{"id":18151,"date":"2021-02-02T15:27:08","date_gmt":"2021-02-02T20:27:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=18151"},"modified":"2025-04-09T18:28:30","modified_gmt":"2025-04-09T22:28:30","slug":"zoloft-side-effects-first-week","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/","title":{"rendered":"Zoloft side effects to expect in the first week"},"content":{"rendered":"<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jxMSrZsGgEI?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">Living with mental health conditions like anxiety or depression can make daily life stressful. An estimated<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/anxiety-statistics\/\"> <span style=\"font-weight: 400;\">31%<\/span><\/a><span style=\"font-weight: 400;\"> of all adults will experience an anxiety disorder at some point in their lives, and statistics show that 264 million adults around the globe have anxiety. In addition, approximately 280 million people around the world are living with depression. There can be an overlap between the disorders, meaning that a person can suffer from both simultaneously. Luckily, there are many treatment options available for people who seek relief from anxiety or depression. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> (sertraline) is a prescription medication used to reduce symptoms of anxiety and depression, and when taken properly, it can make daily life more manageable. Let\u2019s take a more in-depth look at how to take Zoloft, what side effects to look out for in the first week, and what else to expect when starting this medication.\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Zoloft with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tZoloft 50 mg (1 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\" class=\"coupon-see-all-btn\">See Zoloft prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\/what-is\"><b>What is Zoloft?<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/a><\/p>\n<h2 id=\"starting-zoloft\"><span style=\"font-weight: 400;\">Starting Zoloft<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u00a0Zoloft is available in tablet form in dosage strengths of 25 mg, 50 mg, or 100 mg. It\u2019s also available as an oral solution, which must be diluted into four ounces of water, orange juice, lemonade, ginger ale, or lemon\/lime soda before consumption. Your prescriber will typically start at a lower dose and slowly taper up to the right dose for you.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The standard dose of Zoloft for anxiety is 25 mg to 50 mg per day, and for depression, it is 50 mg per day. Depending on your diagnosis and symptoms, your prescriber may go up to as much as 200 mg per day. Zoloft may also be used for obsessive-compulsive disorder (OCD), panic disorder, premenstrual dysphoric disorder (PMDD), and social phobia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It\u2019s important to talk with your healthcare provider about what dosage is right for you because the exact amount of medication you\u2019ll need will vary based on your specific condition, how severe your symptoms are, and whether or not you have any other health problems.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft is typically given once daily. The manufacturer does not specify whether it should be taken in the morning or at night, just that it should be taken at the same time each day. If you find that Zoloft makes you sleepy, taking<\/span><a href=\"https:\/\/www.health.harvard.edu\/mind-and-mood\/antidepressant-side-effects-feeling-better-but-not-quite-right\"><span style=\"font-weight: 400;\"> your dose at night<\/span><\/a><span style=\"font-weight: 400;\"> may be best.\u00a0<\/span><\/p>\n<h3 id=\"how-long-does-it-take-for-zoloft-to-work\"><span style=\"font-weight: 400;\">How long does it take for Zoloft to work?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Once you start taking Zoloft in the right amount as prescribed by your healthcare provider, you can expect it to start showing some improvement in about <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279594\/\"><span style=\"font-weight: 400;\">two to six weeks<\/span><\/a><span style=\"font-weight: 400;\">. Zoloft isn\u2019t the type of medication that will start working on the first day, so you\u2019ll need a little patience while waiting for it to start improving your symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to the <\/span><a href=\"https:\/\/www.nami.org\/About-Mental-Illness\/Treatments\/Mental-Health-Medications\/Types-of-Medication\/Sertraline-(Zoloft)\"><span style=\"font-weight: 400;\">National Alliance on Mental Illness<\/span><\/a><span style=\"font-weight: 400;\">, some of the earliest signs Zoloft is working are improvements in sleep, energy, or appetite. These improvements could happen as soon as one to two weeks into taking the medication. More significant changes, like alleviating symptoms of depression or regaining interest in daily life and physical activity, may take six to eight weeks to show up.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=c158b751-6957-44fb-bd40-73f25c9f171f\"><span style=\"font-weight: 400;\">should not discontinue Zoloft abruptly<\/span><\/a><span style=\"font-weight: 400;\">, as it can cause worsened anxiety, agitation, confusion, headache, and insomnia. If you feel Zoloft is not right for you, your healthcare provider may ask you to give the drug more time, consider a new dose, or they may suggest transitioning to a different medicine. This is a decision you should make with your doctor.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When you first start taking Zoloft, you may begin to notice a few possible side effects. Let&#8217;s look at some of the most common side effects of Zoloft you\u2019ll want to be aware of when you start taking it.<\/span><\/p>\n<h2 id=\"zoloft-side-effects-to-expect-in-the-first-week\"><span style=\"font-weight: 400;\">Zoloft side effects to expect in the first week<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">During the first week of Zoloft treatment, you may experience some initial side effects even if you\u2019re taking the medication exactly as prescribed by your healthcare provider. This happens because it takes time for the body to become used to the medication. Some of the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/sertraline-side-effects\/\"><span style=\"font-weight: 400;\">most common side effects<\/span><\/a><span style=\"font-weight: 400;\"> that people have during their first week of taking Zoloft include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sleepiness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased sex drive\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased sweating<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It is estimated that up to <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11431487\/\"><span style=\"font-weight: 400;\">40%<\/span><\/a><span style=\"font-weight: 400;\"> of people discontinue their antidepressant within the first 30 days of taking it. This is thought to be associated with the fact that you will likely experience side effects before you see improvement in systems of depression or other conditions. Knowing what to expect as therapy begins and having an open dialogue with your prescriber about your concerns is important. Do not abruptly stop treatment without speaking to your prescriber.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For some of these physical side effects, men and women may experience them at a different rate or intensity. For example, a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9292833\/#:~:text=Men%20showed%20more%20incidence%20of%20sexual%20dysfunction%20than,at%20all%20by%20the%20end%20of%20this%20period.\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> evaluating SSRI-induced sexual dysfunction found that men suffer from sexual dysfunction related to this class of drugs more often than women, but when women do, it is more intense. Sexual dysfunction can be characterized by decreased libido, delayed orgasm, delayed or inability to ejaculate, and impotence.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Women also have to be concerned with the effects of Zoloft on their unborn child if they take this medication during pregnancy. Zoloft has been linked to cardiac defects as well as defects in the formation of the baby\u2019s skull. Zoloft is not recommended during pregnancy unless the benefits outweigh the risks, especially in the last trimester.<\/span><\/p>\n<h3 id=\"can-zoloft-make-you-feel-worse-at-first\"><span style=\"font-weight: 400;\">Can Zoloft make you feel worse at first?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Zoloft does not provide immediate relief of symptoms, and for some, it may leave you wondering if what you are feeling is worse than before you started the medication. Depending on what primary condition you are treating, you may have a different response and timeline for improvement than others. There is <\/span><a href=\"https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(19)30366-9\/fulltext\"><span style=\"font-weight: 400;\">data<\/span><\/a><span style=\"font-weight: 400;\"> to suggest that Zoloft begins helping with anxiety symptoms in the first few weeks after you start treatment. Relief from depressive symptoms may not come until closer to the 12-week mark. While depression and anxiety often go hand-in-hand, the delay in improvement of depression may leave you feeling \u201cworse\u201d than you did initially.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft is known to increase suicidal thoughts in teens and young adults, and this is especially true when anxiety and depression are uncontrolled. It is important for a family member or close friend to monitor this group of patients closely, as their risk for these thoughts is highest until their anxiety and depression are better controlled.<\/span><\/p>\n<h3 id=\"how-long-do-zoloft-side-effects-last\"><span style=\"font-weight: 400;\">How long do Zoloft side effects last?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking Zoloft may make you feel uncomfortable or weird at first as your body starts to process the medication. After a week or two, these side effects will go away for most people as their bodies get used to the medication. It\u2019s possible to experience some of these side effects sporadically throughout the duration that you\u2019re taking Zoloft, especially if your provider increases your dose. If they increase the dose, it will take a couple of weeks for your body to appreciate the new dose fully. From there, it can be several more weeks before you may see an improvement in symptoms. Most healthcare professionals will allow for 4-8 weeks between dose adjustments to ensure the new dose&#8217;s full effect is realized.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may be wondering if you should discuss your drug therapy with those around you. Your family and friends have likely noticed the impact depression and anxiety can have on you, but the decision to share your treatment choice is absolutely up to you. Yes, some of the side effects of drug therapy may also be noticeable. Like untreated anxiety and depression, the effects of drug therapy can also impact your daily functioning. Speak to your healthcare professional about the best way to handle any potential impacts on your job or performance of daily activities. While your boss at work should not hold against you that you are seeking treatment for your disorder, you may not feel comfortable sharing this information. Your doctor will be able to walk you through the best options for treating your disorder while maintaining performance expectations and maintaining your privacy.<\/span><\/p>\n<h3 id=\"serious-side-effects-of-zoloft\"><span style=\"font-weight: 400;\">Serious side effects of Zoloft<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although it\u2019s rare, Zoloft can cause more serious side effects like:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual weight loss\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sodium levels\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">An increased risk of bleeding\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye pain that indicates angle-closure glaucoma\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sexual dysfunction, such as delayed ejaculation\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Manic episodes for people with undiagnosed bipolar disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reactions\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures\u00a0<\/span><\/li>\n<\/ul>\n<h4 id=\"black-box-warning-zoloft-and-suicidal-thoughts\"><span style=\"font-weight: 400;\">Black box warning: Zoloft and suicidal thoughts<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Zoloft also comes with a box warning for suicidal thoughts and behaviors. Short-term studies have shown that antidepressants may increase the risk of suicidality in children, adolescents, and young adults when compared to a placebo. If you\u2019re taking Zoloft and start to have extreme mood changes and\/or suicidal thoughts or behaviors, you should seek medical advice right away. You can also reach out to the <\/span><a href=\"https:\/\/suicidepreventionlifeline.org\/\"><span style=\"font-weight: 400;\">National Suicide Prevention Lifeline<\/span><\/a><span style=\"font-weight: 400;\"> at 1-800-273-8255.<\/span><\/p>\n<h2 id=\"precautions-to-take-when-starting-zoloft\"><span style=\"font-weight: 400;\">Precautions to take when starting Zoloft<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">You should not take Zoloft if you have a history of an allergic reaction to sertraline or one of its other ingredients. Zoloft therapy is also contraindicated in patients receiving treatment with a class of drugs known as monoamine oxidase inhibitors (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><span style=\"font-weight: 400;\">MAOIs<\/span><\/a><span style=\"font-weight: 400;\">). Examples of MAOIs include isocarboxazid, selegiline, and phenelzine. If you are taking one of these drugs, you must notify your doctor.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Do not abruptly stop Zoloft or any SSRI without first consulting your prescriber. This can lead to sleep and sensory disturbances, anxiety, and agitation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Suicidal thoughts and ideation may occur in adolescents, teens, and young adults who take Zoloft. This may be worse during the initial few months of therapy or after dose changes. Caregivers and loved ones should monitor this population closely during this time for unusual changes in behavior and irritability.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tell your healthcare provider if you have a history of seizure disorders (epilepsy) or cardiac disorders such as QT prolongation, as Zoloft therapy has a potential risk of making these worse.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you have liver disease, your dose may need to be adjusted by your prescriber.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You should take your first dose while you are home and not needing to drive. Zoloft has been known to cause somnolence in some patients, and you should avoid driving after taking Zoloft until you know how it affects you.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Zoloft has been linked to birth defects, especially when taken late in pregnancy. Zoloft should only be taken during pregnancy if the benefits clearly outweigh the risks.<\/span><\/p>\n<h3 id=\"drug-interactions\"><span style=\"font-weight: 400;\">Drug interactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another thing to consider when taking Zoloft is that it shouldn\u2019t be taken with certain medications. Giving a list of all the medications and over-the-counter supplements you\u2019re taking to your healthcare provider will help reduce your chances of experiencing more serious side effects from interactions with Zoloft. Here\u2019s a list of medications that shouldn\u2019t be taken at the same time as Zoloft:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Medications that increase serotonin\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Triptans (migraine agents)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tricyclic antidepressants\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood thinners such as warfarin\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (NSAIDs)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">St. John\u2019s Wort\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lithium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ultram (tramadol)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nardil (phenelzine)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parnate (tranylcypromine)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marplan (isocarboxazid)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Azilect (rasagiline)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Emsam (selegiline)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orap (pimozide)\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Zoloft shouldn\u2019t be taken at the same time as MAOIs because this could lead to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482377\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">, which causes hallucinations, seizures, comas, tremors, delirium, and other serious side effects. This list of drug interactions is not exhaustive, so it\u2019s important to tell your doctor about all the medications you\u2019re taking or thinking about taking.<\/span><\/p>\n<h3 id=\"foods-to-avoid-while-taking-zoloft\"><span style=\"font-weight: 400;\">Foods to avoid while taking Zoloft<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Like with many other drugs, grapefruit and grapefruit juice can interact with Zoloft absorption. It can slow the metabolism of Zoloft, therefore increasing blood levels of available Zoloft. This is typically only a problem if the intake of grapefruit products is inconsistent. If you are going to ingest grapefruit products, it is best to ingest a consistent amount daily.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-and-coffee\/\"><b>Can you drink coffee while taking Zoloft?<\/b><\/a><\/p>\n<h2 id=\"missed-dose-of-zoloft\"><span style=\"font-weight: 400;\">Missed dose of Zoloft<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nobody is perfect, and missing a dose of Zoloft is bound to happen at one point or another. Taking your medication consistently as prescribed by your doctor is important, but missing a dose isn\u2019t the end of the world if you know what to do when it happens.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cTake your dose as soon as you remember,\u201d says Brian Wind, Ph.D., a clinical psychologist and the chief clinical officer of <\/span><a href=\"https:\/\/journeypure.com\/ask-our-doctors\/author\/dr-brian-wind-ph-d\/\"><span style=\"font-weight: 400;\">JourneyPure<\/span><\/a><span style=\"font-weight: 400;\">. \u201cIf it is nearly time to take the next dose, don&#8217;t take an extra dose to make up for the one you missed. Simply take the next dose. You can experience side effects and an increased risk of relapse if you suddenly stop your medication.&#8221;<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The side effects you might experience if you stop or miss a dose of your medication are mild withdrawal symptoms that happen because of something called antidepressant discontinuation syndrome. According to<\/span> <a href=\"https:\/\/www.aafp.org\/afp\/2006\/0801\/p449.html\"><i><span style=\"font-weight: 400;\">American Family Physician<\/span><\/i><\/a><span style=\"font-weight: 400;\">, antidepressant discontinuation syndrome occurs in about 20% of patients who abruptly discontinue an antidepressant after taking one consistently for at least six weeks. Missing a dose of Zoloft may cause you to have flu-like symptoms, nausea, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5548844\/\"><span style=\"font-weight: 400;\">insomnia<\/span><\/a><span style=\"font-weight: 400;\">, imbalance, or hyperarousal.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The best thing you can do if you miss a dose, just as Dr. Wind says, is to take your next dose as soon as you remember. If you\u2019ve been experiencing any symptoms because of your missed dose, they should go away once you start taking Zoloft consistently again. It may also be a good idea to contact your healthcare provider if you miss a dose just to check in and make sure you don\u2019t need to do anything else.\u00a0<\/span><\/p>\n<h2 id=\"zoloft-overdose\"><span style=\"font-weight: 400;\">Zoloft overdose<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Overdosing on Zoloft is more serious than missing a dose. There are no reported cases of fatal Zoloft overdoses, but taking too much medication can cause serious side effects or health complications. Accidentally or purposefully taking two or more doses of Zoloft could cause:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fainting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In rare cases, taking too much Zoloft can also cause serotonin syndrome, which results in dangerously high levels of the neurotransmitter serotonin in the brain. When there\u2019s too much serotonin in the brain, this can cause confusion, diarrhea, and headaches. More severe symptoms may include seizures, hallucinations, muscle rigidity, and comas.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you think you\u2019ve overdosed on Zoloft and\/or started to experience one or more of these symptoms, you should seek medical attention right away or call the Poison Control hotline at 1-800-222-1222. The hotline is free for anyone to use and offers callers expert and confidential advice.\u00a0<\/span><\/p>\n<h2 id=\"when-to-see-a-doctor-for-zoloft-side-effects\"><span style=\"font-weight: 400;\">When to see a doctor for Zoloft side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Zoloft can be a great medication to treat symptoms of anxiety and depression if it\u2019s taken properly. Being prepared to experience potential side effects is an important part of taking any medication, and knowing what to expect can remove some of the anxiety that often comes from taking a new medication.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you start taking Zoloft and have some mild side effects, remember that that\u2019s normal. It\u2019s also important to remember at what point you should see your doctor because of your side effects. As mentioned throughout this article, more serious side effects like confusion, hallucinations, allergic reactions, seizures, and vomiting require medical attention. If you start to experience worsening depression or anxiety, suicidal thoughts, panic attacks, severe irritability, or aggression, then you should seek immediate medical help.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/side-effects-of-antidepressants\/\"><b>A beginner\u2019s guide to antidepressant side effects<\/b><\/a><\/p>\n<h2 id=\"bottom-line-is-zoloft-safe\"><span style=\"font-weight: 400;\">Bottom line: Is Zoloft safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects, some potentially dangerous, are possible with Zoloft. However, for most people, Zoloft is a very safe and effective treatment for depression and anxiety. <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32394557\/\"><span style=\"font-weight: 400;\">Studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown that while Zoloft may cause more adverse events than Lexapro or Prozac in the same class, it has fewer safety concerns than <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-alternatives\/\"><span style=\"font-weight: 400;\">drugs in related classes<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The potential to experience side effects from medication shouldn\u2019t keep you from getting the treatment you need for your anxiety or depression. Talking with your healthcare provider is the best way to develop a treatment plan that will work best for you and cause the least amount of side effects on your journey to find relief from your symptoms.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/es\/recursos\/zoloft-efectos-secundarios-primera-semana\"><span style=\"font-weight: 400;\">Lea este art\u00edculo en espa\u00f1ol aqu\u00ed.<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Living with mental health conditions like anxiety or depression can make daily life stressful. An estimated 31% of all adults will experience an anxiety disorder at some point in their lives, and statistics show that 264 million adults around the globe have anxiety. In addition, approximately 280 million people around the world are living with [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":53042,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,12752,450],"coauthors":[8861],"class_list":["post-18151","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-medication-side-effects","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Zoloft side effects: What to expect in the first week of taking Zoloft<\/title>\n<meta name=\"description\" content=\"Zoloft is a fairly safe antidepressant, but it does have side effects. Learn about Zoloft&#039;s common, and possibly serious, side effects during the first week.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What to expect in the first week of taking Zoloft\" \/>\n<meta property=\"og:description\" content=\"Learn the side effects you should watch for\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-02T20:27:08+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-04-09T22:28:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"SingleCare Team\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"What to expect in the first week of taking Zoloft\" \/>\n<meta name=\"twitter:description\" content=\"Learn the side effects you should watch for\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"SingleCare Team\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"12 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/\"},\"author\":{\"name\":\"SingleCare Team\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/403ef50a9f402fb9ce49c429659555f5\"},\"headline\":\"Zoloft side effects to expect in the first week\",\"datePublished\":\"2021-02-02T20:27:08+00:00\",\"dateModified\":\"2025-04-09T22:28:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/\"},\"wordCount\":2714,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Zoloft-side-effects.png\",\"keywords\":[\"Anxiety\",\"Depression\",\"Medication side effects\",\"Mental health\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/\",\"name\":\"Zoloft side effects: What to expect in the first week of taking Zoloft\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Zoloft-side-effects.png\",\"datePublished\":\"2021-02-02T20:27:08+00:00\",\"dateModified\":\"2025-04-09T22:28:30+00:00\",\"description\":\"Zoloft is a fairly safe antidepressant, but it does have side effects. Learn about Zoloft's common, and possibly serious, side effects during the first week.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Zoloft-side-effects.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2021\\\/02\\\/Zoloft-side-effects.png\",\"width\":1920,\"height\":1080,\"caption\":\"Zoloft side effects the first week\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/zoloft-side-effects-first-week\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Zoloft side effects to expect in the first week\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/403ef50a9f402fb9ce49c429659555f5\",\"name\":\"SingleCare Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=gcda8e0f4c5718cb7f68c0ee812f6fafb\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g\",\"caption\":\"SingleCare Team\"},\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/singlecareteam\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Zoloft side effects: What to expect in the first week of taking Zoloft","description":"Zoloft is a fairly safe antidepressant, but it does have side effects. Learn about Zoloft's common, and possibly serious, side effects during the first week.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/","og_locale":"en_US","og_type":"article","og_title":"What to expect in the first week of taking Zoloft","og_description":"Learn the side effects you should watch for","og_url":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2021-02-02T20:27:08+00:00","article_modified_time":"2025-04-09T22:28:30+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png","type":"image\/png"}],"author":"SingleCare Team","twitter_card":"summary_large_image","twitter_title":"What to expect in the first week of taking Zoloft","twitter_description":"Learn the side effects you should watch for","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"SingleCare Team","Est. reading time":"12 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/"},"author":{"name":"SingleCare Team","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/403ef50a9f402fb9ce49c429659555f5"},"headline":"Zoloft side effects to expect in the first week","datePublished":"2021-02-02T20:27:08+00:00","dateModified":"2025-04-09T22:28:30+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/"},"wordCount":2714,"commentCount":0,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png","keywords":["Anxiety","Depression","Medication side effects","Mental health"],"articleSection":["Drug Info"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/","url":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/","name":"Zoloft side effects: What to expect in the first week of taking Zoloft","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png","datePublished":"2021-02-02T20:27:08+00:00","dateModified":"2025-04-09T22:28:30+00:00","description":"Zoloft is a fairly safe antidepressant, but it does have side effects. Learn about Zoloft's common, and possibly serious, side effects during the first week.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2021\/02\/Zoloft-side-effects.png","width":1920,"height":1080,"caption":"Zoloft side effects the first week"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Zoloft side effects to expect in the first week"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/403ef50a9f402fb9ce49c429659555f5","name":"SingleCare Team","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=gcda8e0f4c5718cb7f68c0ee812f6fafb","url":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g","caption":"SingleCare Team"},"url":"https:\/\/www.singlecare.com\/blog\/author\/singlecareteam\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/18151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=18151"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/18151\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/53042"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=18151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=18151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=18151"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=18151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}