{"id":17846,"date":"2021-01-07T10:00:13","date_gmt":"2021-01-07T15:00:13","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=17846"},"modified":"2024-03-07T16:36:35","modified_gmt":"2024-03-07T21:36:35","slug":"gout-triggers","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/gout-triggers\/","title":{"rendered":"Understanding risk factors for gout and gout flares"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">You wake one morning to severe throbbing pain and swelling in your big toe. The toe joint is swollen and stiff. When you went to bed, you felt fine. Now you\u2019re in agony. What\u2019s going on?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You might be one of the <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2787544\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">9.2 million<\/span><\/a><span style=\"font-weight: 400;\"> Americans with gout, a form of arthritis that can cause inflammation and severe pain in the joints. The condition is characterized by <\/span><a href=\"https:\/\/www.hopkinsarthritis.org\/arthritis-info\/gout\/clinical-presentation-of-gout\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">painful flares<\/span><\/a><span style=\"font-weight: 400;\">, often occurring at night, that can last for days to weeks, with the worst pain usually building in the first 24 hours. Other symptoms of gout include warmth and redness of the skin around the joint and difficulty using the joint.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When it comes to preventing gout, recognizing risk factors, seeking treatment early, and doing your best to avoid triggers are essential first steps. According to the American College of Rheumatology treatment guidelines, <\/span><a href=\"https:\/\/rheumatology.org\/patients\/gout\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">keeping uric acid levels in the blood below 6 mg\/dl<\/span><\/a><span style=\"font-weight: 400;\"> is important to prevent gout flares. Although flares are temporary, they are painful\u2014but in the long term, gout can cause other issues.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cHyperuricemia and gout are long-term medical problems,\u201d says <\/span><a href=\"https:\/\/mdmercy.com\/centers-of-excellence\/additional-centers\/rheumatology\/our-doctors\/lynn-ludmer-md\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lynn Ludmer, MD<\/span><\/a><span style=\"font-weight: 400;\">, medical director of rheumatology at Mercy Medical Center in Baltimore. \u201cOver time, untreated gout can lead to chronic inflammation and joint damage, which may be permanent.\u201d<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What causes gout?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For centuries, doctors thought gout was predominantly caused by diet. In fact, gout was often called \u201cthe disease of kings\u201d because it was associated with a diet heavy on rich foods and meats as well as alcohol\u2014a diet only the wealthy class could afford.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Scientists now know that the leading cause of gout is genetics, and having a family history of the condition is the most significant risk factor. \u201cPeople should understand that gout is genetic and not their \u2018fault\u2019 just because of their diet,\u201d says <\/span><a href=\"https:\/\/www.hss.edu\/physicians_fields-theodore.asp\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Theodore R. Fields, MD, FACP<\/span><\/a><span style=\"font-weight: 400;\">, a rheumatologist at New York City\u2019s Hospital for Special Surgery. \u201cDietary and lifestyle changes will definitely help, but in only a small number of gout patients are they enough.\u201d<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">8 common risk factors for hyperuricemia and gout<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While genetics are the main risk factor for hyperuricemia and gout, there are other contributors. Here are eight common risk factors for gout. Knowing these\u2014and how to address them\u2014can help you prevent and\/or manage the condition and avoid flare-ups from occurring.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Obesity\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The more you weigh, the harder your kidneys have to work to eliminate waste products like uric acid from your body. In one <\/span><a href=\"https:\/\/www.reuters.com\/article\/us-health-gout-prevention\/obesity-drinking-and-unhealthy-diet-add-to-gout-risk-idUSKBN1W52AA\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\">, published in the journal <\/span><i><span style=\"font-weight: 400;\">Arthritis and Rheumatology<\/span><\/i><span style=\"font-weight: 400;\">, people who were overweight had an 85% greater risk of having hyperuricemia (a precursor to gout) versus healthy-weight people. Obese people were up to 3.5 times more likely than normal-weight individuals to have excess uric acid. The researchers also found that 44% of hyperuricemia cases were attributable to excess weight alone.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Certain foods<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because of their higher purine content, some foods can raise uric acid levels in the blood. They include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Red meat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatty meats, such as bacon<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Organ meats\u2014for example, kidneys, liver, and tripe<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain kinds of seafood, including salmon, sardines, and anchovies; and shellfish, such as mussels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High fructose corn syrup (found in an array of products, particularly sugary drinks like sodas)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcoholic beverages, which contribute to gout not just because of their purine content, but because they also make it harder for the kidneys to excrete excess uric acid<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">So, how much of these foods is okay to have? \u201cWe don\u2019t object to an occasional drink at a special occasion or a small amount of red meat or shrimp, but less is better,\u201d Dr. Fields says. \u201cIt is a quantitative issue, so we advise having as little as you can. Fortunately, a gout diet is a healthy diet, so it\u2019s a net gain in general health to follow a gout-friendly diet.\u201d<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. High blood pressure\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People with high blood pressure (hypertension) have a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3464949\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">2-to-3 fold increased<\/span><\/a><span style=\"font-weight: 400;\"> risk of developing hyperuricemia and gout. What\u2019s more, the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/dehydration-medication\/\"><span style=\"font-weight: 400;\">diuretics<\/span><\/a><span style=\"font-weight: 400;\"> (medications used to increase urination) that are often prescribed to treat high blood pressure can contribute to the problem by <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/gout\/expert-answers\/diuretics-and-gout\/faq-20058146\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">decreasing the amount of uric acid<\/span><\/a><span style=\"font-weight: 400;\"> that\u2019s excreted in urine. Although <\/span><a href=\"https:\/\/arthritis-research.biomedcentral.com\/articles\/10.1186\/s13075-022-02933-4\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">studies have shown<\/span><\/a><span style=\"font-weight: 400;\"> that hypertension does not cause gout, they suggest that managing gout could prevent the risk of developing high blood pressure.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Certain medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In addition to diuretics, other <\/span><a href=\"https:\/\/academic.oup.com\/rheumatology\/article\/56\/5\/679\/2631573\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">medications<\/span><\/a><span style=\"font-weight: 400;\"> that can increase the amount of uric acid or decrease their excretion include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin-adult-low-dose\/what-is\"><span style=\"font-weight: 400;\">Low-dose aspirin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immunosuppressant drugs\u2014for example, those used to prevent organ rejection in transplant patients<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drugs used to treat tuberculosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nicotinic acid, used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/niacin\/what-is\"><span style=\"font-weight: 400;\">niacin<\/span><\/a><span style=\"font-weight: 400;\"> deficiencies (niacin is a B vitamin)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">5. Diabetes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It\u2019s a double-edged sword: <\/span><a href=\"https:\/\/gouteducation.org\/health-conditions\/gout-and-diabetes\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">The Gout Education Society<\/span><\/a><span style=\"font-weight: 400;\"> notes that insulin resistance (a major risk factor for Type 2 diabetes) can lead to gout, and having too-high levels of uric acid in your blood can lead to insulin resistance. The group reports that 26% of people with gout have Type 2 diabetes.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Gender<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Men have a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2860089\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">fourfold increased risk<\/span><\/a><span style=\"font-weight: 400;\"> of developing gout versus women. It seems that the female hormone estrogen helps women keep uric acid levels in check, but that protection starts to fade once menopause hits and estrogen drops. \u201cThere are theories about why estrogen may protect women, including that the kidneys may excrete more uric acid in the presence of estrogen,\u201d explains Dr. Ludmer.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Age<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Gout risk tends to rise with age. That may be because many of the risk factors associated with gout\u2014diabetes, obesity, and high blood pressure\u2014also tend to rise as we age. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2860089\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Men are most likely to develop gout between 40 and 60. For women, it\u2019s 60 to 80 years of age.<\/span><\/a><span style=\"font-weight: 400;\"> Women are able to stave off the disease a bit longer due to the aforementioned protective effects of estrogen.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Trauma to joints<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People who had an injury to or surgery on a joint are more likely to develop gout in that area. \u201cWe know that physical stress can set off gout flares,\u201d says Dr. Fields. \u201cFor example, some people get a gout flare after running. It\u2019s thought that trauma on the big toe actually releases some of the uric acid crystals in the joint lining into the joint fluid, causing inflammation.\u201d<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">6 triggers for acute gout flare-ups<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There\u2019s nothing you can do about your genetics, but you can make healthy lifestyle changes that may help reduce the likelihood of gout flare-ups. Common gout triggers include:<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dehydration: <\/b><span style=\"font-weight: 400;\">The Arthritis Foundation recommends <\/span><a href=\"https:\/\/www.arthritis.org\/health-wellness\/healthy-living\/nutrition\/healthy-eating\/gout-diet-dos-and-donts\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">drinking at least eight glasses of non-alcoholic beverages (preferably water) per day<\/span><\/a><span style=\"font-weight: 400;\">. And if you\u2019re in the midst of a gout attack, double that amount to help flush excess uric acid from your system.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alcohol: <\/b><span style=\"font-weight: 400;\">One alcoholic beer can raise uric acid levels by 6.5%; a nonalcoholic beer can by 4.4%.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stress: <\/b><span style=\"font-weight: 400;\">Experts aren\u2019t sure how, or even <\/span><i><span style=\"font-weight: 400;\">if<\/span><\/i><span style=\"font-weight: 400;\">, stress can lead to gout\u2014but they do know that emotional stress can often lead people to eat and drink more, thus putting them at greater risk of gout.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Certain foods:<\/b><span style=\"font-weight: 400;\"> In addition to limiting foods that can trigger gout, consider adding foods that may help promote the excretion of uric acid and\/or have anti-inflammatory properties. According to the Arthritis Foundation, some of those foods include:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Low-fat dairy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Coffee<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Foods rich in vitamin C (choose those that also are low in the naturally occurring sugar fructose, such as citrus fruits and strawberries)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Non-meat-based proteins, such as peas, lentils, tofu, and leafy green vegetables<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Tart cherries<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hospitalization: <\/b><span style=\"font-weight: 400;\">People with gout are <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6072557\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">10 times more likely<\/span><\/a><span style=\"font-weight: 400;\"> to experience a gout flare during a hospital stay due to stopping gout medications and fluid shifts.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Medications: <\/b><span style=\"font-weight: 400;\">Certain prescriptions, like diuretics, can increase the risk of a gout attack.<\/span><\/li>\n<\/ol>\n<h2><span style=\"font-weight: 400;\">How to treat an acute gout attack<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re experiencing gout pain, see your healthcare provider. \u201cEven if you don\u2019t need medication, you can talk about diet and possible weight loss and discuss when gout needs more aggressive management,\u201d Dr. Fields advises.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Home remedies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Self-help measures that may ease the pain of an acute flare include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ice and elevate the affected joint<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drink lots of water<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Limit activity<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Medication<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cIn people with two or more flares of gout in a year, or gout with a history of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/kidney-stone-treatment-and-medications\"><span style=\"font-weight: 400;\">kidney stones<\/span><\/a><span style=\"font-weight: 400;\"> or decreased kidney function, or gout with tophi [deposits of uric acid under the skin around joints that resemble knobby growths], then they need their uric acid lowered with medication,\u201d explains Dr. Fields.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To treat your flare, your healthcare provider may recommend a short course of anti-inflammatory medications as below:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/is-tylenol-an-nsaid\/\"><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs<\/span><\/a><span style=\"font-weight: 400;\"> (NSAIDs) to reduce pain and swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/colchicine\/what-is\"><span style=\"font-weight: 400;\">Colchicine<\/span><\/a><span style=\"font-weight: 400;\">, which decreases swelling and the buildup of uric acid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Corticosteroids to reduce pain and inflammation. These may be taken by mouth or given via injection.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">To help lower uric acid levels in your body and prevent future attacks, you might receive the following long-term oral medications:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/allopurinol\"><span style=\"font-weight: 400;\">Zyloprim (allopurinol)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/uloric\"><span style=\"font-weight: 400;\">Uloric (febuxostat)<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/probenecid\"><span style=\"font-weight: 400;\">Probalan (probenecid)<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Or you might receive Krystexxa (pegloticase), a drug for IV infusions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is important to keep in mind that your healthcare provider may continue to prescribe a short-term anti-inflammatory medication like colchicine for the first three to six months after they begin prescribing the uric acid-lowering medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cPatients should have an open mind when discussing the possibility of taking medication for gout with their doctor,\u201d Dr. Fields advises. \u201cThe opportunity to be \u2018cured\u2019 of gout is very high if you stay on a medication such as allopurinol.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>You wake one morning to severe throbbing pain and swelling in your big toe. The toe joint is swollen and stiff. When you went to bed, you felt fine. Now you\u2019re in agony. What\u2019s going on? You might be one of the 9.2 million Americans with gout, a form of arthritis that can cause inflammation [&hellip;]<\/p>\n","protected":false},"author":94,"featured_media":55943,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8029],"tags":[12164,19027,11278],"coauthors":[10462],"class_list":["post-17846","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-education","tag-arthritis","tag-home-remedies","tag-singlecare-for-seniors","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>8 gout risk factors and how to prevent flare-ups<\/title>\n<meta name=\"description\" content=\"Age, gender, and certain foods are all risk factors that can lead to gout. 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