{"id":4335,"date":"2019-05-27T14:05:48","date_gmt":"2019-05-27T18:05:48","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3410"},"modified":"2025-12-22T13:33:31","modified_gmt":"2025-12-22T18:33:31","slug":"ranitidine-vs-omeprazole","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ranitidine-vs-omeprazole\/","title":{"rendered":"Ranitidine vs. omeprazole: Differences, similarities, and which one is better for you"},"content":{"rendered":"

Drug overview & main differences<\/a> | Conditions treated<\/a> | Efficacy<\/a> | Insurance coverage and cost comparison<\/a> | Side effects<\/a> | Drug interactions<\/a> | Warnings<\/a> | FAQ<\/a><\/p>\n

In April 2020,<\/i><\/b> Zantac<\/i><\/b> (<\/i><\/b>ranitidine<\/i><\/b>) was recalled by the <\/i><\/b>FDA<\/i><\/b>. Consult your doctor about which medication is right for you. Read more about the recall <\/i><\/b>here<\/i><\/b><\/a>. The original post has been preserved for informational purposes only.<\/i><\/b><\/p>\n

Ranitidine<\/span> and <\/span>omeprazole<\/span> are two medications used to treat <\/span>gastroesophageal reflux disease<\/span>, commonly referred to as <\/span>GERD<\/span><\/a>, <\/span>heartburn<\/span>, or <\/span>acid reflux<\/span>. Gastroesophageal reflux (GER) occurs when your stomach contents come back up into the <\/span>esophagus<\/span>. When this occurs regularly over a long period of time, this is known as <\/span>GERD<\/span>. When untreated or inadequately treated, <\/span>GERD<\/span> can lead to serious complications such as esophagitis, esophageal stricture, and Barrett\u2019s <\/span>Esophagus<\/span>. Uncontrolled <\/span>GERD<\/span> can also lead to <\/span>abdominal pain<\/span>, asthmatic symptoms, voice hoarseness, laryngitis, and dental decay. It is estimated that about <\/span>20% of Americans<\/span><\/a> suffer from <\/span>GERD<\/span>. Some risk factors for <\/span>GERD<\/span> include being overweight, being a smoker, or being pregnant.\u00a0<\/span><\/p>\n

There are a variety of treatment options available for <\/span>GERD<\/span> across multiple classes of medications. There are short-term, fast-acting relief options available without a prescription such as Tums or Maalox for occasional or breakthrough <\/span>acid reflux<\/span> symptom relief<\/span>. <\/span>Ranitidine<\/span> and <\/span>omeprazole<\/span> were formerly prescription-only options for <\/span>GERD<\/span>, but are now available without a prescription as well.\u00a0<\/span><\/p>\n

What are the main differences between ranitidine vs. omeprazole<\/h2>\n

Ranitidine<\/span> is a medication available <\/span>over-the-counter<\/span> or by prescription for the treatment of gastroesophageal reflux. It belongs to a class of drugs known as <\/span>histamine<\/span> type 2-receptor antagonists (H2RAs), and is sometimes better known by the <\/span>brand name<\/span> of <\/span>Zantac<\/span>. <\/span>Ranitidine<\/span> binds to <\/span>gastrointestinal<\/span> histamine<\/span> receptors that are responsible for the release of <\/span>stomach acid secretion<\/span>. This includes baseline secretions as well as those released in response to stimuli such as food. <\/span>Ranitidine<\/span> and <\/span>famotidine<\/span>, another H2RA, have <\/span>little effect<\/span><\/a> on the cytochrome P450 enzyme system, and therefore have fewer drug interactions than the third H2RA, <\/span>cimetidine<\/span>. <\/span>Ranitidine<\/span> is available as an oral tablet or capsule. Solid oral dosage forms are available <\/span>over-the-counter<\/span> or by prescription in strengths of 75mg and 150mg. There is a 300 mg dose that is prescription only. An injectable version of <\/span>ranitidine<\/span> is available as well and is typically only used in medical facilities.<\/span><\/p>\n

Omeprazole<\/span><\/a> is a medication available <\/span>over-the-counter<\/span> or by prescription for the treatment of gastroesophageal reflux. It belongs to a class of drugs known as <\/span>proton pump inhibitors<\/span><\/a> (<\/span>PPIs<\/span>), and is sometimes referred to as the <\/span>brand name<\/span> of <\/span>Prilosec<\/span><\/a>. <\/span>Omeprazole<\/span> inhibits the final step of <\/span>acid secretion<\/span> into the stomach by irreversibly blocking the pump responsible for secreting the acid known as the H+\/ K+ \/ATPase pump. While <\/span>omeprazole<\/span> was the first <\/span>PPI<\/span> on the market and the first to go <\/span>over-the-counter<\/span>, there are others in the class such as <\/span>pantoprazole<\/span>, esomeprazole, <\/span>lansoprazole<\/span>, and dexlansoprazole. <\/span>Omeprazole<\/span> has many dosage forms available including oral tablets, capsules, granules, and powder for reconstitution. The capsules come in 10 mg, 20 mg, and 40 mg strengths, and the tablets are available in a 20 mg form.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Main differences between ranitidine and omeprazole <\/span><\/th>\n<\/tr>\n<\/thead>\n
<\/td>\nRanitidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nH2-receptor antagonist<\/span> (H2RA) (<\/span>H2 blocker<\/span>)<\/span><\/td>\nProton pump inhibitor<\/span> (<\/span>PPI<\/span>)<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic available<\/span><\/td>\nBrand and generic available<\/span><\/td>\n<\/tr>\n
What is the <\/b>brand name<\/b>?<\/b><\/td>\nZantac<\/span><\/td>\nPrilosec<\/span>, <\/span>Prilosec<\/span> OTC<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nOral tablet, oral capsule, solution for injection<\/span><\/td>\nOral tablets, oral capsules, oral granules, and powder for reconstitution<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n75 mg – 150 mg twice daily<\/span><\/td>\n20 mg once daily<\/span><\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nShort-term for acute relief or long-term treatment<\/span><\/td>\n14 days or longer<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nInfants, children, adolescents, and adults<\/span><\/td>\nInfants, children, adolescents, and adults<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by ranitidine and omeprazole<\/h2>\n

Ranitidine<\/span> and <\/span>omeprazole<\/span> each work to decrease the production of <\/span>stomach acid<\/span>, and therefore are each used to treat or prevent some of the same or similar disorders. Pyrosis, better known as <\/span>heartburn<\/span>, that occurs twice or more per week can be treated with either <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span>. Both drugs also are indicated to treat <\/span>gastroesophageal reflux disease<\/span>, whether erosive or non-erosive. Only <\/span>omeprazole<\/span> is approved by the Food and Drug Administration (<\/span>FDA<\/span>) to be used in the treatment of gastric and <\/span>duodenal ulcers<\/span>, though <\/span>ranitidine<\/span> is sometimes used. Use without <\/span>FDA<\/span> approval is known as off-label use.\u00a0<\/span><\/p>\n

One distinguishing feature of <\/span>omeprazole<\/span> is its indication to treat Helicobacter Pylori infection (<\/span>H. Pylori infection<\/span>), the bacteria responsible for the development of many <\/span>ulcers<\/span>. <\/span>Omeprazole<\/span> is used as a part of a multiple-drug regimen to eliminate H. pylori.<\/span><\/p>\n

The following table is a list of approved and potential uses for <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span>. Only your physician can determine if they are an appropriate choice for your condition.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nRanitidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Pyrosis (<\/span>heartburn<\/span>) occurring 2 or more times per week<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Erosive <\/span>GERD<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Non-erosive <\/span>GERD<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Benign <\/span>gastric ulcer<\/span><\/td>\nOff-label<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Duodenal ulcer<\/span><\/td>\nOff-label<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Helicobacter pylori (H. Pylori)<\/span><\/td>\nNo<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Gastric hypersecretory conditions (including <\/span>Zollinger-Ellison Syndrome<\/span>)<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Erosive esophagitis<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
NSAID induced <\/span>ulcer<\/span> prevention<\/span><\/td>\nNo<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Stress gastritis<\/span><\/td>\nNo<\/span><\/td>\nOff-label<\/span><\/td>\n<\/tr>\n
Adjunct treatment in severe allergic reactions<\/span><\/td>\nOff-label<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is Eliquis or Warfarin more effective?<\/h2>\n

An <\/span>early study<\/span><\/a> comparing <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span> for their efficacy in treating <\/span>acid reflux<\/span> or <\/span>heartburn<\/span> found that significantly more patients were still experiencing moderate to severe <\/span>heartburn<\/span> symptoms after eight weeks of treatment with <\/span>ranitidine<\/span> versus <\/span>omeprazole<\/span>. Almost 70% of patients treated with <\/span>omeprazole<\/span> experienced little to no symptoms after eight weeks of treatment.<\/span><\/p>\n

There have been many <\/span>clinical trials<\/span> comparing <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span> with respect to <\/span>reflux esophagitis<\/span>. A <\/span>comparison<\/span><\/a> of these studies found <\/span>omeprazole<\/span> to be twice as effective at healing mucosal defects and lesions of the <\/span>esophagus<\/span>.<\/span><\/p>\n

The availability of <\/span>ranitidine<\/span> has been plagued by large-scale, multi-manufacturer recalls withdrawing the prescription and <\/span>over-the-counter<\/span> ranitidine<\/span> products due to the presence of a chemical known as <\/span>N-nitrosodimethylamine (NDMA)<\/span><\/a> which has been linked to many types of cancer. It has been discovered that NDMA contamination can occur during manufacturing. The <\/span>FDA<\/span> has determined that a very small amount of NDMA is acceptable, but many <\/span>ranitidine<\/span> products were found to have more than the acceptable amount.\u00a0<\/span><\/p>\n

Given the factors for overall safety and efficacy, your <\/span>gastroenterology<\/span> specialist may choose to initiate <\/span>omeprazole<\/span> therapy over <\/span>ranitidine<\/span> for many indications. Ultimately, only your doctor can choose which medication is right for you.<\/span><\/p>\n

Coverage and cost comparison of ranitidine vs. omeprazole<\/h2>\n

Ranitidine<\/span> is not available at this time.<\/span><\/p>\n

Omeprazole<\/span> is both a prescription and <\/span>over-the-counter<\/span> medication. Its coverage by commercial and Medicare insurance plans also varies because it too is available without a prescription. The average retail price for brand-name Prilosec can be expensive, but you can save on generic omeprazole by using a coupon<\/a> from SingleCare.<\/span><\/p>\n\n\n\n\n\n\n\n\n
<\/td>\nRanitidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nVariable<\/span><\/td>\nVariable<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nVariable<\/span><\/td>\nVariable<\/span><\/td>\n<\/tr>\n
Quantity<\/b><\/td>\nN\/A<\/span><\/td>\n30, 20mg capsules<\/span><\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\nN\/A<\/span><\/td>\nLess than $10 if covered<\/span><\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\nN\/A<\/span><\/td>\n$6 at Kroger<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\t\t
\n\t\t\t

Save up to 80% on Omeprazole with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

\n\t\t\t\t
\n\t\t\t\t\tOmeprazole 40 mg (30 Delayed-release capsules)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t
\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$5.78\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t$5.78\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Omeprazole prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n

Common side effects of ranitidine vs. omeprazole<\/h2>\n

Many of the <\/span>common side effects<\/span> of both <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span> are similar. Somnolence, confusion, and agitation have been linked to both drugs, and though the manufacturers do not provide a frequency, they state these are rare. Heart-related conditions such as bradycardia, a lower heart rate, and tachycardia, an increased heart rate, have also been linked to <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span>.<\/span><\/p>\n

Omeprazole<\/span> does not appear to be linked to as many <\/span>gastrointestinal<\/span> side effects as <\/span>ranitidine<\/span> such as nausea, vomiting, and diarrhea.<\/span><\/p>\n

The following list is not intended to be a complete list of potential side effects. Please consult your pharmacist or other <\/span>healthcare<\/span> professional for a complete list.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nRanitidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Side Effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Malaise<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Dizziness<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Somnolence<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Confusion<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Agitation<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Tachycardia<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Bradycardia<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Atrioventricular block<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Constipation<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Diarrhea<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Nausea<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Vomiting<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nNo<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
Hepatitis\u00a0<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Jaundice<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Myalgia<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Rash<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n
Alopecia<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\nYes<\/span><\/td>\nNot reported<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Source: <\/span>Ranitidine<\/span> (<\/span>DailyMed<\/span><\/a>) <\/span>Omeprazole<\/span> (<\/span>DailyMed<\/span><\/a>)<\/span><\/p>\n

Drug interactions of ranitidine vs. omeprazole<\/h2>\n

Ranitidine<\/span> and <\/span>omeprazole<\/span> share some common drug interactions. Both drugs alter the absorption of a class of drugs known as bisphosphonates used to treat osteoporosis. These include alendronate and risedronate. While they are sometimes used with bisphosphonates, they may decrease the efficacy of the drug and leave patients more prone to fracture.<\/span><\/p>\n

Ranitidine<\/span> is known to increase the absorption and decrease the clearance of sulfonylureas such as glimepiride and glyburide. This can lead to low blood sugar, known as hypoglycemia. <\/span>Omeprazole<\/span> does not alter the absorption of sulfonylureas. <\/span>Omeprazole<\/span> may be a better option for diabetics taking sulfonylureas. Blood sugar levels should be monitored if <\/span>ranitidine<\/span> is determined to be necessary.<\/span><\/p>\n

This list is not meant to be all-inclusive of drug interactions for <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span>. Please consult your pharmacist or <\/span>health care<\/span> professional for a complete list.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nRanitidine<\/b><\/td>\nOmeprazole<\/b><\/td>\n<\/tr>\n
Alendronate<\/span><\/a>
\nRisedronate<\/span><\/td>\n		Bisphosphonates<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Amphetamine salts<\/span>
\nDextroamphetamine<\/span><\/td>\n		Amphetamine salts<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Atazanavir<\/span><\/a>
\nDarunavir<\/span><\/td>\n		Antiretrovirals<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Cefditoren<\/span>
\nCefpodoxime<\/span>
\nCefuroxime<\/span><\/a><\/td>\n		Cephalosporin antibiotics<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Glimepiride<\/span>
\nGlipizide<\/span>
\nGlyburide<\/span><\/a><\/td>\n		Sulfonylureas<\/span><\/td>\nYes<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Itraconazole<\/span>
\nKetoconazole<\/span><\/a><\/td>\n		Azole antifungals<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Midazolam<\/span>
\nTriazolam<\/span><\/td>\n		Benzodiazepines<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Warfarin<\/span><\/td>\nAnticoagulant<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Warnings of ranitidine and omeprazole<\/h2>\n

Ranitidine<\/span> should not be taken if you have ever had an allergic reaction to <\/span>ranitidine<\/span> or any other H2RA. The same is true of <\/span>omeprazole<\/span> as it should not be taken if you have ever had an allergic reaction to any <\/span>PPI<\/span>.<\/span><\/p>\n

If you take either <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span> over-the-counter<\/span> and you have indigestion, <\/span>heartburn<\/span>, or <\/span>acid reflux<\/span> symptoms that persist beyond two weeks of continuous treatment, you should consult your physician. There may be more complicated or serious underlying issues.<\/span><\/p>\n

Long-term use<\/span> of <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span>, as well as other drugs in similar classes, increase the risk of overgrowth of dangerous flora (bacteria) in the intestinal tract. By decreasing acid in the digestive tract, the pH of the tract is lowered, making it easier for bacteria like <\/span>Clostridium difficile<\/span><\/a> (C. diff) or Escherichia coli (E. coli) to proliferate. These infections can be serious and very difficult to treat.<\/span><\/p>\n

Ranitidine<\/span> and <\/span>omeprazole<\/span> can impair hepatic liver function. Caution should be used in recommending these drugs in patients with pre-existing liver disease or hepatic impairment. Patients with renal disease may not clear <\/span>ranitidine<\/span> efficiently, leading to an accumulation of <\/span>ranitidine<\/span>.\u00a0<\/span><\/p>\n

Long term use<\/span> of <\/span>ranitidine<\/span> and\/or <\/span>omeprazole<\/span> has been correlated to cyanocobalamin (vitamin B12) deficiency.<\/span><\/p>\n

Long term treatment with <\/span>PPIs<\/span> like <\/span>omeprazole<\/span> also leads to an increased risk of bone fracture, especially of the hip, wrist, and spine. If you have a justified need for long-term <\/span>PPI<\/span> therapy, calcium and vitamin D supplementation may be necessary to decrease the risk of osteoporosis and osteopenia associated with <\/span>PPI<\/span> therapy.<\/span><\/p>\n

Long term treatment with <\/span>omeprazole<\/span> and other <\/span>PPIs<\/span> is linked to gastric polyps, or fundic gland polyps. These are typically asymptomatic but can be seen upon <\/span>endoscopy<\/span>.<\/span><\/p>\n

Frequently asked questions about ranitidine vs. omeprazole<\/h2>\n

What is <\/span>ranitidine<\/span>?<\/span><\/h3>\n

Ranitidine<\/span> is a <\/span>histamine<\/span> type 2-receptor antagonist that is available <\/span>over the counter<\/span> or by prescription. It is available in tablet, capsule, and injectable forms.<\/span><\/p>\n

What is <\/span>omeprazole<\/span>?<\/span><\/h3>\n

Omeprazole<\/span> is a <\/span>proton pump inhibitor<\/span> that is also available <\/span>over the counter<\/span> or by prescription. It is available in tablets, capsules, granules, and powder for reconstitution.<\/span><\/p>\n

Are <\/span>ranitidine<\/span> and <\/span>omeprazole<\/span> the same?<\/span><\/h3>\n

Ranitidine<\/span> and <\/span>omeprazole<\/span> have similar indications for use, but they are not the same. <\/span>Ranitidine<\/span> is a <\/span>histamine<\/span> type 2-receptor antagonist while <\/span>omeprazole<\/span> is a <\/span>proton pump inhibitor<\/span>. Both work to decrease <\/span>stomach acid secretion<\/span>, but they do with different mechanisms of action.<\/span><\/p>\n

Is <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span> better?<\/span><\/h3>\n

Studies<\/span><\/a> have shown <\/span>omeprazole<\/span> to be superior to <\/span>ranitidine<\/span> at reducing symptoms to mild or undetectable at the 8-week mark of treatment. This data combined with recent recalls of <\/span>ranitidine<\/span> products make <\/span>omeprazole<\/span> a good choice for <\/span>acid reflux<\/span> treatment.<\/span><\/p>\n

Can I use <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span> while pregnant?<\/span><\/h3>\n

There are no adequate, well-controlled studies of <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span> in pregnant women. Both drugs have been shown to cross the placenta. <\/span>Ranitidine<\/span> and <\/span>omeprazole<\/span> should not be used without your doctor\u2019s recommendation when you are pregnant. The risks must be compared to the benefits for each individual.\u00a0<\/span><\/p>\n

Ranitidine<\/span> is not recommended for breastfeeding mothers. <\/span>Omeprazole<\/span> is also not recommended. Short-acting <\/span>antacids<\/span> like Tums may be preferred.<\/span><\/p>\n

Can I use <\/span>ranitidine<\/span> or <\/span>omeprazole<\/span> with alcohol?<\/span><\/h3>\n

Some <\/span>studies<\/span><\/a> have shown that <\/span>ranitidine<\/span> gastric alcohol dehydrogenase is responsible for first-pass metabolism of alcohol. This could lead to prolonged elevated serum levels of alcohol, and for that reason, concurrent use of alcohol and <\/span>ranitidine<\/span> is not recommended. This interaction does not exist with <\/span>omeprazole<\/span>, though alcohol should still be consumed in limited quantities.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ In April 2020, Zantac (ranitidine) was recalled by the FDA. Consult your doctor about which medication is right for you. Read more about the recall here. The original post […]<\/p>\n","protected":false},"author":15,"featured_media":11589,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[16414,20949,10708,4350],"coauthors":[10437],"class_list":["post-4335","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-digestive-health","tag-gerd","tag-over-the-counter-medications","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nRanitidine vs. omeprazole: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Ranitidine and Omeprazole are both commonly prescribed to treat digestive conditions. 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