{"id":4316,"date":"2019-05-27T10:03:34","date_gmt":"2019-05-27T14:03:34","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3345"},"modified":"2023-05-16T16:36:56","modified_gmt":"2023-05-16T20:36:56","slug":"codeine-vs-hydrocodone","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/codeine-vs-hydrocodone\/","title":{"rendered":"Codeine vs Hydrocodone: Main Differences and Similarities"},"content":{"rendered":"

Codeine and hydrocodone are two medications that can be prescribed for pain. These medications treat pain that does not respond to typical over-the-counter analgesics. They are both grouped in a class of medications called opioids. Opioids are known to have a potential to be misused or abused due to their painkiller effects. Therefore, a physician\u2019s prescription is required to take these medications. While both medications are in the same class, there are some differences to discuss.<\/p>\n

Codeine<\/h2>\n

Codeine is an opioid analgesic that is indicated for mild to moderately severe pain where prior analgesics have not been effective. Codeine is extensively metabolized in the liver and excreted through the kidneys. It is metabolized to its primary metabolite, morphine and a secondary metabolite, hydrocodone and has an elimination half-life of approximately 3 hours.
\nCodeine comes in oral tablets with strengths of 15 mg, 30 mg, and 60 mg. There is also a 30 mg\/5 mL oral solution available. It is usually dosed every 4 hours as needed.
\nCodeine is a Schedule III or V drug depending on the quantity given. Regardless, this indicates that there is some risk for abuse and dependence on this drug if it is improperly used.<\/p>\n

Hydrocodone<\/h2>\n

Hydrocodone is an opioid analgesic that, unlike codeine, is indicated for moderate to moderately severe pain. In this way, hydrocodone is more potent than codeine. However, hydrocodone is a close relative of codeine that is also metabolized in the liver and excreted through the kidneys. It has a primary metabolite of hydromorphone and a minor metabolite of dihydrocodeine.
\nHydrocodone is typically formulated as a combination with acetaminophen. The hydrocodone portion of this tablet comes in strengths of 2.5 mg, 5 mg, 7.5 mg, and 10 mg. There are also extended release hydrocodone tablets (Zohydro, Hysingla) that range in strengths from 10 mg to 120 mg.<\/p>\n

Codeine vs Hydrocodone Side by Side Comparison<\/h2>\n

Codeine and Hydrocodone are two medications in the same drug class. Their similarities and differences can be found below for a closer look.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Codeine<\/th>\nHydrocodone<\/th>\n<\/tr>\n
Prescribed For<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Mild to moderate pain<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Moderate to severe pain<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Drug Classification<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Opioid<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Opioid<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Manufacturer<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Generic<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Generic<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Common Side Effects<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Drowsiness<\/li>\n
  • Lightheadedness<\/li>\n
  • Dizziness<\/li>\n
  • Sedation<\/li>\n
  • Shortness of breath<\/li>\n
  • Nausea<\/li>\n
  • Vomiting<\/li>\n
  • Sweating<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Constipation<\/li>\n
  • Drowsiness<\/li>\n
  • Dizziness<\/li>\n
  • Headache<\/li>\n
  • Nausea<\/li>\n
  • Vomiting<\/li>\n
  • Pruritus<\/li>\n
  • Lethargy<\/li>\n
  • Fatigue<\/li>\n
  • Chills<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Is there a generic?<\/strong><\/td>\n<\/tr>\n
\n\n
Is it covered by insurance?<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Varies according to your provider<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Varies according to your provider<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Dosage Forms<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Oral tablet<\/li>\n
  • Oral solution<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Oral tablet<\/li>\n
  • Oral capsule<\/li>\n
  • Oral solution<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Average Cash Price<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • $121.91 per 60 tablets (30 mg)<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • $317 (per 100 tablets)<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
SingleCare Discount Price<\/strong><\/td>\n<\/tr>\n
\n\n
Drug Interactions<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Alcohol<\/li>\n
  • CNS depressants<\/li>\n
  • Mixed agonist\/antagonist analgesics<\/li>\n
  • Anticholinergics<\/li>\n
  • MAO inhibitors<\/li>\n
  • Tricyclic antidepressants<\/li>\n
  • CYP3A4 and CYP2D6 inhibitors<\/li>\n
  • CYP3A4 inducers<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Alcohol<\/li>\n
  • CNS depressants<\/li>\n
  • Mixed agonist\/antagonist analgesics<\/li>\n
  • Anticholinergics<\/li>\n
  • MAO inhibitors<\/li>\n
  • Tricyclic antidepressants<\/li>\n
  • CYP3A4 and CYP2D6 inhibitors<\/li>\n
  • CYP3A4 inducers<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
Can I use while planning pregnancy, pregnant, or breastfeeding?<\/strong><\/td>\n<\/tr>\n
\n
    \n
  • Codeine is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Codeine is not recommended while breastfeeding.<\/li>\n<\/ul>\n<\/td>\n
\n
    \n
  • Hydrocodone is in Pregnancy Category C. While adverse effects have been reported in animals, not enough research has been performed in humans. Consult a doctor regarding steps to take while planning pregnancy. Hydrocodone is not recommended while breastfeeding.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Summary<\/h2>\n

    Both codeine and hydrocodone are medications that can be used to treat pain from a variety of conditions. However, hydrocodone is more potent than codeine. While codeine may be more suitable for less severe pain conditions, hydrocodone may be better for more severe pain that requires an extended release formulation.
    \nBoth medications are typically prescribed when pain has not responded to other less potent analgesics. For this reason, codeine and hydrocodone are DEA scheduled medications that carry a risk for abuse and dependence. Both medications are also metabolized in the liver and have several interactions with many drugs. For this reason, it is important to consult with a physician to determine which opioid medication would be best for you.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Codeine and hydrocodone are two medications that can be prescribed for pain. These medications treat pain that does not respond to typical over-the-counter analgesics. They are both grouped in a class of medications called opioids. Opioids are known to have a potential to be misused or abused due to their painkiller effects. Therefore, a physician\u2019s […]<\/p>\n","protected":false},"author":15,"featured_media":47700,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[808],"coauthors":[8669],"class_list":["post-4316","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-pain-management","wpautop"],"acf":[],"yoast_head":"\nCodeine vs Hydrocodone: Main Differences and Similarities<\/title>\n<meta name=\"description\" content=\"Codeine and Hydrocodone are both commonly prescribed to treat pain. 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