{"id":4152,"date":"2019-05-23T10:24:29","date_gmt":"2019-05-23T14:24:29","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=4152"},"modified":"2025-12-08T10:42:47","modified_gmt":"2025-12-08T15:42:47","slug":"nexplanon-vs-mirena","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/nexplanon-vs-mirena\/","title":{"rendered":"Nexplanon vs. Mirena: Differences, similarities, and which is better for you"},"content":{"rendered":"<p><a href=\"#drug-overview-differences\">Drug overview &amp; main differences<\/a> | <a href=\"#conditions-treated\">Conditions treated<\/a> | <a href=\"#efficacy\">Efficacy<\/a> | <a href=\"#insurance-coverage-cost-comparison\">Insurance coverage and cost comparison<\/a> | <a href=\"#side-effects\">Side effects<\/a> | <a href=\"#drug-interactions\">Drug interactions<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#FAQ\">FAQ<\/a><\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/ig7JrwmzJZ8?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">When deciding on an effective and safe birth control method, you may be met with several options, such as birth control pills, birth control implants, and hormonal IUDs (intrauterine devices). The <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK536949\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most effective options<\/span><\/a><span style=\"font-weight: 400;\">, however, are the etonogestrel contraceptive implant and the levonorgestrel intrauterine system (LNG IUD). During the course of a year, fewer than <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8229462\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1 in 100<\/span><\/a><span style=\"font-weight: 400;\"> women will get pregnant while using an implant or intrauterine device.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nexplanon (etonogestrel) and Mirena (levonorgestrel) are non-pill forms of <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/contraceptives\"><span style=\"font-weight: 400;\">birth control<\/span><\/a><span style=\"font-weight: 400;\"> that can help prevent pregnancy. Both drugs contain female hormone analogs called progestins. They do not contain estrogen.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nexplanon is implanted under the skin of the upper arm while Mirena is an intrauterine device (IUD) inserted into the uterus. They work by creating a hostile environment for sperm to prevent the fertilization of an egg. Progestins can also help stop the release of an egg from the ovaries (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ovulation-guide\/\"><span style=\"font-weight: 400;\">ovulation<\/span><\/a><span style=\"font-weight: 400;\">). Continue reading to learn more about the similarities and differences between Nexplanon and Mirena.<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/birth-control\"><strong>Free birth control coupons from SingleCare<\/strong><\/a><\/p>\n<h2 id=\"drug-overview-differences\">What are the main differences between Nexplanon vs. Mirena<\/h2>\n<h3><span style=\"font-weight: 400;\">Nexplanon\u00a0<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/nexplanon\/what-is\"><span style=\"font-weight: 400;\">Nexplanon<\/span><\/a><span style=\"font-weight: 400;\"> is an etonogestrel implant, formerly known as Implanon. It is the size of a matchstick, and it is implanted under the skin of the upper arm by a trained healthcare professional. Nexplanon was approved in 2001 to prevent pregnancy.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nexplanon contains 68 mg of etonogestrel, a type of progestin that closely resembles progesterone. After implantation, Nexplanon releases etonogestrel to help prevent pregnancy for up to <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/021529s019s020lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">three years<\/span><\/a><span style=\"font-weight: 400;\">. After this period of time, it needs to be removed and replaced. However, some <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5752601\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown that Nexplanon may be effective for up to five years.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Mirena<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/mirena-52-mg\/what-is\"><span style=\"font-weight: 400;\">Mirena<\/span><\/a><span style=\"font-weight: 400;\"> is a levonorgestrel-releasing <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/iud-birth-control-contraceptive-guide\/\"><span style=\"font-weight: 400;\">IUD<\/span><\/a><span style=\"font-weight: 400;\"> that is inserted into the uterus as a small T-shaped device. It is inserted directly into the uterus by a trained healthcare professional. Mirena was approved in 2000 to prevent pregnancy and decrease heavy menstrual bleeding.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mirena contains 52 mg of levonorgestrel that is released slowly over time. After implantation, Mirena can help prevent pregnancy for up to <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/021225s042lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seven years<\/span><\/a><span style=\"font-weight: 400;\"> and decrease menstrual bleeding for up to five years. Mirena should be removed and replaced after five years in order to remain effective for menstrual bleeding. Otherwise, it can remain in place for another two years for a total of seven years to prevent pregnancy.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Main differences between Nexplanon vs. Mirena <\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Nexplanon<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Hormonal contraceptive<\/span><br \/>\n<span style=\"font-weight: 400;\">Progestin-only<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Hormonal contraceptive<\/span><br \/>\n<span style=\"font-weight: 400;\">Progestin-only<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">No generic version available<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No generic version available<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Etonogestrel implant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Levonorgestrel intrauterine system<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Subdermal implant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intrauterine device (IUD)<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Nexplanon contains a total of 68 mg of etonogestrel, which is released at a rate of 60 to 70 mcg\/day in week 5 to 6. This rate decreases to 35 to 45 mcg\/day at the end of the first year, 30 to 40 mcg\/day at the end of the second year, and 25 to 30 mcg\/day at the end of the third year.\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Mirena contains a total of 52 mg of levonorgestrel, which is released at a rate of 20 mcg\/day over the first 3 months. This rate decreases to 18 mcg\/day after 1 year, 10 mcg\/day after 5 years, and 8 mcg\/day after 7 years.<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">3 years<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5 to 7 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Women over 18 years old<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Women over 18 years old<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"conditions-treated\">Conditions treated by Nexplanon and Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Both Nexplanon and Mirena are hormonal contraceptives FDA approved to prevent pregnancy. Nexplanon is implanted under the skin (subdermal) to prevent pregnancy for up to three years. Mirena is inserted into the uterus (IUD) to prevent pregnancy for up to seven years.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mirena is also approved to treat heavy menstrual bleeding. Nexplanon is not approved for heavy menstrual bleeding, although it may be used off-label for this purpose.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Nexplanon<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prevention of pregnancy<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Heavy menstrual bleeding<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"efficacy\">Is Nexplanon or Mirena more effective?<\/h2>\n<p><span style=\"font-weight: 400;\">Both Nexplanon and Mirena are effective methods of birth control with a failure rate of less than 1%. They contain progestin, a synthetic form of progesterone, to help suppress ovulation and thicken the cervical mucus. This mechanism of action helps prevent the release and fertilization of an egg.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As long-acting reversible contraceptives (LARCs), these birth control methods can be used for several years. Nexplanon is approved to prevent pregnancy for up to three years while Mirena is approved to prevent pregnancy for up to seven years. Compared to the percentage of women who experience pregnancy with LARCs (less than 1%), there is a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3638209\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">higher percentage<\/span><\/a><span style=\"font-weight: 400;\"> of women who experience a pregnancy in the first year with other forms of birth control: 18% with male condoms, 9% with NuvaRing, 9% with combined or progestin-only oral contraceptives, and 6% with Depo-Provera.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While both Nexplanon and Mirena are highly effective, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7788930\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown that more women who use Nexplanon may discontinue treatment due to side effects after one year. However, both birth control methods are approved as effective and safe.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult a gynecologist for medical advice on the best contraceptive for you. A healthcare provider can also assist with other aspects of family planning.\u00a0<\/span><\/p>\n<h2 id=\"insurance-coverage-cost-comparison\">Coverage and cost comparison of Nexplanon vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Many health insurance plans may help cover the cost of Nexplanon or Mirena. In general, Medicare plans do not provide coverage for birth control. Because no generic versions are available for Nexplanon or Mirena, costs can run high.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Contact your insurance provider or healthcare provider to determine the exact cost of Nexplanon or Mirena. A savings card from SingleCare may help lower the cost of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nexplanon\"><span style=\"font-weight: 400;\">Nexplanon<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mirena-52-mg\"><span style=\"font-weight: 400;\">Mirena<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Nexplanon<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">One implant<\/span><\/td>\n<td><span style=\"font-weight: 400;\">One device<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typical Medicare copay<\/b><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/nexplanon\"><span style=\"font-weight: 400;\">$1,190 at Kroger<\/span><\/a><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/mirena-52-mg\"><span style=\"font-weight: 400;\">$1,179 at Kroger<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em><small>Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of Dec. 8, 2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available.<\/small><\/em><\/p>\n<h2 id=\"side-effects\">Common side effects of Nexplanon vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">The most common side effects of Nexplanon include headache, menstrual changes, vaginal inflammation (vaginitis), weight gain, acne, breast tenderness, abdominal cramping, and mood changes, such as depression. Other side effects may include nausea, dizziness, and back pain.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most common side effects of Mirena are headache, vaginal inflammation (vaginitis), vaginal discharge, abdominal cramping, and menstrual changes or irregular bleeding patterns. Other side effects include nausea, back pain, acne, breast tenderness, and depression.<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Nexplanon<\/b><\/td>\n<td colspan=\"2\"><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Side Effect<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">25%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">16%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vaginitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">15%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Weight gain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acne<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Breast tenderness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">13%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">23%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Menstrual changes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">32%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dizziness<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&#8211;<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Back pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.<\/span><\/i><\/p>\n<p><span style=\"font-weight: 400;\">Source: DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=487f8a62-e142-457c-97cc-2e398fde7594\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Nexplanon<\/span><\/a><span style=\"font-weight: 400;\">), DailyMed (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=dcbd6aa2-b3fa-479a-a676-56ea742962fc\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Mirena<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"drug-interactions\">Drug interactions of Nexplanon vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Drugs that induce or block certain enzymes in the liver, including the CYP3A4 enzyme, can affect blood levels of Nexplanon and Mirena. CYP3A4 inducers like phenytoin, carbamazepine, oxcarbazepine, felbamate, and rifabutin can decrease blood levels of Nexplanon and Mirena, which can decrease the effectiveness of the contraceptive. St. John\u2019s wort can also act as a CYP3A4 inducer.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Drugs that inhibit, or block, the CYP3A4 enzyme can cause increased blood levels of Nexplanon and Mirena. CYP3A4 inhibitors include fluconazole and ketoconazole. Taking these drugs with Nexplanon or Mirena may increase the risk of adverse effects of the contraceptive.\u00a0<\/span><\/p>\n<table class=\"singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug<\/b><\/td>\n<td><b>Drug Class<\/b><\/td>\n<td><b>Nexplanon<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Carbamazepine\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Oxcarbazepine<\/span><br \/>\n<span style=\"font-weight: 400;\">Efavirenz<\/span><br \/>\n<span style=\"font-weight: 400;\">Felbamate\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Griseofulvin<\/span><br \/>\n<span style=\"font-weight: 400;\">Nevirapine\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Phenytoin\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Phenobarbital\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Rifabutin\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Rifampin\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><br \/>\n<span style=\"font-weight: 400;\">Topiramate<\/span><\/td>\n<td><span style=\"font-weight: 400;\">CYP3A4 inducers<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ketoconazole<\/span><br \/>\n<span style=\"font-weight: 400;\">Itraconazole<\/span><br \/>\n<span style=\"font-weight: 400;\">Fluconazole<\/span><br \/>\n<span style=\"font-weight: 400;\">Grapefruit juice<\/span><\/td>\n<td><span style=\"font-weight: 400;\">CYP3A4 inhibitors<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">*This may not be a complete list of all possible drug interactions. Consult a doctor with all medications you may be taking.\u00a0<\/span><\/p>\n<h2 id=\"warnings\">Warnings of Nexplanon and Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Both Nexplanon and Mirena can cause changes in menstrual bleeding patterns. Consult a healthcare provider if bleeding is irregular, painful, or particularly severe.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The use of Nexplanon or Mirena is associated with an increased risk of thrombosis, or blood clots. These contraceptives should be avoided in women with a history of smoking and a cardiovascular event like a heart attack or stroke.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although rare, an ectopic pregnancy can occur while using Nexplanon or Mirena. Consult a healthcare provider if you experience unusual vaginal bleeding or severe abdominal pain with Nexplanon or Mirena.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is not recommended to use Nexplanon or Mirena if you have liver problems, like liver disease or liver tumors.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The use of Nexplanon or Mirena can lead to the development of <\/span><a href=\"https:\/\/reproductive-health-journal.biomedcentral.com\/articles\/10.1186\/s12978-020-01054-y\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">ovarian cysts<\/span><\/a><span style=\"font-weight: 400;\">. These cysts usually go away on their own but may require surgery in some cases.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nexplanon may cause mild insulin resistance and changes in blood sugar levels, especially in women with diabetes.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There is an increased risk of group A streptococcal infections, pelvic inflammatory disease, perforation, and expulsion of the device while using Mirena.\u00a0<\/span><\/p>\n<h2 id=\"FAQ\">Frequently asked questions about Nexplanon vs. Mirena<\/h2>\n<h3><span style=\"font-weight: 400;\">What is Nexplanon?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nexplanon is a birth control implant that contains etonogestrel. It is implanted in the skin of your upper arm to prevent pregnancy. Nexplanon is effective for up to three years, after which it must be removed and replaced. Nexplanon contains 68 mg of etonogestrel.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What is Mirena?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mirena is a hormone-releasing intrauterine device (IUD). It contains 52 mg of levonorgestrel that is released slowly over time. Mirena is effective for preventing pregnancy for up to seven years. It is also approved to treat heavy menstrual bleeding for up to five years.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Are Nexplanon and Mirena the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nexplanon and Mirena are available non-pill birth control options. Although they are both considered long-acting reversible contraceptives (LARCs) that contain a form of progestin, they are not the same. Nexplanon contains etonogestrel and is implanted in the upper arm. Mirena contains levonorgestrel and is inserted into the uterus.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Is Nexplanon or Mirena better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Both Nexplanon and Mirena are long-acting reversible contraceptives that are more effective than other methods of birth control methods, like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/best-birth-control-pill-contraceptive-guide\/\"><span style=\"font-weight: 400;\">birth control pills<\/span><\/a><span style=\"font-weight: 400;\">, diaphragms, and male condoms. The rate of failure is less than 1% with both Nexplanon and Mirena. Mirena may be preferred for women who have heavy menstrual bleeding and want a form of contraception. In addition, Mirena provides protection from pregnancy longer than Nexplanon at seven years versus three years.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult a healthcare provider for the best contraceptive for you. Different types of birth control may be recommended instead of Nexplanon or Mirena. The copper IUD, also known under the brand name Paragard, is a potential alternative to Mirena. Other hormonal IUDs include Skyla, Kyleena, and Liletta.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use Nexplanon or Mirena while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nexplanon and Mirena are contraindicated in known or suspected pregnancy. Consult a healthcare provider if you suspect you are pregnant while using Nexplanon or Mirena.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use Nexplanon or Mirena with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nexplanon and Mirena may potentially cause problems in the liver, and excessive alcohol consumption may increase the risk of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5803674\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">liver damage<\/span><\/a><span style=\"font-weight: 400;\">. However, there are no known interactions between alcohol and Nexplanon or Mirena. Drinking alcohol should have no effect on how well contraceptive implants or IUDs work.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can you gain weight on Nexplanon?\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, Nexplanon may cause weight gain. In <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/021529s019s020lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, women using Nexplanon gained an average of 2.8 pounds after one year and 3.7 pounds after two years. However, it is not known how much of that weight gain is attributed to Nexplanon.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Does Mirena cause weight gain?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Yes, Mirena may cause weight gain. In a <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/021225s042lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\"> of 362 women using Mirena for more than five years, weight gain was reported. Approximately 6% of women reported weight gain between the fifth and seventh year of use. However, it is not known how much of that weight gain is directly caused by Mirena.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What is the Mirena crash?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are reports of women experiencing short-term side effects after the removal of Mirena. While there is no concrete evidence on the cause of it, the Mirena crash may be associated with a temporary hormone imbalance after removal. Symptoms of Mirena crash may include headache, nausea, mood swings, insomnia, fatigue, and acne. These effects are usually temporary. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drug overview &amp; main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ When deciding on an effective and safe birth control method, you may be met with several options, such as birth control pills, birth control implants, and hormonal IUDs (intrauterine [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":12812,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4783,8670],"coauthors":[8669],"class_list":["post-4152","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-birth-control","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nexplanon vs. Mirena: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Nexplanon and Mirena are birth control methods but work in different ways. 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