{"id":26423,"date":"2021-04-14T13:00:21","date_gmt":"2021-04-14T17:00:21","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=26423"},"modified":"2025-09-12T16:36:08","modified_gmt":"2025-09-12T20:36:08","slug":"adderall-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/adderall-side-effects\/","title":{"rendered":"Adderall side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#adderall-side-effects\">Adderall side effects<\/a> |<a href=\"#serious-side-effects\"> Serious side effects<\/a> | <a href=\"#how-long-do-side-effects-last\">How long do side effects last?<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adderall is a central nervous system stimulant that treats the hyperactive-impulsive and inattentive symptoms of ADHD (attention deficit hyperactivity disorder) in adults and children as young as 3 years old. It is also prescribed to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6510672\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">alleviate daytime sleepiness<\/span><\/a><span style=\"font-weight: 400;\"> in adults and children 6 years and older diagnosed with narcolepsy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The active ingredients in Adderall are amphetamine salts. Adderall XR contains the same mixture of amphetamine salts in an extended-release oral capsule. Like all stimulants, Adderall has several side effects, warnings, restrictions, and drug interactions that patients or their caregivers should be familiar with when taking or administering this medication.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/prescription\/adderall\/what-is\">Learn more about Adderall<\/a><\/strong><\/p>\n<h2 id=\"adderall-side-effects\"><span style=\"font-weight: 400;\">Common side effects of Adderall<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effects of Adderall are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach ache<\/span><\/li>\n<li aria-level=\"1\">Headache<\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood swings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast heartbeat (tachycardia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lack of energy<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Weight loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Loss of appetite and weight loss are possible side effects of Adderall. Because of these side effects, some physicians prescribe Adderall off-label for weight loss, and some people acquire the drug illegally for the same purpose. However, Adderall is not approved by the FDA as a weight-loss medication and can have serious side effects that outweigh the benefits of weight loss.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Anxiety<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In Adderall XR clinical trials, anxiety was reported in <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">8% of adults<\/span><\/a><span style=\"font-weight: 400;\">, but not reported for children or adolescents. Anxiety is also a possible sign of Adderall abuse. Severe anxiety or panic attacks may require the discontinuation of Adderall treatment.<\/span><\/p>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of Adderall<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because Adderall changes how the brain works, the drug can produce several serious side effects even at recommended doses. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart-related problems such as increased blood pressure and heart rate, which can increase the risk of heart attacks, strokes, and sudden death (mostly in people with heart problems or heart defects)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental health problems such as the worsening or emergence of psychosis, mania, or tics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggressive behavior<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peripheral vasculopathy (blood vessel damage), including Raynaud\u2019s disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eyesight changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serotonin syndrome, or a rare but potentially life-threatening condition when drugs like Adderall are combined with other drugs that increase levels of serotonin in the brain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Growth suppression in children and adolescents<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potentially severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Adderall withdrawal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When Adderall is taken in high doses over a prolonged period, stopping the drug suddenly can cause adverse effects such as depression, fatigue, increased appetite, agitation, slowness, sleeping too much, or trouble sleeping. Nicknamed \u201cAdderall crash,\u201d these symptoms are actually amphetamine withdrawal symptoms. Initial withdrawal symptoms typically begin <\/span><a href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-58260-3_39\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">within 24 hours<\/span><\/a><span style=\"font-weight: 400;\"> of stopping amphetamines and can persist as less severe symptoms for about three weeks. To avoid withdrawal, a prescribing physician or healthcare professional may steadily reduce the Adderall dose until the drug can be safely discontinued.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Anxiety<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In Adderall XR clinical trials, anxiety was reported in <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">8% of adults<\/span><\/a><span style=\"font-weight: 400;\">, but not reported for children or adolescents. Anxiety is also a possible sign of Adderall abuse. Severe anxiety or panic attacks may require the discontinuation of Adderall treatment.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Other side effects<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Sexual side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Amphetamines can decrease sex drive and even cause impotence (erectile dysfunction). Both effects were reported by 2% to 4% of adults participating in Adderall XR clinical trials. Alternative medications, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ritalin\"><span style=\"font-weight: 400;\">Ritalin<\/span><\/a><span style=\"font-weight: 400;\"> (methylphenidate) for ADHD and the narcolepsy drugs modafinil and armodafinil may be less likely to cause a decrease in libido. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vyvanse\"><span style=\"font-weight: 400;\">Vyvanse<\/span><\/a><span style=\"font-weight: 400;\"> (lisdexamfetamine dimesylate) can cause similar sexual side effects as Adderall, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/strattera\"><span style=\"font-weight: 400;\">Strattera<\/span><\/a><span style=\"font-weight: 400;\"> (atomoxetine), another ADHD drug, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23775507\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">may also cause<\/span><\/a><span style=\"font-weight: 400;\"> sexual side effects.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Dependency, abuse, and misuse<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Adderall and Adderall XR are both <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507808\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Schedule II controlled substances<\/span><\/a><span style=\"font-weight: 400;\"> because of their potential for drug abuse and dependency. Adderall is sometimes misused as a weight loss aid or \u201c<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1524735\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">study drug<\/span><\/a><span style=\"font-weight: 400;\">\u201d by high-school and college students. Prolonged high doses of Adderall can cause dependency and withdrawal symptoms when withdrawn suddenly.<\/span><\/p>\n<h2 id=\"how-long-do-side-effects-last\"><span style=\"font-weight: 400;\">How long do Adderall side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects of Adderall are usually temporary, and they often go away with consistent use of the medication or when the medicine is discontinued. Some severe side effects such as heart-related problems could lead to life-threatening events like heart attacks and strokes. Although rare, the effects of growth suppression in children and adolescents could last a lifetime if the drug is not discontinued.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The long-term use of Adderall may lead to heart muscle disease (cardiomyopathy), brain chemistry changes, or drug abuse. Heart and brain damage <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2670101\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">have been well-documented<\/span><\/a><span style=\"font-weight: 400;\"> in people abusing amphetamines over a prolonged period but have not been well-studied in people taking amphetamines at therapeutic doses. There is some concern that long-term therapeutic use of amphetamines may be a \u201cgateway\u201d to illicit drug use, but <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2670101\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">the evidence is not conclusive<\/span><\/a><span style=\"font-weight: 400;\">. Taking Adderall under the supervision of a doctor and with a valid prescription generally does not result in brain damage or substance abuse.\u00a0<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Adderall contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Like all prescription drugs, Adderall and Adderall XR are not appropriate or safe for everyone. The amphetamines in Adderall can worsen existing medical conditions such as high blood pressure, heart problems, and psychotic disorders, such as bipolar disorder or Tourette\u2019s syndrome. For these reasons, Adderall and Adderall XR are contraindicated for people with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Advanced arteriosclerosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Moderate to severe high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Symptomatic cardiovascular disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperthyroidism (overactive thyroid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitated states<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Patients with a history of drug abuse\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Know hypersensitivity to amphetamines<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Adderall should be used with caution in people with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of seizures or who have had an abnormal brain wave test (EEG)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental health conditions such as psychosis, bipolar disorder, or Tourette syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of circulation problems in the fingers and toes<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Adderall withdrawal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When Adderall is taken in high doses over a prolonged period, stopping the drug suddenly can cause adverse effects such as depression, fatigue, increased appetite, agitation, slowness, sleeping too much, or trouble sleeping. Nicknamed \u201cAdderall crash,\u201d these symptoms are actually amphetamine withdrawal symptoms. Initial withdrawal symptoms typically begin <\/span><a href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-58260-3_39\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">within 24 hours<\/span><\/a><span style=\"font-weight: 400;\"> of stopping amphetamines and can persist as less severe symptoms for about three weeks. To avoid withdrawal, a prescribing physician or healthcare professional may steadily reduce the Adderall dose until the drug can be safely discontinued.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Adderall carries the risk for overdose in part because of its potential for drug abuse or misuse. The maximum recommended daily dose of Adderall is 40 mg a day for ADHD and 60 mg a day for narcolepsy, but symptoms of an overdose can occur at lower doses. These symptoms include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Restlessness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Overactive reflexes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Panic<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal cramps<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High or low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular heartbeat<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">A fatal overdose is often preceded by convulsions and coma. If an overdose is suspected, call a poison helpline or go to an emergency room.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Adderall has been FDA approved for children between the ages of 3 and 17 for the treatment of ADHD and for children older than 6 diagnosed with narcolepsy. Adderall XR, however, is only approved for children between the ages of 6 and older. Unfortunately, the long-term effects of the pediatric use of amphetamines have not been well-studied.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One significant and common side effect of Adderall is the suppression of growth in children. Over time, children taking Adderall may gain less weight and height than <\/span><a href=\"https:\/\/www.cdc.gov\/growthcharts\/index.htm\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">other children<\/span><\/a><span style=\"font-weight: 400;\">. Falling behind on growth is one reason Adderall may be discontinued in children.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The safety of Adderall in pregnant women has not been fully established, but the drug may<\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/35908\/Adderall\/Patient-Education\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\"> cause<\/span><\/a><span style=\"font-weight: 400;\"> premature birth, low birth weight, and amphetamine withdrawal symptoms in a newborn. Women who are pregnant or considering pregnancy should discuss the benefits and possible risks of taking Adderall during pregnancy. Pregnant women taking Adderall or Adderall XR may choose to join the <\/span><a href=\"https:\/\/womensmentalhealth.org\/research\/pregnancyregistry\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">National Pregnancy Registry for Psychiatric Medications<\/span><\/a><span style=\"font-weight: 400;\"> to help track Adderall\u2019s effects on pregnancy.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nursing women <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/35908\/Adderall\/Patient-Education\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">should avoid taking Adderall or Adderall XR<\/span><\/a><span style=\"font-weight: 400;\"> while breastfeeding. The amphetamines in Adderall can be present in breast milk at anywhere from <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Adderall-amphetamine-aspartate-monohydrate-amphetamine-sulfate-dextroamphetamine-saccharate-dextroamphetamine-sulfate-1048\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">2% to 14%<\/span><\/a><span style=\"font-weight: 400;\"> of the dose taken. Adverse effects on nursing babies have not been well-documented, but there is a possibility the infant may experience serious cardiovascular side effects or other adverse effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Senior citizens<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The use of Adderall in people older than 65 has not been studied.<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Adderall interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Adderall has several drug interactions patients or caregivers should review before taking or administering Adderall.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Monoamine oxidase inhibitors (MAOIs)\u2014CONTRAINDICATED:<\/b><span style=\"font-weight: 400;\"> MAO inhibitors are a small family of prescription medications that treat depression (isocarboxazid, tranylcypromine, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/phenelzine-sulfate\"><span style=\"font-weight: 400;\">phenelzine<\/span><\/a><span style=\"font-weight: 400;\">), bacterial infections (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/linezolid\"><span style=\"font-weight: 400;\">linezolid<\/span><\/a><span style=\"font-weight: 400;\"> or tedizolid), cancer (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/procarbazine-hcl\"><span style=\"font-weight: 400;\">procarbazine<\/span><\/a><span style=\"font-weight: 400;\">), Parkinson\u2019s disease (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/selegiline-hcl\"><span style=\"font-weight: 400;\">selegiline<\/span><\/a><span style=\"font-weight: 400;\"> and safinamide), or are used for medical imaging (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methylene-blue\"><span style=\"font-weight: 400;\">methylene blue<\/span><\/a><span style=\"font-weight: 400;\">). Adderall should <\/span><b><i>never<\/i><\/b> <span style=\"font-weight: 400;\">be taken within 14 days of the last dose of an MAO inhibitor. The combination can cause a potentially fatal rise in blood pressure or result in serotonin syndrome, a potentially hazardous drug reaction that occurs when too much serotonin persists in the brain.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Serotonergic drugs:<\/b><span style=\"font-weight: 400;\"> Serotonergic drugs raise serotonin levels in the brain. Adderall is a serotonergic drug. Combining two or more serotonergic drugs raises the risk of serotonin syndrome. Serotonergic drugs that should be avoided or used cautiously with Adderall include certain antidepressants, antipsychotic medications, mood stabilizers, other stimulants, opioids, migraine medications, antinausea drugs, seizure medications, and drugs that treat the symptoms of Parkinson\u2019s disease. Some of these drugs, when combined with Adderall, may increase the risk of seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stimulants:<\/b><span style=\"font-weight: 400;\"> The amphetamines in Adderall are classified as stimulants. They \u201cspeed up\u201d the brain, causing possible side effects such as high blood pressure, fast heartbeat, and anxiety. Combining Adderall with other stimulants, such as caffeine, amphetamines, nasal decongestants, bronchodilators, and appetite suppressants may increase the likelihood or severity of side effects.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Sympathomimetics:<\/b><span style=\"font-weight: 400;\"> The amphetamines in Adderall are also sympathomimetic drugs, which stimulate sympathetic nerves responsible for regulating blood pressure, heart rate, and sweating. Taking Adderall with other sympathomimetic medications such as other amphetamines, decongestants, and weight loss medications (including <a href=\"https:\/\/www.singlecare.com\/blog\/phentermine-vs-adderall\/\">phentermine<\/a>, phendimetrazine, diethylpropion, and benzphetamine all of which are <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/35904\/Adderall\/Drug-Interactions\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">contraindicated<\/span><\/a><span style=\"font-weight: 400;\">) can increase the risk of cardiovascular side effects.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Tricyclic antidepressants:<\/b><span style=\"font-weight: 400;\"> Tricyclic antidepressants can cause a sharp increase in the concentration of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dextroamphetamine-sulfate\"><span style=\"font-weight: 400;\">dextroamphetamine<\/span><\/a><span style=\"font-weight: 400;\"> in the brain, raising the risk of cardiovascular events.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Blood pressure medications (antihypertensives): <\/b><span style=\"font-weight: 400;\">Because one of the side effects of Adderall is high blood pressure, Adderall can reduce the beneficial effects of blood pressure lowering medications.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Glaucoma medications<\/b><span style=\"font-weight: 400;\">: The amphetamines in Adderall also increase pressure in the eye, blunting the positive effects of glaucoma medications.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Adrenergic blockers:<\/b><span style=\"font-weight: 400;\"> Sometimes called alpha blockers and beta blockers, adrenergic blockers interfere with nerve signals to muscles in the heart and blood vessels. They are used to treat high blood pressure, chest pain, and irregular heartbeats. The amphetamines in Adderall can counteract the action of these drugs, reducing their important and life-saving benefits.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>CYP2D6 inhibitors: <\/b><span style=\"font-weight: 400;\">Several types of drugs, called CYP2D6 inhibitors, block the liver enzyme (CYP2D6) the body uses to break down Adderall. The most potent include some selective serotonin reuptake inhibitors (SSRIs), certain antiviral drugs, and quinidine. Healthcare professionals are well-versed in these drugs, so always tell a doctor, pharmacist, or other healthcare provider about any medications being taken when getting a prescription.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Acidifying agents<\/b><span style=\"font-weight: 400;\"><strong>:<\/strong> Drugs or foods that increase stomach acid or urinary acid can decrease the concentration of Adderall in the blood. While not strictly forbidden, acidifiers may make Adderall less effective as a therapy.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alkalinizing agents<\/b><span style=\"font-weight: 400;\"><strong>:<\/strong> Drugs that decrease stomach acid or urinary acid can increase the concentration of Adderall in the blood, raising the risk of side effects. Certain alkalinizing drugs, like antacids, some thiazides, and urinary alkalinizing agents, should be avoided when taking Adderall.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This may not be a complete list of possible drug interactions with Adderall.\u00a0<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid Adderall side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">People taking Adderall commonly experience side effects, particularly loss of appetite, dry mouth, and trouble sleeping. There are, however, potentially more worrisome but rare side effects such as elevated blood pressure or fast heartbeats patients or caregivers may be concerned about. A few tips can help reduce or prevent side effects:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1.\u00a0 Take Adderall as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Take the dose as prescribed and read the medication guide or patient instructions that come with the medicine. For maximum benefit, take Adderall daily unless directed otherwise. Adderall can be taken with or without food. However, foods that increase stomach acid, such as citrus juice, may decrease the body\u2019s absorption of the drug, decreasing its effectiveness. Above all, do not increase the dose or use the medication for another purpose, such as weight loss or studying.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2.\u00a0 Take the first dose of Adderall right after waking up in the morning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The first Adderall dose should be taken upon waking in the morning. Adderall XR should only be taken in the morning.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3.\u00a0 Do not take a late dose of Adderall<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To prevent sleeplessness, a common complaint of Adderall users, avoid taking doses late in the afternoon or early evening. Adderall XR should not be taken in the afternoon.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4.\u00a0 Tell your doctor about all medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because of the risk of side effects, you should tell your prescribing doctor or healthcare provider about:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any medical conditions, such as heart, circulation, or blood pressure problems, as well as an overactive thyroid or a history of seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Psychiatric conditions, especially schizophrenia, bipolar disorder, or Tourette\u2019s syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any history of substance abuse\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All medications, over-the-counter medications, supplements, and remedies being taken<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">5.\u00a0 Avoid taking other stimulants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Other types of stimulants, like caffeine and nasal decongestants, may worsen Adderall\u2019s side effects, so use them conservatively.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6.\u00a0 Avoid antacids and other alkalinizing agents<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Substances that reduce stomach or urinary acid can increase the risk of Adderall\u2019s side effects. The most common alkalinizing agents are antacids. They should be avoided outright when taking Adderall.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7.\u00a0 Practice good sleep hygiene<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Insomnia is one of the most common side effects of Adderall. One area to consider in overcoming amphetamine-induced sleeplessness is good sleep hygiene\u2014go to bed at the same time each night, relax before bedtime, avoid overstimulation, take a break from devices immediately before bed, exercise every day, and maintain a sleep log to track what works and what doesn\u2019t.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8.\u00a0 Take a medication holiday<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When Adderall side effects become a problem, many healthcare providers <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/1087054714548035\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">suggest<\/span><\/a><span style=\"font-weight: 400;\"> taking a \u201c<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/adhd-drug-holiday\/\"><span style=\"font-weight: 400;\">medication holiday\u201d<\/span><\/a><span style=\"font-weight: 400;\"> when the medication is discontinued or the dose reduced for a few days, a few weeks, or even a few months. However, get professional medical advice first. Taking a medication holiday may not be appropriate for some people.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Resources:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/35910\/Adderall\/Monograph\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Adderall<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/266210\/Adderall-XR\/Monograph\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Adderall XR<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Adderall prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=aff45863-ffe1-4d4f-8acf-c7081512a6c0\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Adderall XR prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/Adderall-amphetamine-aspartate-monohydrate-amphetamine-sulfate-dextroamphetamine-saccharate-dextroamphetamine-sulfate-1048\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Amphetamine aspartate monohydrate\/amphetamine sulfate\/dextroamphetamine saccharate\/dextroamphetamine sulfate\u2014drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507808\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Dextroamphetamine-Amphetamine<\/span><\/a><span style=\"font-weight: 400;\">, StatPearls<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/journals.sagepub.com\/doi\/10.1177\/1087054714548035\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Drug holidays from ADHD medication: International experience over the past four decades<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Journal of Attention Disorders<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1524735\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Misuse of \u201cstudy drugs\u201d: prevalence, consequences, and implications for policy,<\/span><\/a> <i><span style=\"font-weight: 400;\">Substance Abuse Treatment, Prevention, and Policy<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7780985\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Orgasmolepsy in narcolepsy type 1 responsiveness to pitolisant: a case report<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Nature and Science of Sleep<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2670101\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Potential adverse effects of amphetamine treatment on brain and behavior: A review<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Molecular Psychiatry<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23775507\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">Profile of sexual and genitourinary treatment-emergent adverse events associated with atomoxetine treatment: a pooled analysis<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Drug Safety<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/fpnotebook.com\/psych\/CD\/StmlntUsDsrdr.htm\"><span style=\"font-weight: 400;\">Stimulant Use Disorder<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Family Practice Notebook<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6510672\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"font-weight: 400;\">The treatment of narcolepsy with amphetamine-based stimulant medications: A call for better understanding<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Journal of Clinical Sleep Medicine<\/span><\/i><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Adderall side effects | Serious side effects | How long do side effects last? | Warnings | Interactions | How to avoid side effects Adderall is a central nervous system stimulant that treats the hyperactive-impulsive and inattentive symptoms of ADHD (attention deficit hyperactivity disorder) in adults and children as young as 3 years old. It [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":26444,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[15107],"coauthors":[8861],"class_list":["post-26423","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-adhd","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Adderall side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Decreased appetite, dry mouth, and trouble sleeping are common Adderall side effects. 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