{"id":33555,"date":"2021-06-01T15:15:39","date_gmt":"2021-06-01T19:15:39","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=33555"},"modified":"2021-06-01T15:15:39","modified_gmt":"2021-06-01T19:15:39","slug":"lyrica-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lyrica-side-effects\/","title":{"rendered":"Lyrica side effects and interactions, and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#lyrica-side-effects\">Lyrica side effects<\/a> | <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#how-long-do-side-effects-last\">How long do side effects last?<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lyrica is a brand-name prescription drug FDA approved to treat nerve pain due to diabetic peripheral neuropathy (nerve damage), nerve pain due to spinal cord injury, pain following a <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/shingles-treatment-and-medications\"><span style=\"font-weight: 400;\">shingles infection<\/span><\/a><span style=\"font-weight: 400;\"> (postherpetic neuralgia), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/fibromyalgia-treatment-and-medications\"><span style=\"font-weight: 400;\">fibromyalgia<\/span><\/a><span style=\"font-weight: 400;\">, and to prevent partial-onset seizures in children and adults with epilepsy. Many people, though, may be prescribed Lyrica off-label for conditions such as restless leg syndrome (RLS), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraines<\/span><\/a><span style=\"font-weight: 400;\">, trigeminal neuralgia, and other stubborn neurological or psychiatric conditions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The active ingredient in Lyrica, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pregabalin\/what-is\"><span style=\"font-weight: 400;\">pregabalin<\/span><\/a><span style=\"font-weight: 400;\">, belongs to a family of drugs called gabapentinoids that work by slowing down nerve signals, allowing the drug to be used as an anticonvulsant for seizure disorder patients and an analgesic for neuropathic pain. Lyrica may not be right for everyone, though. Before taking Lyrica, it helps to be well-informed about side effects, restrictions, drug interactions, and the possibility of abuse and withdrawal associated with this drug.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">RELATED: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lyrica\/what-is\"><span style=\"font-weight: 400;\">Learn more about Lyrica<\/span><\/a><\/p>\n<h2 id=\"lyrica-side-effects\"><span style=\"font-weight: 400;\">Common side effects of Lyrica<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Commonly experienced side effects of Lyrica <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/422105\/Lyrica\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">include<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the hands and feet (peripheral edema)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurry vision or double vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abnormal thinking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Accidental injury<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint or nerve pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Most Lyrica side effects occur in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470341\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">the first two weeks<\/span><\/a><span style=\"font-weight: 400;\">. The most commonly experienced side effects of Lyrica are sleepiness and dizziness. Each can occur in up to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6353204\/table\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">35%<\/span><\/a><span style=\"font-weight: 400;\"> of people taking pregabalin. However, the incidence of Lyrica side effects will depend on the condition being treated and the size of the dose.\u00a0<\/span><\/p>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of Lyrica<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most serious side effects of Lyrica include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidal thoughts and behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Respiratory depression (dangerously shallow or slow breathing)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low platelet counts (serious bruising and bleeding problems)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions including angioedema and potentially life-threatening skin reactions<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Antiepileptic drugs in general raise the risk of suicidal thoughts and behaviors. Unlike some drugs, such as antidepressants, the FDA does not include a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black-box warning<\/span><\/a><span style=\"font-weight: 400;\"> about the risks of suicide when taking pregabalin. Patients and their caregivers, however, should watch carefully for unexplained mood changes or any worsening of existing depression or suicidal thoughts, comments, or behaviors.<\/span><\/p>\n<h2 id=\"how-long-do-side-effects-last\"><span style=\"font-weight: 400;\">How long do Lyrica side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most common side effects of pregabalin, such as drowsiness, dizziness, dry mouth, weakness, and pain, will fade as the body eliminates the drug, usually in a little more than a day. More serious side effects may persist for days or weeks. Some, like allergic reactions, suicidality, or muscle damage may require treatment or hospitalization.<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Lyrica contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As a prescription drug that affects the nervous system, Lyrica carries risks for all patients. Some patients, however, because of pre-existing medical conditions or medications being taken are more at risk for problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Pregabalin is a Schedule V prescription drug, so Lyrica has the potential for abuse, but the risk is low. Pregabalin abuse is mainly found among people with a prior history of substance abuse. Although pregabalin produces a high similar to alcohol, most recorded abuse involves combining it with other illicit drugs.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.practicalpainmanagement.com\/treatments\/pharmacological\/non-opioids\/special-report-abuse-potential-gabapentin-pregabalin\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pregabalin can cause<\/span><\/a><span style=\"font-weight: 400;\"> behavioral dependence, physical tolerance, and withdrawal symptoms, particularly when used in high doses over a long time. Withdrawal symptoms include nausea, sleeplessness, headache, anxiety, diarrhea, itching, and excessive sweating.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A pregabalin overdose could be fatal. If too much Lyrica is taken, seek immediate emergency medical help. Symptoms of pregabalin overdose include reduced consciousness, confusion, agitation, depression, anxiety, and restlessness. Severe overdose can result in seizures, heart block, or death.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lyrica may not be the right medicine for some people to take, and others may be given Lyrica only under heightened monitoring and care.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People allergic to pregabalin will not be given the drug. Pregabalin can cause serious and life-threatening allergic reactions. When taking Lyrica, watch for symptoms such as swelling of the face and throat, hives, blisters, and problems breathing. As with all drugs, get immediate medical care if you suspect a possible allergic reaction to this drug.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Pregnant women may be prescribed Lyrica during their pregnancy if the benefits outweigh the risks. However, pregabalin should not be taken by women who are nursing. Because pregabalin is present in breast milk and could harm a breastfeeding infant, nursing women will be prescribed another medication or will have to stop breastfeeding while taking Lyrica.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lyrica is more likely to cause side effects in people with certain medical conditions, so healthcare providers may prescribe the drug more cautiously and monitor the drug\u2019s effects more closely.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lyrica will require the lowest possible dosing and careful monitoring in people with <\/span><b>chronic obstructive pulmonary disease <\/b><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/copd-treatment-and-medications\"><span style=\"font-weight: 400;\">COPD<\/span><\/a><span style=\"font-weight: 400;\">) or other <\/span><b>lung disease<\/b><span style=\"font-weight: 400;\">. Pregabalin slows down breathing, so it could cause a potentially fatal inability to breathe in enough oxygen in people with lung problems.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lyrica will require close monitoring in patients with <\/span><b>kidney problems<\/b><span style=\"font-weight: 400;\">. The drug is primarily eliminated through the kidneys, so any renal impairment will require lowering the dose and careful observation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>People older than 65<\/b><span style=\"font-weight: 400;\"> are at a higher risk of kidney problems, sedation, and respiratory depression, so side effects will need to be closely monitored. Seniors may be started at the lowest recommended dose for their condition.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Because pregabalin can cause peripheral and facial swelling, people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><b>diabetes<\/b><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><b>congestive heart failure<\/b><\/a><span style=\"font-weight: 400;\">, or <\/span><b>a history of swelling or angioedema<\/b><span style=\"font-weight: 400;\"> will be given the drug cautiously, particularly if they are taking other drugs that may cause swelling or fluid retention as a side effect. People with diabetes taking Lyrica should immediately report any unwanted weight gain to their healthcare provider.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with<\/span><b> a history of <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><b>depression<\/b><\/a><b> or suicidal behavior <\/b><span style=\"font-weight: 400;\">need to be closely monitored for mood changes and suicidality while taking Lyrica.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with <\/span><b>a history of substance abuse<\/b><span style=\"font-weight: 400;\"> will require careful monitoring for signs that Lyrica is being misused, such as decreased effectiveness of the drug, steadily increasing doses, and drug-seeking behaviors.<\/span><\/li>\n<\/ul>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Lyrica interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lyrica may cause problems <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/422104\/Lyrica\/Drug-Interactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">when combined with other drugs<\/span><\/a><span style=\"font-weight: 400;\">, including drugs that slow down the nervous system, drugs that cause edema or fluid retention, and drugs that interfere with the ability of Lyrica to treat seizure disorders.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Many types of drugs are CNS depressants, that is, they slow down nerve signals in the central nervous system. Combining them with Lyrica will worsen\u00a0 side effects such as sedation, dizziness, and respiratory depression. These drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Marijuana<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/gabapentin\"><span style=\"font-weight: 400;\">Gabapentin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sedatives and sleep aids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Benzodiazepines (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lorazepam\"><span style=\"font-weight: 400;\">lorazepam<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Barbiturates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid pain relievers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antipsychotics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antihistamines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antiepileptic drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anti-nausea drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle relaxants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid pain relievers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Parkinson\u2019s disease medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">General anesthetics<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some drugs significantly interfere with Lyrica\u2019s ability to prevent seizures, so these drugs are never used when Lyrica is prescribed to prevent seizures. These drugs include amifampridine, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dalfampridine-er\"><span style=\"font-weight: 400;\">dalfampridine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dalfampridine-er\"><span style=\"font-weight: 400;\">metoclopramide<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/maprotiline-hcl\"><span style=\"font-weight: 400;\">maprotiline<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl\"><span style=\"font-weight: 400;\">bupropion<\/span><\/a><span style=\"font-weight: 400;\">, and muromonab-CD3. Other types of drugs can also reduce the therapeutic benefits of pregabalin in treating seizure disorders, requiring therapies to be monitored and possibly adjusted. These drugs include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amphetamines, stimulants, and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/adhd-treatment-and-medications\"><span style=\"font-weight: 400;\">ADHD medications<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some antiviral medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/penicillins\"><span style=\"font-weight: 400;\">Penicillins<\/span><\/a><span style=\"font-weight: 400;\">, fluoroquinolones, and carbapenem antibiotics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/glucocorticoids\"><span style=\"font-weight: 400;\">Corticosteroids<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Appetite suppressants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">MAO inhibitors, a small class of drugs that includes some antidepressants, antibiotics, and Parkinson\u2019s medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Theophyllines, a class of drugs used to open airways in people with asthma or COPD<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Finally, some types of drugs produce swelling (edema) as a side effect, so the risk of peripheral swelling and weight gain significantly increases when they are combined with Lyrica. These drugs include <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ace-inhibitors\/\"><span style=\"font-weight: 400;\">ACE inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> (blood pressure medications) and certain types of diabetes drugs.<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid Lyrica side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects are commonly experienced among people taking Lyrica, especially sleepiness and dizziness. A few tips can help minimize or manage Lyrica side effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Tell the doctor about all medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A doctor or other healthcare provider prescribing Lyrica will need a full medical history, <\/span><a href=\"http:\/\/labeling.pfizer.com\/ShowLabeling.aspx?id=561&amp;section=MedGuide\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">particularly<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression, mood problems, or suicidal thoughts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lung problems or trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy or any plans to become pregnant<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Plans to father a child<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any past or present drug or alcohol abuse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any history of severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">2. Tell the doctor about all medications being taken<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many of pregabalin\u2019s side effects can be worsened by other drugs, so it\u2019s important to provide the doctor or healthcare professional prescribing Lyrica with a complete list of prescription drugs, over-the-counter medications, remedies, and dietary supplements being taken, especially<\/span><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">ACE inhibitors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioid pain medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any drugs that cause sleepiness, drowsiness, dizziness, or problems with coordination<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">3. Take Lyrica as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Follow all the directions on the prescription label, printed in the medication guide, or provided by a healthcare provider. Do not take more or less than prescribed except under the advice of a doctor or other healthcare professional.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Do not stop taking Lyrica suddenly\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When suddenly discontinued, Lyrica can cause unpleasant withdrawal symptoms. If the medicine is not working or side effects are intolerable, talk to a healthcare provider about the safest way to discontinue Lyrica.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Watch for changes in mood<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People taking Lyrica may start thinking about suicide. Watch for unexplained mood changes such as sadness, depression, anxiety, panic attacks, irritability, hostility, or thinking about suicide. Mood changes may not go away when taking Lyrica, so talk to a healthcare provider for medical advice.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Avoid alcohol when taking Lyrica<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol should be avoided when taking Lyrica. Dizziness, tiredness, sleepiness, and problems with coordination\u2014common side effects of Lyrica\u2014are worsened when alcohol is added to the mix.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Avoid driving or risky activities when taking Lyrica<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lyrica commonly causes sedation and dizziness, so avoid driving or other risky activities when first taking Lyrica. Once you have a better handle on Lyrica\u2019s effects on attention, focus, and coordination, then carefully return to driving or other potentially hazardous activities.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Watch for weight gain or swelling<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People with heart problems or diabetes should watch for weight gain or swelling when taking Lyrica. Talk to a doctor or other healthcare provider if the drug is causing swelling in the extremities or weight seems to be shooting up mysteriously.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">9. Watch for early symptoms of serious side effects<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Unexplained muscle pain or weakness may be a sign that pregabalin is damaging muscle tissue. Immediately call a doctor if muscles feel tender, painful, or weak. Unexplained bruising or unusual bleeding may be signs that pregabalin is causing platelets, the blood cells responsible for blood clots, to fall too low. Skin problems, such as blisters or rash, could be a sign of a serious allergic reaction.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">10. Watch for signs of slow or shallow breathing<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Patients or their caregivers should be especially vigilant for signs of respiratory depression such as slow breathing, shallow breathing, or blue lips, fingers, and toes. These are all indications that the patient\u2019s ability to breathe is not sufficient to provide the rest of the body with oxygen. Don\u2019t confuse these signs with trouble breathing, such as wheezing, gasping, or choking. People with respiratory depression often appear to be breathing normally, but they aren\u2019t breathing enough. Immediate medical attention is required at any sign of respiratory depression.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Related resources for Lyrica side effects:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"http:\/\/labeling.pfizer.com\/ShowLabeling.aspx?id=561&amp;section=MedGuide\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lyrica medication guide<\/span><\/a><span style=\"font-weight: 400;\">, Pfizer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/422108\/Lyrica\/Patient-Education\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lyrica<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=60185c88-ecfd-46f9-adb9-b97c6b00a553\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lyrica prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.lyrica.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Lyrica website<\/span><\/a><span style=\"font-weight: 400;\">, Pfizer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470341\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pregabalin<\/span><\/a><span style=\"font-weight: 400;\">, StatPearls<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6353204\/table\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Pregabalin for neuropathic pain in adults<\/span><\/a><span style=\"font-weight: 400;\">, Cochrane Database for Systematic Reviews<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.practicalpainmanagement.com\/treatments\/pharmacological\/non-opioids\/special-report-abuse-potential-gabapentin-pregabalin\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Special report: the abuse potential of gabapentin and pregabalin<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Practical Pain Management<\/span><\/i><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Lyrica side effects | Serious side effects | How long do side effects last? | Warnings | Interactions | How to avoid side effects Lyrica is a brand-name prescription drug FDA approved to treat nerve pain due to diabetic peripheral neuropathy (nerve damage), nerve pain due to spinal cord injury, pain following a shingles infection [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":33604,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,808,20802],"coauthors":[8861],"class_list":["post-33555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-pain-management","tag-seizures","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Lyrica side effects, interactions, and warnings | SingleCare<\/title>\n<meta name=\"description\" content=\"Dizziness, drowsiness, and dry mouth are common lyrica side effects. 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