{"id":43355,"date":"2021-10-15T09:30:28","date_gmt":"2021-10-15T13:30:28","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=43355"},"modified":"2026-03-15T20:43:45","modified_gmt":"2026-03-16T00:43:45","slug":"zoloft-and-coffee","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zoloft-and-coffee\/","title":{"rendered":"Can you drink coffee while taking Zoloft?"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft (sertraline)<\/span><\/a><span style=\"font-weight: 400;\"> is one of the most commonly prescribed antidepressants. If you\u2019re taking it, it\u2019s likely that you have a condition that sometimes causes <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/insomnia-treatment-and-medications\"><span style=\"font-weight: 400;\">insomnia<\/span><\/a><span style=\"font-weight: 400;\">\u2014like <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\">. On top of that,<\/span> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sleep disturbances may be a side effect<\/span><\/a> <span style=\"font-weight: 400;\">of this type of medication. When you\u2019re reaching for your morning dose of caffeine to wake up after a bad night\u2019s sleep you may wonder: Is it safe to mix Zoloft and coffee? Or sertraline and caffeine for that matter?<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Zoloft with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tZoloft 50 mg (1 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\" class=\"coupon-see-all-btn\">See Zoloft prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"caffeine-and-zoloft-side-effects\"><span style=\"font-weight: 400;\">Caffeine and Zoloft side effects<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/sertraline-side-effects\/\"><span style=\"font-weight: 400;\">Common side effects with Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> include dizziness, drowsiness, trouble sleeping, sexual problems, dry mouth, and possible digestive issues such as loss of appetite, upset stomach and\/or diarrhea. More serious potential side effects include serotonin syndrome, suicidal thoughts and behaviors, seizures, and fast or irregular heart beat. Caffeine may intensify the severity of some symptoms, such as irregular heartbeat or difficulty sleeping, depending on how much is consumed.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-side-effects-first-week\/\"><b>Zoloft side effects: What to expect during the first week<\/b><\/a><\/p>\n<h2 id=\"is-it-safe-to-mix-zoloft-and-coffee\"><span style=\"font-weight: 400;\">Is it safe to mix Zoloft and coffee?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are <\/span><a href=\"https:\/\/www.pfizermedicalinformation.com\/en-us\/zoloft\/drug-interactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">no known interactions between Zoloft and caffeine<\/span><\/a><span style=\"font-weight: 400;\">, but it\u2019s important to consider the\u00a0 effects that caffeine can have on the mental health conditions that Zoloft treats.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt should be safe to drink coffee with Zoloft,\u201d says <\/span><a href=\"https:\/\/www.doximity.com\/pub\/david-schaefer-md-27fe282e\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">David Schaefer, MD<\/span><\/a><span style=\"font-weight: 400;\">, psychiatrist at Southwest Behavioral Health Center in St. George, Utah. \u201cCaffeine and Zoloft are both metabolized by the liver\u2019s CYP450 enzyme system, but via different enzymatic pathways.\u201d\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The bigger concern should be the effects that caffeine can have on depression and anxiety disorders. \u201cExcessive caffeine use can be detrimental in the treatment of depression, anxiety, OCD, PTSD, etc.,\u201d Dr. Schaefer says. The two main reasons are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Sleep disturbances<\/b><span style=\"font-weight: 400;\">: Zoloft and caffeine can both cause difficulty sleeping in some people. Sleep disturbances are also common with those suffering from depression and anxiety disorders. \u201cCaffeine can compound the sleep deficits found in many patients with depression,\u201d Dr. Schaefer says. \u201cInsomnia is also a common symptom of anxiety disorders and decreased sleep has been shown to increase symptoms of anxiety.\u201d<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Stimulants may increase anxiety: <\/b><span style=\"font-weight: 400;\">Those with anxiety disorders may want to avoid drinking a lot of coffee. \u201cBecause caffeine is a stimulant, it can increase symptoms of anxiety or over-alertness, whether related to panic disorder, social anxiety, or PTSD,\u201d Dr. Schaefer explains.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Drinking coffee in moderation may help to mitigate any sleep disturbances or increased anxiety while taking Zoloft. But, there\u2019s a fine line between feeling more alert during the day, and having too much caffeine. \u201c<\/span><span style=\"font-weight: 400;\">Coffee has well-known side effects of causing insomnia and jitteriness in some people, and that is a dose-dependent effect,\u201d says Robert G. Fawcett, MD, author of <\/span><a href=\"https:\/\/www.amazon.com\/Calming-Bipolar-Storm-Patients-Families\/dp\/1538145642\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">Calming the Bipolar Storm<\/span><\/i><\/a><span style=\"font-weight: 400;\">. \u201cSix cups of java may cause a lot of jitteriness and insomnia, whereas one cup may not.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the flip side, Dr. Fawcett points out that people experiencing depression \u201c<\/span><span style=\"font-weight: 400;\">without much anxiety, where a person feels slowed down, lethargic and sleeps excessively,\u201d may actually benefit from some coffee. Most people prefer to drink coffee first thing in the morning, so the timing of your caffeine intake and the timing of your dosage may coincide.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"is-it-better-to-take-zoloft-sertraline-in-the-morning-or-at-night\"><span style=\"font-weight: 400;\">Is it better to take Zoloft (sertraline) in the morning or at night?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Zoloft may be taken in the morning or evening, and it can be taken with or without food. It\u2019s important to take it at a consistent time; and go over any concerns with your healthcare provider.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cZoloft itself can be a bit stimulating for some folks, so I usually prescribed it to be taken in the morning,\u201d Dr. Fawcett says. And Dr. Schaefer agrees: \u201cI generally recommend patients take it in the morning because serotonin reuptake inhibitors can sometimes cause restless sleep and vivid dreams.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Yet, for some people Zoloft may cause drowsiness. In this case it should be taken in the evening. \u201cOccasionally, Zoloft can cause mild somnolence, in which case it can be switched to nighttime dosing,\u201d Dr. Schaefer says.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When Zoloft is taken in the morning in conjunction with drinking coffee, there is some potential for digestive distress. \u201cBoth sertraline (Zoloft) and coffee might stimulate the bowel, so it is possible that taking them together a patient might experience enough diarrhea to necessitate stopping the coffee,\u201d Dr. Fawcett says.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because Zoloft may be taken in the morning or evening, a patient\u2014along with the healthcare team\u2014can decide what works best to mitigate any potential side effects.\u00a0\u00a0\u00a0<\/span><\/p>\n<h2 id=\"what-foods-and-drinks-should-be-avoided-when-taking-zoloft\"><span style=\"font-weight: 400;\">What foods and drinks should be avoided when taking Zoloft?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It\u2019s important to be aware of caffeine intake when taking Zoloft, but there are some other foods and drinks that could potentially interfere with the medication as well. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alcohol:<\/b> <a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-and-alcohol\/\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/a><span style=\"font-weight: 400;\"> can magnify the side effects of Zoloft including causing dizziness, drowsiness, and difficulty concentrating. It can also cause impairment.<\/span><\/li>\n<li aria-level=\"1\"><b>Grapefruit and grapefruit juice:<\/b><span style=\"font-weight: 400;\"> Grapefruit can affect the absorption of many medications, including Zoloft. There is also an<\/span> <a href=\"https:\/\/www.poison.org\/articles\/grapefruit-and-medicines\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">increased risk of side effects or toxicity from the sertraline<\/span><\/a> <span style=\"font-weight: 400;\">when mixed with grapefruit juice.<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<\/ul>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/anti-anxiety-diet\/\"><b>What\u2019s the best diet for anxiety?<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">The most important thing to remember when taking Zoloft, or any other medication, is to go over any concerns involving food and drink interactions with your doctor. Drinking coffee in moderation may work for some patients taking Zoloft, but it\u2019s good to be aware of how caffeine is affecting the health condition a patient is treating.\u00a0\u00a0<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jxMSrZsGgEI?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Zoloft (sertraline) is one of the most commonly prescribed antidepressants. If you\u2019re taking it, it\u2019s likely that you have a condition that sometimes causes insomnia\u2014like anxiety or depression. On top of that, sleep disturbances may be a side effect of this type of medication. When you\u2019re reaching for your morning dose of caffeine to wake [&hellip;]<\/p>\n","protected":false},"author":94,"featured_media":43637,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[451,788],"coauthors":[12545],"class_list":["post-43355","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-depression","tag-drug-safety","franchise-the-jolt","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Is it safe to mix Zoloft and coffee?<\/title>\n<meta name=\"description\" content=\"There aren&#039;t any interactions between Zoloft and coffee but caffeine can intensify Zoloft side effects and symptoms of anxiety and depression.\" \/>\n<meta name=\"robots\" content=\"index, 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