{"id":3314,"date":"2020-02-20T09:00:54","date_gmt":"2020-02-20T14:00:54","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3314"},"modified":"2026-01-06T10:25:42","modified_gmt":"2026-01-06T15:25:42","slug":"armodafinil-vs-modafinil","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/armodafinil-vs-modafinil\/","title":{"rendered":"Armodafinil vs. modafinil: Differences, similarities, and which is better for you"},"content":{"rendered":"

You might struggle with extreme sleepiness during the day if you work the night shift. But with proper treatment like armodafinil (Nuvigil) or modafinil (Provigil), you can stay awake and feel more alert. These medications can be prescribed if you\u2019ve been diagnosed with shift work disorder (SWD), narcolepsy, or obstructive sleep apnea (OSA). As wakefulness-promoting agents, armodafinil and modafinil have stimulant-like effects.\u00a0<\/span><\/p>\n

While their exact mechanism of action is unknown, <\/span>armodafinil<\/span><\/a> and <\/span>modafinil<\/span><\/a> are believed to work in the central nervous system (CNS) and boost dopamine activity in the brain. Their effects may be similar to other stimulants, such as amphetamine (<\/span>Adderall<\/span><\/a>) and methylphenidate (<\/span>Concerta<\/span><\/a>). However, they are structurally different from other stimulants.<\/span><\/p>\n

Both armodafinil and modafinil are <\/span>Schedule IV<\/span><\/a> drugs that carry a risk of abuse and dependence. They are controlled substances only available with a prescription.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between armodafinil and modafinil<\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nArmodafinil<\/b><\/td>\nModafinil<\/b><\/td>\n<\/tr>\n
Drug class<\/span><\/td>\nStimulant-like drug<\/span><\/p>\n

Wakefulness-promoting agent<\/span><\/td>\n

Stimulant-like drug<\/span><\/p>\n

Wakefulness-promoting agent<\/span><\/td>\n<\/tr>\n

Brand\/generic status<\/span><\/td>\nBrand and generic versions available<\/span><\/td>\nBrand and generic versions available<\/span><\/td>\n<\/tr>\n
What is the brand name?<\/span><\/td>\nNuvigil<\/span><\/td>\nProvigil<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/span><\/td>\nOral tablet<\/span><\/td>\nOral tablet<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/span><\/td>\n150\u2013250 mg once per day<\/span><\/td>\n200 mg once per day<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/span><\/td>\nLong-term or as directed by a physician<\/span><\/td>\nLong-term or as directed by a physician<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/span><\/td>\nAdults and young adults 17 years and older<\/span><\/td>\nAdults and young adults 17 years and older<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

What are the main differences between armodafinil and modafinil?<\/span><\/h2>\n

Armodafinil, sold under the brand name Nuvigil, is a newer drug than modafinil. It was <\/span>approved in 2007<\/span><\/a> as the R-enantiomer of modafinil. Enantiomers are molecules that are mirror images of each other\u2014think left and right-handed gloves. In this way, armodafinil has a slightly different chemical structure than modafinil.\u00a0<\/span><\/p>\n

Armodafinil may have a <\/span>longer half-life<\/span><\/a> than modafinil. In some cases, armodafinil may be considered a stronger drug with better wakefulness effects. While both drugs can have similar side effects, some side effects may be more common in one drug versus the other.\u00a0<\/span><\/p>\n

Conditions treated by armodafinil and modafinil<\/span><\/h2>\n

Armodafinil and modafinil are prescription drugs that are FDA-approved to treat daytime sleepiness related to narcolepsy, shift work sleep disorder, and obstructive sleep apnea. These medical conditions are characterized by inadequate feelings of rest, which results in excessive sleepiness. Both drugs improve wakefulness in those who struggle with excessive fatigue and sleepiness throughout the day.\u00a0<\/span><\/p>\n

Armodafinil and modafinil have also been studied for off-label purposes. Some <\/span>studies<\/span><\/a> show that modafinil can be an effective treatment option for fatigue that occurs as a result of cancer and cancer treatment. In adults who are actively receiving cancer treatment, modafinil may help offset excessive tiredness from chemotherapy.<\/span><\/p>\n

Lower doses of modafinil may be effective for treating fatigue symptoms in people with <\/span>multiple sclerosis<\/span><\/a>. However, most data suggest that it should not be used as a first-line option for this condition.<\/span><\/p>\n

Other off-label uses include treatment for psychiatric disorders like <\/span>depression<\/span><\/a> and attention deficit hyperactivity disorder (ADHD). Armodafinil or modafinil may be effective for treating symptoms of these disorders, but they are not recommended as initial treatment options.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nArmodafinil<\/b><\/td>\nModafinil<\/b><\/td>\n<\/tr>\n
Narcolepsy<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Shift work disorder<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Obstructive sleep apnea<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Cancer-related fatigue<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Multiple sclerosis-related fatigue<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Psychiatric disorders such as depression and ADHD<\/span><\/td>\nOff-label<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is armodafinil or modafinil more effective?<\/span><\/h2>\n

In a 12-week randomized, double-blind trial, both armodafinil and modafinil <\/span>improved sleepiness<\/span><\/a> in subjects working the night shift. The results found that armodafinil and modafinil were comparable and had similar safety scores.<\/span><\/p>\n

In a <\/span>meta-analysis<\/span><\/a> of over 10 clinical trials comparing armodafinil and modafinil for obstructive sleep apnea, both drugs were found to be similarly effective for treating sleepiness. Patients taking either drug tolerated side effects and experienced improved daytime wakefulness.\u00a0<\/span><\/p>\n

Still, those who take armodafinil have higher <\/span>plasma concentrations<\/span><\/a> later in the day than those who take modafinil. Higher armodafinil levels in the body may result in better wakefulness than modafinil.\u00a0<\/span><\/p>\n

While either drug can be used to treat excessive daytime sleepiness, it is best to consult a healthcare provider for medical advice. Currently, no definitive studies say one is more effective than the other.<\/span><\/p>\n

Coverage and cost comparison of armodafinil vs. modafinil<\/span><\/h2>\n

Armodafinil is usually prescribed as a 250 mg tablet taken once daily. It is widely available as a generic medication covered by Medicare and insurance plans. Generic armodafinil can cost over $600. However, this price may be lowered with a <\/span>SingleCare discount card<\/span><\/a>.<\/span><\/p>\n

Depending on your insurance plan, modafinil may be covered. In fact, Medicare and most insurance plans cover modafinil for approved purposes. The average cost of generic modafinil may be close to $600. At participating pharmacies, you may be able to use a SingleCare <\/span>savings card for modafinil<\/span><\/a> to save money.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
\n

Armodafinil vs. modafinil costs<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Insurance coverage and costs<\/strong><\/td>\nArmodafinil<\/b><\/td>\nModafinil<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare?<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Standard dosage<\/span><\/td>\n150 mg (30 tablets)<\/span><\/td>\n200 mg (30 tablets)<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/span><\/td>\nVaries<\/span><\/td>\nVaries<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Common side effects of armodafinil vs. modafinil<\/p>\n

The most common side effects of modafinil and armodafinil include headache, nausea, dizziness, and insomnia. Modafinil may be more likely to cause other <\/span>side effects<\/span><\/a>, such as nervousness, nasal congestion (rhinitis), diarrhea, and back pain.\u00a0<\/span><\/p>\n

Both medications can also cause dry mouth, indigestion (dyspepsia), and anxiety. Side effects related to weight loss can also occur. Some people who take armodafinil or modafinil may experience decreased appetite.\u00a0<\/span><\/p>\n

Other rare but serious side effects include allergic reactions such as rash and shortness of breath. Psychiatric side effects such as depression or psychosis are also possible. Seek medical attention if you experience these side effects.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nArmodafinil<\/b><\/td>\nModafinil<\/b><\/td>\n<\/tr>\n
Side Effect<\/span><\/td>\nApplicable?<\/span><\/td>\nFrequency<\/span><\/td>\nApplicable?<\/span><\/td>\nFrequency<\/span><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nYes<\/span><\/td>\n17%<\/span><\/td>\nYes<\/span><\/td>\n34%<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\n7%<\/span><\/td>\nYes<\/span><\/td>\n11%<\/span><\/td>\n<\/tr>\n
Nervousness<\/span><\/td>\nYes<\/span><\/td>\n1%<\/span><\/td>\nYes<\/span><\/td>\n7%<\/span><\/td>\n<\/tr>\n
Insomnia<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\nYes<\/span><\/td>\n6%<\/span><\/td>\n<\/tr>\n
Back pain<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n6%<\/span><\/td>\n<\/tr>\n
Nasal congestion<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n7%<\/span><\/td>\n<\/tr>\n
Indigestion<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Dry mouth<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\n<\/tr>\n
Anxiety<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Decreased appetite<\/span><\/td>\nYes<\/span><\/td>\n1%<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list. Consult your healthcare provider or pharmacist for possible side effects.<\/span><\/i><\/p>\n

Source: DailyMed (<\/span>armodafinil<\/span><\/a>), DailyMed (<\/span>modafinil<\/span><\/a>)\u00a0<\/span><\/p>\n

Drug interactions of armodafinil vs. modafinil<\/span><\/h2>\n

Armodafinil and modafinil share many of the same drug interactions. These medications may affect how many drugs are metabolized or processed in the body. As a result, they can decrease the effectiveness of other medications or increase their side effects.<\/span><\/p>\n

Armodafinil and modafinil may reduce the effectiveness of steroidal <\/span>contraceptives<\/span><\/a>. Alternative methods of contraception are recommended during treatment with armodafinil or modafinil and for one month after discontinuation of these drugs.<\/span><\/p>\n

Armodafinil and modafinil may increase the clearance of cyclosporine from the body. Therefore, taking armodafinil or modafinil with cyclosporine may decrease its effectiveness.\u00a0<\/span><\/p>\n

Armodafinil and modafinil may also increase the levels of certain drugs, including Prilosec (omeprazole), Valium (diazepam), and Dilantin (phenytoin). Increased drug levels may lead to adverse effects.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nArmodafinil<\/b><\/td>\nModafinil<\/b><\/td>\n<\/tr>\n
Estinyl (ethinyl estradiol)<\/span><\/p>\n

Aygestin (norethindrone)<\/span><\/td>\n

Steroidal contraceptive<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Neoral (cyclosporine)<\/span><\/td>\nImmunosuppressant<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Dilantin (phenytoin)<\/span><\/td>\nAnticonvulsant<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Valium (diazepam)<\/span><\/td>\nBenzodiazepine<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Inderal (propranolol)<\/span><\/td>\nBeta blocker<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Prilosec (omeprazole)<\/span><\/td>\nProton pump inhibitor (PPI)<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Anafranil (clomipramine)<\/span><\/td>\nTricyclic antidepressant (TCA)<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list of all possible drug interactions. Consult a healthcare provider about all the medications you may be taking.\u00a0<\/span><\/i><\/p>\n

Warnings of armodafinil and modafinil<\/span><\/h2>\n

Both armodafinil and modafinil can cause serious rash. In cases of severe rash, these drugs should be discontinued immediately.<\/span><\/p>\n

Doses of armodafinil or modafinil may need to be adjusted to improve sleepiness during the day. While optimizing doses, persistent sleepiness can still occur. Therefore, it\u2019s important to avoid driving or participating in dangerous activities when first starting a drug like armodafinil or modafinil.<\/span><\/p>\n

Armodafinil and modafinil may cause psychiatric symptoms, especially in those with a history of <\/span>psychosis<\/span><\/a>, depression, or mania. These medications should be monitored or even discontinued in severe cases of psychiatric effects.\u00a0<\/span><\/p>\n

Stimulant-like drugs may cause <\/span>adverse effects on the heart<\/span><\/a> and cardiovascular system. Those with high blood pressure may need to be monitored when first starting armodafinil or modafinil. Consult a healthcare provider if you experience chest pain, shortness of breath, or palpitations (pounding heartbeat).\u00a0<\/span><\/p>\n

Frequently asked questions about armodafinil vs. modafinil<\/span><\/h2>\n

Are armodafinil and modafinil the same?<\/span><\/h3>\n

Armodafinil and modafinil contain similar ingredients, but they are not the same. Armodafinil contains the R-enantiomer of modafinil, while modafinil contains a racemic mixture of R- and S-modafinil.<\/span><\/p>\n

Is armodafinil or modafinil better?<\/span><\/h3>\n

Armodafinil and modafinil are similar in effectiveness, tolerability, and safety. However, armodafinil may have <\/span>higher levels<\/span><\/a> in the body over the course of the day, so its effects may last longer than those of modafinil.\u00a0<\/span><\/p>\n

Can I use armodafinil or modafinil while pregnant?<\/span><\/h3>\n

No. The use of modafinil or armodafinil is not usually recommended during pregnancy. Discuss your treatment options with a healthcare provider if you are pregnant or breastfeeding.\u00a0<\/span><\/p>\n

Can I use armodafinil or modafinil with alcohol?<\/span><\/h3>\n

It is not recommended to take armodafinil or modafinil while drinking alcohol. Drinking alcohol while on armodafinil or modafinil may increase the risk of adverse effects, such as dizziness, headache, and nausea.\u00a0<\/span><\/p>\n

Can you take armodafinil and modafinil together?<\/span><\/h3>\n

Armodafinil and modafinil should not be taken together as they contain similar active ingredients. Combining them may increase the risk of adverse effects.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

You might struggle with extreme sleepiness during the day if you work the night shift. But with proper treatment like armodafinil (Nuvigil) or modafinil (Provigil), you can stay awake and feel more alert. These medications can be prescribed if you\u2019ve been diagnosed with shift work disorder (SWD), narcolepsy, or obstructive sleep apnea (OSA). As wakefulness-promoting […]<\/p>\n","protected":false},"author":15,"featured_media":12610,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[816],"coauthors":[8669],"class_list":["post-3314","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-sleep","wpautop"],"acf":[],"yoast_head":"\nArmodafinil vs. modafinil: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Armodafinil and modafinil treat sleep disorders, but they work in different ways. 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