{"id":22390,"date":"2021-03-16T13:00:27","date_gmt":"2021-03-16T17:00:27","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=22390"},"modified":"2022-10-31T11:24:10","modified_gmt":"2022-10-31T15:24:10","slug":"humira-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/humira-side-effects\/","title":{"rendered":"Humira side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#common-humira-side-effects\">Common Humira side effects<\/a> | <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#side-effects-timeline\">Side effects timeline<\/a> | <a href=\"#dosing\">Dosing<\/a> | <a href=\"#contraindications\">Contraindications<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a> | <a href=\"#humira-alternatives\">Humira alternatives<\/a> | <a href=\"#faqs\">FAQs<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Humira (adalimumab)\u2014an injection of a naturally-occurring human antibody\u2014induces remission and controls the symptoms of active autoimmune diseases. A healthcare provider may prescribe Humira for <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/arthritis-treatment-and-medications\"><span style=\"font-weight: 400;\">rheumatoid arthritis<\/span><\/a><span style=\"font-weight: 400;\">, ankylosing spondylitis, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/juvenile-arthritis\/\"><span style=\"font-weight: 400;\">juvenile idiopathic arthritis<\/span><\/a><span style=\"font-weight: 400;\">, psoriatic arthritis, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/psoriasis-treatment-and-medications\"><span style=\"font-weight: 400;\">plaque psoriasis<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/crohns-disease-treatment-and-medications\"><span style=\"font-weight: 400;\">Crohn\u2019s disease<\/span><\/a><span style=\"font-weight: 400;\">, ulcerative colitis, uveitis, and hidradenitis suppurativa. In all these conditions, flare-ups occur when the immune system mistakenly attacks healthy tissues.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Humira suppresses the body\u2019s immune response by blocking a chemical produced by the body\u2014tumor necrosis factor or TNF\u2014that causes swelling. As with all medications, the decision to take Humira must balance the benefits and risks of the medication, so it is important to discuss with your doctor the side effects, drug interactions, and warnings associated with the drug.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/humira\/what-is\"><b>Learn more about Humira<\/b><\/a><b> | <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/humira\"><b>Get Humira discounts<\/b><\/a><\/p>\n<h2 id=\"common-humira-side-effects\"><span style=\"font-weight: 400;\">Common side effects of Humira<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Humira suppresses the immune system, so infections and malignancies are common as well as potentially serious side effects. The most common side effects of Humira are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site reactions (redness, swelling, pain, itching, and skin rash)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Upper respiratory infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sinus congestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Development of autoimmune antibodies<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abnormal liver function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flu or cold symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Back pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased levels of fat in the bloodstream<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated serum cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">By far the most common adverse reaction to Humira is <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=608d4f0d-b19f-46d3-749a-7159aa5f933d\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">injection site reactions<\/span><\/a><span style=\"font-weight: 400;\">. As many as 1 in 5 patients will experience pain, redness, swelling, itching, or bleeding. Fortunately, these are generally mild and don\u2019t last long. It generally does not necessitate discontinuation of treatment. Those who did end up discontinuing treatment experienced a more serious rash or flare of their medical disorder.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One of the more worrisome potential adverse events is an increased risk of infections, some of them very serious. Humira works by slowing your body\u2019s natural immune system and response. This helps to calm the symptoms of diseases such as rheumatoid arthritis or Crohn\u2019s disease because your immune system is often overactive in these disorders and makes them worse. Unfortunately, slowing your immune system leaves you more vulnerable to viral infections and bacterial infections. Some of the <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=608d4f0d-b19f-46d3-749a-7159aa5f933d\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most serious infections<\/span><\/a><span style=\"font-weight: 400;\"> observed in patients treated with Humira include pneumonia, septic arthritis, cellulitis, diverticulitis, and tuberculosis. Patients taking Humira must use extra caution to avoid unnecessary exposure to tuberculosis, including travel to areas where tuberculosis is more commonly spread. Make sure your doctor is made aware of any travel plans or live vaccinations you intend to get while taking Humira.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Does Humira cause hair loss or weight gain?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In very rare cases, Humira may cause some hair loss.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unexplained weight loss or weight gain, though, is not directly caused by Humira. However, its active ingredient increases the risk of lymphoma, leukemia, and other cancers, many of which are characterized by loss of appetite and involuntary weight loss. Talk to a doctor immediately if you notice weight loss, decreased appetite, or getting full on a small amount of food while taking Humira.<\/span><\/p>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of Humira<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because Humira suppresses the immune system, patients are at an increased risk of severe and even life-threatening infections and cancers. As with all antibody injections, allergic reactions are also a risk. The most severe side effects of Humira are<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious or life-threatening infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cancer (lymphoma, leukemia, non-melanoma skin cancer, and other malignancies)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe or life-threatening allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tuberculosis or hepatitis B virus reactivation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Exacerbation or onset of nervous system disorders such as multiple sclerosis or optic neuritis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems (atrial fibrillation, tachycardia, cardiac arrhythmia, chest pain, heart attack)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening of congestive heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lupus-like syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lowered blood cell counts or anemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver damage or failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gallstones<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cataracts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Arthritis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">You should stop taking Humira and seek immediate medical attention if you experience any of the following adverse reactions when taking Humira:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever, fatigue, loss of appetite, abdominal pain, or other <\/span><b>signs of a hepatitis B infection<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swollen glands, tiredness, fever, chills, night sweats, loss of appetite, involuntary weight loss, unusual lumps, easy bruising or bleeding, or other <\/span><b>common signs of cancer<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives, facial swelling, blistering, purple skin, trouble breathing, drop in blood pressure, dizziness, fainting, or other <\/span><b>signs of a severe allergic reaction or anaphylaxis<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue, fever, joint pain, facial rash, sunlight-induced skin lesions, shortness of breath, and other <\/span><b>signs of lupus-like syndrome<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Racing heartbeat, palpitations, chest pain, swelling in the lower legs, or other <\/span><b>signs of heart irregularities or symptoms of heart failure<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Humira injections may be discontinued if any of these conditions are experienced.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You should immediately talk to your doctor about the possibility of discontinuing Humira if you experience:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever, cough, swelling, chills, swollen glands, loss of appetite, abdominal pain, or other <\/span><b>signs of infection<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness, fatigue, pale skin, fast heartbeat, easy bruising or bleeding, or other <\/span><b>signs of blood problems<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yellow skin, yellowing eyes, right-side upper abdominal pain, abdominal swelling, disorientation, and other <\/span><b>signs of acute liver problems<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness, vision changes, muscle stiffness, muscle spasms, tingling, numbness, or other <\/span><b>signs of<\/b> <b>nervous system disorders<\/b><span style=\"font-weight: 400;\">.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Humira is administered only once every two weeks, so doctors and patients have time to reconsider Humira in the face of adverse effects.<\/span><\/p>\n<h2 id=\"side-effects-timeline\"><span style=\"font-weight: 400;\">How long do Humira side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Humira side effects will vary in onset and duration. Injection site or allergic reactions typically occur within minutes of the injection and last a few minutes to a few days. The first injection will always be performed by a healthcare professional in a clinical setting to monitor for possible allergic reactions. Other common side effects such as headache, sinus congestion, nausea, and flu or cold symptoms are also brief and can be treated with over-the-counter medications and rest.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Long Term Humira Side Effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Serious side effects, such as liver problems, infections, and blood problems will take weeks or months to develop and may continue to worsen as long as Humira is taken. Severe infections, cancer, liver failure, heart problems, and auto-antibodies may have long-term or life-long consequences even after Humira is discontinued. Regular office visits and tests are necessary to monitor the longer-term effects of Humira.<\/span><\/p>\n<h2 id=\"dosing\"><span style=\"font-weight: 400;\">Humira dosing for approved indications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Humira is indicated and highly effective in treating a variety of disorders. For many, Humira use has significantly improved their quality of life. Dosing is not the same in everyone or for every disorder it is used for. Dosing in children, when approved, is weight based. Below is a table comparing dosages approved by the Food and Drug Administration (FDA) for the most common possible uses of Humira. Your doctor will prescribe your dose of Humira based on your diagnosis.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Indication<\/b><\/td>\n<td><b>Adult dosage<\/b><\/td>\n<td><b>Pediatric dosage<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Moderate to severe rheumatoid arthritis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not indicated in pediatrics for this use<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Moderate to severe polyarticular juvenile idiopathic arthritis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10 mg or 20mg every 2 weeks (weight based dosage)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Psoriatic arthritis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not indicated in pediatrics for this use<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Ankylosing spondylitis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not indicated in pediatrics for this use<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Plaque psoriasis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">80 mg subcutaneously on day 1, then 40 mg subcutaneously every 2 weeks starting one week later<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Not indicated in pediatrics for this use<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Crohn\u2019s disease<\/b><\/td>\n<td><span style=\"font-weight: 400;\">160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weight of 40 kg or more: 160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Weight of 17 to 39 kg:80 mg subcutaneously on day 1, then 40 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 20 mg subcutaneously every 2 weeks<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Ulcerative colitis<\/b><\/td>\n<td><span style=\"font-weight: 400;\">160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weight of 40 kg or more: 160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Weight of 17 to 39 kg:80 mg subcutaneously on day 1, then 40 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 20 mg subcutaneously every 2 weeks<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Hidradenitis suppurativa<\/b><\/td>\n<td><span style=\"font-weight: 400;\">160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Weight of 40 kg or more: 160 mg subcutaneously on day 1, then 80 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 40 mg subcutaneously every 2 weeks<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Weight of 17 to 39 kg:80 mg subcutaneously on day 1, then 40 mg subcutaneously on day 14, then on day 29 begin maintenance dose of 20 mg subcutaneously every 2 weeks<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Humira contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Humira is not always the right medication for everyone. People with infections, latent infections, exposure to tuberculosis, a history of cancer, congestive heart failure, nerve disorders such as multiple sclerosis, liver disease, or allergies to the drug or any of its ingredients may not be suitable candidates for taking Humira.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Serious infections<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira contains a black-box warning for serious infections. Humira will be discontinued if a serious infection, sepsis, or invasive fungal infection develops while taking the drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients will need to be tested for tuberculosis (TB) before and during treatment with Humira. Any patient who tests positive for latent tuberculosis will require TB treatment before receiving Humira. The drug will be discontinued if a patient develops TB during treatment as a very serious TB infection can occur.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Patients at risk for hepatitis B or histoplasmosis infections will also be tested before receiving Humira. Again, the drug will be discontinued if injections reactivate a latent hepatitis B infection.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Malignancies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira and other TNF blockers contain a black-box warning for malignancies, particularly lymphoma. Some patients on Humira and other TNF blockers have developed hepatosplenic T-cell lymphoma (HSTCL), an aggressive, rare, and often fatal type of lymphoma. Patients who have been treated for any cancer other than non-melanoma skin cancer may not be suitable candidates for treatment with Humira or similar TNF blockers. If a malignancy develops during treatment, Humira may be discontinued.\u00a0\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Nervous system disorders<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Patients with demyelinating disorders such as multiple sclerosis, Guillain-Barre syndrome, peripheral demyelinating disease, or optic neuritis may not be suitable candidates for Humira therapy. Demyelinating diseases are progressive nerve disorders that slowly strip away the protective sheath around nerve branches, decreasing their ability to pass nerve signals. Humira can cause flare-ups of any of these disorders, so Humira therapy will require constant monitoring in these patients.\u00a0\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Congestive heart failure<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira can worsen congestive heart failure, so patients with congestive heart failure will need to be monitored closely when taking Humira.\u00a0\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Allergies<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Patients with allergies to the drug, any of its ingredients, or rubber and latex may not be suitable candidates for Humira. The drug will be discontinued at any sign of a severe allergic reaction.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Clinical data suggests that the relative risk of major birth defects is no higher in women treated with Humira versus those who are not. As a protein, Humira does pass through the placenta to the fetus. Few antibodies pass to the unborn baby during the first trimester, but the passage of antibodies steadily increases until it maximizes in the third trimester. Pregnant women may want to discuss with their doctors the risks and benefits of taking Humira during their pregnancy.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira is considered safe to take when breastfeeding infants. Humira does not appear to affect milk production or harm breastfeeding infants. Humira is present in breast milk but at one percent or less of its concentration in the bloodstream. It is also a protein, so it will be broken down in the infant\u2019s digestive system.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira does not produce physical dependence or withdrawal symptoms. There are no known cases of Humira or other TNF blocker abuse.<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Humira interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some biologic immune-suppressing drugs should never be used with Humira because, in combination with Humira, these drugs dangerously suppress the immune system. Humira will not be prescribed in combination with the following immunosuppressants:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orencia (abatacept)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kineret (anakinra)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Remicade (infliximab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Enbrel (etanercept)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cimzia (certolizumab pegol)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Simponi (golimumab)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Humira may enhance the effects of other immune-suppressing or immune-modulating drugs, increasing the risk of infection and cancer. A doctor will exercise caution when prescribing Humira with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Imuran (azathioprine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Purinethol (6-mercaptopurine)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cladribine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rituxan (rituximab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Xgeva (denosumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ocrevus (ocrelizumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Actemra (tocilizumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gilenya (fingolimod)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mayzent (siponimod)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Daliresp (roflumilast)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Humira increases the toxicity and amplifies the side effects of certain medications, including the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Arava (leflunomide)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ilaris (canakinumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tysabri (natalizumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Entyvio (vedolizumab)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prograf (tacrolimus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elidel (pimecrolimus)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Arcalyst (rilonacept)\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Humira reduces the therapeutic effects of some drugs such as warfarin, vaccines, and echinacea. Although there is no danger, the healthcare team may need to modify these other prescriptions or their dosing.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The manufacturer of Humira does not indicate that alcohol should be avoided. It is possible, then, that drinking alcohol in moderation while taking Humira is safe. This may not be true, however, for patients with liver problems. Humira can cause liver problems and\u2014in very rare cases\u2014liver failure, so consult with a doctor about drinking alcohol while taking Humira.<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid Humira side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most drugs cause side effects, so there is no guaranteed way to avoid side effects when taking medications. However, you can reduce the risk and severity of side effects with a few tips.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Tell your doctor about all your medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because of the risk of serious side effects, you should tell your doctor about:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Active or previous infections (particularly hepatitis B or tuberculosis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of cancer, nervous system disorders (such as multiple sclerosis or Guillain-Barre syndrome), or heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are pregnant or breastfeeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any medications or dietary supplements you may be taking, including over-the-counter medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recent or forthcoming vaccinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Numbness, tingling, vision problems, or muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rubber or latex allergies<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">When taking Humira, inform your doctor immediately if you fall ill or get pregnant. Do not start taking any drug or dietary supplement until talking to your doctor first.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Keep all follow-up medical appointments<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Patients on Humira will be monitored to prevent serious side effects. This will require regular blood tests and office visits to catch problems before they develop into serious medical problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Avoid infections<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira makes patients more vulnerable to infections. To keep yourself safe, practice social distancing, wear a mask in public, avoid people with infections, wash your hands regularly, shower regularly, and carry and regularly use hand sanitizer. The risk of serious infections while taking Humira shouldn\u2019t be taken lightly.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Avoid live vaccines<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">You can receive vaccinations while taking Humira as long as they are not live vaccines. When given to immune-compromised patients, live vaccines not only carry a risk of causing an infection, the infection might spread throughout the entire body. Talk to a healthcare provider before taking a vaccine while taking Humira. The best practice is to get fully up-to-date on vaccines before starting Humira or any other immune-suppressing medication. When Humira is discontinued, wait at least two months before getting a live vaccine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Keep a list of all your medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To reduce the risk of side effects and potentially hazardous drug-drug interactions, it is always a good idea to keep a list of all your medications updated at all times. Include any over-the-counter medications, vitamins, and herbal supplements that you take regularly. Always show that list when seeing your doctor or when filling a prescription.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Regularly switch the injection site<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira\u2019s most common side effects are injection site reactions. The easiest way to control injection site reactions is to change up the injection site with each injection. Humira is injected subcutaneously once every two weeks in the abdomen or thigh, so consider rotating the injection between each thigh and the abdomen. Avoid giving the injection into skin that is tender, irritated, red, swollen, bruised, or itchy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You might also reduce injection site reactions by removing the pre-filled syringe or pen injector from the refrigerator before the injection. Humira can be in a room temperature environment for up to 30 minutes prior to injection.\u00a0 Make sure, however, it is not exposed to sunlight. Do not try to warm the medication in any other way.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Ask your doctor about citrate-free Humira<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Citric acid is a buffer that helps to keep injectable medications\u2014particularly proteins such as Humira\u2014stable over several months of storage. Citrate buffers, however, often cause significant pain for a few minutes after the injection. If Humira injection pain is too much to bear, ask your doctor about citrate-free Humira as an alternative.\u00a0<\/span><\/p>\n<h2 id=\"humira-alternatives\"><span style=\"font-weight: 400;\">What are some Humira alternatives?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Humira is a TNF-alfa inhibitor, and this class of prescription drugs suppress your body\u2019s reaction to tumor necrosis factor (TNF). When an inflammatory process begins in your body, whether it presents as psoriasis, arthritis, or in the gastrointestinal tract like colitis, TNF is released and your body\u2019s reaction (sometimes overreaction) is difficult to control on its own. This class of drugs calm the TNF response. Other drugs in this class include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/enbrel\"><span style=\"font-weight: 400;\">Enbrel<\/span><\/a><span style=\"font-weight: 400;\"> (etanercept), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/remicade\"><span style=\"font-weight: 400;\">Remicade<\/span><\/a><span style=\"font-weight: 400;\"> (infliximab), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/simponi\"><span style=\"font-weight: 400;\">Simponi<\/span><\/a><span style=\"font-weight: 400;\"> (golimumab). The active ingredient in Humira, adalimumab, is the active ingredient in other branded TNF-alfa products by the names of Amjevita and Cyltezo. There are other antirheumatics (immunosuppressant) drugs which can be treatment alternatives to Humira and TNF-alfa inhibitors. These include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/plaquenil\"><span style=\"font-weight: 400;\">Plaquenil<\/span><\/a><span style=\"font-weight: 400;\"> (hydroxychloroquine), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/imuran\"><span style=\"font-weight: 400;\">Imuran<\/span><\/a><span style=\"font-weight: 400;\"> (azathioprine), <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rinvoq\"><span style=\"font-weight: 400;\">Rinvoq<\/span><\/a><span style=\"font-weight: 400;\"> (upadacitinib), and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/orencia\"><span style=\"font-weight: 400;\">Orencia<\/span><\/a><span style=\"font-weight: 400;\"> (abatacept).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Remember, only your doctor can decide which treatment is best for you.<\/span><\/p>\n<h2 id=\"faqs\"><span style=\"font-weight: 400;\">Frequently asked questions about Humira<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">What does Humira treat?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira treats a variety of inflammatory conditions where the body\u2019s natural response causes severe, unwanted conditions. While there are many approved indications for Humira, the most common conditions for which Humira is prescribed include:\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr>\n<td><b>Moderate to severe rheumatoid arthritis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Moderate to severe polyarticular juvenile idiopathic arthritis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Psoriatic arthritis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Ankylosing spondylitis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Plaque psoriasis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Crohn\u2019s disease<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Ulcerative colitis<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Hidradenitis suppurativa<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span style=\"font-weight: 400;\">When do Humira\u2019s side effects start?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The most common side effect of Humira is an injection site reaction, and this can occur almost immediately after the injection. This typically presents as redness and swelling, and it may itch or be painful. Other side effects, such as liver damage, take months to develop.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">How long do Humira side effects last?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Injection site reactions for most patients will last for a few minutes up to an hour or two, and typically will self-resolve without intervention. The rare but more serious adverse events such as liver damage or\u00a0 life-threatening infections can have life-long consequences even if you stop Humira treatment.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What are the long term effects of Humira?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Heart damage, liver disease, and blood irregularities are potential long term effects of Humira, and unfortunately they aren\u2019t typically visible to the naked eye. In order to reduce the risk of long term side effects, it is important to maintain your regular visits to your physician and perform routine blood tests and screenings as your prescriber orders them.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Will Humira make you gain weight?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Humira does not directly cause weight loss or weight gain. If you experience involuntary weight changes while taking Humira, check in with your doctor immediately as this could be a symptom of something more serious.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can you drink alcohol while taking Humira?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol consumption can be damaging to the liver, as can Humira. Consuming alcohol while on Humira increases the risk of liver damage and the long term effects related to this damage. It is best to refrain from drinking alcohol while receiving Humira treatment.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Related resources to Humira side effects:<\/span><\/h2>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557889\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Adalimumab<\/span><\/a><span style=\"font-weight: 400;\">, StatPearls<\/span><\/li>\n<li><a href=\"https:\/\/www.statpearls.com\/ArticleLibrary\/viewarticle\/18291\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Biologic response modifiers<\/span><\/a><span style=\"font-weight: 400;\">, StatPearls<\/span><\/li>\n<li><a href=\"https:\/\/www.europeanpharmaceuticalreview.com\/article\/13699\/breaking-old-habits-moving-away-from-commonly-used-buffers-in-pharmaceuticals\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Breaking old habits: moving away from commonly used buffers in pharmaceuticals<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">European Pharmaceutical Review<\/span><\/i><\/li>\n<li><a href=\"https:\/\/online.epocrates.com\/drugs\/330010\/Humira\/Monograph\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Humira<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li><a href=\"https:\/\/www.humirapro.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Humira for healthcare professionals<\/span><\/a><span style=\"font-weight: 400;\">, AbbVie<\/span><\/li>\n<li><a href=\"https:\/\/www.rxabbvie.com\/pdf\/humira_medguide.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Humira medication guide<\/span><\/a><span style=\"font-weight: 400;\">, AbbVie<\/span><\/li>\n<li><a href=\"https:\/\/www.rxabbvie.com\/pdf\/humira.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Humira prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, AbbVie<\/span><\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482425\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Tumor necrosis factor inhibitors<\/span><\/a><span style=\"font-weight: 400;\">, StatPearls<\/span><\/li>\n<li><a href=\"https:\/\/www.practicalpainmanagement.com\/treatments\/pharmacological\/tumor-necrosis-factor-tnf-inhibitors-clinical-primer\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Tumor necrosis factor inhibitors: a clinical primer<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Practical Pain Management<\/span><\/i><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Common Humira side effects | Serious side effects | Side effects timeline | Dosing | Contraindications | Interactions | How to avoid side effects | Humira alternatives | FAQs Humira (adalimumab)\u2014an injection of a naturally-occurring human antibody\u2014induces remission and controls the symptoms of active autoimmune diseases. A healthcare provider may prescribe Humira for rheumatoid arthritis, [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":22455,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[715,12164,790,12752],"coauthors":[8861],"class_list":["post-22390","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-antibiotics","tag-arthritis","tag-chronic-disease","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Humira side effects, warnings, interactions, and more | SingleCare<\/title>\n<meta name=\"description\" content=\"Common side effects of Humira are headache, rash, and nausea. 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