{"id":35676,"date":"2021-06-26T15:18:20","date_gmt":"2021-06-26T19:18:20","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=35676"},"modified":"2026-03-27T10:11:55","modified_gmt":"2026-03-27T14:11:55","slug":"prednisolone-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/prednisolone-side-effects\/","title":{"rendered":"Prednisolone side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone\">Prednisolone<\/a> is a widely-used prescription drug that treats a wide range of medical conditions. Called a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\"><span style=\"font-weight: 400;\">corticosteroid<\/span><\/a><span style=\"font-weight: 400;\"> or glucocorticoid, prednisolone pills reduce inflammation, block the immune system, fight leukemia or lymphoma, or can be used to replace cortisol, the body\u2019s natural corticosteroid hormone. Similar to prednisolone, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone-sodium-phosphate\"><span style=\"font-weight: 400;\">prednisolone sodium phosphate<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone-acetate\"><span style=\"font-weight: 400;\">prednisolone acetate<\/span><\/a><span style=\"font-weight: 400;\"> may be prescribed as eye drops to treat eye swelling.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As with all corticosteroids, prednisolone commonly causes side effects. Some can be severe and even life-threatening. Side effects can sometimes be made worse when other drugs are taken. Prednisolone can also worsen pre-existing medical conditions. A little understanding of how prednisolone works as well as a few tips can help minimize problems when taking prednisolone.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Common side effects of prednisolone<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most people will experience side effects when given prednisolone. Corticosteroids are powerful hormones and affect nearly every major system in the body. Many common side effects are dose-dependent, so higher doses are more likely to cause side effects. The <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/6505\/prednisolone\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most common side effects<\/span><\/a><span style=\"font-weight: 400;\"> of prednisolone are:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Skin problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acne<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Facial redness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning skin (when taken long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin discoloration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin spots<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unwanted hair growth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow wound healing (when taken long-term)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Mental and mood changes<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood swings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Nervous system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Problems with falling asleep or staying asleep<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vertigo<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ucsfhealth.org\/education\/faq-prednisone\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/a><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Digestive system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Appetite changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heartburn<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Fluid and electrolyte problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention (edema)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sodium retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potassium loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Endocrine (hormone) disorders<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased glucose tolerance<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Menstrual irregularities<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Redistribution of body fat (called Cushingoid appearance: puffy face, obese torso, and buffalo hump)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Muscle problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of muscle mass<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Common side effects of prednisolone eye drops<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effects of prednisolone eye drops are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye irritation, itching, or burning<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased fluid pressure in the eye<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pupil dilation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Foreign body sensation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drooping eyelid<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Taste changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Serious side effects of prednisolone<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Serious side effects of prednisolone are often dose-dependent and many are primarily due to long-term use.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Mental and mood changes<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Steroid psychosis<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Nervous system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated fluid pressure in the brain<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Digestive system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach ulcers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Perforation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the pancreas<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Fluid and electrolyte problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-pressure-treatment-and-medications\"><span style=\"font-weight: 400;\">Hypertension<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dangerously low potassium levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Congestive heart failure<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Endocrine (hormone) disorders<\/span><\/h3>\n<ul>\n<li><span style=\"font-weight: 400;\">Adrenal insufficiency<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Cushing syndrome<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400;\">Growth suppression in children (when used long-term)<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Withdrawal symptoms if stopped abruptly<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Muscle and bone problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone tissue death<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/a><span style=\"font-weight: 400;\"> (when used long-term)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Immune system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immune suppression (when used long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kaposi\u2019s sarcoma (when used long-term)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Eye problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/a><span style=\"font-weight: 400;\"> (when used long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cataracts (when used long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Protruding eyeballs<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Difficulty breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anaphylaxis<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you are taking prednisolone and experience symptoms of an allergic reaction such as hives, difficulty breathing, or swelling around the lips, tongue, or face, get emergency medical help right away.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Serious side effects of prednisolone eye drops<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When instilled into the eyes, the most serious side effects of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone-acetate\/what-is\"><span style=\"font-weight: 400;\">prednisolone acetate<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone-sodium-phosphate\/what-is\"><span style=\"font-weight: 400;\">prednisolone sodium phosphate<\/span><\/a><span style=\"font-weight: 400;\"> eye drops are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning of the cornea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning of the whites of the eye<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Corneal sores<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Perforation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Delayed eye wound healing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Optic nerve damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eye infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated fluid pressure in the eye<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">How long do prednisolone side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many common side effects of prednisolone will rapidly resolve once the drug is stopped. Fluid retention, swelling, mood changes, rash, redness, elevated blood pressure, abdominal discomfort, and irregular menstrual periods are rapidly reversed. Weight gain during a short course of prednisolone is mostly due to fluid retention, so it\u2019s reversed relatively quickly once the drug is no longer taken. However, weight loss after several weeks or months of prednisolone treatment will take diet and exercise to fix.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects may take longer to resolve such as infections, acne, muscle damage, or tendon damage. Adrenal insufficiency due to high doses or long-term use of prednisolone can take <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6b201232-4a52-487c-b963-a98539469e5d\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">months<\/span><\/a><span style=\"font-weight: 400;\"> to return to normal. Withdrawal is a less severe form of adrenal insufficiency and usually takes only a few weeks for symptoms to clear (but may take longer). Some severe side effects, such as diabetes, cataracts, or osteoporosis, can turn into chronic or life-long conditions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For people taking prednisolone eye drops, irritation, burning, and blurred vision usually only last a few minutes. Other side effects such as vision problems, dilated pupils, and drooping eyelids get better within a few days of stopping the medicine. Some conditions such as vision loss, cataracts, or glaucoma could become lifelong medical conditions.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Prednisolone contraindications &amp; warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Prednisolone is a powerful medication that affects nearly every system in the body. Not everyone can take prednisolone without special care.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisolone is not a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/controlled-substances-act\/\"><span style=\"font-weight: 400;\">controlled substance<\/span><\/a><span style=\"font-weight: 400;\">. It is not commonly abused, but it can cause physical dependence and withdrawal by reducing the body\u2019s ability to produce cortisol.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The standard prednisolone dose ranges from 5 to 60 mg daily, but some conditions are treated with much higher doses. Unfortunately, the effects of a significantly large overdose taken over a short period <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a3776c70-3d72-4792-8a13-8fcb0a711bc2\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">have not been studied<\/span><\/a><span style=\"font-weight: 400;\">. Because side effects are dose-dependent, any excessive amount of prednisolone can be expected to increase the likelihood and severity of side effects. If there\u2019s any reason to believe that too much prednisolone has been taken, call a poison helpline and seek emergency medical aid.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisolone may cause problems in people with certain pre-existing medical conditions. For some people, prednisolone can never be given <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/6503\/prednisolone\/Contradindications-Cautions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">if they have<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity to prednisolone<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A fungal infection of the body\u2019s organs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cerebral malaria<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Although other people with pre-existing conditions can take prednisolone, doses may need adjusting or they may need to be monitored for problems.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Because prednisolone weakens the immune system, people who are <\/span><b>immune-suppressed<\/b><span style=\"font-weight: 400;\"> or who have <\/span><b>active infections<\/b><span style=\"font-weight: 400;\">, <\/span><b>tuberculosis<\/b><span style=\"font-weight: 400;\">, <\/span><b>exposure to measles or chickenpox<\/b><span style=\"font-weight: 400;\">,<\/span> <span style=\"font-weight: 400;\">or any <\/span><b>increased<\/b> <b>risk of infection<\/b><span style=\"font-weight: 400;\">, will have to be closely monitored for infections when taking prednisolone.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with an active <\/span><b>herpes zoster infection of the eye <\/b><span style=\"font-weight: 400;\">should not use prednisolone due to an increased risk of corneal perforation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prednisolone can cause ulcers and perforation, so people with <\/span><b>peptic ulcers<\/b><span style=\"font-weight: 400;\">, <\/span><b>diverticulitis<\/b><span style=\"font-weight: 400;\">, <\/span><b>ulcerative colitis<\/b><span style=\"font-weight: 400;\">, <\/span><b>intestinal surgery<\/b><span style=\"font-weight: 400;\">, or any other <\/span><b>risk of perforation<\/b><span style=\"font-weight: 400;\"> will be prescribed prednisolone cautiously and monitored for gastrointestinal problems.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Side effects are enhanced in people with <\/span><b>cirrhosis<\/b><span style=\"font-weight: 400;\"> and <\/span><b>hypothyroidism<\/b><span style=\"font-weight: 400;\">, so dosing may need to be adjusted.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Pregnant women<\/b><span style=\"font-weight: 400;\"> should talk with a healthcare professional before taking the drug. Healthcare providers prescribe prednisolone cautiously during the first trimester of pregnancy.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Nursing women<\/b><span style=\"font-weight: 400;\"> will also need to talk with a healthcare provider. Oral corticosteroids do pass into breast milk and could affect an infant\u2019s hormone balance and growth.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Prednisolone is used cautiously in <\/span><b>children<\/b><span style=\"font-weight: 400;\"> and <\/span><b>adolescents<\/b><span style=\"font-weight: 400;\">. Long-term prednisolone treatment could stunt a child\u2019s growth.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other medical conditions that will require extra care and monitoring during prednisolone treatment include:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Mental illness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Heart problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Myasthenia gravis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Multiple sclerosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Seizure disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Adrenal gland tumor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Swelling of the optic nerve<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Prednisolone interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Taking prednisolone with other prescription or over-the-counter drugs can worsen side effects or cause other health problems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">First, because prednisolone suppresses the immune system, no one receiving prednisolone can be given a live vaccine or Imlygic (talimogene laherparepvec), a live virus used to treat skin cancer. When taking prednisolone, these vaccines could erupt into an active infection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prednisolone also should not be taken with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mifepristone\"><span style=\"font-weight: 400;\">mifepristone<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/desmopressin-acetate-spray\"><span style=\"font-weight: 400;\">desmopressin<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other drugs may require caution or monitoring when combined with prednisolone. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>NSAIDs: <\/b><span style=\"font-weight: 400;\">Combining prednisolone with nonsteroidal anti-inflammatory drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">)\u2014such as aspirin or ibuprofen\u2014or salicylates raises the risk of severe gastrointestinal side effects including perforation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Immune<\/b><span style=\"font-weight: 400;\">&#8211;<\/span><b>suppressing drugs<\/b><span style=\"font-weight: 400;\">: Immunosuppressants taken with prednisolone\u2014a drug that also suppresses the immune system\u2014can leave patients dangerously vulnerable to infections and cancer.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Allergy skin tests<\/b><span style=\"font-weight: 400;\">: Because prednisolone suppresses the immune system, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/allergy-treatment-and-medications\"><span style=\"font-weight: 400;\">allergy<\/span><\/a><span style=\"font-weight: 400;\"> skin tests are less reliable.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vaccines<\/b><span style=\"font-weight: 400;\">: Live vaccines should not be administered when taking immunosuppressive doses of prednisolone. Inactivated vaccines may be given, but the response cannot be predicted.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Loop and thiazide diuretics<\/b><span style=\"font-weight: 400;\">: Because of the risk of potassium depletion, prednisolone is used cautiously with <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretics<\/span><\/a><span style=\"font-weight: 400;\"> that do not spare potassium. Other drugs that deplete potassium, such as macrolide antibiotics (like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/clarithromycin\"><span style=\"font-weight: 400;\">clarithromycin<\/span><\/a><span style=\"font-weight: 400;\">), will also be used cautiously. People taking these combinations may need regular blood tests to monitor potassium levels.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Quinolone antibiotics<\/b><span style=\"font-weight: 400;\">: Combining prednisolone with quinolone antibiotics such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/moxifloxacin-hcl\"><span style=\"font-weight: 400;\">moxifloxacin<\/span><\/a><span style=\"font-weight: 400;\"> increases the risk of tendon rupture.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Migraine medications and stimulants<\/b><span style=\"font-weight: 400;\">: <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/triptans\"><span style=\"font-weight: 400;\">Triptans<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">ergot drugs<\/span><\/a><span style=\"font-weight: 400;\">, amphetamines, stimulants, and some allergy drugs can add to elevated blood pressure caused by prednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Androgens<\/b><span style=\"font-weight: 400;\">: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/testosterone\"><span style=\"font-weight: 400;\">Testosterone<\/span><\/a><span style=\"font-weight: 400;\"> and similar drugs raise the risk of fluid retention and high blood pressure when combined with prednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Estrogens<\/b><span style=\"font-weight: 400;\">: Estrogens may increase the effects of prednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diabetes drugs<\/b><span style=\"font-weight: 400;\">: Prednisolone may interfere with the ability of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\"> drugs to control <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-blood-glucose-levels\/\"><span style=\"font-weight: 400;\">high blood sugar<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antihypertensives: <\/b><span style=\"font-weight: 400;\">Prednisolone may interfere with the effectiveness of drugs given to reduce blood pressure.<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">How to avoid prednisolone side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For most people, prednisolone will cause unwanted side effects. There are, however, a few tips that can help minimize or manage these problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Take prednisolone as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Take the dose as prescribed, usually <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Prednisolone-Syrup-prednisolone-781\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">5\u201360 mg<\/span><\/a><span style=\"font-weight: 400;\"> per day. Prednisolone is usually scheduled to be taken at a particular time of day, so try to take the dose at the correct time.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Tell the doctor about all medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid side effects, tell the doctor or other healthcare provider giving you prednisolone about all your medical conditions, <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/6508\/prednisolone\/Patient-Education\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">particularly<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Herpes infection of the eye<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fungal infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach ulcers, diverticulitis, or ulcerative colitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental illness or psychosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thyroid problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multiple sclerosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Myasthenia gravis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy or pregnancy plans<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding or any plans to breastfeed<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Certain drug interactions can cause problems, so make sure the doctor or other healthcare provider knows about all prescription drugs, over-the-counter drugs, and supplements that are taken regularly. When seeing any other healthcare or provider, tell them you are taking prednisolone.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Take prednisolone with food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid stomach upset, nausea, and vomiting, take prednisolone with food or milk.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Avoid NSAIDs and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen make the digestive system more likely to be hurt by stomach acid. So avoid them when taking any corticosteroid.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Eat a healthy diet<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid weight gain, eat a healthy diet when taking prednisolone. Lean protein can satisfy the increased appetite without causing weight gain. Reducing salt intake to <\/span><a href=\"https:\/\/www.ucsfhealth.org\/education\/guidelines-for-a-low-sodium-diet\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">less than 2,000 mg a day<\/span><\/a><span style=\"font-weight: 400;\"> can help prevent weight gain, fluid retention, and sodium retention. Eat potassium-rich foods to help prevent potassium loss. A nutritionist can help design a prednisolone-friendly diet.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Exercise moderately<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another way to avoid weight gain and even promote weight loss is to exercise moderately. The key is to take it easy. Prednisolone can affect muscle strength, muscle mass, connective tissues, and bone density, especially when taken long-term. Ask your doctor about an appropriate and safe exercise regimen.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Take calcium and vitamin D supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisolone disrupts the body\u2019s ability to regulate calcium and, as a result, leeches calcium from the bones. To help reduce bone loss, take calcium and vitamin D supplements when taking prednisolone. Your healthcare professional can advise you on the appropriate dose.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Avoid infections<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The body is less able to fight off infections during prednisolone treatment. Avoid people who are sick. Wash your hands regularly. Get medical advice if you notice signs of infection such as high fever or pain during urination.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">9. Do not stop taking prednisolone without consulting your doctor<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisolone can cause withdrawal symptoms when stopped suddenly. These symptoms could last for weeks or even months depending on the dose and duration of prednisolone treatment. The best way to stop taking prednisolone\u2014even for short-term treatment\u2014is a tapered dose prescribed by a doctor or other healthcare professional.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Resources:<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4561462\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Corticosteroid-induced bradycardia<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Canadian Pharmacists Journal<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.njmonline.nl\/getpdf.php?id=1060\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Episodes of shortness of breath induced by prednisone<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">The Netherlands Journal of Medicine<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ucsfhealth.org\/education\/faq-prednisone\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FAQ: Prednisone<\/span><\/a><span style=\"font-weight: 400;\">, UCSF Health<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ucsfhealth.org\/education\/guidelines-for-a-low-sodium-diet\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Guidelines for a low sodium diet<\/span><\/a><span style=\"font-weight: 400;\">, UCSF Health<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/6505\/prednisolone\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Prednisolone<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/192505\/prednisolone-acetate-ophthalmic\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Prednisolone acetate<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a3776c70-3d72-4792-8a13-8fcb0a711bc2\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Prednisolone sodium phosphate oral solution prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/Prednisolone-Syrup-prednisolone-781\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Prednisolone syrup drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Prednisolone is a widely-used prescription drug that treats a wide range of medical conditions. Called a corticosteroid or glucocorticoid, prednisolone pills reduce inflammation, block the immune system, fight leukemia or lymphoma, or can be used to replace cortisol, the body\u2019s natural corticosteroid hormone. Similar to prednisolone, prednisolone sodium phosphate or prednisolone acetate may be prescribed [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":35678,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,12752],"coauthors":[8861],"class_list":["post-35676","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prednisolone side effects, interactions, warnings and safety information<\/title>\n<meta name=\"description\" content=\"Nausea, diarrhea, and fatigue common prednisolone side effects. 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