{"id":40808,"date":"2021-09-18T13:48:07","date_gmt":"2021-09-18T17:48:07","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=40808"},"modified":"2026-02-17T14:38:15","modified_gmt":"2026-02-17T19:38:15","slug":"synthroid-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/synthroid-side-effects\/","title":{"rendered":"How to reduce Synthroid side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/synthroid\"><span style=\"font-weight: 400;\">Synthroid (levothyroxine)<\/span><\/a><span style=\"font-weight: 400;\"> is a prescription <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/thyroxines\/\"><span style=\"font-weight: 400;\">thyroid hormone replacement<\/span><\/a><span style=\"font-weight: 400;\"> used to treat hypothyroidism and certain types of thyroid cancer in adults and children. It is a synthetic form of T4, a hormone that helps regulate metabolism throughout the body. Synthroid comes in many dose strengths, and the right dose depends on your individual needs. Like all medications, it can cause side effects and interact with other drugs, so proper dosing and monitoring are important.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/synthroid\/what-is\"><b>What is Synthroid?<\/b><\/a><b> |\u00a0 <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/thyroid-causes\"><b>What causes thyroid problems?<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Levothyroxine with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tLevothyroxine 75 mcg (90 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$10.00<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/levothyroxine-sodium#blog-cta\" class=\"coupon-see-all-btn\">See Levothyroxine prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Common side effects of Synthroid<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many Synthroid side effects are mild and improve as your body adjusts or after a dose change. Contact your healthcare provider if symptoms are severe or do not go away.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Common side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast or irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety, nervousness, or shaking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased appetite\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Excess sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea, stomach pain, or diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache or fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heat intolerance<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular menstrual periods<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle cramps<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight changes<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Weight changes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hypothyroidism often causes weight gain due to a slower metabolism. When people start Synthroid, their metabolism returns to normal, which may lead to mild weight loss.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Weight loss varies by person and is often modest. In some people, weight does not change or may increase. Weight loss from Synthroid is not a fat-loss drug effect and is <\/span><a href=\"https:\/\/journals.lww.com\/co-endocrinology\/Abstract\/2012\/10000\/Thyroid_hormone_and_obesity.14.aspx\"><span style=\"font-weight: 400;\">often related to water loss<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Synthroid should never be used for weight loss. Taking too much can cause serious or life-threatening side effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Headache<\/span><\/h3>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24665276\/\"><span style=\"font-weight: 400;\">Headaches can occur as a symptom of hypothyroidism<\/span><\/a><span style=\"font-weight: 400;\">, but they can also be a side effect of Synthroid. If you develop new or worsening headaches or migraines, tell your healthcare provider. A dose adjustment may be needed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Seek immediate medical care for severe, persistent, or worsening headaches.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Irregular periods<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Thyroid problems can affect menstrual cycles. Synthroid itself may also cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/late-period\/\"><span style=\"font-weight: 400;\">irregular periods<\/span><\/a><span style=\"font-weight: 400;\">. Blood tests are needed to determine whether symptoms are related to thyroid levels or dosing.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/female-thyroid-problem-symptoms\"><b>Signs of thyroid problems in females<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">Diarrhea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Diarrhea is a common and usually temporary side effect. Seek medical care if diarrhea is severe, long-lasting, or occurs with fever or dehydration.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Hair loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hair thinning or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/why-is-my-hair-falling-out\/\"><span style=\"font-weight: 400;\">hair loss<\/span><\/a><span style=\"font-weight: 400;\"> can occur with thyroid disorders or with <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18728176\/\"><span style=\"font-weight: 400;\">excess thyroid hormone<\/span><\/a><span style=\"font-weight: 400;\">. Hair loss may improve once thyroid levels are balanced.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If hair loss starts after beginning Synthroid, tell your healthcare provider. A dose change may help.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/hair-loss-treatment-and-medications\"><b>Hair loss treatments and medications<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">Serious side effects of Synthroid<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Synthroid use is associated with several serious, potentially fatal side effects. It is important to seek medical care if you experience any of the serious side effects below.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain or symptoms that feel like a heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rapid heart rate<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening heart disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased pressure in the skull (mainly in children)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Early bone growth plate closure in children or infants<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Side effects can also be directly reported to the FDA using the <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/scripts\/medwatch\/index.cfm\"><span style=\"font-weight: 400;\">MedWatch Reporting Form.<\/span><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose symptoms<\/span><\/h3>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279036\/\"><span style=\"font-weight: 400;\">Taking too much Synthroid<\/span><\/a><span style=\"font-weight: 400;\"> can be dangerous and may be fatal. Synthroid overdose affects the heart and nervous system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Signs of overdose include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nervousness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Rare but serious overdose effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion or acute psychosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures or convulsions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thyroid storm<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dangerous heart rhythm changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Death<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Overdose may happen accidentally, through misuse for weight loss, or if children swallow the medication. If an overdose is suspected, call Poison Control at 800-222-1222 or seek emergency care immediately.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/prescription\/synthroid\/dosage\"><b>Synthroid dosage guide<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Severe allergic reactions to Synthroid are very rare. Mild reactions, such as <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4406571\/\"><span style=\"font-weight: 400;\">skin rash<\/span><\/a><span style=\"font-weight: 400;\">, are more likely due to inactive ingredients rather than the hormone itself.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Anxiety<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Low thyroid hormone levels can cause anxiety. Synthroid may improve anxiety if caused by hypothyroidism. However, according to the drug label, anxiety from Synthroid is primarily due to high doses. Blood tests can help guide dose adjustments.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do Synthroid side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most mild side effects improve once the dose is adjusted. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6987785\/\"><span style=\"font-weight: 400;\">Hair loss in children has been shown to reverse when the dose is reduced<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some effects, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/heart-palpitations\/\"><span style=\"font-weight: 400;\">heart rhythm problems<\/span><\/a><span style=\"font-weight: 400;\"> or bone loss, may take longer to develop and can be serious. Older adults and people with heart disease need careful monitoring.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Long-term dosing problems may affect:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone density, especially in postmenopausal women<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Growth and development in children<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Always tell your healthcare provider about side effects and how long they last.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Synthroid should not be used in people with untreated adrenal insufficiency. Taking levothyroxine before glucocorticoid therapy in people with adrenal insufficiency may result in adrenal crisis. Treating the adrenal condition must happen first to avoid an adrenal crisis.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Synthroid is not addictive. However, misuse for weight loss can be dangerous. There are no withdrawal symptoms from stopping Synthroid, but stopping it suddenly can cause hypothyroidism symptoms to return.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">This medication comes with a black box warning. Synthroid should never be used to treat obesity or for weight loss. High doses can cause life-threatening toxicity.<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">Cardiac adverse reactions in older adults or in people with cardiac disease\u00a0<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Overtreatment with Synthroid can increase heart rate and strain the heart. Older adults and people with heart disease should start on lower doses and increase slowly based on blood test results.<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">Other precautions<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Synthroid is not recommended for:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Benign thyroid nodules<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Non-toxic goiter<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Temporary thyroid inflammation that usually resolves on its own<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It may also:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsen blood sugar control in people with diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reduce bone mineral density with long-term overuse<\/span><\/li>\n<\/ul>\n<h4><span style=\"font-weight: 400;\">Pregnancy and breastfeeding<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Pregnant women may need <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/synthroid-and-pregnancy\"><span style=\"font-weight: 400;\">higher doses of Synthroid<\/span><\/a><span style=\"font-weight: 400;\">. Untreated <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/hypothyroidism-and-pregnancy\/\"><span style=\"font-weight: 400;\">hypothyroidism during pregnancy<\/span><\/a><span style=\"font-weight: 400;\"> can harm the fetus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Synthroid is generally considered <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/synthroid-and-breastfeeding\/\"><span style=\"font-weight: 400;\">safe during breastfeeding<\/span><\/a><span style=\"font-weight: 400;\"> and may help support milk production.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many medications, even over-the-counter medicine and supplements, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/thyroid-medication-interactions\/\"><span style=\"font-weight: 400;\">affect how Synthroid is absorbed<\/span><\/a><span style=\"font-weight: 400;\">. Always share a full medication list with your healthcare provider.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Usually, recommendations are given to take Synthroid on an empty stomach <\/span><a href=\"http:\/\/singlecare.com\/blog\/can-you-take-synthroid-at-night\"><span style=\"font-weight: 400;\">in the morning<\/span><\/a><span style=\"font-weight: 400;\">, at least 30 to 60 minutes before eating or taking other medication.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"3\">\n<h3 style=\"text-align: center;\"><span style=\"font-weight: 400;\">Synthroid drug interactions<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug type<\/b><\/td>\n<td><b>Interaction<\/b><\/td>\n<td><b>What to do<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Antacids<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Reduced absorption<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adjust Synthroid dose<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/drug-classes\/proton-pump-inhibitors\"><span style=\"font-weight: 400;\">Proton pump inhibitors<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Reduced absorption<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adjust Synthroid dose<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Iron or calcium<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Reduced absorption<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 4 hours apart<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/drug-classes\/bile-acid-sequestrants\"><span style=\"font-weight: 400;\">Bile acid sequestrants<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Increase binding<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Take 4 hours apart<\/span><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/drug-classes\/contraceptives\"><span style=\"font-weight: 400;\">Hormonal contraceptives containing estrogen<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">May affect thyroid hormone transport proteins and alter thyroid levels\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Monitor free T4 levels (not regular T4)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/synthroid-and-coffee\/\"><b>Synthroid and coffee<\/b><\/a><b> | <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/biotin-and-synthroid\/\"><b>Biotin and Synthroid<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">Brand-name Synthroid may have fewer side effects than generic<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some patients have reported better tolerance with brand-name levothyroxine (Synthroid, Levoxyl, Unithroid, Tirosint) versus generic. Although most studies show little to no evidence of these differences between brand and generic, <\/span><a href=\"https:\/\/www.empr.com\/home\/mpr-first-report\/aace-2017\/brand-vs-generic-levothyroxine-effect-on-tsh-lab-data-compared\/\"><span style=\"font-weight: 400;\">one study<\/span><\/a><span style=\"font-weight: 400;\"> showed that Synthroid was more effective than generic levothyroxine.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For the majority of medications, there is no chemical difference between brand and generic formulas. However, questions have been raised about thyroid hormone replacements.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/fda-acts-ensure-thyroid-drugs-dont-lose-potency-expiration-date\"><span style=\"font-weight: 400;\">The FDA requires levothyroxine products to contain 95% to 105% of the labeled dose<\/span><\/a><span style=\"font-weight: 400;\">. As you\u2019ve read above, levothyroxine has a very narrow therapeutic range, and the dose must be carefully adjusted to keep thyroid levels balanced. A slight variation in strength could mean taking more or less than your intended dose, which can affect how well your thyroid condition is controlled.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Brand-name levothyroxine tablets may be more consistent in potency than generic formulations. Therefore, some people notice new or returning symptoms after switching from brand-name to generic levothyroxine. In most cases, however, patients can be reassured by studies demonstrating <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2771041?utm_source=openevidence&amp;utm_medium=referral\"><span style=\"font-weight: 400;\">equal efficacy between brand and generic levothyroxine<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jamainternalmedicine\/fullarticle\/2789278?utm_source=openevidence&amp;utm_medium=referral\"><span style=\"font-weight: 400;\">between levothyroxine tablets from different generic manufacturers<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, the <\/span><a href=\"https:\/\/www.fda.gov\/consumers\/consumer-updates\/generic-drugs-undergo-rigorous-fda-review\"><span style=\"font-weight: 400;\">FDA does not require<\/span><\/a><span style=\"font-weight: 400;\"> generic drug manufacturers to use the same inactive ingredients as the brand-name version. If you are sensitive or allergic to inactive ingredients of generic levothyroxine, you may tolerate brand-name Synthroid better.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you\u2019re taking generic levothyroxine and experiencing side effects or difficulty controlling thyroid levels, ask your healthcare provider about switching to a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/levothyroxine-alternatives\/\"><span style=\"font-weight: 400;\">brand-name alternative<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How to avoid Synthroid side effects<\/span><\/h2>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take Synthroid exactly as prescribed<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take it on an empty stomach, 30-60 minutes before eating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid grapefruit products<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tell your provider about all medications and supplements you take<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoid taking it with antacids, or take antacids and Synthroid at least four hours apart<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Do not stop taking it without medical advice<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Get regular blood tests to <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tsh-test\/\"><span style=\"font-weight: 400;\">monitor thyroid levels<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Store the medication at room temperature and out of reach of children<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seek medical care for serious side effects or allergic reactions<\/span><\/li>\n<\/ol>\n<h2><span style=\"font-weight: 400;\">Expert takeaway<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cSynthroid and its generic version, levothyroxine, are the first-line options for treatment of hypothyroidism. Poor efficacy and side effects are most commonly related to over- or underdosing of the drug, so monitoring of TSH levels is essential to ensure ideal dose titration,\u201d says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/chad-shaffer-2b6120206\/\"><span style=\"font-weight: 400;\">Chad Shaffer, MD<\/span><\/a><span style=\"font-weight: 400;\">, a member of the <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/author\/chad-shaffer-md\/\"><span style=\"font-weight: 400;\">SingleCare Medical Board<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Synthroid (levothyroxine) is a prescription thyroid hormone replacement used to treat hypothyroidism and certain types of thyroid cancer in adults and children. It is a synthetic form of T4, a hormone that helps regulate metabolism throughout the body. Synthroid comes in many dose strengths, and the right dose depends on your individual needs. Like all [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":40809,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,3896],"coauthors":[20759],"class_list":["post-40808","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-thyroid","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How to avoid Synthroid side effects<\/title>\n<meta name=\"description\" content=\"Many side effects are actually symptoms of too much Synthroid. 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