{"id":3531,"date":"2018-12-18T12:38:33","date_gmt":"2018-12-18T17:38:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3531"},"modified":"2025-12-09T14:01:27","modified_gmt":"2025-12-09T19:01:27","slug":"famotidine-vs-omeprazole","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/","title":{"rendered":"Famotidine vs. omeprazole for GERD, acid reflux, and ulcers"},"content":{"rendered":"

Famotidine<\/span><\/a> and <\/span>omeprazole<\/span><\/a> are medications commonly used to treat a number of digestive problems, such as gastroesophageal reflux disease (GERD) or a duodenal ulcer. These drugs work by decreasing acid production in the stomach. Although they can be found over the counter (OTC), famotidine and omeprazole can also be prescribed by a healthcare provider.<\/span><\/p>\n

Antacids like<\/span> Tums<\/span><\/a> (calcium carbonate) are often tried first before starting something stronger, such as an H2 blocker like famotidine or a proton pump inhibitor (PPI) like omeprazole. Fortunately, famotidine and omeprazole are generic medications that are widely available. While they are both acid reducers, they differ in how they work and how they\u2019re used.<\/span><\/p>\n

What are the main differences between famotidine and omeprazole?<\/b><\/h2>\n

Famotidine<\/span><\/a> is also known by its brand name, Pepcid. It is classified as an<\/span> H2 blocker<\/span><\/a>. Famotidine works by blocking a protein in stomach cells. This blocks acid from being released into the stomach.<\/span><\/p>\n

The <\/span>effects of famotidine<\/span><\/a> can be felt within one hour and can last up to 12 hours. Famotidine tablets are taken once or twice daily, depending on the condition being treated.<\/span><\/p>\n

Omeprazole<\/span><\/a> can be purchased as a brand-name drug called Prilosec or Prilosec OTC. Unlike famotidine, omeprazole is classified as a<\/span> proton pump inhibitor (PPI)<\/span><\/a>. It works by directly blocking proton pumps in the lining of the stomach to stop acid production.<\/span><\/p>\n

Generally, the <\/span>effects of omeprazole<\/span><\/a> can be felt quickly within one hour after taking it. Its antisecretory effect can last up to 72 hours, which is much longer than that of famotidine. However, the OTC version of omeprazole can take <\/span>one to four days<\/span><\/a> to reach its full effect. Omeprazole is usually taken once daily.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Main differences between famotidine and omeprazole<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

\u00a0<\/span><\/td>\nFamotidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nH2 Blocker<\/span><\/td>\nProton Pump Inhibitor (PPI)<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic version available<\/span><\/td>\nBrand and generic version available<\/span><\/td>\n<\/tr>\n
What is the brand name?<\/b><\/td>\nPepcid<\/span><\/td>\nPrilosec<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nTablet<\/span><\/p>\n

Tablet, chewable<\/span><\/p>\n

Powder for oral suspension<\/span><\/p>\n

Injection<\/span><\/td>\n

Capsule, delayed-release<\/span><\/p>\n

Tablet, delayed-release<\/span><\/p>\n

Orally disintegrating tablet, delayed-release<\/span><\/p>\n

Powder for oral suspension<\/span><\/p>\n

Injection<\/span><\/td>\n<\/tr>\n

What is the standard dosage?<\/b><\/td>\nDuodenal ulcers: 40 mg once daily or 20 mg twice daily for up to 8 weeks<\/span><\/p>\n

GERD: 20 mg twice daily for up to 6 weeks<\/span><\/p>\n

Erosive esophagitis: 20- 40 mg twice daily for up to 12 weeks<\/span><\/p>\n

Dosage depends on the condition being treated<\/span><\/td>\n

Duodenal ulcers: 20 mg once daily for up to 4 weeks<\/span><\/p>\n

GERD: 20 mg once daily for up to 4 weeks<\/span><\/p>\n

Erosive esophagitis: 20 mg once daily<\/span><\/p>\n

Dosage depends on the condition being treated<\/span><\/td>\n<\/tr>\n

How long is the typical treatment?<\/b><\/td>\nUp to 6 or 12 weeks or longer\u00a0<\/span><\/td>\nUp to 4 to 8 weeks or longer\u00a0<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nAdults and certain children<\/span><\/td>\nAdults and certain children<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by famotidine and omeprazole<\/b><\/h2>\n

Famotidine and omeprazole can be prescribed to treat GERD, duodenal ulcers, and stomach ulcers. Both medications are also FDA approved to treat<\/span> erosive esophagitis<\/span><\/a> (EE), or inflammation of the lining of the esophagus. Erosive esophagitis is often caused by GERD.<\/span><\/p>\n

Prescription famotidine and omeprazole can also be used to treat <\/span>hypersecretory conditions<\/span><\/a>, such as Zollinger-Ellison syndrome, systemic mastocytosis, and multiple endocrine adenoma syndrome. Hypersecretory conditions are characterized by excessive acid production that can be temporary or permanent.<\/span><\/p>\n

Over-the-counter (OTC) versions of <\/span>famotidine<\/span><\/a> and <\/span>omeprazole<\/span><\/a> are often used for the relief of occasional or frequent<\/span> heartburn<\/span><\/a>.\u00a0<\/span><\/p>\n

Omeprazole is also FDA approved to treat<\/span> Helicobacter pylori<\/span><\/a>, or H. pylori, infections when taken in combination with antibiotics.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nFamotidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Gastroesophageal reflux disease (GERD)<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Duodenal ulcers<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Stomach ulcers<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Heartburn<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Erosive esophagitis<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Hypersecretory conditions<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
H. pylori infection<\/span><\/td>\nOff-label<\/span><\/a><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is famotidine or omeprazole more effective?<\/b><\/h2>\n

For GERD<\/h3>\n

Both famotidine and omeprazole can be effective drugs for treating<\/span> GERD<\/span><\/a> and other digestive conditions. However, omeprazole is a <\/span>more potent and longer-acting<\/span><\/a> drug than famotidine.<\/span><\/p>\n

For ulcers<\/h3>\n

One clinical trial<\/span><\/a> directly compared 20 mg of omeprazole once daily to 40 mg of famotidine once nightly in 60 patients with duodenal ulcers. After two to four weeks of treatment, healing rates were higher with omeprazole than with famotidine. Researchers concluded that omeprazole is more effective than famotidine for rapidly healing duodenal ulcers.\u00a0<\/span><\/p>\n

Randomized clinical trials have shown that PPIs are<\/span> more effective in treating duodenal ulcers<\/span><\/a> than H2 blockers. PPIs were found to significantly increase ulcer healing compared to H2 blockers. No significant differences were found between the PPIs that were studied, which included Prevacid (<\/span>lansoprazole<\/span><\/a>), <\/span>Protonix<\/span><\/a> (pantoprazole), and Aciphex (<\/span>rabeprazole<\/span><\/a>).<\/span><\/p>\n

For people who take blood thinners<\/h3>\n

In people who take blood thinners, such as <\/span>clopidogrel<\/span><\/a> and <\/span>aspirin<\/span><\/a>, a PPI or H2 blocker may be used to prevent stomach bleeding. One systematic review found that PPIs were superior to H2 blockers in <\/span>preventing bleeding in the stomach<\/span><\/a>. The studies in the review compared PPIs, such as <\/span>Prilosec<\/span><\/a> (omeprazole) and <\/span>Nexium<\/span><\/a> (esomeprazole), and H2 blockers, such as <\/span>Pepcid<\/span><\/a> (famotidine) and <\/span>Zantac<\/span><\/a> (ranitidine). However, according to its <\/span>prescribing information<\/span><\/a>, clopidogrel should not be taken with omeprazole or esomeprazole as these drugs can significantly decrease clopidogrel\u2019s effectiveness.\u00a0<\/span><\/p>\n

It\u2019s important to seek medical advice from your healthcare provider before taking famotidine or omeprazole. They can help determine which drug is the best option for you.\u00a0<\/span><\/p>\n

RELATED: <\/b>Pepcid vs Zantac<\/b><\/a><\/p>\n

Coverage and cost comparison of famotidine vs. omeprazole<\/b><\/h2>\n

Most Medicare Part D plans and other insurance plans will cover generic famotidine tablets. Famotidine can cost an average cash price of around $89 for 60, 20 mg tablets without insurance coverage. If you\u2019re looking to save on the cash price of famotidine, you may be able to use a SingleCare famotidine coupon. With a <\/span>SingleCare famotidine coupon<\/span><\/a>, you could pay as little as $5 for 60, 20 mg tablets.<\/span><\/p>\n

Omeprazole delayed-release capsules are covered by most Medicare and insurance plans. The average retail cost of omeprazole is around $178 for 30, 40 mg delayed-release capsules. You may be able to use a SingleCare coupon card to lower this cost. With a <\/span>SingleCare omeprazole coupon<\/span><\/a>, you may be able to reduce the price to around $6 for 30, 40 mg delayed-release capsules.<\/span><\/p>\n\n\n\n\n\n\n\n\n
Coverage & cost details<\/b><\/td>\nFamotidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare?<\/b><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\n$0\u2013$21<\/span><\/td>\n$0\u2013$19<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$5 for 60, 20 mg tablets of generic famotidine at Kroger<\/span><\/td>\n$6 for 30, 40 mg delayed-release capsules of generic omeprazole at Kroger<\/span><\/td>\n<\/tr>\n
Free coupon<\/b><\/td>\nFree famotidine coupons<\/span><\/a><\/td>\nFree omeprazole coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Dec. 9, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/small><\/p>\n

Common side effects of famotidine and omeprazole<\/b><\/h2>\n

The most common side effects of famotidine are headache, dizziness, constipation, and diarrhea. The most common side effects of omeprazole are headache, abdominal pain, diarrhea, flatulence, nausea, and vomiting. Omeprazole may be more likely than famotidine to cause certain gastrointestinal side effects, such as flatulence or gas.<\/span><\/p>\n

Serious side effects include allergic reactions to any of the ingredients in these medications. Allergic reactions can include rash or trouble breathing. Seek medical attention if you experience serious adverse effects.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0Side effects<\/b><\/td>\nFamotidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
<\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Headache<\/span><\/td>\nYes<\/span><\/td>\n\u22651%<\/span><\/td>\nYes<\/span><\/td>\n7%<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\n\u22651%<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Constipation<\/span><\/td>\nYes<\/span><\/td>\n\u22651%<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\n\u22651%<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\n<\/tr>\n
Stomach ache<\/span><\/td>\nYes<\/span><\/td>\n<1%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\n<1%<\/span><\/td>\nYes<\/span><\/td>\n4%<\/span><\/td>\n<\/tr>\n
Vomiting<\/span><\/td>\nYes<\/span><\/td>\n<1%<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\n<\/tr>\n
Flatulence<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\nYes<\/span><\/td>\n3%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list. Consult your doctor or pharmacist for possible side effects.<\/span><\/i><\/p>\n

Source: DailyMed (<\/span>famotidine<\/span><\/a>), DailyMed (<\/span>omeprazole<\/span><\/a>)<\/span><\/p>\n

Drug interactions of famotidine vs. omeprazole<\/b><\/h2>\n

Famotidine and omeprazole may need to be avoided with drugs that depend on stomach acid for absorption. These drugs include certain cancer drugs, such as Tarceva (erlotinib) and Tasigna (nilotinib), and antifungals, such as <\/span>ketoconazole<\/span><\/a> and <\/span>itraconazole<\/span><\/a>. Taking famotidine or omeprazole can decrease the absorption of these drugs and decrease their overall effectiveness.<\/span><\/p>\n

Famotidine can also interact with tizanidine, a<\/span> muscle relaxer<\/span><\/a> that is broken down by the CYP1A2 enzyme in the liver. Famotidine can increase levels of tizanidine in the body, which can lead to low blood pressure (hypotension), slow heartbeat (bradycardia), or extreme drowsiness.<\/span><\/p>\n

Omeprazole can interact with several drugs. Certain drugs may slow the break down of omeprazole in the body, which increases its levels in your system. These include Vfend (voriconazole) and Cardizem (diltiazem). Other drugs can speed up omeprazole\u2019s break down in your body, which reduces its levels in your system. Examples include Rifadin (rifampin) and Norvir (ritonavir). Omeprazole may also interact with other drugs, such as Coumadin (warfarin), Trexall (methotrexate), and Celexa (citalopram).\u00a0<\/span><\/p>\n

Famotidine and omeprazole may interact with other drugs not described here. It is important to tell your healthcare provider about all medications you take before starting treatment with famotidine or omeprazole.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nFamotidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Atazanavir<\/span><\/p>\n

Rilpivirine<\/span><\/p>\n

Nelfinavir<\/span><\/p>\n

Ledipasvir\/sofosbuvir<\/span><\/p>\n

Fosamprenavir<\/span><\/td>\n

Antiretrovirals<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Erlotinib<\/span><\/p>\n

Dasatinib<\/span><\/td>\n

Chemotherapy<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Ketoconazole<\/span><\/p>\n

Itraconazole<\/span><\/td>\n

Antifungal<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Tizanidine<\/span><\/td>\nMuscle relaxer<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Tacrolimus<\/span><\/p>\n

Methotrexate<\/span><\/td>\n

Immunosuppressant<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Warfarin<\/span><\/td>\nAnticoagulant<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Rifampin<\/span><\/td>\nAntibiotic<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This may not be a complete list of all possible drug interactions. Consult a doctor about all the medications you may be taking.<\/span><\/i><\/p>\n

Warnings of famotidine and omeprazole<\/b><\/h2>\n

Severe GERD symptoms or ulcers may be a sign of gastrointestinal cancer in some people. Additional testing and monitoring may be needed for people who don\u2019t respond to treatment with a PPI or H2 blocker.<\/span><\/p>\n

Famotidine should be used with caution in<\/span> elderly people<\/span><\/a> or those with kidney problems, as the drug can reach higher levels in the body in these populations.. As a result, these people may be at higher risk of side effects of famotidine.\u00a0<\/span><\/p>\n

Unlike famotidine, omeprazole and other PPIs can increase the risk of<\/span> osteoporosis<\/span><\/a> and bone fractures when used long-term. In addition, omeprazole use, especially in a hospital setting, may lead to an increased risk of Clostridium difficile-related diarrhea. One study found that proton pump inhibitors are associated with<\/span> greater risks of serious adverse effects<\/span><\/a>, like pneumonia and<\/span> C. diff<\/span> infections<\/span><\/a>, when compared to H2 blockers in critically ill patients.\u00a0<\/span><\/p>\n

Overall, omeprazole tends to have more warnings and precautions associated with it compared to famotidine. Consult a healthcare provider about other <\/span>possible safety concerns<\/span><\/a> with H2 blockers and PPIs.\u00a0<\/span><\/p>\n

Frequently asked questions about famotidine vs. omeprazole<\/b><\/h2>\n

Are famotidine and omeprazole the same?<\/b><\/h3>\n

Famotidine and omeprazole are not the same. Although they treat similar gastrointestinal problems, they are different drugs. Famotidine is an H2 blocker and omeprazole is a PPI.<\/span><\/p>\n

Is famotidine or omeprazole better?<\/b><\/h3>\n

Omeprazole is considered to be more potent than famotidine. The effects of omeprazole also last longer than the effects of famotidine.However, omeprazole may have more serious adverse effects associated with its use, such as an increased risk of osteoporosis and C.diff diarrhea with long-term use.<\/span><\/p>\n

Can I take omeprazole and famotidine together?<\/b><\/h3>\n

There are no drug interactions between omeprazole and famotidine, and each works differently to decrease stomach acid. In most cases, one medication is enough to provide reflief. But, there are some situations where your healthcare provider may prescribe these drugs together.\u00a0<\/span><\/p>\n

One study<\/span><\/a> found that combining famotidine and omeprazole was more effective for acid control than famotidine or omeprazole alone. Researchers concluded that the long-acting effects of omeprazole could be complementary to the relatively fast-acting effects of famotidine. Still, more studies are needed to determine whether combining omeprazole and famotidine is appropriate.\u00a0<\/span><\/p>\n

Can I use famotidine or omeprazole while pregnant?<\/b><\/h3>\n

It\u2019s not known whether famotidine or omeprazole are safe to take during pregnancy. . Consult your healthcare provider when choosing a<\/span> treatment option while pregnant<\/span><\/a> or breastfeeding.<\/span><\/p>\n

Can I use famotidine or omeprazole with alcohol?<\/b><\/h3>\n

Alcohol does not interact with the way famotidine and omeprazole work. However, alcohol may <\/span>increase the risk<\/span><\/a> of acid reflux symptoms. It\u2019s best to limit yourself to drinking alcohol in moderation or avoiding alcohol altogether, especially if you notice an increase in symptoms or side effects.<\/span><\/p>\n

What is the safest heartburn medication to take long term?<\/b><\/h3>\n

It depends. Each medication has its own risks, however, omeprazole can cause more long-term adverse effects in comparison to famotidine. These include osteoporosis, low vitamin B-12 and magnesium levels, and fundic gland polyps (a type of noncancerous growth in the stomach). For this reason, omeprazole is typically only taken for 4 to 8 weeks. In addition, omeprazole has more potential <\/span>drug interactions<\/span><\/a> than famotidine. Therefore, it\u2019s best to talk to your healthcare provider about which drug is safest for you. They can weigh the potential risks and benefits of each medication and take into account your medical history and current medications.\u00a0<\/span><\/p>\n

Is it ok to take Pepcid every day?<\/b><\/h3>\n

Pepcid is typically taken on a daily basis for up to12 weeks at a time. The duration of treatment depends on the condition that is being treated. Talk to your doctor to find out how long you should be taking Pepcid. Consider lifestyle changes in addition to medications to help relieve heartburn that occurs more frequently.<\/span><\/p>\n

What is the fastest-acting heartburn medicine?<\/b><\/h3>\n

Antacids usually work the fastest for treating heartburn symptoms. Antacids like Tums<\/span> (calcium carbonate) can neutralize acid within<\/span> 30 minutes<\/span><\/a> of taking them. Compared to famotidine, calcium carbonate was found to have a<\/span> faster onset of action<\/span><\/a>. While they give quick relief of heartburn, antacid effects do not last for the whole day. H2 blockers and PPIs last longer and are reserved for more chronic digestive conditions like GERD.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Famotidine and omeprazole are medications commonly used to treat a number of digestive problems, such as gastroesophageal reflux disease (GERD) or a duodenal ulcer. These drugs work by decreasing acid production in the stomach. Although they can be found over the counter (OTC), famotidine and omeprazole can also be prescribed by a healthcare provider. Antacids […]<\/p>\n","protected":false},"author":15,"featured_media":10146,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[16414,20949],"coauthors":[8669],"class_list":["post-3531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-digestive-health","tag-gerd","wpautop"],"acf":[],"yoast_head":"\nCompare Prilosec vs. Pepcid for heartburn relief<\/title>\n<meta name=\"description\" content=\"Discover the key differences between famotadine vs. omeprazole. Learn how each drug works, common side effects, and which conditions they treat. Compare their uses, effectiveness, and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Famotidine vs. omeprazole: Which is better?\" \/>\n<meta property=\"og:description\" content=\"We compare and contrast the two GERD drugs\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-18T17:38:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-09T19:01:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gerardo Sison, Pharm.D.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Famotidine vs. omeprazole: Which is better?\" \/>\n<meta name=\"twitter:description\" content=\"We compare and contrast the two GERD drugs\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gerardo Sison, Pharm.D.\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/\"},\"author\":{\"name\":\"SingleCare Team\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/403ef50a9f402fb9ce49c429659555f5\"},\"headline\":\"Famotidine vs. omeprazole for GERD, acid reflux, and ulcers\",\"datePublished\":\"2018-12-18T17:38:33+00:00\",\"dateModified\":\"2025-12-09T19:01:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/\"},\"wordCount\":2221,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/12\\\/Famotidine-vs-Omeprazole.png\",\"keywords\":[\"Digestive health\",\"GERD\"],\"articleSection\":[\"Drug vs. Drug\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/\",\"name\":\"Compare Prilosec vs. Pepcid for heartburn relief\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/12\\\/Famotidine-vs-Omeprazole.png\",\"datePublished\":\"2018-12-18T17:38:33+00:00\",\"dateModified\":\"2025-12-09T19:01:27+00:00\",\"description\":\"Discover the key differences between famotadine vs. omeprazole. Learn how each drug works, common side effects, and which conditions they treat. Compare their uses, effectiveness, and more.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/12\\\/Famotidine-vs-Omeprazole.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/12\\\/Famotidine-vs-Omeprazole.png\",\"width\":1920,\"height\":1080,\"caption\":\"Comparing heartburn medications: Famotidine vs omeprazole\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/famotidine-vs-omeprazole\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Famotidine vs. omeprazole for GERD, acid reflux, and ulcers\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/403ef50a9f402fb9ce49c429659555f5\",\"name\":\"SingleCare Team\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=gcda8e0f4c5718cb7f68c0ee812f6fafb\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g\",\"caption\":\"SingleCare Team\"},\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/singlecareteam\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Compare Prilosec vs. Pepcid for heartburn relief","description":"Discover the key differences between famotadine vs. omeprazole. Learn how each drug works, common side effects, and which conditions they treat. Compare their uses, effectiveness, and more.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/","og_locale":"en_US","og_type":"article","og_title":"Famotidine vs. omeprazole: Which is better?","og_description":"We compare and contrast the two GERD drugs","og_url":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2018-12-18T17:38:33+00:00","article_modified_time":"2025-12-09T19:01:27+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png","type":"image\/png"}],"author":"Gerardo Sison, Pharm.D.","twitter_card":"summary_large_image","twitter_title":"Famotidine vs. omeprazole: Which is better?","twitter_description":"We compare and contrast the two GERD drugs","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Gerardo Sison, Pharm.D.","Est. reading time":"11 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/"},"author":{"name":"SingleCare Team","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/403ef50a9f402fb9ce49c429659555f5"},"headline":"Famotidine vs. omeprazole for GERD, acid reflux, and ulcers","datePublished":"2018-12-18T17:38:33+00:00","dateModified":"2025-12-09T19:01:27+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/"},"wordCount":2221,"commentCount":0,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png","keywords":["Digestive health","GERD"],"articleSection":["Drug vs. Drug"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/","url":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/","name":"Compare Prilosec vs. Pepcid for heartburn relief","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png","datePublished":"2018-12-18T17:38:33+00:00","dateModified":"2025-12-09T19:01:27+00:00","description":"Discover the key differences between famotadine vs. omeprazole. Learn how each drug works, common side effects, and which conditions they treat. Compare their uses, effectiveness, and more.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2018\/12\/Famotidine-vs-Omeprazole.png","width":1920,"height":1080,"caption":"Comparing heartburn medications: Famotidine vs omeprazole"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/famotidine-vs-omeprazole\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Famotidine vs. omeprazole for GERD, acid reflux, and ulcers"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/403ef50a9f402fb9ce49c429659555f5","name":"SingleCare Team","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=gcda8e0f4c5718cb7f68c0ee812f6fafb","url":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7c56ea35da6164263b446caa5424dd8beeb331518803b6043b40932812936fb2?s=96&d=mm&r=g","caption":"SingleCare Team"},"url":"https:\/\/www.singlecare.com\/blog\/author\/singlecareteam\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/3531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=3531"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/3531\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/10146"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=3531"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=3531"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=3531"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=3531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}