{"id":26289,"date":"2021-04-20T13:00:23","date_gmt":"2021-04-20T17:00:23","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=26289"},"modified":"2025-03-10T11:36:41","modified_gmt":"2025-03-10T15:36:41","slug":"linzess-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/linzess-side-effects\/","title":{"rendered":"Linzess side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Linzess is a prescription medication that contains linaclotide and is used to treat chronic constipation, particularly in conditions like irritable bowel syndrome with constipation (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ibs-treatment-and-medications\"><span style=\"font-weight: 400;\">IBS-C<\/span><\/a><span style=\"font-weight: 400;\">) and chronic idiopathic constipation (CIC). It works by increasing fluid in the intestines, making it easier to pass stools. If you\u2019re considering this medication or have just started treatment, it\u2019s important to know about its common side effects, drug interactions, and other safety information.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/linzess\/what-is\"><b>What is Linzess?<\/b><\/a><b>\u00a0 |<\/b><a href=\"https:\/\/www.singlecare.com\/blog\/linzess-without-insurance\/\"> <b>How much is Linzess without insurance?<\/b><\/a><\/p>\n<h2 id=\"is-linzess-dangerous\"><span style=\"font-weight: 400;\">Is Linzess dangerous?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Linzess is generally considered safe and effective in adults and children aged 6 and older. However, like all medications, it may cause side effects, some of which can be serious. In <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/202811s021lbl.pdf\"><span style=\"font-weight: 400;\">studies<\/span><\/a><span style=\"font-weight: 400;\"> comparing Linzess to a placebo in IBS-C patients, 9% of patients taking Linzess stopped taking the medication early due to side effects, compared to 3% of patients taking the placebo. In longer studies lasting up to 18 months, 29% of patients had their dose of Linzess reduced or temporarily stopped due to side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While Linzess is not considered dangerous when used as directed, it may not be the best choice for everyone. It\u2019s important to be aware of the potential side effects and consult a healthcare provider for any severe or long-lasting symptoms.<\/span><\/p>\n<h2 id=\"common-side-effects-of-linzess\"><span style=\"font-weight: 400;\">Common side effects of Linzess<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For many adults with IBS-C or CIC and children with functional constipation, the benefits of taking it often outweigh the potential side effects. Here are the most common <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=09beda19-56d6-4a56-afdc-9a77b70b2ef3\"><span style=\"font-weight: 400;\">side effects of Linzess<\/span><\/a><span style=\"font-weight: 400;\">:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea: Diarrhea is the most common side effect of Linzess and is characterized by loose, watery stools that occur more frequently than usual. Often, diarrhea starts within the first two weeks of taking Linzess.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach-area pain: While taking Linzess, some people may feel pain or discomfort in their stomach area. This pain might feel like cramping or aching in your belly.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas: Linzess can cause gas to build up in your digestive system. This might make you pass gas or burp more often than usual, which can be uncomfortable.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bloating: Bloating is characterized by a feeling of fullness, tightness, or swelling in the abdomen. This can happen when gas builds up in your digestive system.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viral inflammation of the intestines (gastroenteritis): Sometimes, people taking Linzess may get a viral infection that causes inflammation in their stomach and intestines. This condition is called gastroenteritis, and it can cause symptoms like diarrhea, vomiting, and stomach pain.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache: Some people who take Linzess may get headaches. These headaches can be mild or severe and may be caused by different things related to the medication.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The severity of these side effects can vary from person to person. While some people may experience mild symptoms, others might face more adverse effects. It&#8217;s important to consult a healthcare provider to discuss any concerns and determine the best course of action if side effects worsen.\u00a0<\/span><\/p>\n<h2 id=\"serious-side-effects-of-linzess\"><span style=\"font-weight: 400;\">Serious side effects of Linzess<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">In rare cases, Linzess can cause serious side effects that may require medical attention.<\/span><\/p>\n<h3 id=\"severe-diarrhea\"><span style=\"font-weight: 400;\">Severe diarrhea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking Linzess and start to have diarrhea that worsens or won\u2019t go away, especially if you have bloody or black stools, then you should stop taking Linzess and contact your doctor to see if continuing the medication is right for you. Your healthcare provider can provide medical advice on what to do. In rare cases, severe diarrhea can lead to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK578208\/\"><span style=\"font-weight: 400;\">dizziness or fainting<\/span><\/a><span style=\"font-weight: 400;\">, and hospitalization may be necessary to replace lost electrolytes from dehydration.\u00a0<\/span><\/p>\n<h3 id=\"allergic-reactions\"><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Severe allergic reactions to Linzess are rare but possible. Anaphylaxis, in particular, is a serious reaction that can be life-threatening if not treated quickly. Symptoms may include trouble breathing, swelling in the throat, hives, or a rash. If you find yourself dizzy or unable to breathe after taking Linzess, it&#8217;s important to get medical help immediately.\u00a0<\/span><\/p>\n<h3 id=\"weight-loss\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Weight changes are not a side effect reported in placebo-controlled trials with Linzess. However, because the medication can cause diarrhea, some people may experience weight loss. Diarrhea can lead to a loss of water and electrolytes from the body, which may contribute to weight loss if it isn\u2019t treated right away. If you experience severe diarrhea while taking Linzess, you should stop taking it and call your doctor right away. This is especially important for older adults who may be more prone to dehydration.\u00a0\u00a0<\/span><\/p>\n<h2 id=\"how-long-do-linzess-side-effects-last\"><span style=\"font-weight: 400;\">How long do Linzess side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">How long side effects last depends on the individual and how their body processes the medication. For the average person taking Linzess, diarrhea is a common but temporary side effect. In clinical trials, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5350198\/\"><span style=\"font-weight: 400;\">around one-third<\/span><\/a><span style=\"font-weight: 400;\"> of participants who experienced diarrhea during the first week of treatment saw their symptoms resolve within a week.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although many side effects will resolve in the short term, it\u2019s possible to have longer-lasting side effects. For example, some people might have diarrhea that lasts up to a month. If you\u2019ve been taking Linzess for more than two weeks and your side effects aren\u2019t going away, it may be a good idea to contact your doctor to make sure that what you\u2019re experiencing is okay.\u00a0\u00a0<\/span><\/p>\n<p><b>Note:<\/b><span style=\"font-weight: 400;\"> Linzess is not a laxative and does not start working immediately. Most people will start to feel relief from their chronic constipation symptoms about a week after starting Linzess. The manufacturer suggests IBS-C patients typically see improvements in their medical condition over <\/span><a href=\"https:\/\/www.linzess.com\/savings-and-support\/faqs\"><span style=\"font-weight: 400;\">12 weeks<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0\u00a0\u00a0<\/span><\/p>\n<h2 id=\"linzess-contraindications-warnings\"><span style=\"font-weight: 400;\">Linzess contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Contraindications and warnings are important factors to consider when using medications like Linzess. They help determine who should not take the drug because it could cause harmful side effects or not work as intended.\u00a0<\/span><\/p>\n<h3 id=\"children-under-2-years-old\"><span style=\"font-weight: 400;\">Children under 2 years old\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although Linzess is approved in children aged 6 to 17 years old with functional constipation, it\u2019s not approved for all children. Linzess shouldn\u2019t be taken by pediatric patients younger than 2 years of age because its safety and efficacy for this age group haven\u2019t been established. Linzess may cause severe dehydration in young children.\u00a0<\/span><\/p>\n<h3 id=\"people-with-bowel-blockage\"><span style=\"font-weight: 400;\">People with bowel blockage<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People with known or suspected mechanical gastrointestinal obstruction (bowel blockage) should not take Linzess. This is because the medication works by increasing fluid in the intestines to help with bowel movements, which can worsen the blockage and lead to serious health problems.<\/span><\/p>\n<h3 id=\"women-who-are-pregnant-or-breastfeeding\"><span style=\"font-weight: 400;\">Women who are pregnant or breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Linzess should be avoided during pregnancy or while breastfeeding unless its use is approved by a doctor. Animal studies suggest Linzess may harm an unborn baby. However, Linzess has not been adequately studied in pregnant women. Although there is no human data available to suggest that Linzess causes fetal harm or is harmful to infants if it passes into breast milk, it should not be used unless the benefits outweigh the risks.\u00a0<\/span><\/p>\n<h3 id=\"older-adults\"><span style=\"font-weight: 400;\">Older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Older adults over 65 should be carefully monitored while taking Linzess. The effects of Linzess have not been specifically studied in this population. No dose adjustment is required, but elderly patients may have higher rates of liver and kidney problems that require more caution while taking this medication.<\/span><\/p>\n<h2 id=\"linzess-interactions\"><span style=\"font-weight: 400;\">Linzess interactions\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are no known drug interactions with Linzess indicated on the drug label. However, caution may be recommended while taking certain medications that may amplify the side effects of Linzess.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Laxatives such as sodium phosphate, magnesium citrate, and polyethylene glycol should be avoided when starting Linzess because they can increase the risk of diarrhea and dehydration. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/dehydration-medication\/\"><span style=\"font-weight: 400;\">Other medications<\/span><\/a><span style=\"font-weight: 400;\"> like diuretics can also increase the risk of dehydration. Therefore, it\u2019s best to consult your healthcare provider about all your medications, including prescription drugs, over-the-counter medicine, and supplements.<\/span><\/p>\n<h2 id=\"how-to-avoid-linzess-side-effects\"><span style=\"font-weight: 400;\">How to avoid Linzess side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">While completely avoiding Linzess side effects may not be possible, there are some things you can do to reduce their severity.<\/span><\/p>\n<h3 id=\"1-take-the-recommended-dosage\"><span style=\"font-weight: 400;\">1. Take the recommended dosage<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The daily recommended <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/linzess\/dosage\"><span style=\"font-weight: 400;\">dose of Linzess<\/span><\/a><span style=\"font-weight: 400;\"> for IBS-C is 290 mcg taken on an empty stomach at least 30 minutes before the first meal of the day. The recommended daily dose of Linzess for CIC is 145 mcg, which is taken at least 30 minutes before the first meal of the day. A dosage of 72 mcg taken once per day may also be used for patients with CIC who have a low tolerability for Linzess.\u00a0 Taking your medication at the same time each day helps your body get used to it and can reduce the severity of side effects.<\/span><\/p>\n<h3 id=\"2-store-linzess-properly\"><span style=\"font-weight: 400;\">2. Store Linzess properly<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Knowing how to properly store your medication is important to make sure it remains as effective as possible. Taking expired or improperly stored medication could result in the medication not working properly and may even cause unwanted side effects. Linzess should be stored in its original container at room temperature in a dry place. It\u2019s also important to leave the drying agent that comes in the bottle inside of the bottle to prevent excess moisture from affecting the medication.<\/span><\/p>\n<h3 id=\"3-share-your-medical-history-with-your-doctor\"><span style=\"font-weight: 400;\">3. Share your medical history with your doctor<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sharing your complete medical history with your healthcare provider can help them review your potential risk of side effects with Linzess. For example, by sharing a list of all medications and supplements you are currently taking, your doctor can identify any possible interactions that may lead to side effects. If necessary, your doctor can adjust your dosage or consider an alternative medication if side effects continue.<\/span><\/p>\n<h3 id=\"4-listen-to-your-body\"><span style=\"font-weight: 400;\">4. Listen to your body<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It&#8217;s important to listen to your body when taking Linzess. If you start to experience any side effects, let your doctor know right away so they can help you manage them. Many people can take Linzess for a long time without serious issues if they follow the instructions, but everyone can react differently to the medication.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Linzess is a prescription medication that contains linaclotide and is used to treat chronic constipation, particularly in conditions like irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It works by increasing fluid in the intestines, making it easier to pass stools. If you\u2019re considering this medication or have just started treatment, it\u2019s [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":26310,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[16414,12752],"coauthors":[8861],"class_list":["post-26289","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-digestive-health","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Linzess side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Diarrhea and weight loss are possible Linzess side effects. 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