{"id":20578,"date":"2021-03-01T17:26:08","date_gmt":"2021-03-01T22:26:08","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=20578"},"modified":"2025-12-04T13:36:28","modified_gmt":"2025-12-04T18:36:28","slug":"omeprazole-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/omeprazole-side-effects\/","title":{"rendered":"Omeprazole side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole\"><span style=\"font-weight: 400;\">Omeprazole<\/span><\/a><span style=\"font-weight: 400;\"> (brand name: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prilosec\"><span style=\"font-weight: 400;\">Prilosec<\/span><\/a><span style=\"font-weight: 400;\">) is a prescription and over-the-counter (OTC) medication that reduces stomach acid. It is part of a class of drugs called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/proton-pump-inhibitors\"><span style=\"font-weight: 400;\">proton pump inhibitors (PPIs)<\/span><\/a><span style=\"font-weight: 400;\"> and is most often taken as a capsule or tablet. Omeprazole is used to treat symptoms of gastroesophageal reflux disease (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/gerd-treatment-and-medications\"><span style=\"font-weight: 400;\">GERD<\/span><\/a><span style=\"font-weight: 400;\">), stomach and duodenal ulcers, and other conditions that cause excess stomach acid.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although omeprazole can be purchased without a prescription, the drug has several side effects, some quite serious. Knowing the potential side effects, warnings, contraindications, and drug interactions can help determine if omeprazole is the right drug to take.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">RELATED: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole\/what-is\"><span style=\"font-weight: 400;\">Learn more about omeprazole<\/span><\/a><\/p>\n<h2 id=\"common-omeprazole-side-effects\"><span style=\"font-weight: 400;\">Common omeprazole side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539786\/\"><span style=\"font-weight: 400;\">common side effects of omeprazole<\/span><\/a><span style=\"font-weight: 400;\"> are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Omeprazole is sometimes combined with the antibiotics clarithromycin and amoxicillin to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/h-pylori-symptoms\"><span style=\"font-weight: 400;\">H. pylori<\/span><\/a><span style=\"font-weight: 400;\">, an infection linked to gastritis (irritation of the stomach lining) and stomach ulcers. The most common adverse effects of combining omeprazole with these medications are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taste changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tongue discoloration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nasal congestion<\/span><\/li>\n<\/ul>\n<h3 id=\"omeprazole-and-constipation\"><span style=\"font-weight: 400;\">Omeprazole and constipation<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole may cause constipation in some people, although it\u2019s less common than other digestive side effects like diarrhea and gas. In <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/019810s102,022056s019lbl.pdf\"><span style=\"font-weight: 400;\">clinical trials<\/span><\/a><span style=\"font-weight: 400;\"> of over 3,000 patients, constipation occurred in 2% of patients. However, it wasn\u2019t reported to be a severe side effect. It might appear within the first few days of treatment and subside as the body adjusts to the drug.<\/span><\/p>\n<h3 id=\"omeprazole-and-weight-gain\"><span style=\"font-weight: 400;\">Omeprazole and weight gain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Significant weight gain has been linked with years-long use of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2761557\/\"><span style=\"font-weight: 400;\">omeprazole and other PPIs<\/span><\/a><span style=\"font-weight: 400;\"> to treat heartburn or GERD symptoms. The reasons are unclear, but it is thought to be due to increased appetite when symptoms are better controlled.<\/span><\/p>\n<h2 id=\"serious-side-effects-of-omeprazole\"><span style=\"font-weight: 400;\">Serious side effects of omeprazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Serious side effects are rare for omeprazole but may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Severe diarrhea<\/b><b>: <\/b><span style=\"font-weight: 400;\">C. difficile is<\/span> <span style=\"font-weight: 400;\">a bacterial infection of the colon that can cause severe diarrhea and fever.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver disease:<\/b><span style=\"font-weight: 400;\"> Omeprazole can alter liver function and sometimes lead to liver disease or liver failure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Lupus: <\/b><span style=\"font-weight: 400;\">Omeprazole may cause the onset or worsening of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/lupus-flare-symptoms\"><span style=\"font-weight: 400;\">lupus erythematosus<\/span><\/a><span style=\"font-weight: 400;\">, an autoimmune condition marked by rash and skin redness.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Allergic reactions:<\/b><span style=\"font-weight: 400;\"> Hypersensitivity reactions can be mild to severe, including anaphylaxis, rapid skin swelling (angioedema), severe skin reactions, trouble breathing, and swelling in the kidney\u2019s filtration tubes (interstitial nephritis).<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These side effects are often linked to long-term use or high doses of omeprazole. Because of this, the prescribing information states that omeprazole should be used at the lowest effective dose for the shortest period of time.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other serious side effects may include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bone loss<\/b><span style=\"font-weight: 400;\">: Used long-term, omeprazole can reduce the absorption of calcium. The body balances this loss by pulling calcium from the bones, leading to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/bone-density-test-results\/\"><span style=\"font-weight: 400;\">osteoporosis<\/span><\/a><span style=\"font-weight: 400;\"> and an increased risk of bone fractures. Patients taking omeprazole continuously over the long term (one year or longer) may need to take calcium supplements and\/or prescription medication to help prevent osteoporosis and the risk of fractures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Low magnesium<\/b><span style=\"font-weight: 400;\">: Long-term use of omeprazole can also lower magnesium levels in the body. Low magnesium (hypomagnesemia) can lead to muscle cramps, an irregular heartbeat, tremors, or seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Growths<\/b><span style=\"font-weight: 400;\">: Omeprazole has been linked to <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/stomach-polyps\/symptoms-causes\/syc-20377992\"><span style=\"font-weight: 400;\">fundic gland polyps<\/span><\/a><span style=\"font-weight: 400;\">, which are usually benign, small growths along the stomach lining. Rarely, in patients with Zollinger-Ellison syndrome, omeprazole has also been linked to slow-growing tumors (carcinoids) in the duodenum, the first part of the small intestine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Low vitamin B12<\/b><span style=\"font-weight: 400;\">: Using omeprazole or other acid-suppressing medications daily for long periods of time (usually longer than 3 years) may reduce the absorption of vitamin B12 due to low stomach acid. Although rare, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/b12-deficiency-symptoms\"><span style=\"font-weight: 400;\">vitamin B12 deficiency<\/span><\/a><span style=\"font-weight: 400;\"> has been reported in people taking omeprazole long-term.<\/span><\/li>\n<\/ul>\n<h3 id=\"omeprazole-and-cancer\"><span style=\"font-weight: 400;\">Omeprazole and cancer<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is a popular notion that omeprazole and other PPIs may increase the risk of stomach cancer. Research on the association of omeprazole with stomach cancer is mixed, with <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12010335\/\"><span style=\"font-weight: 400;\">some studies<\/span><\/a><span style=\"font-weight: 400;\"> showing omeprazole (or any PPI) can increase the risk of stomach cancer.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More importantly, omeprazole could mask the symptoms of stomach cancer. In other words, people could start taking omeprazole for heartburn, but the symptoms may be caused by a malignancy. Symptoms such as frequent heartburn should always be evaluated by a healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Omeprazole side effects by dosage<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A higher dose of omeprazole may lead to greater side effects. For example, a dose of 40 mg of omeprazole may lead to more gastrointestinal side effects like stomach discomfort, diarrhea, and gas. The risk of serious side effects may be increased not only with higher doses but also with long-term use of high doses. For this reason, omeprazole is typically reserved for <\/span><a href=\"https:\/\/www.health.harvard.edu\/blog\/proton-pump-inhibitors-should-i-still-be-taking-this-medication-202209062809\"><span style=\"font-weight: 400;\">short-term use<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Omeprazole with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tOmeprazole 40 mg (30 Delayed-release capsules)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.78<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$5.78<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/omeprazole#blog-cta\" class=\"coupon-see-all-btn\">See Omeprazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"how-long-do-omeprazole-side-effects-last\"><span style=\"font-weight: 400;\">How long do omeprazole side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The body clears omeprazole in a few hours, so many mild side effects will fade in that time. However, the effects of omeprazole on the stomach lining typically last for three or more days, which means some side effects may linger for a few days after stopping omeprazole.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Side effects caused by combining omeprazole with antibiotics, such as taste changes or tongue discoloration, usually resolve a few days after the antibiotics are discontinued. Serious side effects associated with omeprazole, however, like bone loss, liver disease, or kidney problems, may take longer to get better. All side effects should be reported to your healthcare provider.<\/span><\/p>\n<h2 id=\"omeprazole-contraindications-warnings\"><span style=\"font-weight: 400;\">Omeprazole contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Omeprazole is an effective medication that has a low incidence of possible side effects when used in the short term. However, omeprazole may not be for everyone, particularly when used over the long term.<\/span><\/p>\n<h3 id=\"dependency\"><span style=\"font-weight: 400;\">Dependency<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Chronic use of omeprazole can lead to serious and debilitating side effects. In particular, people taking omeprazole for a long time may develop <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3093718\/\"><span style=\"font-weight: 400;\">a kind of physical dependency<\/span><\/a><span style=\"font-weight: 400;\"> since the body gets used to decreased acid production. Stopping the medication could cause the stomach to create more acid than usual, leading to a rebound effect and a return of acid reflux and heartburn symptoms.\u00a0<\/span><\/p>\n<h3 id=\"allergies\"><span style=\"font-weight: 400;\">Allergies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole should not be taken by anyone with severe hypersensitivity to omeprazole or any of the inactive ingredients of this medication.<\/span><\/p>\n<h3 id=\"people-with-liver-problems\"><span style=\"font-weight: 400;\">People with liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole is processed by the liver. Patients with liver problems can generally take omeprazole (if approved by a healthcare provider), but the dosage may be lower than usual.<\/span><\/p>\n<h3 id=\"people-of-asian-descent\"><span style=\"font-weight: 400;\">People of Asian descent<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People of Asian descent may <\/span><a href=\"https:\/\/journals.lww.com\/annals-of-medicine-and-surgery\/abstract\/9900\/long_term_proton_pump_inhibitor_use_and_risk_of.3598.aspx\"><span style=\"font-weight: 400;\">have an increased risk of dementia<\/span><\/a><span style=\"font-weight: 400;\"> from proton pump inhibitors such as omeprazole. People of Asian descent are also less likely to have the gene variants that <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK100895\/\"><span style=\"font-weight: 400;\">break down omeprazole<\/span><\/a><span style=\"font-weight: 400;\"> quickly. <\/span><span style=\"font-weight: 400;\">The prescribing information for omeprazole recommends a lower dose in these patients<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prescription omeprazole is approved to treat GERD symptoms and erosive esophagitis in children who are 1 to 16 years of age. OTC omeprazole should not be given to children. If the liquid formulation (packets for oral suspension) is not available, the medication can be compounded by a compounding pharmacy. The contents of a capsule may also be mixed with a tablespoon of applesauce and immediately consumed, along with a glass of water.<\/span><\/p>\n<h3 id=\"older-adults\"><span style=\"font-weight: 400;\">Older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In the initial clinical trials, omeprazole had the same safety record in older adults as it does for other adults. However, more recent studies suggest that omeprazole may come with an <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12347867\/\"><span style=\"font-weight: 400;\">increased risk of certain side effects<\/span><\/a><span style=\"font-weight: 400;\"> in older adults, such as bone loss, kidney problems, and possible dementia.<\/span><\/p>\n<h3 id=\"pregnancy-and-breastfeeding\"><span style=\"font-weight: 400;\">Pregnancy and breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are no definitive studies on the safety of omeprazole use during pregnancy. The prescribing information advises that pregnant women should use omeprazole only if it\u2019s absolutely necessary.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Omeprazole may be present in breast milk in small amounts and is not expected to cause harm to a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK582884\/\"><span style=\"font-weight: 400;\">nursing infant<\/span><\/a><span style=\"font-weight: 400;\">. However, it\u2019s important to consult a healthcare provider about whether to discontinue omeprazole.<\/span><\/p>\n<h2 id=\"omeprazole-interactions\"><span style=\"font-weight: 400;\">Omeprazole interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In general, food does not affect the absorption or effectiveness of omeprazole. However, since the goal is to reduce stomach acid, it\u2019s best to avoid foods that overstimulate stomach acid secretion, such as spicy foods, fatty foods, sodas, alcohol, and coffee.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Like many drugs, omeprazole can <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/omeprazole-interactions\/\"><span style=\"font-weight: 400;\">interact with other medications<\/span><\/a><span style=\"font-weight: 400;\"> or substances. The following medicines may interact with omeprazole:\u00a0<\/span><\/p>\n<h3 id=\"antiretrovirals\"><span style=\"font-weight: 400;\">Antiretrovirals<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole is contraindicated while taking rilpivirine, an HIV medication, because omeprazole can reduce its absorption. As a result, omeprazole can decrease the effectiveness of rilpivirine. Omeprazole may need to be avoided with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hiv-treatment-and-medications\"><span style=\"font-weight: 400;\">other antivirals<\/span><\/a><span style=\"font-weight: 400;\"> like atazanavir and nelfinavir because of similar effects. Taking omeprazole with saquinavir, however, could increase the levels of saquinavir and lead to toxic effects of the antiviral.\u00a0<\/span><\/p>\n<h3 id=\"drugs-that-rely-on-stomach-acid-for-absorption\"><span style=\"font-weight: 400;\">Drugs that rely on stomach acid for absorption<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because omeprazole reduces stomach acidity, it may decrease how well some medications are absorbed, which may make them less effective. Examples include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Iron salts\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antifungals\"><span style=\"font-weight: 400;\">Antifungals<\/span><\/a><span style=\"font-weight: 400;\"> such as Nizoral (ketoconazole) or Sporanox (itraconazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cancer drugs such as Tarceva (erlotinib), Sprycel (dasatinib), and Tasigna (nilotinib)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Synthroid (levothyroxine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cellcept (mycophenolate mofetil)<\/span><\/li>\n<\/ul>\n<h3 id=\"blood-thinners-and-antiplatelets\"><span style=\"font-weight: 400;\">Blood thinners and antiplatelets<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many people take blood thinners to help treat blood clots. However, omeprazole interacts with the blood thinner warfarin and could potentially cause abnormal bleeding. If you are on omeprazole and warfarin, your doctor will monitor you closely and may need to change the dosage of your medication(s).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Omeprazole also interacts with the antiplatelet agents Plavix (clopidogrel) and Pletal (cilostazol).\u00a0 Plavix should <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/clopidogrel-interactions\/\"><span style=\"font-weight: 400;\">not be taken with omeprazole<\/span><\/a><span style=\"font-weight: 400;\">. If you take Pletal with omeprazole, the dosage of Pletal may need to be adjusted.\u00a0<\/span><\/p>\n<h3 id=\"drugs-whose-levels-increase-when-taken-with-omeprazole\"><span style=\"font-weight: 400;\">Drugs whose levels increase when taken with omeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole can increase the toxicity and risk of side effects of some prescription drugs by either increasing their absorption or slowing down the body\u2019s metabolism of the drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">These drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trexall (methotrexate)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prograf (tacrolimus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dilantin (phenytoin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Valium (diazepam)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lanoxin (digoxin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Celexa (citalopram)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">These drugs can generally be taken with omeprazole, but a healthcare professional may need to monitor therapy and reduce doses if necessary.<\/span><\/p>\n<h3 id=\"drugs-that-decrease-omeprazole-s-effectiveness\"><span style=\"font-weight: 400;\">Drugs that decrease omeprazole\u2019s effectiveness<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some drugs speed up the body\u2019s metabolism of omeprazole, reducing its effectiveness. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The antibiotics Rifadin (rifampin), Priftin (rifapentine), and Mycobutin (rifabutin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some antiviral drugs, such as Norvir (ritonavir)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/cystic-fibrosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Cystic fibrosis<\/span><\/a><span style=\"font-weight: 400;\"> drugs Orkambi (lumacaftor-ivacaftor)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><\/li>\n<\/ul>\n<h3 id=\"diuretics-water-pills\"><span style=\"font-weight: 400;\">Diuretics (water pills)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretics<\/span><\/a><span style=\"font-weight: 400;\"> with omeprazole can increase the risk of low magnesium. Therapy may need to be monitored or modified.<\/span><\/p>\n<h2 id=\"how-to-avoid-omeprazole-side-effects\"><span style=\"font-weight: 400;\">How to avoid omeprazole side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When taken as directed for a limited time, omeprazole has minimal side effects. A few tips can help keep side effects to a minimum:\u00a0<\/span><\/p>\n<h3 id=\"1-take-omeprazole-as-directed\"><span style=\"font-weight: 400;\">1.\u00a0 Take omeprazole as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Take the daily dose as prescribed at the time prescribed. Prilosec OTC should be taken in the morning before breakfast. For prescription omeprazole, the prescribing doctor or other healthcare professional will specify a time of day to take the medication. Don\u2019t increase or decrease the dose on your own, and don\u2019t take a double dose in place of a missed dose. The medicine must be taken daily over the full period to realize its full benefits.\u00a0<\/span><\/p>\n<h3 id=\"2-avoid-taking-omeprazole-long-term\"><span style=\"font-weight: 400;\">2.\u00a0 Avoid taking omeprazole long-term<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Only take omeprazole for the short-term, anywhere from 10 days to eight weeks. Very few medical conditions require omeprazole to be taken for longer periods. Continual use of omeprazole not only raises the risk of side effects in general, but it also raises the risk of more serious side effects. If the medicine seems to require long-term use, talk to a healthcare provider about alternative drugs.\u00a0<\/span><\/p>\n<h3 id=\"3-tell-your-doctor-about-all-your-medical-conditions-and-medications\"><span style=\"font-weight: 400;\">3.\u00a0 Tell your doctor about all your medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because of the risk of side effects, you should tell your doctor about:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any physical conditions you may have, particularly\u00a0<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Chronic chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Persistent nausea, vomiting, stomach pain, or unexplained weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Low levels of magnesium or calcium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Liver or kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Pregnancy or breastfeeding<\/span><\/li>\n<\/ul>\n<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All prescription medications, OTC drugs, herbal remedies, and dietary supplements you\u2019re taking<\/span><\/li>\n<\/ul>\n<h3 id=\"4-talk-to-a-healthcare-professional-before-taking-otc-omeprazole\"><span style=\"font-weight: 400;\">4.\u00a0 Talk to a healthcare professional before taking OTC omeprazole<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Omeprazole can be easily purchased without a prescription. Still, because of the risk of overuse, physical dependency, and side effects, seek medical advice from a healthcare professional before taking OTC omeprazole. Dietary and lifestyle changes may also need to be considered.<\/span><\/p>\n<h3 id=\"5-take-omeprazole-30-60-minutes-before-eating\"><span style=\"font-weight: 400;\">5.\u00a0 Take omeprazole 30\u201360 minutes before eating<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Chances are, the doctor\u2019s prescription, medication guide, or package will have an instruction that reads, \u201cTake before a meal.\u201d The general practice is to take omeprazole <\/span><a href=\"https:\/\/www.researchgate.net\/publication\/12312177_Proton_pump_inhibitors_Better_acid_suppression_when_taken_before_a_meal_than_without_a_meal\"><span style=\"font-weight: 400;\">30 to 60 minutes<\/span><\/a><span style=\"font-weight: 400;\"> before eating.<\/span><\/p>\n<h3 id=\"6-avoid-acid-raising-foods-and-drugs\"><span style=\"font-weight: 400;\">6.\u00a0 Avoid acid-raising foods and drugs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many foods or drugs stimulate the stomach lining to increase acid production. These include <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/gerd-diet\/\"><span style=\"font-weight: 400;\">spicy foods<\/span><\/a><span style=\"font-weight: 400;\">, fried foods, fatty meats, cheeses, peppers, citrus fruits, chocolate, coffee, alcohol, soda pop, aspirin, peppermint, and some mineral supplements. Eating spicy foods will not increase the risk of omeprazole side effects, but they may increase the amount of acid in the stomach and blunt the effects of the medicine.<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects-of-omeprazole\"><span style=\"font-weight: 400;\">How to treat side effects of omeprazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most side effects of omeprazole aren\u2019t severe enough to require medical attention. They can often be managed at home in different ways and only last temporarily. For digestive side effects like nausea and gas, it can be helpful to stay hydrated, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/home-remedies-for-heartburn\/\"><span style=\"font-weight: 400;\">eat smaller meals<\/span><\/a><span style=\"font-weight: 400;\">, and avoid triggering foods. In some cases, short-term OTC medications may be used, but it\u2019s best to consult a doctor or pharmacist first.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Seek medical help for any serious or unusual symptoms, such as severe diarrhea, fever, persistent vomiting, joint pain, unusual tiredness, or signs of a severe allergic reaction, such as rash or difficulty breathing. These could indicate more serious side effects of omeprazole that may require medical attention.<\/span><\/p>\n<h2 id=\"bottom-line-is-omeprazole-safe\"><span style=\"font-weight: 400;\">Bottom line: Is omeprazole safe?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Omeprazole is generally safe to take when taken as directed. Those who take omeprazole at high doses for longer periods are more likely to experience serious side effects. For those who take omeprazole at the lowest effective dosage, most side effects are short-term and mild.\u00a0<\/span><\/p>\n<h2 id=\"expert-takeaway\"><span style=\"font-weight: 400;\">Expert takeaway<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Gerardo Sison, Pharm.D., and a member of the SingleCare Medical Board, says, \u201cMost side effects can be avoided by using omeprazole for the shortest duration possible and at the lowest effective dose. Don\u2019t rely on OTC omeprazole for persistent heartburn without first consulting a healthcare provider. Long-term daily use is linked to more serious side effects.\u201d<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Omeprazole (brand name: Prilosec) is a prescription and over-the-counter (OTC) medication that reduces stomach acid. It is part of a class of drugs called proton pump inhibitors (PPIs) and is most often taken as a capsule or tablet. Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD), stomach and duodenal ulcers, and other [&hellip;]<\/p>\n","protected":false},"author":99,"featured_media":20865,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[16414,10708],"coauthors":[10668],"class_list":["post-20578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-digestive-health","tag-over-the-counter-medications","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Learn how to manage common and serious omeprazole reactions<\/title>\n<meta name=\"description\" content=\"Omeprazole helps relieve heartburn and GERD, but it can cause mild to serious side effects. 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