{"id":39477,"date":"2021-08-12T10:37:40","date_gmt":"2021-08-12T14:37:40","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=39477"},"modified":"2026-02-06T11:46:48","modified_gmt":"2026-02-06T16:46:48","slug":"colchicine-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/colchicine-side-effects\/","title":{"rendered":"How to manage colchicine side effects"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">If you are one of the 12.1 million Americans living with gout, your healthcare provider may have prescribed an <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/gout-treatment-and-medications\"><span style=\"font-weight: 400;\">anti-gout medication<\/span><\/a><span style=\"font-weight: 400;\"> named <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/colchicine\"><span style=\"font-weight: 400;\">colchicine<\/span><\/a><span style=\"font-weight: 400;\"> to help ease your symptoms.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Colchicine is an FDA-approved drug that is safe for use in both adults and children aged 4 and older. Colchicine side effects most commonly involve gastrointestinal symptoms like diarrhea, nausea, vomiting, and abdominal pain, which usually go away within a couple of weeks. However, serious side effects like toxicity and kidney injury are also possible.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Colchicine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. 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Most are related to gastrointestinal symptoms, but all are usually short-lived. The most common symptoms to be aware of when using colchicine include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cramping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore throat<\/span><\/li>\n<\/ul>\n<h3 id=\"colchicine-and-diarrhea\"><span style=\"font-weight: 400;\">Colchicine and diarrhea<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/diarrhea-treatment-and-medications\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/a><span style=\"font-weight: 400;\"> is the most prevalent complication seen with its use. A <\/span><a href=\"https:\/\/www.acpjournals.org\/doi\/full\/10.7326\/M16-0461\"><span style=\"font-weight: 400;\">systematic review<\/span><\/a><span style=\"font-weight: 400;\"> was performed in 2017 that found diarrhea could be seen in as many as 3 out of 4 patients prescribed the original recommended dosage for colchicine. This dosage has since been studied and adjusted. Because of the potential gastrointestinal concerns associated with colchicine, the lowest effective dose is always recommended.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cDue to the common side effect of diarrhea with the use of colchicine, providers need to be especially careful when prescribing this medication in certain patient populations,\u201d says <\/span><a href=\"https:\/\/gastrodoc1.com\/\"><span style=\"font-weight: 400;\">Jesse Houghton, MD, FACG<\/span><\/a><span style=\"font-weight: 400;\">, a senior medical director of Gastroenterology at Southern Ohio Medical Center. \u201cUsing this medication in patients with ulcerative colitis, Crohn\u2019s disease, or even in those with IBS-D, may result in severe diarrhea, dehydration, or a flare of their GI condition.\u201d<\/span><\/p>\n<h2 id=\"serious-side-effects-of-colchicine\"><span style=\"font-weight: 400;\">Serious side effects of colchicine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although colchicine is considered a safe drug, serious <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/9605\/colchicine\/Adverse-Reactions\"><span style=\"font-weight: 400;\">adverse effects<\/span><\/a><span style=\"font-weight: 400;\"> are associated with its use. If any of the following symptoms occur while using colchicine, contact your medical provider immediately for further medical attention.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Myelosuppression (decreased bone marrow activity)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Leukopenia (reduced white blood cells)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thrombocytopenia (reduced platelets)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Granulocytopenia (reduced granulocytes)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pancytopenia (all three\u00a0 blood cell lines are reduced)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aplastic anemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Myopathy (disease of muscle tissue)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rhabdomyolysis (a serious condition of muscle fibers being broken down)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Neuropathy (nerve damage)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hepatotoxicity (liver damage)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nephrotoxicity (kidney damage)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Multiple organ failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Disseminated intravascular coagulation (abnormal blood clotting in the body)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypersensitivity reaction<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reversible azoospermia (absence of viable sperm in semen)<\/span><\/li>\n<\/ul>\n<h3 id=\"colchicine-toxicity\"><span style=\"font-weight: 400;\">Colchicine toxicity<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Since there is minimal room for error when dosing colchicine safely, you must be aware of certain symptoms that may represent signs of toxicity. Gastrointestinal symptoms, the most common side effects with the use of colchicine, are usually the first symptoms of toxicity. When these symptoms (usually diarrhea and vomiting) occur, the medication is frequently stopped, as continuing the medication could result in more serious adverse effects occurring. Rare but extremely dangerous symptoms may involve multiorgan failure, which frequently leads to death.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Colchicine toxicity is commonly divided into <\/span><a href=\"https:\/\/journals.lww.com\/em-news\/fulltext\/2009\/09000\/lessons_from_the_courtroom__colchicine_toxicity.20.aspx\"><span style=\"font-weight: 400;\">three stages<\/span><\/a><span style=\"font-weight: 400;\">:\u00a0<\/span><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stage one involves the common and initial symptoms of diarrhea, nausea, and vomiting. These symptoms may cause severe dehydration, leading to low blood pressure and an abnormal number of blood cells. This stage typically lasts anywhere from 1-12 hours.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stage two usually lingers for 1-7 days and involves more catastrophic complications such as bone marrow suppression, multi-organ failure, kidney failure, altered mental status, and heart attack.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Finally, for those individuals who survive stage two, there is stage three, which includes hair loss and rebound elevated blood counts that will last 1-2 weeks.<\/span><\/li>\n<\/ol>\n<p><span style=\"font-weight: 400;\">Because the stages of colchicine toxicity may overlap, close monitoring is vital if any symptoms begin to occur, even minor ones. Early intervention may be required to prevent fatalities associated with its use.<\/span><\/p>\n<h3 id=\"kidney-injury\"><span style=\"font-weight: 400;\">Kidney injury<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Acute kidney injury accounts for about 9% of adverse events reported in <\/span><a href=\"https:\/\/fis.fda.gov\/sense\/app\/95239e26-e0be-42d9-a960-9a5f7f1c25ee\/sheet\/45beeb74-30ab-46be-8267-5756582633b4\/state\/analysis\"><span style=\"font-weight: 400;\">FAERS<\/span><\/a><span style=\"font-weight: 400;\">. <\/span><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/08860220601166644\"><span style=\"font-weight: 400;\">Studies<\/span><\/a><span style=\"font-weight: 400;\"> show kidney damage as well as the potential for kidney failure from the direct toxic effect of colchicine on the kidney tubules. Most studies show that acute kidney damage from colchicine use is reversible. Typically, kidney damage related to colchicine is a direct result of chronic use of the medication at high doses. Because kidney damage is always a concern with any medication, colchicine management should be monitored closely by a medical professional.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h2 id=\"how-long-do-colchicine-side-effects-last\"><span style=\"font-weight: 400;\">How long do colchicine side effects last?<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Category<\/b><\/td>\n<td><b>Examples<\/b><\/td>\n<td><b>Typical timeline<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Common side effects<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Diarrhea, nausea, vomiting, cramping, abdominal pain, fatigue, headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Usually short-lived; may start within <\/span><a href=\"https:\/\/calpoison.org\/news\/diagnosis-treatment-colchicine-poisoning\"><span style=\"font-weight: 400;\">2 hours<\/span><\/a><span style=\"font-weight: 400;\"> and last days to weeks<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Serious side effects<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Myelosuppression, rhabdomyolysis, neuropathy, liver or kidney damage, multiorgan failure<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Require immediate medical attention; may begin 8-72 hours after exposure<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Long-term side effects like numbness are less common with colchicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Quicker onset of symptoms appears to be found more with the use of intravenous colchicine versus the oral formulation.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While colchicine can help manage gout symptoms, it is not intended to cure gout and is not recommended for long-term use for pain management.<\/span><\/p>\n<h2 id=\"colchicine-contraindications-and-warnings\"><span style=\"font-weight: 400;\">Colchicine contraindications and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There is a wide range of medications that should be monitored closely or avoided when someone is prescribed colchicine.<\/span><\/p>\n<h3 id=\"contraindications\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Colchicine is absolutely contraindicated with certain HIV\/antivirals, macrolide antibiotics, cancer medications, antifungals, and heart prescription drugs. These have the potential to increase the amount of colchicine levels in the body, which can result in colchicine toxicity and other serious side effects. This is especially true if liver or kidney disease is present.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of these medications include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Atazanavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Clarithromycin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cyclosporine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itraconazole<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ketoconazole<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lopinavir\/Ritonavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ribociclib<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ritonavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Saquinavir<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Voriconazole<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Voxilaprevir<\/span><\/li>\n<\/ul>\n<h4 id=\"other-drug-interactions\"><span style=\"font-weight: 400;\">Other drug interactions:<\/span><\/h4>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Statins<\/b><span style=\"font-weight: 400;\">. This includes popular cholesterol medications such as atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Antibiotics<\/b><span style=\"font-weight: 400;\">. Antibiotics such as ciprofloxacin and erythromycin should be avoided as they pose a risk of muscle pain and damage when combined with colchicine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>NSAIDs<\/b><span style=\"font-weight: 400;\">. Certain anti-inflammatories should also be closely monitored. Examples include indomethacin and naproxen.<\/span><\/li>\n<\/ul>\n<h4 id=\"vitamin-and-food-interactions\"><span style=\"font-weight: 400;\">Vitamin and food interactions<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Supplements such as vitamin B12, turmeric, milk thistle, or ginkgo should always be disclosed to your healthcare provider due to potential interactions when added with colchicine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, any products containing grapefruit should be avoided as they may cause unwanted side effects with colchicine use.<\/span><\/p>\n<h3 id=\"abuse-and-dependence\"><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Colchicine is not a habit-forming drug and does not pose any risk of dependency. Additionally, there are no withdrawal symptoms documented with the discontinuation of the medicine.<\/span><\/p>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It is recommended that <\/span><a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/23247096211029744\"><span style=\"font-weight: 400;\">no more than 0.5 mg\/kg <\/span><\/a><span style=\"font-weight: 400;\">body weight of colchicine be prescribed per day, in order to prevent a fatal overdose of the medication.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Understanding how to properly use this medication is important, as there is no antidote to reverse its effects. Currently, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/activated-charcoal-benefits\/\"><span style=\"font-weight: 400;\">activated charcoal<\/span><\/a><span style=\"font-weight: 400;\"> and saline flushing are the traditional treatments for an overdose and should be started as quickly as possible.<\/span><\/p>\n<h3 id=\"restrictions\"><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u00a0Do not use colchicine if you have:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Known allergic reaction to the medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver disease\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease\u00a0<\/span><\/li>\n<\/ul>\n<h3 id=\"pregnancy-and-breastfeeding\"><span style=\"font-weight: 400;\">Pregnancy and breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Colchicine has been shown to be <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29029311\/\"><span style=\"font-weight: 400;\">safe for use during pregnancy<\/span><\/a><span style=\"font-weight: 400;\"> with no adverse effects noted to the fetus or mother.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">No adverse effects in breastfed infants have been reported in studies of colchicine, and many experts consider it safe during breastfeeding; however, according to the <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501213\/\">Drugs and Lactation Database (LactMed)<\/a>,\u00a0the highest levels of colchicine in breastmilk occur 2-4 hours after a dose, so avoid breastfeeding during this time to minimize infant exposure.\u00a0<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Colchicine has been approved for use in pediatric patients as young as 4 years old. This is only for the treatment of the genetic condition Familial Mediterranean Fever (FMF). Gout prophylaxis can be used only for those aged 16 or older.<\/span><\/p>\n<h3 id=\"seniors\"><span style=\"font-weight: 400;\">Seniors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Close monitoring is needed when prescribing colchicine to seniors. Kidney function in older patients may be decreased, leading to inadequate processing of colchicine in the body. This increases the risk of colchicine side effects. To counteract this possibility, a lower dose of colchicine or a different medication altogether may be considered.\u00a0\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/gout-treatment-and-medications\"><b>Compare other gout medications<\/b><\/a><\/p>\n<h2 id=\"how-to-avoid-colchicine-side-effects\"><span style=\"font-weight: 400;\">How to avoid colchicine side effects<\/span><\/h2>\n<ol>\n<li><b>Provide your healthcare provider with a current list of all medications.<\/b><span style=\"font-weight: 400;\"> Include all prescription and over-the-counter medications, vitamins, and herbal supplements.<\/span><\/li>\n<li><b>Discuss your complete medical history with your provider. <\/b><span style=\"font-weight: 400;\">Because colchicine toxicity poses a higher risk for those with certain medical conditions, a complete history should be provided so that it can be determined if you are a good candidate to take this medication. Disclosure of liver disease, kidney disease, pregnancy, or breastfeeding is important.<\/span><\/li>\n<li><b>Always take colchicine on time. <\/b><span style=\"font-weight: 400;\">Keep a record of when you should take your medication. If you miss a dose, take it as soon as you remember. If the missed dose is close to your next scheduled dose, take that one instead.<\/span><\/li>\n<li><b>Take colchicine as directed by your healthcare professional. <\/b><span style=\"font-weight: 400;\">Do not take more or less of this medication without the guidance of your physician. Even small increases in colchicine can be life-threatening and may not improve symptoms. Colchicine dosing will vary based on your age, the medical condition being treated, your medical history, and how you react to the medication. If your symptoms are not improving, do not take more medication or for longer than recommended.\u00a0\u00a0<\/span>\n<ul>\n<li><b>Acute gout<\/b><span style=\"font-weight: 400;\">: When taking colchicine for an acute gout flare, usually larger doses are prescribed at first. The medication should be discontinued as soon as the pain goes away. If any acute symptoms of diarrhea, vomiting, nausea, or stomach pain occur, the medication should be discontinued immediately.<\/span><\/li>\n<li><b>Gout prevention<\/b><span style=\"font-weight: 400;\">: When taking colchicine for an extended time for gout prevention, smaller dosages will be given, but for longer periods of time. This medication may be given in addition to other gout medications like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/allopurinol\"><span style=\"font-weight: 400;\">allopurinol<\/span><\/a><span style=\"font-weight: 400;\">. Depending on other medical conditions that may need treatment, colchicine may be prescribed for the rest of someone\u2019s life. Close monitoring may be required in this scenario, along with laboratory testing.\u00a0<\/span><\/li>\n<\/ul>\n<\/li>\n<li><b>Monitor symptoms closely. <\/b><span style=\"font-weight: 400;\">An overdose of colchicine can be fatal. Contact your healthcare provider immediately if you notice any of the following:<\/span><\/li>\n<\/ol>\n<ol>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Little or no urinating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Numbness or tingling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Weak pulse<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Slow heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Weak or shallow breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Fainting<\/span><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<h2 id=\"expert-takeaway\"><span style=\"font-weight: 400;\">Expert takeaway<\/span><\/h2>\n<p><b>Clinical perspective: Jesse Houghton, MD, FACG<\/b><\/p>\n<blockquote><p><span style=\"font-weight: 400;\">\u201cWhen I see colchicine on my patient\u2019s medication list, I spend a little extra time reviewing their other medications, including herbals and supplements, since this medication is one that is known to have multiple potential interactions. That said, it is a tried and true effective medication for gout flares and gout prevention. With proper monitoring, it can significantly improve the lives of my patients who suffer from gout.\u201d<\/span><\/p><\/blockquote>\n<p><b>Expert bio: <\/b><span style=\"font-weight: 400;\">Dr. Houghton is a board-certified gastroenterologist and Senior Medical Director of Gastroenterology at Southern Ohio Medical Center and member of the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/author\/jesse-p-houghton\/\"><span style=\"font-weight: 400;\">SingleCare Medical Review Board<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are one of the 12.1 million Americans living with gout, your healthcare provider may have prescribed an anti-gout medication named colchicine to help ease your symptoms. Colchicine is an FDA-approved drug that is safe for use in both adults and children aged 4 and older. Colchicine side effects most commonly involve gastrointestinal symptoms [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":39478,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,788,12752],"coauthors":[20627],"class_list":["post-39477","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-drug-safety","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Can colchicine cause diarrhea? A guide to side effects<\/title>\n<meta name=\"description\" content=\"Common side effects include diarrhea and nausea, but serious toxicity and kidney injury can occur. 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