{"id":4165,"date":"2019-05-24T12:17:43","date_gmt":"2019-05-24T16:17:43","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=4165"},"modified":"2020-10-17T17:32:49","modified_gmt":"2020-10-17T21:32:49","slug":"midazolam-nasal-spray-seizure-treatment-fda-approval","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/news\/midazolam-nasal-spray-seizure-treatment-fda-approval\/","title":{"rendered":"FDA approves Nayzilam spray for seizures"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">There is some big news for people with epilepsy who experience seizure clusters or prolonged seizures. On May 20, 2019, the Food and Drug Administration approved the <\/span><a href=\"https:\/\/www.ucb.com\/stories-media\/Press-Releases\/article\/UCB-announces-NAYZILAM-midazolam-nasal-spray-now-approved-by-FDA-to-treat-intermittent-stereotypic-episodes-of-frequent-seizure-activity-in-people-living-with-epilepsy-in-the-U-S\"><span style=\"font-weight: 400;\">first-ever nasal spray for treating seizures<\/span><\/a><span style=\"font-weight: 400;\">: <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/nayzilam\"><span style=\"font-weight: 400;\">Nayzilam<\/span><\/a><span style=\"font-weight: 400;\"> (midazolam).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The drug, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/midazolam-hcl\"><span style=\"font-weight: 400;\">midazolam<\/span><\/a><span style=\"font-weight: 400;\">, has been around for decades. However, this is the first time that it is available as a nasal spray for the treatment of seizures.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Why is midazolam used for epilepsy?\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Approximately 150,000 Americans have uncontrolled epilepsy with seizure clusters. Frequent or prolonged seizures come with a great deal of risk, including injury and brain damage. So when people have these types of seizures, they need care immediately.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cUrgent treatment generally cannot be in the form of a pill, because a) the patient has to cooperate with swallowing the pill, which may not be possible after one or more seizures, and b) a pill takes a minimum of 45 minutes to even begin to work\u2014that\u2019s often far too long,\u201d says <\/span><a href=\"https:\/\/www.jefferson.edu\/university\/jmc\/departments\/neurology\/faculty\/mintzer.html\"><span style=\"font-weight: 400;\">Scott Mintzer<\/span><\/a><span style=\"font-weight: 400;\">, MD, professor of neurology at Thomas Jefferson University in Philadelphia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For this reason, many patients end up in the ER to get medication through an IV. But doctors wanted to find an easier way to get the medication into the body\u2014preferably something that could be administered at home by a caregiver.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatments-and-medications\/\" target=\"_blank\" rel=\"noopener noreferrer\"><b>Epilepsy treatments and medications<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">How does midazolam work?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Midazolam nasal spray provides that option. Patients can carry it around in their pockets to use in the event of an emergency, potentially saving themselves from a catastrophic outcome. Dr. Mintzer explains that \u201cmidazolam nasal spray will, hopefully, make emergency treatment at home much more widely used among patients with seizures.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Prior to the FDA approval of this midazolam for seizures, doctors had already been using it for sedation purposes, and often administer it through the nose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cNasal absorption of many IV drugs is equivalent or similar to IV administration,\u201d says Amy Baxter, MD, the CEO of <\/span><a href=\"https:\/\/buzzyhelps.com\/\"><span style=\"font-weight: 400;\">Pain Care Labs<\/span><\/a><span style=\"font-weight: 400;\"> in Atlanta. \u201cMidazolam works immediately for 20 to 40 minutes, so it is a great drug of choice if IV access is not available.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Baxter continues: \u201cBottom line\u2014the FDA is recognizing what emergency physicians have known for quite some time. In an emergency situation, getting an IV drug into the bloodstream using the mucosa of the nose is a safe and effective drug delivery option to stop a patient from continuing to seize.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The people who will benefit most from this nasal spray are those who experience their seizures in clusters, or people who have seizures lasting more than a few minutes. Nayzilam is approved for patients 12 years and older. At the moment, there are no known contraindications for the nasal spray. But as always, you should talk to your doctor to see if midazolam nasal spray is the right choice.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>There is some big news for people with epilepsy who experience seizure clusters or prolonged seizures. On May 20, 2019, the Food and Drug Administration approved the first-ever nasal spray for treating seizures: Nayzilam (midazolam). The drug, midazolam, has been around for decades. However, this is the first time that it is available as a [&hellip;]<\/p>\n","protected":false},"author":69,"featured_media":6927,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4114],"tags":[4141],"coauthors":[8859],"class_list":["post-4165","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-fda-approvals","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nayzilam (midazolam), first nasal spray for seizure treatment, approved by FDA<\/title>\n<meta name=\"description\" content=\"People with epilepsy now have a fast-acting medication to stop seizures. 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