{"id":4340,"date":"2019-12-12T09:52:58","date_gmt":"2019-12-12T14:52:58","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=3444"},"modified":"2026-04-06T14:10:47","modified_gmt":"2026-04-06T18:10:47","slug":"xyzal-vs-zyrtec","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/xyzal-vs-zyrtec\/","title":{"rendered":"Xyzal vs. Zyrtec: Which allergy medicine is better?"},"content":{"rendered":"

Allergies can cause miserable symptoms like runny nose, itchy or watery eyes, sneezing, and congestion. If you experience these symptoms, you are not alone\u2014allergies affect more than 100 million Americans every year. Fortunately, there are many <\/span>allergy medications<\/span><\/a>, both prescription and over-the-counter (OTC), to help relieve those bothersome symptoms. <\/span>Xyzal<\/span><\/a> and <\/span>Zyrtec<\/span><\/a> both may significantly relieve allergy symptoms, but there are some differences between the two drugs. Continue reading to learn more about Xyzal and Zyrtec.<\/span><\/p>\n

Are Xyzal and Zyrtec the same?<\/span><\/h2>\n

Xyzal (levocetirizine) and Zyrtec (cetirizine) are two popular medications that are both available over the counter to provide allergy relief. Both drugs are approved by the Food and Drug Administration (FDA). Xyzal, though OTC, is also available by prescription in its generic form. Both Xyzal and Zyrtec are oral antihistamines, also called H1 blockers. They block the action of histamine, relieving symptoms of allergies such as runny nose and watery or itchy eyes. Xyzal and Zyrtec are considered second-generation antihistamines. These drugs are known as non-sedating, but they still may cause some drowsiness. However, they\u2019re less sedating than first-generation antihistamines such as Benadryl (diphenhydramine).\u00a0<\/span><\/p>\n

Looking at the generic names of Xyzal and Zyrtec, levocetirizine, and cetirizine, you may notice that the ingredients sound very similar. This is because they are chemically similar. Xyzal and Zyrtec are often referred to as non-sedating antihistamines, but they still do have the potential to cause some drowsiness. However, Xyzal may cause less drowsiness than Zyrtec due to its slight difference in chemical structure.\u00a0<\/span><\/p>\n

RELATED:<\/b>\u00a0<\/b>Zyrtec details<\/b><\/a><\/p>\n

What are the main differences between Xyzal and Zyrtec?<\/span><\/h2>\n

Xyzal and Zyrtec are antihistamines and are both available in brand and generic. The generic of Xyzal (and active ingredient) is levocetirizine, and the generic of Zyrtec is cetirizine. Xyzal and Zyrtec can both be used by adults and children. For children, the dosage depends on the child\u2019s age and formulation. Consult your child\u2019s healthcare provider or pharmacist for dosing questions based on your child\u2019s age and symptoms.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Main differences between Xyzal and Zyrtec<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nXyzal<\/b><\/td>\nZyrtec<\/b><\/td>\n<\/tr>\n
Drug class<\/strong><\/td>\nAntihistamine<\/span><\/td>\nAntihistamine<\/span><\/td>\n<\/tr>\n
Brand\/generic status<\/strong><\/td>\nBrand and generic<\/span><\/td>\nBrand and generic<\/span><\/td>\n<\/tr>\n
What is the generic name?<\/strong><\/td>\nLevocetirizine\u00a0<\/span><\/td>\nCetirizine\u00a0<\/span><\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/strong><\/td>\nTablet, oral solution<\/span><\/td>\nTablet (oral, chewable), capsule, oral solution<\/span><\/td>\n<\/tr>\n
What is the standard dosage?<\/strong><\/td>\nAdults: 2.5\u20135 mg every evening<\/span><\/p>\n

Children: Varies by age, but typically 1.25\u20135 mg every evening<\/span><\/td>\n

Adults: 5\u201310 mg daily<\/span><\/p>\n

Children: Varies by age, but typically 2.5\u201310 mg daily<\/span><\/td>\n<\/tr>\n

How long is the typical treatment?<\/strong><\/td>\nVaries\u00a0<\/span><\/td>\nVaries\u00a0<\/span><\/td>\n<\/tr>\n
Who typically uses the medication?<\/strong><\/td>\nAdults and children<\/span><\/td>\nAdults and children<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by Xyzal and Zyrtec<\/span><\/h2>\n

OTC Xyzal can be used to treat allergies in adults and children 2 years and older and is not recommended for use in children under 2 years old.\u00a0<\/span><\/p>\n

Prescription Xyzal is indicated for the relief of symptoms associated with perennial allergic rhinitis (having nasal allergy symptoms most days of the year) in patients ages 6 years and older. It is also indicated for the treatment of chronic hives in adults and children ages 6 years and older.\u00a0<\/span><\/p>\n

OTC Zyrtec can be used to treat allergy symptoms or hives in adults and children 2 years and older in formulations such as oral solution or chewable tablets, and adults and children 6 years and older in tablet formulation. In some cases, healthcare providers may recommend a small dose of Zyrtec oral solution in children younger than 2 years old when needed. This should only be given if recommended by the healthcare provider.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n
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Conditions treated by Xyzal and Zyrtec<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Condition<\/b><\/td>\nXyzal*<\/b><\/td>\nZyrtec*<\/b><\/td>\n<\/tr>\n
Perennial allergic rhinitis<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Chronic idiopathic urticaria (chronic hives)<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n
Seasonal allergic rhinitis<\/span><\/td>\nYes\u00a0<\/span><\/td>\nYes\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
*Consult the directions on the package or a healthcare provider or pharmacist for help with children\u2019s dosing.<\/span><\/i>\u00a0<\/span><\/h5>\n

Is Xyzal or Zyrtec more effective?<\/span><\/h2>\n

Clinical studies<\/span><\/a> of Xyzal showed that the drug was significantly more effective than placebo (inactive medicine) in treating symptoms of perennial allergic rhinitis as well as chronic idiopathic urticaria (hives).\u00a0<\/span><\/p>\n

Zyrtec <\/span>clinical studies<\/span><\/a> showed that the drug was significantly more effective than placebo in treating symptoms of perennial allergic rhinitis, seasonal allergic rhinitis, and chronic idiopathic urticaria.<\/span><\/p>\n

Studies comparing Xyzal and Zyrtec have varying results, with some studies preferring Xyzal and some preferring Zyrtec. <\/span>Some studies<\/span><\/a> found them to be comparable in how well they worked. In practice, both drugs are effective. The question of which drug is better may be a matter of trial and error, as well as personal preference.\u00a0<\/span><\/p>\n

Coverage and cost comparison of Zyrtec vs. Xyzal<\/span><\/h2>\n

Zyrtec is available over the counter in both brand and generic. The average retail price of brand-name Zyrtec for 30, 10 mg tablets costs about $25. You can purchase the generic version of Zyrtec for about $3 using a <\/span>free SingleCare Coupon<\/span><\/a>. Zyrtec is typically not covered by insurance or Medicare prescription plans; however, some state Medicaid plans may cover generic cetirizine.<\/span><\/p>\n

Xyzal is available in both prescription (generic) and OTC form (both brand and generic). The average retail price of generic Xyzal, levocetirizine, is about $106 for 30, 5 mg tablets, but it can be purchased for about $7 with a free SingleCare <\/span>levocetirizine coupon<\/span><\/a>. Insurance and Medicare prescription plans typically cover the generic prescription form of levocetirizine.\u00a0<\/span><\/p>\n

In order to use a SingleCare card or coupon when purchasing an OTC version of Xyzal or Zyrtec, a prescription is required.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
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Cost and coverage of Xyzal vs. Zyrtec<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nXyzal<\/b><\/td>\nZyrtec<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/span><\/td>\nYes; generic prescription form<\/span><\/td>\nNo (because it is only OTC); some states may cover generic under Medicaid<\/span><\/td>\n<\/tr>\n
Typically covered by Medicare prescription plans?<\/span><\/td>\nYes; generic prescription form<\/span><\/td>\nNo<\/span><\/td>\n<\/tr>\n
Standard dosage<\/span><\/td>\n30, 5 mg tablets<\/span><\/td>\n30, 10 mg tablets\u00a0<\/span><\/td>\n<\/tr>\n
Typical Medicare prescription plan copay<\/span><\/td>\n$0\u201320<\/span><\/td>\nN\/A<\/span><\/td>\n<\/tr>\n
SingleCare cost*<\/span><\/td>\n$7\u00a0<\/span><\/a><\/td>\n$3\u00a0<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
*Cost at the time of publication. Drug prices fluctuate and vary by pharmacy.\u00a0<\/span><\/h5>\n

Common side effects of Xyzal vs. Zyrtec<\/span><\/h2>\n

Xyzal and Zyrtec have similar side effects. The most common side effects are drowsiness, dry mouth, and fatigue.<\/span><\/p>\n

Drowsiness<\/span><\/h3>\n

Xyzal and Zyrtec are both generally tolerated very well. They can both cause drowsiness. However, they cause less drowsiness than older antihistamines like <\/span>Benadryl <\/span><\/a>(diphenhydramine). Since Xyzal and Zyrtec are chemically similar, they have similar side effects, including drowsiness. However, drowsiness is reported more often with Zyrtec than with Xyzal. So, if drowsiness is a concern, Xyzal may be a better option. Also, taking the antihistamine at night can help you avoid drowsiness, and the medication will help relieve symptoms while you sleep, which helps you wake up feeling rested.<\/span><\/p>\n

Dry mouth<\/span><\/h3>\n

Antihistamines such as Xyzal and Zyrtec can cause a dry mouth. To relieve a dry mouth, you can try chewing sugarless gum or sucking on sugarless candy\u2014choosing sugarless can help you avoid cavities. You can also sip on water throughout the day, let ice chips melt in your mouth, or try a saliva-substitute product. Choosing low-sugar, non-acidic, moist foods can help as well. If you use mouthwash, avoid products that contain alcohol. Instead, choose a mouthwash designed for people with dry mouth. You can also use a humidifier in your room at night to add moisture to the air.<\/span><\/p>\n

Other side effects may occur. Consult your healthcare professional for a complete list of side effects.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
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Xyzal and Zyrtec side effects<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nXyzal<\/b><\/td>\nZyrtec<\/b><\/td>\n<\/tr>\n
Side effect<\/strong><\/td>\nApplicable?<\/span><\/td>\nFrequency*<\/span><\/td>\nApplicable?<\/span><\/td>\nFrequency<\/span><\/td>\n<\/tr>\n
Somnolence (drowsiness)<\/strong><\/td>\nYes<\/span><\/td>\n5-6%<\/span><\/td>\nYes<\/span><\/td>\n14%<\/span><\/td>\n<\/tr>\n
Nasopharyngitis (common cold)<\/strong><\/td>\nYes<\/span><\/td>\n4-6%<\/span><\/td>\nNo<\/span><\/td>\n–<\/span><\/td>\n<\/tr>\n
Pharyngitis (sore throat)<\/strong><\/td>\nYes<\/span><\/td>\n1-2%<\/span><\/td>\nYes<\/span><\/td>\n2%<\/span><\/td>\n<\/tr>\n
Fatigue<\/strong><\/td>\nYes<\/span><\/td>\n1-4%<\/span><\/td>\nYes<\/span><\/td>\n5.9%<\/span><\/td>\n<\/tr>\n
Dry mouth<\/strong><\/td>\nYes<\/span><\/td>\n2-3%<\/span><\/td>\nYes<\/span><\/td>\n5%<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
*Frequency can vary by dose.\u00a0<\/span>Source: DailyMed (Xyzal), Pfizer (Zyrtec)<\/span><\/h5>\n

Drug interactions of Xyzal vs. Zyrtec<\/span><\/h2>\n

Do not use alcohol with Xyzal or Zyrtec. The combination can cause impairment and affect alertness.\u00a0<\/span><\/p>\n

Additionally, central nervous system (CNS) depressant medications should not be taken in combination with either drug due to additive effects on slowing down brain activity. CNS depressants include drugs such as anxiety medications, insomnia medications, opioid pain medications, barbiturates, and muscle relaxants. Certain CNS depressants are sometimes referred to as sedatives or tranquilizers.\u00a0<\/span><\/p>\n

Other drug interactions may occur with Xyzal or Zyrtec. Consult your healthcare provider for a full list of drug interactions.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n
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Medication interactions of Xyzal vs. Zyrtec<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug<\/b><\/td>\nInteracts with Xyzal?<\/b><\/td>\nInteracts with Zyrtec?<\/b><\/td>\n<\/tr>\n
Alcohol<\/span><\/td>\nYes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n
Central nervous system (CNS) depressants, for example:<\/span><\/p>\n
    \n
  • Anxiety medications such as Xanax (alprazolam)<\/span><\/li>\n
  • Sleeping medications such as Ambien (zolpidem)<\/span><\/li>\n
  • Opioid pain medications such as oxycodone<\/span><\/li>\n
  • Barbiturates such as phenobarbital<\/span><\/li>\n
  • Muscle relaxants such as cyclobenzaprine<\/span><\/li>\n<\/ul>\n<\/td>\n
Yes<\/span><\/td>\nYes<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Xyzal and Zyrtec warnings<\/span><\/h2>\n

Xyzal and Zyrtec warnings include somnolence (sleepiness) and fatigue. You should avoid driving until you know how you react to Xyzal or Zyrtec. You should not drink alcohol while taking Xyzal or Zyrtec because the combination can affect alertness and cause impairment.\u00a0<\/span><\/p>\n

Xyzal and Zyrtec may also cause urinary retention and should be used with caution in patients with a prostate condition. Consult your healthcare provider for medical advice if you have prostate problems.\u00a0<\/span><\/p>\n

Consult your healthcare provider for medical advice if you are pregnant or breastfeeding. Xyzal is generally not recommended for use while breastfeeding. If you are already taking Xyzal or Zyrtec and become pregnant, consult your healthcare provider.\u00a0<\/span><\/p>\n

Xyzal and Zyrtec alternatives<\/span><\/h2>\n

If Xyzal or <\/span>Zyrtec<\/span><\/a> do not work for you, other alternatives are available. You can speak to your healthcare provider for a recommendation. Examples of other antihistamines include:\u00a0<\/span><\/p>\n