{"id":4336,"date":"2019-05-27T10:18:19","date_gmt":"2019-05-27T14:18:19","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3418"},"modified":"2023-08-04T16:04:10","modified_gmt":"2023-08-04T20:04:10","slug":"skyla-vs-mirena","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/skyla-vs-mirena\/","title":{"rendered":"Skyla vs. Mirena: Differences, similarities, and which is better for you"},"content":{"rendered":"<p><a href=\"#drug-overview-differences\">Drug overview &amp; main differences<\/a> | <a href=\"#conditions-treated\">Conditions treated<\/a> | <a href=\"#efficacy\">Efficacy<\/a> | <a href=\"#insurance-coverage-cost-comparison\">Insurance coverage and cost comparison<\/a> | <a href=\"#side-effects\">Side effects<\/a> | <a href=\"#drug-interactions\">Drug interactions<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#FAQ\">FAQ<\/a><\/p>\n<p><iframe loading=\"lazy\" width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/ig7JrwmzJZ8?rel=0\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> are <\/span><span style=\"font-weight: 400;\">intrauterine systems<\/span><span style=\"font-weight: 400;\"> used for <\/span><span style=\"font-weight: 400;\">contraception<\/span><span style=\"font-weight: 400;\">. These devices are placed in the female uterus to help prevent pregnancy. They are commonly referred to as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/iud-birth-control-contraceptive-guide\/\"><span style=\"font-weight: 400;\">IUDs<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">intrauterine devices<\/span><span style=\"font-weight: 400;\">). Hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> are just one type of <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> method. Other <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/contraceptives\"><span style=\"font-weight: 400;\">forms of birth control<\/span><\/a><span style=\"font-weight: 400;\"> include barrier methods (male and female condoms), oral <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> pills (OCPs or <\/span><span style=\"font-weight: 400;\">birth control pills<\/span><span style=\"font-weight: 400;\">), and spermicides.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> have an interesting history. Dating back to 1909, the first <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> were very crude. Various formulations of the <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12285000\/\"><span style=\"font-weight: 400;\">early devices<\/span><\/a><span style=\"font-weight: 400;\"> did not have persistent use due to their association with infection risk, <\/span><span style=\"font-weight: 400;\">ectopic pregnancy<\/span><span style=\"font-weight: 400;\">, infertility, and early hysterectomy. Prior to <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Paragard<\/span><span style=\"font-weight: 400;\"> was the most common <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> on the market. <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> came to market in the year 2000 as the first of its shape and kind. <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> followed in 2013. Both release the <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> hormone, <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">LNG<\/span><span style=\"font-weight: 400;\">), though in different amounts. This is why they are referred to as hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\">. There are <\/span><span style=\"font-weight: 400;\">non-hormonal IUDs<\/span><span style=\"font-weight: 400;\"> that do not release any hormones such as the <\/span><span style=\"font-weight: 400;\">copper IUD<\/span><span style=\"font-weight: 400;\">. There are also other hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> on the market such as <\/span><span style=\"font-weight: 400;\">Kyleena<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Liletta<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> are good <\/span><span style=\"font-weight: 400;\">hormonal birth control options<\/span><span style=\"font-weight: 400;\"> for patients who are looking for <\/span><span style=\"font-weight: 400;\">estrogen<\/span><span style=\"font-weight: 400;\">-free, <\/span><span style=\"font-weight: 400;\">long-acting<\/span> <span style=\"font-weight: 400;\">birth control<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are many differences and similarities between <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> detailed below.<\/span><\/p>\n<h2 id=\"drug-overview-differences\">What are the main differences between Skyla vs. Mirena<\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/skyla\/what-is\"><span style=\"font-weight: 400;\">Skyla<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">) is a <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> method available by prescription only. It is an <\/span><span style=\"font-weight: 400;\">intrauterine device<\/span><span style=\"font-weight: 400;\"> containing 13.5 mg of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">. Once inserted into the uterus, it begins releasing at a rate of 14 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\">\/ day for the first 24 days. By one year, the release rate slows to 6 <\/span><span style=\"font-weight: 400;\">mcg\/day<\/span><span style=\"font-weight: 400;\">. By year three, the rate typically slows to 5 <\/span><span style=\"font-weight: 400;\">mcg\/day<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> should be replaced at the end of the third year. <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> should only be placed by trained <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\">. There are multiple mechanisms by which <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> prevents pregnancy. First, it causes a thickening of the <\/span><span style=\"font-weight: 400;\">cervical mucus<\/span><span style=\"font-weight: 400;\"> which inhibits sperm passage to the <\/span><span style=\"font-weight: 400;\">cervix<\/span><span style=\"font-weight: 400;\">. It also inhibits sperm motility and function. Finally, this <\/span><span style=\"font-weight: 400;\">method of birth control<\/span><span style=\"font-weight: 400;\"> alters the endometrium (the lining of the uterus).\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/mirena-52-mg\/what-is\"><span style=\"font-weight: 400;\">Mirena<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">) is also a <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> device only available by prescription and can be used to prevent pregnancy for up to five years. <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> also carries an additional approval by the Food and Drug Administration (<\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\">) to be used to slow <\/span><span style=\"font-weight: 400;\">heavy menstrual bleeding<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">menstrual periods<\/span><span style=\"font-weight: 400;\">). When used for this purpose, it can remain inserted for up to seven years. Like <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\">, it should only be inserted by a trained <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> contains 52 mg of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\"> in each device. Initially, <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> releases 20 <\/span><span style=\"font-weight: 400;\">mcg<\/span><span style=\"font-weight: 400;\"> a day for approximately three months. From there it declines to 18 <\/span><span style=\"font-weight: 400;\">mcg\/day<\/span><span style=\"font-weight: 400;\"> after one year, 10 <\/span><span style=\"font-weight: 400;\">mcg\/day<\/span><span style=\"font-weight: 400;\"> after five years, and 8 <\/span><span style=\"font-weight: 400;\">mcg\/day<\/span><span style=\"font-weight: 400;\"> after seven years. It should be removed and replaced after five years for pregnancy prevention, or removed and replaced after seven years if utilized to slow <\/span><span style=\"font-weight: 400;\">heavy menstrual bleeding<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> share common mechanisms of action.<\/span><\/p>\n<table class=\"singlecare-table\">\n<thead>\n<tr>\n<th><span class=\"title\">Main differences between Skyla and Mirena<\/span><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Skyla<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Drug class<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Intrauterine <\/span><span style=\"font-weight: 400;\">contraceptives<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intrauterine <\/span><span style=\"font-weight: 400;\">contraceptives<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Brand\/generic status<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Brand only<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Brand only<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the generic name?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Levonorgestrel<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Levonorgestrel<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What form(s) does the drug come in?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Intrauterine device<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Intrauterine device<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>What is the standard dosage?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">One device inserted every 3 years<\/span><\/td>\n<td><span style=\"font-weight: 400;\">One device inserted every 5-7 years<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>How long is the typical treatment?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">3 years, and can be repeated<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5-7 years and can be repeated<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Who typically uses the medication?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Adult and adolescent females<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Adult and adolescent females<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"conditions-treated\">Conditions treated by Skyla and Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> are each a type of <\/span><span style=\"font-weight: 400;\">intrauterine system<\/span><span style=\"font-weight: 400;\"> used to prevent pregnancy. <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> also has an approved indication to be used to slow <\/span><span style=\"font-weight: 400;\">heavy menstrual bleeding<\/span><span style=\"font-weight: 400;\">. <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> has been used off-label for endometriosis patients to ease symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is important to note that while most <\/span><span style=\"font-weight: 400;\">emergency contraceptive<\/span><span style=\"font-weight: 400;\"> pills are also composed of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> are not to be used as a type of <\/span><span style=\"font-weight: 400;\">emergency contraception<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><b>Condition<\/b><\/td>\n<td><b>Skyla<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Pregnancy prevention<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Menorrhagia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Endometriosis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Off-label<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"efficacy\">Is Skyla or Mirena more effective?<\/h2>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> were studied in thousands of subjects in clinical trials prior to coming to market. The manufacturers of <\/span><a href=\"https:\/\/labeling.bayerhealthcare.com\/html\/products\/pi\/Skyla_PI.pdf\"><span style=\"font-weight: 400;\">Skyla<\/span><\/a><span style=\"font-weight: 400;\"> report a 0.9% pregnancy rate and therefore a 99.1% success rate of preventing pregnancy when used as intended. The manufacturers of <\/span><a href=\"https:\/\/labeling.bayerhealthcare.com\/html\/products\/pi\/Mirena_PI.pdf\"><span style=\"font-weight: 400;\">Mirena<\/span><\/a><span style=\"font-weight: 400;\"> report a 0.7% pregnancy rate and therefore a 99.3% success rate of preventing pregnancy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When considering <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> to treat menorrhagia, there are comparisons of it to hysterectomy or endometrial ablation. One <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21535970\/\"><span style=\"font-weight: 400;\">systematic review<\/span><\/a><span style=\"font-weight: 400;\"> suggests that satisfaction overall is higher with hysterectomy. However, <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> is more cost-effective than either option, and may be a good first choice when considering the other methods are much more invasive.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is not intended to be <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\">. Only your doctor can help you decide what is best for you.<\/span><\/p>\n<h2 id=\"insurance-coverage-cost-comparison\">Coverage and cost comparison of Skyla vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> is a prescription-only device that is typically not covered by Medicare. It is covered by some commercial plans. Commercial plans must have at least one type of hormonal <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> in their coverage formulary, though which one they choose may vary. The average retail price for <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> is about $1322. A free SingleCare <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/skyla\"><span style=\"font-weight: 400;\">coupon<\/span><\/a><span style=\"font-weight: 400;\"> can lower the cost to approximately $872.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> is also a prescription-only device that is typically not covered by Medicare. It is covered by some commercial plans. The out-of-pocket cost for <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> is about $1300. A <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mirena-52-mg\"><span style=\"font-weight: 400;\">Mirena coupon<\/span><\/a><span style=\"font-weight: 400;\"> offered by SingleCare can provide a discounted price of $1043.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td><b>Skyla<\/b><\/td>\n<td><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by insurance?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">Formulary dependent<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Formulary dependent<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typically covered by Medicare Part D?<\/b><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<td><span style=\"font-weight: 400;\">No<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Quantity<\/b><\/td>\n<td><span style=\"font-weight: 400;\">1, 13.5 mg vaginal insert<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1, 52 mg vaginal insert<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>Typical Medicare copay<\/b><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<td><span style=\"font-weight: 400;\">N\/A<\/span><\/td>\n<\/tr>\n<tr>\n<td><b>SingleCare cost<\/b><\/td>\n<td><span style=\"font-weight: 400;\">$872-$930<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$1046-$1116<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 id=\"side-effects\">Common side effects of Skyla vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">The most common <\/span><span style=\"font-weight: 400;\">possible side effects<\/span><span style=\"font-weight: 400;\"> of both <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> are pain, <\/span><span style=\"font-weight: 400;\">cramping<\/span><span style=\"font-weight: 400;\">, and bleeding after placement, changes in menstrual bleeding, missed <\/span><span style=\"font-weight: 400;\">menstrual cycles<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">ovarian cysts<\/span><span style=\"font-weight: 400;\">. Less <\/span><span style=\"font-weight: 400;\">common side effects<\/span><span style=\"font-weight: 400;\"> include abdominal pain, acne, headaches, and inflammation of the vaginal area.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> can cause rare, serious <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> as well including <\/span><span style=\"font-weight: 400;\">ectopic pregnancy<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">pelvic infection<\/span><span style=\"font-weight: 400;\">, other serious infections, <\/span><span style=\"font-weight: 400;\">pelvic inflammatory disease<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">PID<\/span><span style=\"font-weight: 400;\">), and <\/span><span style=\"font-weight: 400;\">perforation<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<table class=\" singlecare-table\">\n<tbody>\n<tr class=\"header-row\">\n<td><\/td>\n<td colspan=\"2\"><b>Skyla<\/b><\/td>\n<td colspan=\"2\"><b>Mirena<\/b><\/td>\n<\/tr>\n<tr>\n<td><b>Side Effect<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<td><b>Applicable?<\/b><\/td>\n<td><b>Frequency<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vulvovaginitis<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">20.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">10.5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Ovarian cyst<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">13.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7.5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Dysmenorrhea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8.6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6.4%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Increased bleeding<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">7.8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">11.9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Breast pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5.3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">8.5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Genital\/ <\/span><span style=\"font-weight: 400;\">vaginal discharge<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">4.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">14.9%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Device expulsion<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Abdominal\/pelvic<\/span><\/p>\n<p><span style=\"font-weight: 400;\">pain<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12.7%\/6.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">22.6%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Nausea<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">5.5%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Acne<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">13.6%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6.8%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Alopecia<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">1.2%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">&lt;5%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Headache<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">12.4%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">16.3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Migraine<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">2.3%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">16.3%<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Depression<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">3.8%<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Yes<\/span><\/td>\n<td><span style=\"font-weight: 400;\">6.4%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-weight: 400;\">Source: <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=9f44ff35-e052-49cd-a1c2-0bfd87d49309\"><span style=\"font-weight: 400;\">DailyMed<\/span><\/a><span style=\"font-weight: 400;\">) <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=dcbd6aa2-b3fa-479a-a676-56ea742962fc\"><span style=\"font-weight: 400;\">DailyMed<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/p>\n<h2 id=\"drug-interactions\">Drug interactions of Skyla vs. Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Because the <\/span><span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> effect of hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> is mediated by the direct release of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\"> into the uterine cavity, the mechanism is unlikely to be interrupted by drug interactions. <\/span><span style=\"font-weight: 400;\">Bayer<\/span><span style=\"font-weight: 400;\"> Healthcare Pharmaceuticals, the manufacturer of both <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">, have not done drug-to-drug interaction studies.<\/span><\/p>\n<h2 id=\"warnings\">Warnings of Skyla and Mirena<\/h2>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> both carry a risk of <\/span><span style=\"font-weight: 400;\">ectopic pregnancy<\/span><span style=\"font-weight: 400;\">. While the risk is very low, if you suspect you become pregnant while having an <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> in place, you should contact your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> immediately.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If a woman does become pregnant with an <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> like <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> in place and it isn\u2019t removed immediately, it can lead to sepsis, premature labor, and premature delivery. Unfortunately, there are risks associated with removal including spontaneous abortion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cases of Group A Streptococcal sepsis (GAS) have been reported shortly after insertion. This is why aseptic insertion technique by a trained <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> is necessary in order to reduce this risk. GAS can be fatal if not treated quickly.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Women with a history of <\/span><span style=\"font-weight: 400;\">pelvic inflammatory disease<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">PID<\/span><span style=\"font-weight: 400;\">) should not have a hormonal <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> placed unless there has been a case of a successful intrauterine pregnancy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Perforation<\/span><span style=\"font-weight: 400;\"> or puncturing of the uterus is a risk with <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">. This can lead to migration of the device, <\/span><span style=\"font-weight: 400;\">perforation<\/span><span style=\"font-weight: 400;\"> of the intestine, and abscesses.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Partial or complete expulsion from the body can occur. If this occurs, the risk of getting pregnant goes up immediately, and not everyone is aware when this happens. This can be confirmed by ultrasound. It should be suspected if you notice an increase in bleeding.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Women with a history of or suspected case of breast cancer should not use any hormonal <\/span><span style=\"font-weight: 400;\">contraceptives<\/span><span style=\"font-weight: 400;\">, including hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> like <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">. These patients should inquire about <\/span><span style=\"font-weight: 400;\">birth control options<\/span><span style=\"font-weight: 400;\"> that are hormone-free.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> may lead to <\/span><span style=\"font-weight: 400;\">irregular bleeding<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">menstrual periods<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> will not prevent <\/span><span style=\"font-weight: 400;\">sexually transmitted infections<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">STIs<\/span><span style=\"font-weight: 400;\">) or HIV\/AIDS transmisson.<\/span><\/p>\n<h2 id=\"FAQ\">Frequently asked questions about Skyla vs. Mirena<\/h2>\n<h3><span style=\"font-weight: 400;\">What is <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\">?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">) is a hormonal <\/span><span style=\"font-weight: 400;\">intrauterine device<\/span> <span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> method available by prescription only. It contains 13.5 mg of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">, and is approved to prevent pregnancy for 3 years.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What is <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">) is a hormonal <\/span><span style=\"font-weight: 400;\">intrauterine device<\/span> <span style=\"font-weight: 400;\">contraceptive<\/span><span style=\"font-weight: 400;\"> method available by prescription only. It contains 52 mg of <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">, and is approved to prevent pregnancy for 5 years. It can also be placed for the purpose of slowing menstrual bleeding and is approved to be placed for this purpose for 7 years.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Are <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> the same?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> are both hormonal <\/span><span style=\"font-weight: 400;\">IUDs<\/span><span style=\"font-weight: 400;\"> approved for use in preventing pregnancy. They each release the same hormone, <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\">, but the <\/span><span style=\"font-weight: 400;\">amount of hormones<\/span><span style=\"font-weight: 400;\"> is not the same and is not released over the same period of time.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Is <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> better?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> prevents pregnancy 99.1% of the time with proper placement. <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">\u2019s success rate is slightly higher at 99.3%.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> while pregnant?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">No, you should not have an <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> placed while you are pregnant. Your <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> is required to check your pregnancy status prior to insertion.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Can I use <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> with alcohol?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It is safe to consume alcohol in moderation while you have a hormonal <\/span><span style=\"font-weight: 400;\">IUD<\/span><span style=\"font-weight: 400;\"> in place. <\/span><span style=\"font-weight: 400;\">Side effects<\/span><span style=\"font-weight: 400;\"> like nausea may be <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/alcohol-and-birth-control-pills\/\"><span style=\"font-weight: 400;\">compounded by alcohol<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Does <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> have fewer <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> than <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\">?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">Mirena<\/span><span style=\"font-weight: 400;\"> have similar <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">, though some are more or less common with each choice.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Does <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> make you gain weight?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Weight gain<\/span><span style=\"font-weight: 400;\"> is not expected with <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">Bayer<\/span><span style=\"font-weight: 400;\"> does not report this as a <\/span><span style=\"font-weight: 400;\">side effect<\/span><span style=\"font-weight: 400;\">. There is little to no systemic absorption of the <\/span><span style=\"font-weight: 400;\">levonorgestrel<\/span><span style=\"font-weight: 400;\"> to cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/can-birth-control-cause-weight-gain\/\"><span style=\"font-weight: 400;\">weight gain<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">What are the <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\">?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The most <\/span><span style=\"font-weight: 400;\">common side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">Skyla<\/span><span style=\"font-weight: 400;\"> are bleeding after placement, changes in menstrual bleeding, missed <\/span><span style=\"font-weight: 400;\">menstrual cycles<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">ovarian cysts<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Drug overview &amp; main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ Skyla and Mirena are intrauterine systems used for contraception. These devices are placed in the female uterus to help prevent pregnancy. They are commonly referred to as IUDs (intrauterine [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":12811,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[4783,4350],"coauthors":[10437],"class_list":["post-4336","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-birth-control","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Skyla vs. Mirena: Differences, similarities, and which is better for you<\/title>\n<meta name=\"description\" content=\"Skyla and Mirena are intrauterine devices (IUDs)\u2014contraceptives. 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