{"id":45357,"date":"2021-10-28T18:27:43","date_gmt":"2021-10-28T22:27:43","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=45357"},"modified":"2025-12-16T13:58:04","modified_gmt":"2025-12-16T18:58:04","slug":"zoloft-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/zoloft-alternatives\/","title":{"rendered":"Zoloft alternatives for depression and anxiety"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/jxMSrZsGgEI?rel=0\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><span style=\"font-weight: 400;\"> (sertraline) is a brand-name prescription antidepressant that treats <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">depression<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">anxiety<\/span><\/a><span style=\"font-weight: 400;\">. As a selective serotonin reuptake inhibitor (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ssris\/\"><span style=\"font-weight: 400;\">SSRI<\/span><\/a><span style=\"font-weight: 400;\">), Zoloft increases serotonin levels in the brain to improve mood. Along with major depressive disorder (MDD), Zoloft also treats panic disorder (PD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Zoloft may not work for everyone. In cases where Zoloft doesn\u2019t work or causes intolerable side effects, a healthcare provider may suggest a different type of antidepressant or anxiety medication or a nonpharmaceutical treatment.\u00a0<\/span><\/p>\n<h2 id=\"what-can-i-take-instead-of-zoloft\"><span style=\"font-weight: 400;\">What can I take instead of Zoloft?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Alternative prescription medications that treat depression include other types of SSRIs, other classes of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/antidepressants\/\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as serotonin-norepinephrine reuptake inhibitors (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/snris\/\"><span style=\"font-weight: 400;\">SNRIs<\/span><\/a><span style=\"font-weight: 400;\">), <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antidepressants\"><span style=\"font-weight: 400;\">atypical antidepressants<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/atypical-antipsychotics\"><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, tricyclic antidepressants (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">TCAs<\/span><\/a><span style=\"font-weight: 400;\">), and monoamine oxidase inhibitors (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/maois\/\"><span style=\"font-weight: 400;\">MAOIs<\/span><\/a><span style=\"font-weight: 400;\">). For anxiety, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">treatment options<\/span><\/a><span style=\"font-weight: 400;\"> include other SSRIs, SNRIs, buspirone, TCAs, and benzodiazepines. These options may be more suitable for certain individuals due to their different uses, side effect profiles, and dosages.<\/span><\/p>\n<table class=\" singlecare-table\" role=\"table\">\n<thead>\n<tr>\n<th colspan=\"4\">\n<h3 id=\"compare-zoloft-alternatives\"><span style=\"font-weight: 400;\">Compare Zoloft alternatives<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Price without insurance<\/b><\/td>\n<td><b>SingleCare price<\/b><\/td>\n<td><b>Savings options<\/b><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\/what-is\"><span style=\"font-weight: 400;\">Zoloft<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sertraline-hcl\/what-is\"><span style=\"font-weight: 400;\">sertraline<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$544 for 30, 50 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9 for 30, 50 mg tablets of generic sertraline at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\/what-is\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/escitalopram-oxalate\/what-is\"><span style=\"font-weight: 400;\">escitalopram<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$564 for 30, 10 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9 for 30, 10 mg tablets of generic escitalopram at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl\/what-is\"><span style=\"font-weight: 400;\">Fluoxetine<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$68 for 30, 20 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 20 mg capsules of generic fluoxetine at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/prozac\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\/what-is\"><span style=\"font-weight: 400;\">Effexor XR <\/span><\/a><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/venlafaxine-hcl-er\/what-is\"><span style=\"font-weight: 400;\">venlafaxine extended-release<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$779 for 30, 150 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 150 mg capsules of generic venlafaxine ER at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\/what-is\"><span style=\"font-weight: 400;\">Duloxetine<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">$229 for 30, 60 mg capsules<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$8 for 30, 60 mg capsules of generic duloxetine at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\/what-is\"><span style=\"font-weight: 400;\">Wellbutrin XL<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl-er-sr\/what-is\"><span style=\"font-weight: 400;\">(bupropion <\/span><\/a><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl-er-xl\/what-is\"><span style=\"font-weight: 400;\">extended-release<\/span><\/a><a href=\"https:\/\/www.singlecare.com\/prescription\/bupropion-hcl-er-sr\/what-is\"><span style=\"font-weight: 400;\">)<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$3,636 for 30, 300 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9 for 30, 300 mg tablets of generic bupropion ER at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/paxil\/what-is\"><span style=\"font-weight: 400;\">Paxil<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/paroxetine-hcl\/what-is\"><span style=\"font-weight: 400;\">paroxetine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$756 for 30, 20 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$4 for 30, 20 mg tablets of generic paroxetine at Walmart<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/paxil\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/celexa\/what-is\"><span style=\"font-weight: 400;\">Celexa<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/citalopram-hydrobromide\/what-is\"><span style=\"font-weight: 400;\">citalopram<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$407 for 30, 20 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 20 mg tablets of generic citalopram at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/celexa\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\/what-is\"><span style=\"font-weight: 400;\">Pristiq<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\"><span style=\"font-weight: 400;\">desvenlafaxine ER<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$543 for 30, 100 mg extended-release tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$18 for 30, 100 mg tablets of generic desvenlafaxine ER at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/trintellix\/what-is\"><span style=\"font-weight: 400;\">Trintellix<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(vortioxetine)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$677 for 30, 20 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$466 for 30, 20 mg tablets of brand-name Trintellix at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/trintellix\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/viibryd\/what-is\"><span style=\"font-weight: 400;\">Viibryd<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vilazodone-hcl\/what-is\"><span style=\"font-weight: 400;\">vilazodone<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$434 for 30, 40 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$36 for 30, 40 mg tablets of generic vilazodone at CVS Pharmacy<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/viibryd\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\/what-is\"><span style=\"font-weight: 400;\">Trazodone<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$38 for 30, 50 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$6 for 30, 50 mg tablets of generic trazodone at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/trazodone-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/remeron\/what-is\"><span style=\"font-weight: 400;\">Remeron<\/span><\/a><\/p>\n<p><span style=\"font-weight: 400;\">(<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/mirtazapine\/what-is\"><span style=\"font-weight: 400;\">mirtazapine<\/span><\/a><span style=\"font-weight: 400;\">)\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$246 for 30, 15 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$9 for 30, 15 mg tablets of generic mirtazapine at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/remeron\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\/what-is\"><span style=\"font-weight: 400;\">Amitriptyline<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">$27 for 30, 25 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$4 for 30, 25 mg tablets of generic amitriptyline at Walmart<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/buspirone-hcl\/what-is\"><span style=\"font-weight: 400;\">Buspirone<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">$46 for 60, 5 mg tablets<\/span><\/td>\n<td><span style=\"font-weight: 400;\">$5 for 60, 5 mg tablets of generic buspirone at Kroger<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/buspirone-hcl\"><span style=\"font-weight: 400;\">See latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i><span style=\"font-weight: 400;\">Prescription drug prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 12\/16\/2025. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under \u201cSavings options\u201d to see the latest drug prices.<\/span><\/i><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Zoloft with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tZoloft 50 mg (1 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$8.72<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/zoloft#blog-cta\" class=\"coupon-see-all-btn\">See Zoloft prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"top-5-zoloft-alternatives\"><span style=\"font-weight: 400;\">Top 5 Zoloft alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Any of the prescription medications above may be prescribed if Zoloft is not working for anxiety or depression. However, the following prescription drugs are some of the most common alternatives.<\/span><\/p>\n<h3 id=\"1-lexapro-escitalopram\"><span style=\"font-weight: 400;\">1. Lexapro (escitalopram)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Zoloft and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\/what-is\"><span style=\"font-weight: 400;\">Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> are both SSRIs indicated for the treatment of depression. Lexapro is also FDA-approved to treat generalized anxiety disorder. Because both medications belong to the same drug class, they have <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/lexapro-side-effects\/\"><span style=\"font-weight: 400;\">similar side effects<\/span><\/a><span style=\"font-weight: 400;\"> such as headache, nausea, and insomnia. Lexapro was shown in some, but not all, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4047306\/\"><span style=\"font-weight: 400;\">clinical studies<\/span><\/a><span style=\"font-weight: 400;\"> to be more effective in treating depression and better tolerated than Zoloft. The <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lexapro\/dosage\"><span style=\"font-weight: 400;\">standard dose for Lexapro<\/span><\/a><span style=\"font-weight: 400;\"> is 10 mg daily with a maximum dose of 20 mg per day.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/lexapro-vs-zoloft\/\"><b>Lexapro vs. Zoloft<\/b><\/a><\/p>\n<h3 id=\"2-fluoxetine\"><span style=\"font-weight: 400;\">2. Fluoxetine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Better known as Prozac, its original but discontinued brand-name version, fluoxetine is another SSRI medication that works in the same way as Zoloft to increase serotonin activity. Like Zoloft, fluoxetine is approved by the Food and Drug Administration (FDA) to treat depression, panic disorder, and OCD. Additionally, fluoxetine is approved to reduce binge-eating and vomiting in people with bulimia nervosa. Both drugs are similar in <\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/194478\"><span style=\"font-weight: 400;\">effectiveness<\/span><\/a><span style=\"font-weight: 400;\"> for depressive symptoms, but <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/prozac-side-effects\/\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> has a <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9386738\/\"><span style=\"font-weight: 400;\">lower risk<\/span><\/a><span style=\"font-weight: 400;\"> of causing diarrhea compared to Zoloft. The <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\/dosage\"><span style=\"font-weight: 400;\">standard dose for Prozac<\/span><\/a><span style=\"font-weight: 400;\"> is 20 mg daily and should not exceed 80 mg per day.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/zoloft-vs-prozac\/\"><b>Prozac vs. Zoloft<\/b><\/a><\/p>\n<h3 id=\"3-effexor-or-effexor-xl-venlafaxine\"><span style=\"font-weight: 400;\">3. Effexor or Effexor XL (venlafaxine)<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If an SSRI like Zoloft does not improve symptoms, your healthcare provider may suggest trying a different class of antidepressants called SNRIs. These drugs increase levels of norepinephrine as well as serotonin, so they may be more effective for some patients. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\/what-is\"><span style=\"font-weight: 400;\">Effexor XR<\/span><\/a><span style=\"font-weight: 400;\"> is one such medication that is indicated for the treatment of depression and anxiety disorders. SNRIs overall are associated with certain specific side effects more frequently than SSRIs; Effexor XR, in particular, may increase blood pressure, more so when given at higher doses, with the usual dose range going from 75 to 225 mg per day (extended-release version).\u00a0<\/span><\/p>\n<p><b>\u00a0RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/effexor-vs-zoloft\/\"><b>Effexor vs. Zoloft<\/b><\/a><\/p>\n<h3 id=\"4-duloxetine\"><span style=\"font-weight: 400;\">4. Duloxetine<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Duloxetine is another SNRI medication, but people may know it better under its original but discontinued brand name, Cymbalta. Unlike Zoloft, duloxetine is also prescribed for nerve pain or <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/current-and-upcoming-chronic-pain-management\/\"><span style=\"font-weight: 400;\">chronic pain<\/span><\/a><span style=\"font-weight: 400;\"> in addition to depression and anxiety. Therefore, Cymbalta may be more therapeutic in individuals who have both depression and pain symptoms. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/cymbalta-side-effects\/\"><span style=\"font-weight: 400;\">Common side effects of duloxetine<\/span><\/a><span style=\"font-weight: 400;\"> include gastrointestinal disturbances and headache, but it is generally well-tolerated. Cymbalta is usually <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\/dosage\"><span style=\"font-weight: 400;\">started at a dose<\/span><\/a><span style=\"font-weight: 400;\"> of 30 to 60 mg daily.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/cymbalta-vs-zoloft\/\"><b>Cymbalta vs. Zoloft<\/b><\/a><\/p>\n<h3 id=\"5-wellbutrin-or-wellbutrin-xl-bupropion\"><span style=\"font-weight: 400;\">5. Wellbutrin or Wellbutrin XL (bupropion)<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-xl\/what-is\"><span style=\"font-weight: 400;\">Wellbutrin XL<\/span><\/a><span style=\"font-weight: 400;\"> has a different mechanism of action than Zoloft. It\u2019s a norepinephrine and dopamine reuptake inhibitor (DNRI). DNRIs are typically stimulants, so bupropion doesn\u2019t have many of the sedative effects of other antidepressants. It is also less likely to cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/news\/sex-on-ssris\/\"><span style=\"font-weight: 400;\">sexual dysfunction<\/span><\/a><span style=\"font-weight: 400;\"> or weight gain. In fact, people on Wellbutrin <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4850471\/\"><span style=\"font-weight: 400;\">are more likely to lose weight<\/span><\/a><span style=\"font-weight: 400;\"> than to gain weight, a common side effect of antidepressants. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/wellbutrin-sr\/dosage\"><span style=\"font-weight: 400;\">Wellbutrin XL has a typical dose<\/span><\/a><span style=\"font-weight: 400;\"> of 150 to 300 mg daily, and it may be more suitable for certain patients due to its different side effect profile.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/wellbutrin-vs-zoloft\/\"><b>Wellbutrin vs. Zoloft<\/b><\/a><\/p>\n<h2 id=\"over-the-counter-depression-or-anxiety-medications\"><span style=\"font-weight: 400;\">Over-the-counter depression or anxiety medications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are many over-the-counter medications and supplements that promise improved mood. Some do work, but not enough to adequately relieve the symptoms of clinical depressive or anxiety disorders. The <\/span><a href=\"https:\/\/www.apa.org\/depression-guideline\/guideline.pdf\"><span style=\"font-weight: 400;\">American Psychiatric Association (APA) guidelines<\/span><\/a><span style=\"font-weight: 400;\"> for treating major depressive disorder only recommend St. John\u2019s wort. In a 2008 <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7032678\/\"><span style=\"font-weight: 400;\">systematic review<\/span><\/a><span style=\"font-weight: 400;\"> of its use in patients with major depression, St. John\u2019s wort was found to be similarly effective as standard antidepressants. However, this supplement has significant drug interactions and can reduce the effectiveness of other drugs when taken together.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other possible OTC supplements that may improve mood include <\/span><a href=\"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.2012.12010009\"><span style=\"font-weight: 400;\">creatinine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/journals.lww.com\/bsam\/abstract\/2018\/02000\/acetyl_l_carnitine_supplementation_and_the.4.aspx\"><span style=\"font-weight: 400;\">carnitine<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0165032719317604\"><span style=\"font-weight: 400;\">glycyrrhizic acid<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/karger.com\/pps\/article\/88\/5\/263\/283146\/International-Society-for-Nutritional-Psychiatry\"><span style=\"font-weight: 400;\">omega-3 fatty acids<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/psychiatryonline.org\/pb\/assets\/raw\/sitewide\/practice_guidelines\/guidelines\/mdd-1410197717630.pdf\"><span style=\"font-weight: 400;\">S-adenosyl-L-methionine<\/span><\/a><span style=\"font-weight: 400;\"> (SAMe), and <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28988944\/\"><span style=\"font-weight: 400;\">zinc<\/span><\/a><b>. <\/b><span style=\"font-weight: 400;\">The evidence for the effectiveness of these supplements is not definitive, so they are not recommended in the APA guidelines. Because supplements are not reliable and may have drug interactions, always get medical advice from a healthcare professional before starting any new supplements.<\/span><\/p>\n<h2 id=\"natural-alternatives-to-zoloft\"><span style=\"font-weight: 400;\">Natural alternatives to Zoloft<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are several natural alternatives to Zoloft that may offer some relief from depression and anxiety:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Talk therapy: <\/b><span style=\"font-weight: 400;\">Speaking with a mental health specialist can improve depression and anxiety symptoms and provide an important addition or alternative to drug therapy. The most effective psychotherapy, and one widely recommended in the <\/span><a href=\"https:\/\/www.apa.org\/depression-guideline\/guideline.pdf\"><span style=\"font-weight: 400;\">APA guidelines<\/span><\/a><span style=\"font-weight: 400;\">, is cognitive-behavioral therapy (CBT), which focuses on changing negative thoughts and behaviors.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Exercise: <\/b><span style=\"font-weight: 400;\">Regular exercise has been shown to boost endorphins, improve sleep, and increase serotonin function in the brain.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Sleep:<\/b><span style=\"font-weight: 400;\"> Adopting good sleep hygiene can significantly improve the quality of sleep, which in turn greatly enhances mood.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dietary changes:<\/b><span style=\"font-weight: 400;\"> A diet high in omega-3 fats and tryptophan could be associated with better mood.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Alternative treatments: <\/b><span style=\"font-weight: 400;\">The APA guidelines suggest considering yoga, acupuncture, or bright light therapy as possibly helpful for depression.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">For clinical mood disorders or serious mental health conditions like OCD, natural remedies are not a replacement for diagnosis and treatment from a medical professional. Consult a healthcare provider for medical advice before starting any natural therapies.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/depression-diet\/\"><b>The best diet for depression<\/b><\/a><\/p>\n<h2 id=\"how-to-switch-to-a-zoloft-alternative\"><span style=\"font-weight: 400;\">How to switch to a Zoloft alternative<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If Zoloft is not working well for you or improving your quality of life, it may be time to switch to an alternative. However, there are several things to consider before deciding to make this change. Alternative medications may have different side effects and benefits, and some treatments may fit your lifestyle and values more than others. Cost is another factor to think about because depression treatments are usually given long-term. Before making any medication changes, talk to your healthcare provider about the following:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Side effects experienced with the current medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">What symptoms did not get better on the current medication<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any part of your lifestyle or schedule that makes one treatment option easier than another<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are interested in supplements or alternative remedies that might help your symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The cost of any potential medication or therapy\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">To avoid withdrawal symptoms, a gradual reduction in dose is often recommended instead of abrupt discontinuation. Make sure to follow your healthcare provider\u2019s instructions about how to safely taper off Zoloft. Your healthcare provider can also help you navigate different treatment options to find the right one that suits your needs and goals.<\/span><\/p>\n<h2 id=\"choosing-the-right-path-for-depression-treatment\"><span style=\"font-weight: 400;\">Choosing the right path for depression treatment<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Depression treatment always starts with talking with a healthcare professional. The key insight about depression is that patients aren\u2019t thinking or acting the way they normally do, so it helps to listen to the medical advice of a trained professional. For clinical depression, often the best way to start is with pharmaceutical treatment. It will take a while to get the right drug and dosage that balances effectiveness with possible side effects. Pills are often not enough, so a commitment to psychotherapy is key to overcoming clinical depression. All of this takes time. The drugs take weeks or months. Psychotherapy can take longer. The only way to succeed is to continue to work with your healthcare team on finding the best treatment regimen for you.<\/span><\/p>\n<h2 id=\"expert-takeaway\"><span style=\"font-weight: 400;\">Expert takeaway<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><span style=\"font-weight: 400;\">Based on a long track record of safety and effectiveness, Zoloft ranks among the commonly prescribed antidepressants, as well as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/most-prescribed-drugs-2023\/\"><span style=\"font-weight: 400;\">drugs overall<\/span><\/a><span style=\"font-weight: 400;\">, in the country,\u201d says Chad Shaffer, MD, member of the SingleCare Medical Board. \u201cWhen it is ineffective or not tolerated, a trial of a different SSRI, if two have not already been tried, an SNRI, or bupropion is often recommended.\u201d\u00a0<\/span><\/p>\n<p><i><span style=\"font-weight: 400;\">The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of 12\/16\/2025. Prices vary by pharmacy. Visit our <\/span><\/i><a href=\"https:\/\/www.singlecare.com\/prescription\/zoloft\"><i><span style=\"font-weight: 400;\">Zoloft coupon<\/span><\/i><\/a><i><span style=\"font-weight: 400;\"> page<\/span><\/i><i><span style=\"font-weight: 400;\"> for updated Zoloft prices near you.<\/span><\/i><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Zoloft (sertraline) is a brand-name prescription antidepressant that treats depression or anxiety. As a selective serotonin reuptake inhibitor (SSRI), Zoloft increases serotonin levels in the brain to improve mood. Along with major depressive disorder (MDD), Zoloft also treats panic disorder (PD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and premenstrual [&hellip;]<\/p>\n","protected":false},"author":87,"featured_media":45359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[9777,451,450],"coauthors":[20753],"class_list":["post-45357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-anxiety","tag-depression","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Find safe alternatives when Zoloft isn\u2019t working or causes side effects<\/title>\n<meta name=\"description\" content=\"Explore how 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