{"id":3637,"date":"2019-01-30T12:39:57","date_gmt":"2019-01-30T17:39:57","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3637"},"modified":"2025-09-12T13:54:32","modified_gmt":"2025-09-12T17:54:32","slug":"lovastatin-vs-atorvastatin","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lovastatin-vs-atorvastatin\/","title":{"rendered":"Lovastatin vs. atorvastatin: Differences, similarities, and which one is better for you"},"content":{"rendered":"<p><a href=\"#drug-overview-differences\">Drug overview &amp; main differences<\/a> | <a href=\"#conditions-treated\">Conditions treated<\/a> | <a href=\"#efficacy\">Efficacy<\/a> | <a href=\"#insurance-coverage-cost-comparison\">Insurance coverage and cost comparison<\/a> | <a href=\"#side-effects\">Side effects<\/a> | <a href=\"#drug-interactions\">Drug interactions<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#FAQ\">FAQ<\/a><\/p>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin are generic prescription drugs used to treat high cholesterol levels in the blood (hypercholesterolemia). High blood cholesterol levels can increase the risk of heart disease and atherosclerosis, which are diseases that can lead to other cardiovascular problems. Statin medications like lovastatin and atorvastatin are commonly prescribed to help lower cholesterol levels and decrease the risk of heart attack, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/signs-of-a-stroke\/\"><span style=\"font-weight: 400;\">stroke<\/span><\/a><span style=\"font-weight: 400;\">, and chest pain.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin are part of a class of drugs called HMG-coA reductase inhibitors, or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">statins<\/span><\/a><span style=\"font-weight: 400;\">. They work by blocking the enzyme needed to produce cholesterol in the liver. Many statin drugs can decrease low-density lipoprotein (LDL) cholesterol levels by 30-50% on average.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Continue reading to learn more about the differences and similarities between lovastatin and atorvastatin.<\/span><\/p>\n<h2 id=\"drug-overview-differences\"><span style=\"font-weight: 400;\">What are the main differences between lovastatin and atorvastatin?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/lovastatin\/what-is\"><span style=\"font-weight: 400;\">Lovastatin<\/span><\/a><span style=\"font-weight: 400;\"> is also known by the brand names Mevacor, Altocor, and Altoprev. In addition to treating high cholesterol levels, it is used to prevent and treat coronary arteriosclerosis, or coronary artery disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lovastatin is available as a 10 mg, 20 mg, and 40 mg immediate-release oral tablet. Altoprev is a brand-name extended-release version that is available as a 20 mg, 40 mg, or 60 mg oral tablet. Lovastatin immediate-release tablets are recommended to be taken with an evening meal, while the extended-release tablets may be administered without food. Lovastatin is recommended to be taken at night because it has a short half-life of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK540994\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1-2 hours<\/span><\/a><span style=\"font-weight: 400;\">, and it works best when most cholesterol is produced during the night, or when dietary intake is lowest.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium\/what-is\"><span style=\"font-weight: 400;\">Atorvastatin<\/span><\/a><span style=\"font-weight: 400;\"> is the generic name for Lipitor. It is used to treat high cholesterol levels and reduce the risk of heart attacks, strokes, and chest pain in people who currently have or are at risk of heart disease.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Atorvastatin is available as a 10 mg, 20 mg, 40 mg, and 80 mg oral tablet. It is usually taken once daily in the morning or evening. Atorvastatin can be taken at any time of the day as long as it is taken around the same time every day. It has a long half-life of around <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/020702s077lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">14 hours<\/span><\/a><span style=\"font-weight: 400;\">. Atorvastatin can be taken with or without food since food intake does not affect the absorption of atorvastatin.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td style=\"text-align: center;\"><\/td>\n<td style=\"text-align: center;\"><b>Lovastatin<\/b><\/td>\n<td style=\"text-align: center;\"><b>Atorvastatin<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">HMG-CoA reductase inhibitor\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Statin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">HMG-CoA reductase inhibitor\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Statin<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic version available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand and generic version available<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the brand name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Mevacor<\/span><br \/>\n<span style=\"font-weight: 400;\">Altoprev<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Lipitor<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><br \/>\n<span style=\"font-weight: 400;\">Oral tablet, extended-release<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Oral tablet<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">10 to 40 mg once daily (immediate-release)<\/span><br \/>\n<span style=\"font-weight: 400;\">20 to 60 mg once daily (extended-release)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10 to 80 mg once daily<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Treatment with lovastatin is long-term to manage cholesterol levels and maintain a lower risk of heart attack and stroke.<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Treatment with atorvastatin is long-term to manage cholesterol levels and maintain a lower risk of heart attack and stroke.<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><br \/>\n<span style=\"font-weight: 400;\">Children and adolescents aged 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adults<\/span><br \/>\n<span style=\"font-weight: 400;\">Children and adolescents aged 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"conditions-treated\"><span style=\"font-weight: 400;\">Conditions treated by lovastatin and atorvastatin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Statin medications like lovastatin and atorvastatin are approved by the Food and Drug Administration to treat people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-treatment-and-medications\"><span style=\"font-weight: 400;\">high cholesterol levels<\/span><\/a><span style=\"font-weight: 400;\">. These medications can help lower total cholesterol (total-C) levels and low-density lipoprotein cholesterol (LDL-C) levels. These statins can help treat those with <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/high-triglycerides-treatment-options\/\"><span style=\"font-weight: 400;\">high levels of triglycerides (TG)<\/span><\/a><span style=\"font-weight: 400;\">, another type of fat, or lipid, in the blood. Statins can also help increase high-density lipoprotein cholesterol (HDL-C) levels, which are known to be associated with protective effects on the heart.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin are lipid-lowering drugs approved to prevent heart attacks, stroke, and chest pain in patients with coronary heart disease. Other risk factors for complications from cardiovascular disease include <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\">, high blood pressure, and smoking. The American Heart Association and American College of Cardiology recommend statins to those at high risk of developing cardiovascular complications.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td style=\"text-align: center;\"><b>Condition<\/b><\/td>\n<td style=\"text-align: center;\"><b>Lovastatin<\/b><\/td>\n<td style=\"text-align: center;\"><b>Atorvastatin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Hypercholesterolemia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Hyperlipoproteinemia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Hypertriglyceridemia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Heart attack and stroke prevention<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Atherosclerosis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"efficacy\"><span style=\"font-weight: 400;\">Is lovastatin or atorvastatin more effective?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin are effective statin drugs for lowering cholesterol levels. The most effective statin is the one that lowers cholesterol levels the most without causing severe side effects. Factors such as cost, dosage, and side effects can affect whether one statin will be better than another for a given person.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A meta-analysis published in the <\/span><em><a href=\"https:\/\/academic.oup.com\/eurjpc\/article\/20\/4\/641\/5937327\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">European Journal of Preventive Cardiology<\/span><\/a><\/em><span style=\"font-weight: 400;\">\u00a0found that atorvastatin was more effective than lovastatin and other statins for preventing heart attacks in those with or at risk of heart disease. The study also evaluated the effectiveness of other statin drugs <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/atorvastatin-vs-simvastatin\/\"><span style=\"font-weight: 400;\">like simvastatin<\/span><\/a><span style=\"font-weight: 400;\">, pravastatin, fluvastatin, and rosuvastatin. When compared to placebo, all statins included in the study were found to be effective in the primary prevention of major coronary events.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to a systematic review and network meta-analysis of 50 clinical trials published in the journal <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7201823\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\"><em>Cardiovascular Therapeutics<\/em><\/span><\/a><span style=\"font-weight: 400;\">, rosuvastatin was found to be the most effective statin for lowering LDL-C levels. Atorvastatin ranked second for lowering LDL-C levels. Lovastatin ranked first for lowering total cholesterol and triglyceride levels, however. Other statin drugs included in the analysis included pitavastatin, simvastatin, pravastatin, fluvastatin, and lovastatin.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Atorvastatin is considered a <\/span><a href=\"https:\/\/www.aafp.org\/afp\/2014\/0815\/p260.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">moderate-intensity<\/span><\/a><span style=\"font-weight: 400;\"> or high-intensity statin therapy that can reduce LDL-C levels by 30-50% or more than 50% depending on the dosage. Lovastatin is considered a low-intensity or moderate-intensity statin therapy that can reduce LDL-C levels by less than 30% to between 30% and 50% depending on the dosage. It is important to consult a healthcare provider for medical advice regarding the most effective statin medication for your condition.\u00a0<\/span><\/p>\n<h2 id=\"insurance-coverage-cost-comparison\"><span style=\"font-weight: 400;\">Coverage and cost comparison of lovastatin vs. atorvastatin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most Medicare and insurance plans will cover lovastatin. The copay will depend on the insurance plan and its coverage policy. Without insurance, lovastatin can cost an average cash price of $235. Savings options such as a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lovastatin\"><span style=\"font-weight: 400;\">prescription discount card for lovastatin<\/span><\/a><span style=\"font-weight: 400;\"> may help reduce this cost to less than $25 at participating pharmacies.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Atorvastatin is usually covered by most Medicare and insurance plans. Most plans will cover most, if not all, of the cost of the medication. The average cash price of <a href=\"https:\/\/www.singlecare.com\/blog\/atorvastatin-without-insurance\/\">atorvastatin without insurance<\/a> is $20-$30. A prescription discount card is available to help <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/atorvastatin-calcium\"><span style=\"font-weight: 400;\">reduce the cost of an atorvastatin prescription<\/span><\/a><span style=\"font-weight: 400;\">. The exact cost of the prescription will depend on the dosage and quantity prescribed.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td style=\"text-align: center;\"><\/td>\n<td style=\"text-align: center;\"><b>Lovastatin<\/b><\/td>\n<td style=\"text-align: center;\"><b>Atorvastatin<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">20 mg once daily<\/span><\/td>\n<td><span style=\"font-weight: 400;\">20 mg once daily<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typical Medicare copay<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$0<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">$15<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$0<\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\">$16<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$25+<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$3+<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"side-effects\"><span style=\"font-weight: 400;\">Common side effects of lovastatin vs. atorvastatin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effects of lovastatin are abdominal pain, constipation, weakness, muscle pain, and headache. The most common <a href=\"https:\/\/www.singlecare.com\/blog\/lipitor-side-effects\/\">side effects of atorvastatin<\/a> are muscle pain, diarrhea, nasopharyngitis, joint pain, and urinary tract infections. Lovastatin and atorvastatin, like other statin drugs, can cause serious side effects in the muscles, such as <\/span><a href=\"https:\/\/www.cedars-sinai.org\/health-library\/diseases-and-conditions\/m\/myopathy.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">myopathy<\/span><\/a><span style=\"font-weight: 400;\"> and rhabdomyolysis. Symptoms of myopathy and rhabdomyolysis include muscle pain and weakness. Both statin drugs can also cause liver enzyme abnormalities, which may need to be monitored throughout treatment.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td style=\"text-align: center;\"><\/td>\n<td style=\"text-align: center;\" colspan=\"2\"><b>Lovastatin<\/b><\/td>\n<td style=\"text-align: center;\" colspan=\"2\"><b>Atorvastatin<\/b><\/td>\n<\/tr>\n<tr>\n<td style=\"text-align: center;\"><b>Side Effect<\/b><\/td>\n<td style=\"text-align: center;\"><b>Applicable?<\/b><\/td>\n<td style=\"text-align: center;\"><b>Frequency<\/b><\/td>\n<td style=\"text-align: center;\"><b>Applicable?<\/b><\/td>\n<td style=\"text-align: center;\"><b>Frequency<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Joint pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">0.5-1%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Diarrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Constipation<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Indigestion<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Muscle pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Urinary tract infection<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nasopharyngitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">*<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">*<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Edema<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">*<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your healthcare provider to learn more.<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/lookup.cfm?setid=5c707089-fb5b-4016-8ca7-11bbcfb57854\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">DailyMed (Lovastatin)<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2e94161c-3360-4fb0-bb3a-048fdc1d137a\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">DailyMed (Atorvastatin)<\/span><\/a><\/p>\n<h2 id=\"drug-interactions\"><span style=\"font-weight: 400;\">Drug interactions of lovastatin vs. atorvastatin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin can interact with many of the same drugs. Lovastatin and atorvastatin are primarily metabolized, or processed, in the liver by the CYP3A4 enzyme. Drugs that block the CYP3A4 enzyme are known as CYP3A4 inhibitors. When taken with CYP3A4 inhibitors, blood levels of lovastatin or atorvastatin can increase. Increased levels of statin medications can lead to an increased risk of muscle pain and other adverse events. Examples of CYP3A4 inhibitors include certain antibiotics, antifungals, and HIV protease inhibitors. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/grapefruit-juice-with-medicine-other-foods\/\"><span style=\"font-weight: 400;\">Grapefruit juice<\/span><\/a><span style=\"font-weight: 400;\"> can also act as a CYP3A4 inhibitor and should be avoided while taking a statin drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Drugs that induce the CYP3A4 enzyme can increase the metabolism of lovastatin or atorvastatin and decrease statin blood levels. Decreased blood levels of a statin can lead to decreased effectiveness of the medication. CYP3A4 inducers include rifampin and carbamazepine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Using lovastatin or atorvastatin with fibrates or high doses of niacin can increase the risk of muscle-related side effects. The combined use of these statins with fibrates or niacin may need to be monitored.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td style=\"text-align: center;\"><b>Drug<\/b><\/td>\n<td style=\"text-align: center;\"><b>Drug Class<\/b><\/td>\n<td style=\"text-align: center;\"><b>Lovastatin<\/b><\/td>\n<td style=\"text-align: center;\"><b>Atorvastatin<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Clarithromycin<\/span><br \/>\n<span style=\"font-weight: 400;\">Erythromycin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antibiotics<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Itraconazole<\/span><br \/>\n<span style=\"font-weight: 400;\">Ketoconazole<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antifungals<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ritonavir<\/span><br \/>\n<span style=\"font-weight: 400;\">Lopinavir<\/span><br \/>\n<span style=\"font-weight: 400;\">Simeprevir<\/span><br \/>\n<span style=\"font-weight: 400;\">Darunavir<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Protease inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Rifampin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antimycobacterial<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Anticonvulsant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Gemfibrozil<\/span><br \/>\n<span style=\"font-weight: 400;\">Fenofibrate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Fibrates<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Niacin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Antihyperlipidemic<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">*Consult a healthcare professional for other drug interactions<\/span><\/i><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Warnings of lovastatin and atorvastatin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The use of statins carries a risk of skeletal muscle effects such as myopathy and rhabdomyolysis. The risk of myopathy may be increased in older patients, patients with uncontrolled <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypothyroidism-treatment-and-medications\"><span style=\"font-weight: 400;\">hypothyroidism<\/span><\/a><span style=\"font-weight: 400;\">, and patients with kidney problems. A healthcare provider should be consulted if muscle pain, weakness, or tenderness persists while on a statin.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Immune-Mediated Necrotizing Myopathy (IMNM) is a type of autoimmune myopathy that has been reported with statin use. Individuals with persistent muscle pain and kidney problems may need to discontinue their use of statins.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Statins, like lovastatin and atorvastatin, can cause increased liver enzyme levels. Liver enzyme levels may need to be checked before and during treatment with a statin. In patients with <\/span><a href=\"https:\/\/medlineplus.gov\/liverdiseases.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">active liver disease<\/span><\/a><span style=\"font-weight: 400;\">, the use of lovastatin or atorvastatin is not recommended.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The dosage of lovastatin may need to be adjusted in those with kidney problems. In contrast, the dosage of atorvastatin may not need to be adjusted in those with kidney problems. Consult a healthcare provider about other warnings and precautions before starting treatment with lovastatin or atorvastatin.\u00a0<\/span><\/p>\n<h2 id=\"FAQ\"><span style=\"font-weight: 400;\">Frequently asked questions about lovastatin vs. atorvastatin<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">What is lovastatin?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lovastatin is a generic statin drug that is also known by the brand names Mevacor, Altocor, and Altoprev. It is available in immediate-release oral tablets with strengths of 10 mg, 20 mg, and 40 mg. It is also available in extended-release oral tablets with strengths of 20 mg, 40 mg, and 60 mg. Immediate-release lovastatin tablets are typically taken with an evening meal.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What is atorvastatin?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Atorvastatin is a generic statin drug that is also known by the brand name Lipitor. It is available as a 10 mg, 20 mg, 40 mg, and 80 mg oral tablet. It is usually taken once daily in the morning or evening to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-lower-cholesterol\/\"><span style=\"font-weight: 400;\">lower blood cholesterol levels<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Are lovastatin and atorvastatin the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both lovastatin and atorvastatin are FDA-approved, cholesterol-lowering drugs. They both work as HMG-CoA reductase inhibitors that decrease the production of cholesterol in the liver. However, lovastatin has a shorter half-life than atorvastatin, and it is usually recommended to be taken at night. Atorvastatin has a longer half-life than lovastatin, and it can be taken in the morning or evening. Both statins can lower LDL cholesterol and increase HDL cholesterol.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Is lovastatin or atorvastatin better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Lovastatin and atorvastatin are both effective forms of statin therapy. Depending on the dosage prescribed, lovastatin is classified as a low- to moderate-intensity statin drug while atorvastatin is classified as a moderate- to high-intensity statin drug. Atorvastatin is generally considered a more potent drug than lovastatin for lowering LDL-cholesterol levels. However, atorvastatin may carry a higher risk of myopathy in higher doses compared to lovastatin.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use lovastatin or atorvastatin while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Statin use is <\/span><a href=\"https:\/\/utswmed.org\/medblog\/statins-pregnancy-familial-hypocholesteremia\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">not recommended<\/span><\/a><span style=\"font-weight: 400;\"> in women who are pregnant. Lovastatin and atorvastatin are in pregnancy category X. This means that these medications are likely to cause harm to an unborn fetus. Consult a prescribing healthcare provider for treatment options while pregnant.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use lovastatin or atorvastatin with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drinking alcohol in moderation is not likely to cause problems while taking lovastatin or atorvastatin. Statin drugs carry a risk of liver toxicity; these drugs can affect liver function and cause liver enzyme abnormalities. Consuming large amounts of alcohol can harm the liver and increase the risk of liver disease and other liver problems. The consumption of alcohol while taking a statin medication should be done with caution.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drug overview &amp; main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ Lovastatin and atorvastatin are generic prescription drugs used to treat high cholesterol levels in the blood (hypercholesterolemia). High blood cholesterol levels can increase the risk of heart disease and [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":11635,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[790,737,20952],"coauthors":[8669],"class_list":["post-3637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-chronic-disease","tag-heart-health","tag-high-cholesterol","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Lovastatin vs. atorvastatin: Differences, similarities, and which one is better for you<\/title>\n<meta name=\"description\" content=\"Lovastatin and atorvastatin treat coronary arteriosclerosis but work in different ways. 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