{"id":30230,"date":"2021-04-30T09:00:38","date_gmt":"2021-04-30T13:00:38","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=30230"},"modified":"2026-03-17T10:21:02","modified_gmt":"2026-03-17T14:21:02","slug":"lipitor-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lipitor-side-effects\/","title":{"rendered":"Lipitor side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/lipitor\">Lipitor<\/a> is a brand-name prescription drug used to lower cholesterol and triglyceride levels in the blood. Atorvastatin, the active ingredient in Lipitor, belongs to a <a href=\"https:\/\/www.singlecare.com\/blog\/is-atorvastatin-a-blood-thinner\/\">family of drugs called statins<\/a> or HMG-CoA reductase inhibitors. It works by reducing the liver\u2019s production of LDL cholesterol and increasing the liver\u2019s removal of LDL cholesterol from the blood. Also known as the \u201cbad\u201d cholesterol, LDL cholesterol or low-density lipoprotein can build up and clog the blood vessels.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Statins also work to increase the levels of \u201cgood\u201d cholesterol (HDL cholesterol) and reduce levels of certain fats called triglycerides that can damage the blood vessels. In addition, statins like Lipitor may help prevent heart attacks, strokes, and other cardiovascular problems<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Learn about Lipitor\u2019s side effects, contraindications, warnings, and potential drug interactions.<\/span><b><\/b><\/p>\n<h2><span style=\"font-weight: 400;\">Common side effects of Lipitor<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lipitor has been widely used for over 20 years, so <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/statin-side-effects\/\"><span style=\"font-weight: 400;\">its side effects<\/span><\/a><span style=\"font-weight: 400;\"> are well-known. The most commonly reported side effects are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Common cold symptoms, such as sore throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain in the arms or legs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach upset<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle spasms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Common cold symptoms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020702s077lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">placebo-controlled clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, common cold symptoms were the most commonly reported side effect of Lipitor. The common cold, also known as nasopharyngitis, involves swelling of the back of the throat and nasal passages. Symptoms may include a sore throat, runny nose, sneezing, and coughing.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Joint and muscle pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Joint pain, or arthralgia, is another common side effect of Lipitor. Some people may also experience muscle pain or general pain in the arms and legs along with pain in the joints. <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/1691918\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">One study<\/span><\/a><span style=\"font-weight: 400;\"> from the Journal of the American Medical Association found that people taking statins have a 19% higher chance of experiencing musculoskeletal pain than people who are not taking statins. Joint and muscle pain may affect a person\u2019s ability to exercise, which may contribute to possible weight gain.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Diarrhea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In addition to common cold symptoms and pain in the joints or muscles, Lipitor can also cause gastrointestinal side effects. Around <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020702s077lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">7%\u200b\u200b<\/span><\/a><span style=\"font-weight: 400;\"> of people in clinical trials experienced diarrhea while taking Lipitor. Diarrhea may also be accompanied by other gastrointestinal side effects like nausea, stomach upset, or nausea.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects reported with Lipitor include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flatulence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ringing in the ears<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated liver enzymes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased blood sugar levels, which could worsen or lead to <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental impairment or memory loss<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Muscle pain or weakness is one of the most common reasons people stop taking Lipitor. If muscle problems arise, a healthcare professional might reduce the dose, switch to a different statin, or stop treatment for a while.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Serious side effects of Lipitor<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lipitor can cause severe and even life-threatening side effects including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain, tenderness, or weakness (myopathy)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe muscle damage and breakdown of the muscle (rhabdomyolysis) that can lead to kidney failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nerve damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lung injury and scarring<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immune-mediated necrotizing myopathy (a rare autoimmune disorder of the skeletal muscles)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Myopathy and rhabdomyolysis<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People who take statins may be at an increased risk of severe side effects that affect the muscles. The use of Lipitor has been associated with myopathy, which includes symptoms like muscle pain, tenderness, or weakness. In severe cases, myopathy can worsen and develop into <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/rhabdomyolysis\/\"><span style=\"font-weight: 400;\">rhabdomyolysis<\/span><\/a><span style=\"font-weight: 400;\">, or the breakdown of the muscle tissue.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Creatinine kinase (CK) is an enzyme that is released into the blood when there is muscle damage. Because CK is filtered by the kidneys, high CK levels can take a toll on the kidneys and cause severe kidney damage or kidney failure. A healthcare provider will often run blood tests to check CK levels if they suspect myopathy or rhabdomyolysis.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Immune-mediated necrotizing myopathy\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Immune-mediated necrotizing myopathy, also known as necrotizing autoimmune myopathy, is a rare autoimmune condition that can result from the use of Lipitor. This condition develops when the immune system starts attacking the muscle cells, leading to the death of the muscle tissue. Symptoms may include extreme fatigue, difficulty walking up stairs or getting up from a sitting position, and weakness of the muscles (particularly those closest to the body, such as the back, shoulders, and neck).<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lipitor, especially <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/23247096211014050\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">in high doses<\/span><\/a><span style=\"font-weight: 400;\">, can lead to liver problems, such as liver injury and liver disease. Symptoms of liver injury include jaundice, fatigue, dark urine, and decreased appetite. Initially, someone taking Lipitor may experience increased levels of the aspartate aminotransferase (AST) and alanine aminotransferase (ALT) liver enzymes. Elevated liver enzyme tests could signify liver problems; therefore, healthcare providers often check liver enzyme levels before starting therapy with a statin.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A serious allergic reaction to Lipitor is rare. However, cases have been reported. An allergic reaction to Lipitor may include signs or symptoms like severe rash, itching, trouble breathing, and swelling of the face, lips, or throat.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do Lipitor side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lipitor is typically cleared from the body in about 77 hours, or three days, with a half-life of about <\/span><a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Atorvastatin#section=Biological-Half-Life\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">20 to 30 hours<\/span><\/a><span style=\"font-weight: 400;\">. Side effects could last as long as the medication is being taken. Healthcare providers may still recommend taking the medication if side effects are minor and develop at the start of treatment. Side effects are usually mild and temporary, and the severity of side effects may dissipate over time as the body adapts to the medication. If side effects persist or worsen, contact a healthcare provider.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Serious side effects such as muscle damage and severe allergic reactions may require immediate medical attention and discontinuation of the drug. Muscle pain and weakness could last for <\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc0908215\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">several months<\/span><\/a><span style=\"font-weight: 400;\"> after Lipitor has been discontinued. If left untreated, serious side effects can lead to lifelong complications. Some side effects, such as lung injury and muscle damage, may be irreversible and require lifelong treatment.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Lipitor contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although effective at reducing cholesterol levels and lowering the risk of heart attack or stroke, Lipitor may not be suitable for everyone. Continue reading to learn about misuse, withdrawal, overdose, and how Lipitor may worsen pre-existing medical conditions.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lipitor is not a drug subject to abuse or psychological dependence. When statins are discontinued after long-term use, however, LDL cholesterol levels can quickly rebound to higher than normal. Because increased LDL cholesterol can lead to cardiovascular events, stopping a drug like Lipitor may lead to an increased risk of heart attacks and strokes.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is possible for most people to safely stop taking a statin, but <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7027549\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">there are no concrete guidelines<\/span><\/a><span style=\"font-weight: 400;\"> for discontinuing statin therapy in older people. If a statin is not working, get professional medical advice before stopping the medication.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">High doses of Lipitor can increase the risk of <\/span><a href=\"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.118.312782\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">statin toxicity<\/span><\/a><span style=\"font-weight: 400;\">, which can lead to serious side effects. You may experience symptoms such as muscle pain, muscle weakness, and muscle inflammation, plus high levels of creatine kinase in the blood. When muscles are damaged, the cells leak creatine kinase and a protein called myoglobin into the bloodstream. If muscle damage is severe enough, the kidneys can be injured by the substances released from the dead muscle cells.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">An overdose can be a concern while taking statins. Some people who take several other medications or have other health conditions may forget to take their dose correctly\u2014forgetting a dose one day and taking too high of a dose another day. To prevent an overdose, medication reminders such as daily alarms can be helpful.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If an overdose is suspected, get emergency medical attention. When taking statins, talk to a doctor or other healthcare professional if you feel unusual muscle pain or muscle weakness while taking Lipitor. Muscle pain and muscle weakness are possible signs of statin toxicity.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Certain people should never take Lipitor, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with active liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Women who are pregnant<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Women who are breastfeeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People who are allergic to atorvastatin or any other ingredients in Lipitor<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Lipitor may be less effective or more hazardous with certain medical conditions or lifestyle choices, including:<\/span><b><\/b><\/p>\n<ul>\n<li aria-level=\"1\"><b>Kidney problems: <\/b><span style=\"font-weight: 400;\">People with kidney impairment may be more likely to experience muscle problems, including severe muscle damage while taking Lipitor. The drug can still be prescribed in people with kidney problems with no dose adjustments needed.<\/span><\/li>\n<li aria-level=\"1\"><b>Thyroid problems:<\/b><span style=\"font-weight: 400;\"> People with an underactive thyroid (hypothyroidism) are at an increased risk of developing muscle pain, muscle weakness, and severe muscle damage while taking Lipitor or other statins, such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/zocor\"><span style=\"font-weight: 400;\">Zocor<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/simvastatin\"><span style=\"font-weight: 400;\">simvastatin<\/span><\/a><span style=\"font-weight: 400;\">). Uncontrolled hypothyroidism may need to be treated before starting statin therapy.<\/span><\/li>\n<li aria-level=\"1\"><b>Liver impairment:<\/b><span style=\"font-weight: 400;\"> Because of an increased risk of liver damage, Lipitor is not prescribed to people with active liver disease. Lipitor may also be prescribed with caution in people with a history of liver problems. The Food and Drug Administration (FDA) <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">recommends<\/span><\/a><span style=\"font-weight: 400;\"> blood tests to assess liver function before Lipitor is first prescribed.<\/span><\/li>\n<li aria-level=\"1\"><b>Alcohol consumption:<\/b><span style=\"font-weight: 400;\"> Men and women who heavily consume alcohol daily are at a higher risk of liver disease than other men and women. People with chronic alcoholic liver disease are more likely to experience liver problems with Lipitor. Tell your doctor if you drink more than two alcoholic drinks daily before starting treatment with Lipitor.<\/span><\/li>\n<li aria-level=\"1\"><b>Diabetes:<\/b><span style=\"font-weight: 400;\"> Lipitor and other statins can worsen <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4926726\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">hyperglycemia and A1c<\/span><\/a><span style=\"font-weight: 400;\"> levels in people with diabetes. The American Diabetic Association (ADA) guidelines <\/span><a href=\"https:\/\/care.diabetesjournals.org\/content\/32\/suppl_2\/S384\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">suggest<\/span><\/a><span style=\"font-weight: 400;\"> that, rather than prescribe a fixed-dose, healthcare professionals prescribe and adjust statin doses based on target LDL levels to minimize Lipitor\u2019s effects on blood sugar levels. It is important to tell your doctor if you have a history or risk of diabetes before taking Lipitor.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Recent stroke:<\/b><span style=\"font-weight: 400;\"> In people who have recently experienced a stroke or transient ischemic attack (TIA, or \u201cmini-stroke\u201d), Lipitor may increase the risk of bleeding in the brain (hemorrhagic stroke). There may be an <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020702s077lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increased risk<\/span><\/a><span style=\"font-weight: 400;\"> of hemorrhagic stroke in people taking at least 80 mg of Lipitor within six months of a stroke or TIA.\u00a0<\/span><\/li>\n<li aria-level=\"1\"><b>Advanced age: <\/b><span style=\"font-weight: 400;\">People older than 65 are more likely to experience muscle pain, muscle weakness, and muscle damage. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7921957\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Studies<\/span><\/a><span style=\"font-weight: 400;\"> suggest Lipitor be used cautiously in older patients due to an increased risk of myopathy. However, providers may recommend Lipitor to prevent future medical problems caused by high cholesterol levels. The balance of long-term benefits versus short-term risks evolves as people get older and their expected lifespan shortens. When a person reaches a certain age, a healthcare professional may suggest reducing or stopping statin therapy.\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"list-style-type: none;\"><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Lipitor interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lipitor may not be safe to take with certain drugs. Certain combinations should be avoided, but others may require monitoring or treatment adjustments. Some of these drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Azole antifungal medications (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/itraconazole\"><span style=\"font-weight: 400;\">itraconazole<\/span><\/a><span style=\"font-weight: 400;\"> and ketoconazole)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain antibiotics (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><span style=\"font-weight: 400;\"> and rifampin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">AIDS\/HIV or hepatitis antiviral medications (such as ritonavir, saquinavir, and darunavir)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fibrates (such as gemfibrozil)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain immune suppressant drugs (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclosporine\"><span style=\"font-weight: 400;\">cyclosporine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain heart failure medications (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/digoxin\"><span style=\"font-weight: 400;\">digoxin<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Niacin (vitamin B3)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Birth control pills<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Lipitor is mainly metabolized, or processed, in the liver by the CYP3A4 enzyme. Drugs that block this enzyme, also known as CYP3A4 inhibitors, can decrease the metabolism of Lipitor and increase the overall blood levels of Lipitor. Certain azole antifungals, some macrolide antibiotics, and many antivirals can increase the risk of Lipitor side effects when taken with Lipitor.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Drugs that promote the actions of the CYP3A4 enzyme, also known as CYP3A4 inducers, can increase the metabolism and decrease the effectiveness of Lipitor. When combined with Lipitor, drugs like rifampin may decrease the effectiveness of Lipitor.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lipitor may also affect how other drugs work in the body. For example, Lipitor can increase the blood levels of birth control pills, which may increase the risk of side effects from the birth control pills. Lipitor may also increase the blood levels of digoxin, a heart failure medication that is usually taken with other drugs. People taking birth control pills or digoxin may need to be monitored for potential adverse effects if they are also taking Lipitor.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our heart health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Heart Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Avoid large amounts of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/grapefruit-juice-with-medicine-other-foods\/\"><span style=\"font-weight: 400;\">grapefruit or grapefruit juice<\/span><\/a><span style=\"font-weight: 400;\">. Grapefruit can block the CYP3A4 enzyme and interfere with the breakdown of Lipitor in the body. Statin toxicity is a possibility if a statin is mixed with grapefruit.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is recommended to avoid high-fat or high-cholesterol foods while taking Lipitor. These foods may increase cholesterol levels and make Lipitor less effective.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always talk to your doctor or another healthcare provider before taking Lipitor to help avoid interactions with foods or other medications.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How to avoid Lipitor side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lipitor can prevent life-threatening problems when it is taken every day over the long term. As with all medications, however, Lipitor can cause unwanted side effects. Since Lipitor may be a lifelong treatment, it\u2019s helpful to learn a few ways to both minimize adverse effects and promote the potential benefits of the drug.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Take Lipitor as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Most importantly, take Lipitor as directed at the same time every day. Follow all the directions given by a healthcare provider or those that come with the prescription drug pamphlet. Healthcare providers typically prescribe 10 to 80 mg of Lipitor per day, and they usually prescribe it to be taken as a long-term treatment. Do not change the dose, skip a dose, or stop the medicine without talking to a doctor or healthcare professional.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Use an alarm or reminder<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid missing a dose or accidentally taking extra doses, use a medication diary, calendar, or smartphone app. It can help to schedule your daily dose into your daily routine, such as before breakfast, after dinner, or before bedtime.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Tell the doctor about all medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Before taking Lipitor, make sure the doctor or other healthcare professional prescribing Lipitor is fully informed about your medical history including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any current or past medical conditions, including kidney disease, liver disease, diabetes, and thyroid problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy, breastfeeding, or plans to get pregnant or breastfeed<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">All over-the-counter and prescription drugs, supplements, and herbal remedies being taken<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Daily alcohol consumption<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">4. Keep all follow-up appointments\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lipitor\u2019s effects cannot be felt or monitored at home. Be sure to keep all follow-up appointments with your healthcare provider. Blood tests may be necessary to ensure the drug is working and not causing side effects. Tracking any side effects you experience may help prevent serious medical complications.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Watch for signs of possible side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many of Lipitor\u2019s most serious side effects may not be evident until they\u2019ve become serious problems. Keep watch for any muscle problems, including muscle aches, tenderness, or unusual weakness. Even if the muscle pain seems mild, tell a doctor who can order special lab tests to see if there is any muscle damage.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rarely, Lipitor can cause changes in thinking or memory. If mental abilities seem to be deteriorating, talk to your prescribing doctor. Lipitor can also damage the liver, so look for signs of liver impairment, such as jaundice (yellowing of the skin, eyes, or mucous membranes), dark urine, tiredness, or pain in the upper right part of the stomach area.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may need to switch to a different medication or discontinue statins altogether if you experience any muscle, liver, or cognitive problems.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lipitor is a brand-name prescription drug used to lower cholesterol and triglyceride levels in the blood. Atorvastatin, the active ingredient in Lipitor, belongs to a family of drugs called statins or HMG-CoA reductase inhibitors. It works by reducing the liver\u2019s production of LDL cholesterol and increasing the liver\u2019s removal of LDL cholesterol from the blood. 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