{"id":4560,"date":"2019-06-25T14:28:51","date_gmt":"2019-06-25T18:28:51","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=4560"},"modified":"2026-03-17T16:19:53","modified_gmt":"2026-03-17T20:19:53","slug":"latuda-vs-seroquel","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/latuda-vs-seroquel\/","title":{"rendered":"Latuda vs. Seroquel: Differences, similarities, and which one is better for you"},"content":{"rendered":"

Main differences between Latuda and Seroquel<\/a> | <\/span> Conditions treated by Latuda and Seroquel<\/a> | Is Latuda or Seroquel more effective?<\/a> | Coverage and cost comparison<\/a> | Common side effects<\/a> | Drug interactions<\/a> | Warnings<\/a> | FAQ<\/a>\u00a0<\/span><\/p>\n

Latuda<\/span> and <\/span>Seroquel<\/span> are two prescription drugs used in the treatment of disorders associated with <\/span>mental health<\/span>, primarily <\/span>schizophrenia<\/span> and <\/span>bipolar disorder<\/span>. <\/span>Schizophrenia<\/span><\/a> is typically diagnosed between the ages of 16 and 30 after a first episode of <\/span>psychosis<\/span>. Psychosis is a group of symptoms that can include trouble thinking clearly, suspicious or paranoid ideas, social withdrawal, or trouble communicating, among others.<\/span>\u00a0<\/span>Bipolar disorder<\/span><\/a> is characterized by unusual shifts in mood, energy, activity levels, and concentration. Bipolar disorder can occur in children, though it isn\u2019t typically diagnosed until adolescence or late teen years.<\/span>\u00a0<\/span><\/p>\n

Schizophrenia<\/span> and <\/span>bipolar disorder<\/span> can be very debilitating and have a significant impact on life if left untreated. While non-drug treatment, such as psychotherapy and exercise, can be very effective, many individuals will require prescription drug treatment. <\/span>Latuda<\/span> (<\/span>lurasidone<\/span>) and <\/span>Seroquel<\/span> (<\/span>quetiapine<\/span>) are two medications used in the <\/span>treatment of schizophrenia<\/span>, <\/span>bipolar disorder<\/span>, and other <\/span>mental health-<\/span>related conditions.\u00a0<\/span><\/p>\n

What are the main differences between <\/span>Latuda<\/span> and <\/span>Seroquel<\/span>?<\/span><\/h2>\n

Latuda<\/span><\/a> (<\/span>lurasidone<\/span>) is a prescription medication classified as an <\/span>atypical antipsychotic<\/span>. <\/span>Latuda<\/span> is indicated in the <\/span>treatment of schizophrenia<\/span> and depression associated with <\/span>bipolar I disorder<\/span>. The exact mechanism of action for <\/span>Latuda<\/span> is not known. <\/span>Latuda<\/span> is understood to reduce both positive and negative symptoms of <\/span>schizophrenia<\/span> through its central nervous system (CNS) action on <\/span>dopamine<\/span> and <\/span>serotonin<\/span> receptors<\/span>. <\/span>Latuda<\/span> is available as an oral tablet in 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg tablets.\u00a0<\/span><\/p>\n

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Seroquel<\/span><\/a> (<\/span>quetiapine<\/span>) is also an <\/span>atypical antipsychotic<\/span> prescription medication. It has been on the market longer than <\/span>Latuda<\/span> and is available generically. Like <\/span>Latuda<\/span>, it is used in the <\/span>treatment of schizophrenia<\/span> and <\/span>bipolar disorder<\/span>, but <\/span>Seroquel<\/span> is also approved to be used in the treatment of major depression. <\/span>Seroquel<\/span> is thought to work similarly to <\/span>Latuda<\/span> in its CNS dopaminergic and serotonergic actions. It is available in oral tablet form in both immediate-release and <\/span>extended-release<\/span> formulations. The immediate-release comes in strengths of 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg. The <\/span>extended-release<\/span> comes in 50 mg, 150 mg, 200 mg, 300 mg, and 400 mg.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
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Main differences between Latuda and Seroquel<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

<\/td>\nLatuda<\/b><\/td>\nSeroquel<\/b><\/td>\n<\/tr>\n
Drug class<\/b><\/td>\nAtypical antipsychotic<\/td>\nAtypical antipsychotic<\/td>\n<\/tr>\n
Brand\/generic status<\/b><\/td>\nBrand and generic available<\/td>\nBrand and generic available<\/td>\n<\/tr>\n
What is the generic name?<\/b><\/td>\nLurasidone<\/td>\nQuetiapine<\/td>\n<\/tr>\n
What form(s) does the drug come in?<\/b><\/td>\nOral tablet<\/td>\nImmediate-release and extended-release oral tablets<\/td>\n<\/tr>\n
What is the standard dosage?<\/b><\/td>\n40 mg once daily<\/td>\n150 mg to 300 mg per day<\/td>\n<\/tr>\n
How long is the typical treatment?<\/b><\/td>\nLong-term maintenance<\/td>\nLong-term maintenance<\/td>\n<\/tr>\n
Who typically uses the medication?<\/b><\/td>\nChildren >10 years old, adolescents, adults<\/td>\nAdults<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Conditions treated by <\/span>Latuda<\/span> and <\/span>Seroquel<\/span><\/h2>\n

The Food and Drug Administration (<\/span>FDA<\/span>) approves prescription medication indications for use after extensive <\/span>clinical trials<\/span>. <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> share indications for <\/span>schizophrenia<\/span> and <\/span>bipolar disorder<\/span><\/a> treatment. <\/span>Seroquel<\/span> has an additional indication to treat major depression.<\/span><\/p>\n

Latuda<\/span> and <\/span>Seroquel<\/span> are both also used \u201coff-label,\u201d meaning they are used in the treatment of disorders for which the <\/span>FDA<\/span> has not officially granted approval. <\/span>Seroquel<\/span> is used off-label in the treatment of obsessive-compulsive disorder (<\/span>OCD<\/span><\/a>), borderline personality disorder, and in severe cases of behavioral and psychological symptoms of dementia. <\/span>Latuda<\/span> is also used off-label in severe cases of behavioral and psychological symptoms of dementia.<\/span><\/p>\n

The following table outlines the most common uses for <\/span>Latuda<\/span> and <\/span>Seroquel<\/span>. Only your <\/span>healthcare<\/span> provider can determine if either of these drugs is right for you.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n
Condition<\/b><\/td>\nLatuda<\/b><\/td>\nSeroquel<\/b><\/td>\n<\/tr>\n
Schizophrenia<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Bipolar disorder<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Behavioral and psychological symptoms of dementia (BPSD)<\/td>\nOff-label<\/td>\nOff-label<\/td>\n<\/tr>\n
Major depression (adjunct)<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n
Major depression (monotherapy)<\/td>\nNo<\/td>\nOff-label<\/td>\n<\/tr>\n
Obsessive-compulsive disorder (OCD)<\/td>\nNo<\/td>\nOff-label<\/td>\n<\/tr>\n
Borderline personality disorder (BPD)<\/td>\nNo<\/td>\nOff-label<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Is <\/span>Latuda<\/span> or <\/span>Seroquel<\/span> more effective?<\/span><\/h2>\n

It is difficult to assess head-to-head comparisons of efficacy between two <\/span>atypical antipsychotics<\/span> in <\/span>mental health<\/span> disorders. Many evaluate different parameter types. A 12-month, <\/span>double-blind study<\/span><\/a> compared <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> for their efficacy in preventing relapse in <\/span>schizophrenia<\/span>. At the 12-month mark, <\/span>Latuda<\/span> was associated with higher rates of maintained remission of <\/span>schizophrenia<\/span> symptoms and a reduced risk of hospitalization. <\/span>Seroquel<\/span> was associated with higher incidences of <\/span>metabolic<\/span> changes and <\/span>weight gain<\/span> in the same period of time.<\/span><\/p>\n

A separate <\/span>systematic review<\/span><\/a> compared the two drugs for efficacy and adverse events in the treatment of <\/span>bipolar depression<\/span>. The Montgomery-Asberg Depression Rating Scale (MADRS) was used as the key measurement for clinical efficacy. There was no statistical difference between <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> with this measure. However, <\/span>Latuda<\/span> was associated with significantly fewer adverse events versus <\/span>Seroquel<\/span>, including <\/span>weight gain<\/span> and <\/span>metabolic<\/span> changes.<\/span><\/p>\n

This information is not intended to be <\/span>medical advice<\/span>. Only your <\/span>healthcare<\/span> provider can determine what treatment is right for you.<\/span><\/p>\n

Coverage and cost comparison of <\/span>Latuda<\/span> vs. <\/span>Seroquel<\/span><\/h2>\n

Latuda<\/span> is a prescription drug that is covered by most commercial and Medicare insurance plans, though copays may vary greatly with various plans. The out-of-pocket price for <\/span>Latuda<\/span> can be as much as $1775 for a one-month supply. With a <\/span>coupon<\/span><\/a> from SingleCare, you could save and pay about $1300.<\/span><\/p>\n

Seroquel<\/span> is also a prescription drug that is covered by almost all commercial and Medicare insurance plans. The cost without insurance for a one-month supply of Seroquel is more than $250.<\/span>\u00a0With a SingleCare <\/span>coupon<\/span><\/a>, anyone can access the generic for less than $5 at participating pharmacies.<\/span><\/p>\n\n\n\n\n\n\n\n\n
<\/td>\nLatuda<\/b><\/td>\nSeroquel<\/b><\/td>\n<\/tr>\n
Typically covered by insurance?<\/b><\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Typically covered by Medicare Part D?<\/b><\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Quantity<\/b><\/td>\n30, 40 mg tablets<\/td>\n30, 25 mg tablets<\/td>\n<\/tr>\n
Typical Medicare copay<\/b><\/td>\n$29-$1300<\/td>\n$10<\/td>\n<\/tr>\n
SingleCare cost<\/b><\/td>\n$1300-$1500<\/td>\n$5-$30<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Save on schizophrenia medication<\/a><\/strong><\/p>\n

Common side effects of Latuda<\/span> vs. <\/span>Seroquel<\/span><\/h2>\n

While <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> are used to treat overlapping <\/span>mental health<\/span> disorders, their adverse event and <\/span>side effect<\/span> profiles differ from each other. <\/span>Latuda<\/span> carries a relatively low incidence of diarrhea, while <\/span>Seroquel<\/span> is more likely to cause constipation. <\/span>Seroquel<\/span> is associated with small rates of increased appetite and <\/span>weight gain,<\/span> while <\/span>Latuda<\/span> has no association with those <\/span>adverse effects<\/span>. Both drugs have been linked to <\/span>somnolence<\/span>, but <\/span>Seroquel<\/span> more so. In fact, <\/span>Latuda<\/span> has also been associated with insomnia. Generally speaking, <\/span>Latuda<\/span> has a <\/span>lower incidence of adverse events<\/span><\/a> as compared to <\/span>Seroquel<\/span> and may be better tolerated in the general population.<\/span><\/p>\n

You should always check with your pharmacist or <\/span>healthcare<\/span> provider to get a complete list of adverse events.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\nLatuda<\/b><\/td>\nSeroquel<\/b><\/td>\n<\/tr>\n
Side Effect<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\nApplicable?<\/b><\/td>\nFrequency<\/b><\/td>\n<\/tr>\n
Blurred vision<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n4<\/td>\n<\/tr>\n
Dry mouth<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n44<\/td>\n<\/tr>\n
Hypersecretion\/ salivation<\/td>\nYes<\/td>\n1<\/td>\nNo<\/td>\nn\/a<\/td>\n<\/tr>\n
Constipation<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n10<\/td>\n<\/tr>\n
Diarrhea<\/td>\nYes<\/td>\n5<\/td>\nNo<\/td>\nn\/a<\/td>\n<\/tr>\n
Fatigue<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n10<\/td>\n<\/tr>\n
Weight gain<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n4<\/td>\n<\/tr>\n
Increased appetite<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n5<\/td>\n<\/tr>\n
Arthralgia<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n3<\/td>\n<\/tr>\n
Akathisia<\/td>\nYes<\/td>\n11<\/td>\nYes<\/td>\n4<\/td>\n<\/tr>\n
Somnolence\/ sedation<\/td>\nYes<\/td>\n16<\/td>\nYes<\/td>\n57<\/td>\n<\/tr>\n
Tremor<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n2<\/td>\n<\/tr>\n
Extrapyramidal symptoms (EPS)\/ tardive dyskinesia<\/td>\nNo<\/td>\nn\/a<\/td>\nYes<\/td>\n3<\/td>\n<\/tr>\n
Insomnia<\/td>\nYes<\/td>\n10<\/td>\nNo<\/td>\nn\/a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Source: Daily Med (<\/span>Latuda<\/span><\/a>) Daily Med (<\/span>Seroquel<\/span><\/a>)<\/span><\/p>\n

Drug interactions<\/span> of <\/span>Latuda<\/span> vs. <\/span>Seroquel<\/span><\/h2>\n

Latuda<\/span> and <\/span>Seroquel<\/span> are substrates of the enzyme CYP3A4, meaning their <\/span>metabolism<\/span> is dependent upon this enzyme. Other drugs that either induce or inhibit this enzyme will affect the <\/span>metabolism<\/span> and effects of both drugs.\u00a0<\/span><\/p>\n

Strong <\/span>inhibitors<\/span> of CYP3A4, such as the antifungals ketoconazole or voriconazole, could increase exposure to <\/span>Latuda<\/span> and <\/span>Seroquel<\/span>. This is also the case with the antibiotic clarithromycin, commonly known as Biaxin. Concurrent use of these drugs should be avoided whenever possible.<\/span><\/p>\n

Strong inducers of CYP3A4 will speed up the <\/span>metabolism<\/span> of <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> and decrease their availability and therefore the effectiveness. Examples of drugs that can do this are antiepileptics such as phenytoin or carbamazepine. It is best to avoid concurrent use or make dose adjustments when necessary.<\/span><\/p>\n

This is not meant to be a complete list of interactions. You should always check with your pharmacist or <\/span>healthcare<\/span> provider to get a complete list of potential <\/span>drug interactions<\/span>.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Drug<\/b><\/td>\nDrug Class<\/b><\/td>\nLatuda<\/b><\/td>\nSeroquel<\/b><\/td>\n<\/tr>\n
Hydrocodone<\/p>\n

Oxycodone<\/p>\n

Dihydrocodeine<\/td>\n

Opioid agonists<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Alfuzosin<\/a><\/td>\nAlpha-1 receptor antagonist<\/td>\nno<\/td>\nYes<\/td>\n<\/tr>\n
Alogliptin<\/a><\/td>\nDipeptidyl peptidase-4 (DPP-4) inhibitors<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Amiodarone<\/a><\/td>\nClass III antiarrhythmic<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Azithromycin<\/p>\n

Clarithromycin<\/td>\n

Macrolide antibiotics<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Brexpiprazole<\/p>\n

Olanzapine<\/p>\n

Aripiprazole<\/p>\n

Ziprasidone<\/p>\n

Risperidone<\/td>\n

Atypical antipsychotic medications<\/td>\nYes<\/td>\nNo<\/td>\n<\/tr>\n
Buprenorphine<\/td>\nMixed opiate agonist-antagonist<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Diltiazem<\/td>\nAntihypertensive<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Itraconazole<\/a><\/p>\n

Ketoconazole<\/p>\n

Voriconazole<\/td>\n

Antifungals<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Carbamazepine<\/a><\/p>\n

Phenytoin<\/td>\n

Antiepileptic<\/td>\nYes<\/td>\nYes<\/td>\n<\/tr>\n
Quinidine<\/td>\nAntimalarial drug<\/td>\nNo<\/td>\nYes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Warnings of <\/span>Latuda<\/span> and <\/span>Seroquel<\/span><\/h2>\n

You should avoid <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> in patients with a known hypersensitivity to either drug or a drug in the <\/span>atypical antipsychotic<\/span> class.<\/span><\/p>\n

Both adults and children may experience an increase in depression and suicidal thoughts while on <\/span>antidepressants<\/span> and antipsychotic drugs. Children and young adults seem to experience a more significant increase in depression and suicidal thoughts. This risk exists until medications keep these disorders in remission. These groups should be monitored closely while on these types of medications.<\/span><\/p>\n

Caution should be used in older adult patients, especially those with dementia-related <\/span>psychosis<\/span> or Alzheimer’s disease. An increased risk of cerebrovascular events, such as stroke, is a concern in these patients.<\/span><\/p>\n

Neuroleptic Malignant Syndrome<\/span> (NMS) is a risk of antipsychotic treatment. Symptoms include rigid muscles, altered mental status, and irregular pulse or <\/span>blood pressure<\/span>. While rare, it can be fatal, and patients should be monitored for signs and symptoms.<\/span><\/p>\n

Seroquel<\/span> can cause orthostatic hypotension, sometimes called syncope. This is a drop in <\/span>blood pressure<\/span> that can cause significant dizziness and unsteadiness upon standing. This phenomenon can increase the risk of a fall, especially in older patients.\u00a0<\/span><\/p>\n

Metabolic<\/span> changes are <\/span>possible side effects<\/span> that have been linked to <\/span>atypical antipsychotics<\/span>. This can lead to hyperglycemia (high <\/span>blood sugar<\/span>), dyslipidemia (high <\/span>cholesterol<\/span>), and <\/span>weight gain<\/span>.\u00a0<\/span><\/p>\n

Discontinuation of any antipsychotic medication should be done under the direct supervision of your psychiatrist or medical provider.<\/p>\n

Frequently asked questions about <\/span>Latuda<\/span> vs. <\/span>Seroquel<\/span><\/h2>\n

What is <\/span>Latuda<\/span>?<\/span><\/h3>\n

Latuda<\/span> is an <\/span>atypical antipsychotic<\/span> prescription medication. It has effects on both <\/span>serotonin<\/span> and <\/span>dopamine<\/span> neurotransmitter pathways. It is available in oral tablet form in various strengths.<\/span><\/p>\n

What is <\/span>Seroquel<\/span>?<\/span><\/h3>\n

Seroquel<\/span> is also an <\/span>atypical antipsychotic<\/span> prescription medication. It has effects on both <\/span>serotonin<\/span> and <\/span>dopamine<\/span> neurotransmitter pathways. It is available as oral immediate-release and <\/span>extended-release<\/span> tablets in various strengths.<\/span><\/p>\n

Are <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> the same?<\/span><\/h3>\n

While both <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> are <\/span>atypical antipsychotics<\/span>, they are not the same. They have overlapping indications for use, but also have some unique indications as well.<\/span><\/p>\n

Is <\/span>Latuda<\/span> or <\/span>Seroquel<\/span> better?<\/span><\/h3>\n

Studies<\/span><\/a> show <\/span>Latuda<\/span> to be relatively equal to or superior to <\/span>Seroquel<\/span> in the treatment of <\/span>mental health<\/span> disorders. The choice between the two may come down to the indication it is being used for and the potential for adverse events.<\/span><\/p>\n

Can I use <\/span>Latuda<\/span> or <\/span>Seroquel<\/span> while pregnant?<\/span><\/h3>\n

Latuda and Seroquel lack adequate, well-controlled studies in pregnant women to determine safety. Use should be limited to situations when the benefit clearly outweighs the risks.<\/p>\n

Can I use <\/span>Latuda<\/span> or <\/span>Seroquel<\/span> with alcohol?<\/span><\/h3>\n

Alcohol can cause an altered mental state and <\/span>impairment<\/span>, and while it does not directly interact with <\/span>Latuda<\/span> or <\/span>Seroquel<\/span>, patients taking either drug should limit alcohol intake.<\/span><\/p>\n

Can I take <\/span>Latuda<\/span> and <\/span>Seroquel<\/span> together?<\/span><\/h3>\n

Latuda<\/span> and <\/span>Seroquel<\/span> are not designed to be used together. Your <\/span>healthcare<\/span> provider can help you decide which is best for you.<\/span><\/p>\n

Does <\/span>Latuda<\/span> make you sleepy?<\/span><\/h3>\n

The <\/span>manufacturer<\/span><\/a> does report that a significant number of patients can experience <\/span>somnolence<\/span> on <\/span>Latuda<\/span>. However, insomnia is also reported.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Main differences between Latuda and Seroquel | Conditions treated by Latuda and Seroquel | Is Latuda or Seroquel more effective? | Coverage and cost comparison | Common side effects | Drug interactions | Warnings | FAQ\u00a0 Latuda and Seroquel are two prescription drugs used in the treatment of disorders associated with mental health, primarily schizophrenia […]<\/p>\n","protected":false},"author":15,"featured_media":12632,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8313],"tags":[450,4350],"coauthors":[10437],"class_list":["post-4560","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-vs-drug","tag-mental-health","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nLatuda vs Seroquel: Main differences and similarities<\/title>\n<meta name=\"description\" content=\"Latuda and Seroquel are prescription drugs used to treat schizophrenia. 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