:6849,&quot;3&quot;:{&quot;1&quot;:0},&quot;9&quot;:1,&quot;10&quot;:2,&quot;12&quot;:0,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;}\" data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Common side effects of tretinoin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Even though tretinoin topical creams are great for treating <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/acne-treatment-and-medications\"><span style=\"font-weight: 400;\">acne<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/acne-scar-treatment-and-medications\"><span style=\"font-weight: 400;\">acne scars<\/span><\/a><span style=\"font-weight: 400;\">, fine lines, wrinkles, and skin discolorations, they can still cause side effects, just like any other medication. Here are some of the most common tretinoin side effects:\u00a0\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Blistering<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Crusty skin<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Dry skin<\/span><\/li>\n<li style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/blog\/medications-sun-sensitivity\/\"><span style=\"font-weight: 400;\">Increased sensitivity to the sun<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Itching<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Pain surrounding the treated areas<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Peeling or flaky skin<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Redness<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Scaling of the skin\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Skin irritation<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Skin discoloration<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Stinging or burning<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Swelling<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Worsening of acne<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Many tretinoin side effects, like skin peeling, will go away within <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2699641\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">two to six weeks<\/span><\/a><span style=\"font-weight: 400;\"> of treatment. Once the medication starts to stimulate new collagen production, it can begin to fade dark spots, treat pimples, tighten neck skin, and make the skin look younger overall. It may take anywhere from three to six months for someone to see their sunspots or fine wrinkles start to fade, but this is because tretinoin takes time to become effective.\u00a0\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Serious side effects of tretinoin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Using tretinoin may cause more severe or long-term side effects. If any of the tretinoin side effects listed above become severe, contact your healthcare provider or dermatologist.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unlike some other medications, most of the side effects of tretinoin are skin reactions. Topical tretinoin usually doesn\u2019t cause side effects like hair loss, diarrhea, or weight loss, but it does irritate some people\u2019s skin. Even though tretinoin is a vitamin A derivative, it isn\u2019t stored in the liver, and it <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548568\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">doesn\u2019t cause chronic liver disease<\/span><\/a><span style=\"font-weight: 400;\"> that\u2019s often associated with excessive vitamin A intake.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In rare cases, tretinoin may cause side effects that require medical attention. If you\u2019re using tretinoin and experience eye redness and swelling, severe swelling or burning of the skin, or blistering, it\u2019s best to seek medical advice as soon as possible.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you start to have severe itching, hives, difficulty breathing, swelling of the face or throat, or lightheadedness, you should seek medical attention right away. You may be allergic to tretinoin. Allergic reactions can be life-threatening.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIf side effects are experienced from the use of tretinoin cream, stopping abruptly is absolutely reasonable and recommended,\u201d says Erum Ilyas, MD, a board-certified dermatologist and the founder of <\/span><a href=\"https:\/\/www.montgomery-dermatology.com\/erum-ilyas-md\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Montgomery Dermatology<\/span><\/a><span style=\"font-weight: 400;\">. \u201cOnce the product is discontinued, depending on the severity of the symptoms, it can take upward of a week to resolve completely. To help reduce the inflammation and heal faster, as this can feel like a chemical burn or sunburn at its worst, using topical hydrocortisone found over the counter twice daily for a week can help this clear quickly.\u201d<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Tretinoin warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Just like with any medication, tretinoin comes with warnings that anyone who uses it should be aware of:<\/span><\/p>\n<ul>\n<li><b>Indications: <\/b><span style=\"font-weight: 400;\">Tretinoin is safe for most people to use, but it should be used cautiously by people who have sensitive skin or eczema, as it may irritate their skin.\u00a0<\/span><\/li>\n<li><b>Age restrictions: <\/b><span style=\"font-weight: 400;\">It\u2019s not yet known if tretinoin is safe for children under the age of <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=08ab7e0c-1437-455f-815c-98904d96a289\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">12<\/span><\/a><span style=\"font-weight: 400;\">, but it\u2019s okay for children and adults 12 years of age or older.\u00a0<\/span><\/li>\n<li><b>Pregnancy and nursing: <\/b><span style=\"font-weight: 400;\">Pregnant women and women who are breastfeeding should talk to their dermatologist or healthcare provider about using tretinoin because it\u2019s unknown how it affects fetuses or breastmilk.<\/span><\/li>\n<li><b>Strengths: <\/b><span style=\"font-weight: 400;\">Tretinoin creams (brand names include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/retin-a\"><span style=\"font-weight: 400;\">Retin-A<\/span><\/a><span style=\"font-weight: 400;\"> , <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/avita\"><span style=\"font-weight: 400;\">Avita<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/renova\"><span style=\"font-weight: 400;\">Renova<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/atralin\"><span style=\"font-weight: 400;\">Atralin<\/span><\/a><span style=\"font-weight: 400;\">) are usually available in different strengths such as 0.025%, 0.05%, and 0.1%. A cream with a higher strength may cause more irritation than a cream with a lower strength. For example, 0.025% tretinoin cream is typically used for mild cases of acne, whereas a more potent cream of 0.1% may be used for more serious skin concerns like wrinkles.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Tretinoin interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Don\u2019t use tretinoin in combination with <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Retin-A-Cream-and-Gel-tretinoin-643\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">certain medications<\/span><\/a><span style=\"font-weight: 400;\">. Using tretinoin with any of the following medicines may cause a negative interaction to occur:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Aminolevulinic acid<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Aminolevulinic acid topical<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Benzoyl peroxide<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Isotretinoin<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Methoxsalen<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Methyl aminolevulinate topical<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Porfimer<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Resorcinol<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Salicylic acid<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Sulfur topical<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Verteporfin<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Other skincare and hair products<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Using tretinoin with other acne products should be avoided unless otherwise instructed by a medical professional, according to the United States Food and Drug Administration (<\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/psg\/Tretinoin_Topical%20cream_NDA%20017522_RV%20Nov%202018.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">FDA<\/span><\/a><span style=\"font-weight: 400;\">). Combining products can cause severe skin irritation and dryness. The same goes for using fragrant lotions, peels, harsh exfoliants, astringents, and alcohol-based cleansers or hair removal products simultaneously as tretinoin. You might also avoid trying new make-up during treatment, as you won\u2019t know how your skin could react to it. Your dermatologist will be able to help you pick products that won\u2019t cause additional skin irritation.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Birth control<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tretinoin may interfere with oral contraceptives. If you are taking a birth control pill, let your healthcare provider know. Minipills may not be effective during tretinoin treatment.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How to avoid tretinoin side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">One of the best ways to avoid possible side effects of tretinoin is to follow the drug information located on the package or in the medication guide. If your doctor or dermatologist writes you a prescription for tretinoin and the instructions they give you are different from the manufacturer\u2019s instructions, then it\u2019s best to follow your doctor&#8217;s instructions. <\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How to use tretinoin<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Here are some best practices when using tretinoin products:\u00a0<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Tretinoin is typically applied once per day in the evening.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Apply tretinoin to affected areas in a thin layer on clean and dry skin. You should wait up to 30 minutes before applying tretinoin after cleaning your skin.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Once the cream absorbs into the skin, apply a moisturizer to soothe the skin and combat potential dryness.<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Applying excessive amounts of tretinoin onto the skin to make acne go away faster will not work. This can make the skin worse by causing extreme dryness, peeling, or redness.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">It may take up to six weeks of tretinoin treatment to see results.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\"><span style=\"font-weight: 400;\">Make sure to use sunscreen, especially in the summertime. Exposure to the sun can worsen peeling and other side effects.\u00a0<\/span><\/li>\n<\/ol>\n<p>Note: <span style=\"font-weight: 400;\">Tretinoin should never be applied and then washed off because it\u2019s meant to soak into the skin where it can start to work on problem areas. It\u2019s unsafe to use tretinoin under the eyes or on the lips. It\u2019s too strong for these sensitive areas and could cause serious <\/span><span style=\"font-weight: 400;\">eye irritation<\/span><span style=\"font-weight: 400;\"> if it gets in or near the eyes.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How do I stop tretinoin purging?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some people will experience tretinoin purging when they first start using it. Tretinoin purging is when the skin gets worse before it gets better. Tretinoin speeds up the skin cell turnover process, causing some initial breakouts, drying, and peeling. These symptoms eventually go away and leave clearer skin underneath. You can use a good moisturizer, stay hydrated, and use a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/does-sunscreen-expire\/\"><span style=\"font-weight: 400;\">sunscreen with at least SPF 30<\/span><\/a><span style=\"font-weight: 400;\"> to prevent tretinoin purging, but it may not be possible to avoid it entirely.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How often to use tretinoin<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Tretinoin is safe to use every day, but using it often may cause irritation for some people. If you\u2019re finding that daily use of tretinoin is irritating your skin, you might try using it every other day or every couple of days until the skin adjusts. Using too much tretinoin at one time can also cause irritation, so you could always try applying less of the cream each time you apply it.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Apply tretinoin to clean skin, followed by a moisturizer. Using a moisturizer after applying tretinoin will help prevent dry skin that many people experience from the product.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Even though tretinoin is a strong topical medication, it\u2019s generally considered <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16060712\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">safe and effective<\/span><\/a><span style=\"font-weight: 400;\"> for long-term use. Most people can expect to see results within four to six weeks and will continue to see results for as long as they use it. While it\u2019s possible for tretinoin to eliminate some dark spots and discolorations, it\u2019s also possible for acne to come back once discontinuing tretinoin. Tretinoin only treats the symptoms of acne. It can\u2019t cure what\u2019s causing acne or change how someone&#8217;s skin behaves. Everyone will react to the medication a little bit differently.\u00a0\u00a0\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">When can I stop using tretinoin?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The amount of time someone needs to use tretinoin will vary on a case-by-case basis. Some people\u2019s skin will clear up faster than others, which means they\u2019ll use it for a shorter amount of time. Other people may have to use tretinoin longer to eliminate stubborn skin problems like dark spots or wrinkles. Most people stop taking tretinoin when their skin clears up or if it isn&#8217;t working after trying it for a while. A dermatologist is the best person to ask about when to start or stop taking tretinoin.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tretinoin is a vitamin A derivative (retinoid) topical cream used to treat skin conditions like acne and facial discoloration. Although it\u2019s mainly used topically on the skin, its oral form can be used with other chemotherapy drugs to treat acute promyelocytic leukemia. Tretinoin is only available by prescription because it\u2019s stronger and more aggressive than [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":16733,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[650,12752],"coauthors":[8861],"class_list":["post-16684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-acne","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Tretinoin side effects and interactions, and how to avoid them<\/title>\n<meta name=\"description\" content=\"The best way to prevent tretinoin side effects (skin irritation, dryness, tretinoin purging) is to use it correctly. 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