{"id":36882,"date":"2021-07-12T10:22:34","date_gmt":"2021-07-12T14:22:34","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=36882"},"modified":"2024-07-30T14:09:38","modified_gmt":"2024-07-30T18:09:38","slug":"methylprednisolone-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/methylprednisolone-side-effects\/","title":{"rendered":"Methylprednisolone side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"#common-side-effects\">Common methylprednisolone side effects<\/a> | <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#how-long-do-side-effects-last\">How long do side effects last?<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a><\/p>\n<p><span style=\"font-weight: 400;\">Methylprednisolone is a common systemic corticosteroid used for a large number of medical conditions. For most, methylprednisolone is used for its anti-inflammatory and immune-suppressing properties. Methylprednisolone is usually taken as a tablet, but healthcare providers may use injections of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/solu-medrol\"><span style=\"font-weight: 400;\">Solu-Medrol<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methylprednisolone-sodium-succ\"><span style=\"font-weight: 400;\">methylprednisolone sodium succinate<\/span><\/a><span style=\"font-weight: 400;\">) or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/depo-medrol\"><span style=\"font-weight: 400;\">Depo-Medrol<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methylprednisolone-acetate\"><span style=\"font-weight: 400;\">methylprednisolone acetate<\/span><\/a><span style=\"font-weight: 400;\">) instead.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Methylprednisolone belongs to a subclass of corticosteroids known as glucocorticoids. Glucocorticoids are synthetic versions of the naturally occurring steroid hormone in your body known as cortisol, and they affect nearly every system in the body. A wide range of side effects affecting all parts of the body is common. In addition, the drug may sometimes cause serious problems in people with certain pre-existing conditions or who are taking other types of drugs.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/methylprednisolone\/what-is\"><b>What is Methylprednisolone?<\/b><\/a><\/p>\n<h2 id=\"common-side-effects\">Common side effects of methylprednisolone<\/h2>\n<p><span style=\"font-weight: 400;\">As with all corticosteroid medications, methylprednisolone results in several unwanted side effects. Lengthy treatment or high doses are more likely to produce these side effects. The <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/25305\/methylprednisolone\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most common<\/span><\/a><span style=\"font-weight: 400;\"> are:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Skin problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acne<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Facial redness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bruising easily<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin discoloration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin spots<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unwanted hair growth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excessive sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow wound healing (when taken long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site reactions (when administered as an injection)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Mental and mood changes<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood swings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Euphoria<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Nervous system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness and vertigo<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Digestive system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal discomfort<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Appetite changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tarry stools<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Fluid and electrolyte problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention (edema)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sodium retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potassium depletion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Endocrine (hormone) disorders<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased glucose tolerance<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in menstrual periods<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Redistribution of body fat (called Cushingoid appearance: puffy face, obese torso, and buffalo hump)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Muscle problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of muscle mass<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects\">Serious side effects of methylprednisolone<\/h2>\n<p><span style=\"font-weight: 400;\">Serious and possibly life-threatening side effects of methylprednisolone include:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Mental and mood changes<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Steroid psychosis<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Nervous system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Convulsions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated fluid pressure in the brain<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Digestive system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach ulcers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Perforation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the pancreas<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Fluid and electrolyte problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dangerously low potassium levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><span style=\"font-weight: 400;\">Congestive heart failure<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-pressure-treatment-and-medications\"><span style=\"font-weight: 400;\">Hypertension<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney failure (scleroderma renal crisis)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Endocrine (hormone) disorders<\/span><\/h3>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Adrenal insufficiency<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cushing syndrome<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Growth suppression in children (when used long-term)<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal symptoms\u00a0<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Muscle and bone problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased calcium absorption (when used long-term)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone tissue death (osteonecrosis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/a><span style=\"font-weight: 400;\"> (when used long-term)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Immune system problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immune suppression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kaposi\u2019s sarcoma (a type of skin cancer)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Eye problems<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Protruding eyeballs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/a><span style=\"font-weight: 400;\"> (when used long-term)<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cataracts (when used long-term)<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anaphylaxis (fast heartbeat, trouble breathing, wheezing, confusion, and shock)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Methylprednisolone sodium succinate is sometimes administered intravenously. Depending on the rate of administration, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544340\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">people can experience<\/span><\/a><span style=\"font-weight: 400;\"> high blood pressure, changes in the heart\u2019s rhythm, and even death as adverse effects of the IV.<\/span><\/p>\n<h2 id=\"how-long-do-side-effects-last\">How long do side effects last?<\/h2>\n<p><span style=\"font-weight: 400;\">The most commonly experienced side effects of methylprednisolone fade away quickly after the last dose is given, particularly if the drug is taken in small amounts for only a few days. When the body\u2019s natural concentration of corticosteroids returns to normal, edema, mood, blood pressure, electrolyte balance, and the digestive system also return to normal. Even extra weight rapidly falls away because the weight gain caused by a short course of corticosteroids is due to fluid retention. Severe allergic reactions and dangerously low potassium levels can be quickly reversed with treatment but will require immediate medical care.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other side effects may take a few days or weeks to get better, such as acne, unwanted hair growth, or infections. Thin skin, fat redistribution, muscle loss, and weight gain due to a long course of methylprednisolone treatment may take several weeks to reverse. Intervention, such as diet and exercise, may be required.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Adrenal insufficiency, if mild, can cause symptoms of withdrawal which typically take a few weeks to fade. For severe cases of adrenal insufficiency and Cushing\u2019s syndrome, it may take months or over a year to return to normal.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of methylprednisolone\u2019s most severe side effects such as osteoporosis or bone tissue death may persist for years. Others, such as diabetes or kidney failure may have lifelong consequences.<\/span><\/p>\n<h2 id=\"warnings\">Methylprednisolone contraindications &amp; warnings<\/h2>\n<p><span style=\"font-weight: 400;\">Methylprednisolone has powerful physiological effects on nearly the entire body. Some people may not be suitable for this medicine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Methylprednisolone is not considered an addictive drug nor is it commonly abused. However, this medicine does cause physical dependence and withdrawal because of its effects on the body\u2019s endocrine system. Methylprednisolone may inadvertently decrease your body\u2019s natural cortisol production, which is important for your everyday life. This dependence is managed by gradually weaning patients off the drug with steadily decreasing doses so that your body gradually begins to maintain its own cortisol levels again.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Methylprednisolone is usually taken in doses ranging from 5 to 60 mg, but much higher doses may be used. Very large doses of methylprednisolone are not toxic, but will significantly raise the risk and severity of side effects. If too much methylprednisolone is taken, call a poison helpline for medical advice. Emergency medical help may be needed.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Contraindications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Methylprednisolone can be so hazardous in people with certain medical conditions that the drug is never used. Called \u201c<\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/6503\/prednisolone\/Contradindications-Cautions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">contraindications<\/span><\/a><span style=\"font-weight: 400;\">,\u201d conditions that completely rule out methylprednisolone are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity to methylprednisolone or other corticosteroids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Systemic fungal infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cerebral malaria<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Methylprednisolone sodium succinate, an alternative form of methylprednisolone administered as an intramuscular or intravenous injection, is also contraindicated in:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Premature infants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">People with hypersensitivity to milk proteins<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=9a7b3837-e038-48bf-97e9-78ad463760dc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Methylprednisolone acetate<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=e86fbda8-00e4-4d54-841a-59dea6c15e70\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">methylprednisolone sodium succinate<\/span><\/a><span style=\"font-weight: 400;\"> injections are never injected into the spinal cord (epidural injection) because of potentially serious side effects. They also <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=9a7b3837-e038-48bf-97e9-78ad463760dc\"><span style=\"font-weight: 400;\">cannot be injected into the muscles<\/span><\/a><span style=\"font-weight: 400;\"> in anyone with idiopathic thrombocytopenic purpura.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Only <\/span><span style=\"font-weight: 400;\">methylprednisolone sodium succinate<\/span><span style=\"font-weight: 400;\"> may be given intravenously. Never give formulations of methylprednisolone acetate intravenously. All forms of methylprednisolone are never to be given intrathecally, and epidural administration carries many risks you should cover with your provider before providing consent.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Other medical conditions may require caution, monitoring, or even treatment modifications to avoid problems.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Immune suppression: <\/b><span style=\"font-weight: 400;\">Methylprednisolone weakens the immune system, making people more vulnerable to infections. Close attention to signs of infection is required when giving methylprednisolone to people who are immune-suppressed, have active infections, have a latent or active tuberculosis infection, or who have been exposed to measles or chickenpox.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Herpes zoster infection of the eye: <\/b><span style=\"font-weight: 400;\">People with a herpetic eye infection are at risk of eye perforation when taking methylprednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Gastrointestinal problems: <\/b><span style=\"font-weight: 400;\">Ulcers and sores are also more likely in people at risk for gastrointestinal perforation. This includes people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcer-treatment-and-medications\"><span style=\"font-weight: 400;\">peptic ulcer disease<\/span><\/a><span style=\"font-weight: 400;\"> (PUD), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcerative-colitis-treatment-and-medications\"><span style=\"font-weight: 400;\">ulcerative colitis<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diverticulitis-treatment-and-medications\"><span style=\"font-weight: 400;\">diverticulitis<\/span><\/a><span style=\"font-weight: 400;\">, or any recent intestinal surgery in which one part of the intestine was connected to another part.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Thyroid problems: <\/b><span style=\"font-weight: 400;\">An underactive thyroid <\/span><span style=\"font-weight: 400;\">increases the risks of methylprednisolone side effects<\/span><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mental illness:<\/b><span style=\"font-weight: 400;\"> Corticosteroid treatment can worsen existing emotional problems or psychotic tendencies.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Seizure disorder:<\/b><span style=\"font-weight: 400;\"> Seizures, a possible side effect of methylprednisolone, are more likely in people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatment-and-medications\"><span style=\"font-weight: 400;\">a history of seizures<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diabetes:<\/b><span style=\"font-weight: 400;\"> Methylprednisolone increases the body\u2019s production of sugar, raising blood sugar and making glucose levels harder to control with medications. Dose adjustments of oral medications or insulins may need to occur.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Hypertension:<\/b><span style=\"font-weight: 400;\"> Methylprednisolone increases blood pressure, so blood pressure medications may need to be changed or the doses increased.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Cirrhosis:<\/b><span style=\"font-weight: 400;\"> Methylprednisolone can injure the liver, worsening any existing liver disease.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Myasthenia gravis:<\/b><span style=\"font-weight: 400;\"> Although methylprednisolone is often used to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/myasthenia-gravis-treatment-and-medications\"><span style=\"font-weight: 400;\">myasthenia gravis<\/span><\/a><span style=\"font-weight: 400;\">, it is used with great caution for other medical conditions in people with myasthenia gravis.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Systemic sclerosis:<\/b><span style=\"font-weight: 400;\"> People with systemic sclerosis are at an increased risk of scleroderma renal crisis when taking methylprednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Osteoporosis:<\/b><span style=\"font-weight: 400;\"> Long-term use of methylprednisolone can cause significant bone loss, so people with or at risk for osteoporosis will require monitoring while taking this drug.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heart disease:<\/b><span style=\"font-weight: 400;\"> Because methylprednisolone causes fluid retention and electrolyte imbalances, anyone with congestive heart failure or who has recently experienced a heart attack will need to be monitored when taking methylprednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Blood clotting disorders:<\/b><span style=\"font-weight: 400;\"> Methylprednisolone can increase the coagulability of blood causing blood clots in the vascular system and thromboembolism. It should be used with extreme caution in patients with pre-existing coagulation disorders.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other medical conditions that will require extra care and monitoring include:<\/span>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Adrenal gland tumor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Swelling of the optic nerve<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Pregnancy and nursing<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking methylprednisolone during pregnancy is a discussion pregnant women must have with their healthcare provider. Methylprednisolone crosses the placenta and may cause problems for the fetus, including low birth rate, premature birth, and adrenal suppression. Because of possible problems, healthcare providers use methylprednisolone very carefully in pregnant women in their first trimester.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nursing women also need to talk about the possible risks of methylprednisolone treatment when breastfeeding. Methylprednisolone is present in breast milk and could affect a baby\u2019s hormones or stunt the infant\u2019s growth.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Methylprednisolone is FDA approved for use in children as young as newborns. Even so, methylprednisolone can suppress the growth of a child, so long-term treatment will require monitoring.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"interactions\">Methylprednisolone interactions<\/h2>\n<p><span style=\"font-weight: 400;\">As with all corticosteroids, methylprednisolone can cause problems when combined with certain types of drugs.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Live vaccines: <\/b><span style=\"font-weight: 400;\">Methylprednisolone suppresses the immune system, so no one taking methylprednisolone can receive a live vaccine.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Immune<\/b><span style=\"font-weight: 400;\">&#8211;<\/span><b>suppressants<\/b><span style=\"font-weight: 400;\">: Drugs that suppress the immune system will worsen methylprednisolone\u2019s effects on the immune system. The combination can leave patients dangerously vulnerable to infections and cancer. Drugs like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclosporine\"><span style=\"font-weight: 400;\">cyclosporine<\/span><\/a><span style=\"font-weight: 400;\"> can worsen methylprednisolone side effects.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>NSAIDs: <\/b><span style=\"font-weight: 400;\">Both methylprednisolone and nonsteroidal anti-inflammatory drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">) can damage the stomach, esophagus, and intestines. Combining these medications raises the risk of side effects such as ulcers and perforation.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Loop and thiazide diuretics<\/b><span style=\"font-weight: 400;\">: The combination increases the risk of potassium depletion, a significant side effect of methylprednisolone. Potassium levels will need to be checked regularly when these drugs are combined with methylprednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Estrogens<\/b><span style=\"font-weight: 400;\">: Estrogens used for hormone replacement can increase the incidence and severity of methylprednisolone side effects.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Migraine medications<\/b><span style=\"font-weight: 400;\">: Both migraine medications and methylprednisolone significantly raise blood pressure. Other drugs that significantly increase blood pressure include stimulants and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/epinephrine\"><span style=\"font-weight: 400;\">epinephrine<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Quinolone antibiotics<\/b><span style=\"font-weight: 400;\">: Tendon rupture is a risk when methylprednisolone is combined with quinolone antibiotics (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ciprofloxacin-hcl\"><span style=\"font-weight: 400;\">ciprofloxacin<\/span><\/a><span style=\"font-weight: 400;\">).\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Androgens<\/b><span style=\"font-weight: 400;\">: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/testosterone\"><span style=\"font-weight: 400;\">Testosterone<\/span><\/a><span style=\"font-weight: 400;\"> can increase the incidence and severity of fluid retention when combined with methylprednisolone.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antipsychotics<\/b><span style=\"font-weight: 400;\">: Drugs that treat psychosis and related conditions may change the heart\u2019s rhythm. Methylprednisolone alters the body\u2019s electrolyte balance and worsens these heart problems.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Diabetes drugs<\/b><span style=\"font-weight: 400;\">: Methylprednisolone raises the body\u2019s production of glucose so it may impair the ability of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\"> drugs to keep <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-blood-glucose-levels\/\"><span style=\"font-weight: 400;\">blood sugar under control<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Blood pressure drugs: <\/b><span style=\"font-weight: 400;\">Methylprednisolone raises blood pressure, reducing the ability of blood pressure drugs to control high blood pressure.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Mifepristone:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/mifepristone\"><span style=\"font-weight: 400;\">Mifepristone<\/span><\/a><span style=\"font-weight: 400;\"> is a potentially hazardous drug used only under a restricted pharmacy program. Because of the risk of adrenal insufficiency, <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b63fad9b-7f12-4400-9019-b0586054e534\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">it is never given with corticosteroids<\/span><\/a><span style=\"font-weight: 400;\"> such as methylprednisolone.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Desmopressin nasal spray:<\/b> <a href=\"https:\/\/www.singlecare.com\/prescription\/desmopressin-acetate-spray\"><span style=\"font-weight: 400;\">Desmopressin nasal spray<\/span><\/a><span style=\"font-weight: 400;\"> is never combined with any steroid medication due to the risk of severe sodium loss.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-side-effects\">How to avoid methylprednisolone side effects<\/h2>\n<p><span style=\"font-weight: 400;\">Unfortunately, methylprednisolone causes side effects in many people. Because methylprednisolone affects so many aspects of the body, there are several different ways to manage these effects. Here are the top 10:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Tell the doctor about all medical conditions and medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Any healthcare provider prescribing or administering methylprednisolone must know about all existing medical conditions and medications being taken. Pre-existing medical conditions or drug interactions can cause unwanted or even serious side effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Tell all other healthcare providers about methylprednisolone<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When taking methylprednisolone, tell all other medical professionals about this drug. The best advice is to carry a card or wear a medical alert tag that can notify healthcare professionals about any corticosteroids being taken.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Take methylprednisolone as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Always take this medicine as directed. The usual dose is <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Prednisolone-Syrup-prednisolone-781\"><span style=\"font-weight: 400;\">5\u201360 mg<\/span><\/a><span style=\"font-weight: 400;\"> per day, but the dose will be determined by your healthcare professional and may be adjusted.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Take methylprednisolone as scheduled<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Always follow the dosing schedule assigned by the prescriber. To prevent hormone disruption, most doctors will instruct patients to take methylprednisolone early in the morning. If scheduled doses are being regularly missed, ask a pharmacist for <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-medication-reminder-apps\/\"><span style=\"font-weight: 400;\">useful tools<\/span><\/a><span style=\"font-weight: 400;\"> that can serve as reminders.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Take prednisolone with food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It\u2019s okay to take methylprednisolone tablets with food or milk. It\u2019s also a good way to avoid stomach upset and other digestive system problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Avoid NSAIDs and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Speaking of gastrointestinal problems, the risk of heartburn, stomach acid problems, stomach ulcers, and even perforation goes up when methylprednisolone is taken with nonsteroidal anti-inflammatory drugs (NSAIDs). If pain or fever is a problem, use different over-the-counter pain relievers like <\/span><span style=\"font-weight: 400;\">acetaminophen<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Be extra careful about catching infections<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Methylprednisolone weakens the body\u2019s ability to fight off infections. While taking this drug, try to avoid people with infections. Regular hand washing and showering are also in order. If you notice any signs of an infection, talk to a healthcare provider immediately and before the infection gets too serious.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Eat a healthy diet<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It\u2019s not amusing to see one\u2019s weight go up while taking methylprednisolone. Most of the weight gain is due to sodium retention, so switch to a low-sodium diet while taking this drug. Methylprednisolone also increases the body\u2019s weight by ramping up the body\u2019s production of glucose, so it\u2019s also a good idea to go on a healthy, lean protein diet. To avoid potassium depletion, make sure to eat plenty of potassium-rich foods.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">9. Take calcium and vitamin D supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another good diet idea is to take calcium and vitamin D supplements to prevent bone loss while on methylprednisolone. Some healthcare providers may prescribe calcium supplements to people who already have osteoporosis.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">10. Do not stop taking methylprednisolone<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The side effects of methylprednisolone can be unpleasant, but steroid withdrawal might be worse. Like all glucocorticoids, methylprednisolone can cause withdrawal when stopped all of a sudden. Get professional medical advice before stopping this medicine. You will be put on a gradually decreasing dose to minimize withdrawal symptoms.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Common methylprednisolone side effects | Serious side effects | How long do side effects last? | Warnings | Interactions | How to avoid side effects Methylprednisolone is a common systemic corticosteroid used for a large number of medical conditions. For most, methylprednisolone is used for its anti-inflammatory and immune-suppressing properties. Methylprednisolone is usually taken as [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":36888,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,12164,10965,16414,788,12752],"coauthors":[8861],"class_list":["post-36882","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-arthritis","tag-asthma","tag-digestive-health","tag-drug-safety","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Methylprednisolone side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"Skin rash, hives, acne are common methylprednisolone side effects. 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