{"id":47448,"date":"2021-11-24T11:50:24","date_gmt":"2021-11-24T16:50:24","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=47448"},"modified":"2025-12-17T12:12:13","modified_gmt":"2025-12-17T17:12:13","slug":"estradiol-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/estradiol-side-effects\/","title":{"rendered":"Estradiol side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\/what-is\"><span style=\"font-weight: 400;\">Estradiol<\/span><\/a><span style=\"font-weight: 400;\"> is a generic prescription medication that is approved by the Food and Drug Administration (FDA) primarily to treat symptoms of menopause, such as hot flashes and vaginal dryness. When taking estradiol or any medication, it\u2019s important to weigh the benefits and risks, including potential side effects.<\/span><\/p>\n<h2 id=\"what-is-estradiol\"><span style=\"font-weight: 400;\">What is estradiol?<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\"><span style=\"font-weight: 400;\">Estradiol (E2)<\/span><\/a><span style=\"font-weight: 400;\"> is the strongest of three forms of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/estrogens\/\"><span style=\"font-weight: 400;\">estrogen<\/span><\/a><span style=\"font-weight: 400;\"> naturally produced by the female body. These also include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estrone\"><span style=\"font-weight: 400;\">estrone (E1)<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estriol\"><span style=\"font-weight: 400;\">estriol (E3)<\/span><\/a><span style=\"font-weight: 400;\">, which are hormones that bind to the body&#8217;s estrogen receptors. Both estradiol and estriol can be used as hormone replacement therapy in postmenopausal women, but estradiol is far more commonly used. Estriol is only available in compounded drugs that are not approved by the Food and Drug Administration (FDA).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Estradiol is available as a tablet, transdermal patch, gel, vaginal cream, or vaginal ring. Estradiol brand names include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/alora\"><span style=\"font-weight: 400;\">Alora<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estrogel\"><span style=\"font-weight: 400;\">Estrogel<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vagifem\"><span style=\"font-weight: 400;\">Vagifem<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/climara\"><span style=\"font-weight: 400;\">Climara<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estrace\"><span style=\"font-weight: 400;\">Estrace<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/menopause-questions-and-answers\/\"><b>Questions to ask your doctor about menopause<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Estradiol with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tEstradiol 1 mg (30 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.74<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/estradiol#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$4.74<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/estradiol#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/estradiol#blog-cta\" class=\"coupon-see-all-btn\">See Estradiol prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n<h2 id=\"common-side-effects-of-estradiol\"><span style=\"font-weight: 400;\">Common side effects of estradiol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many common side effects of estradiol improve with time. A healthcare professional will work with you to find the best form of estradiol for your particular needs. Some of the more common side effects of estradiol <\/span><a href=\"https:\/\/medlineplus.gov\/druginfo\/meds\/a605041.html\"><span style=\"font-weight: 400;\">include:<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal spotting or breakthrough bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breast tenderness or pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach cramps, nausea, or bloating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This isn\u2019t a complete list of common side effects. Talk with your healthcare provider about any new or worsening symptoms you experience after starting estradiol.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Topical estradiol may also cause a skin reaction at the site of patch or gel application.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vaginal cream or rings may cause irritation, itching, or yeast infections.<\/span><\/p>\n<h2 id=\"serious-side-effects-of-estradiol\"><span style=\"font-weight: 400;\">Serious side effects of estradiol<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though serious side effects are not common when taking estradiol, the following may occur:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood clots, heart attack, and stroke<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased risk of cancer in the breast, ovary, and uterus<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gallbladder disease and pancreatitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Intestinal obstruction, vaginal ulcers, or toxic shock syndrome (when using the vaginal ring)\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The risk of serious side effects is typically lower for people using local estradiol replacement in the form of vaginal creams. This isn\u2019t a complete list of possible serious side effects. Your healthcare provider can best help you evaluate the potential risks and benefits of estradiol therapy based on your symptoms and your health conditions.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/female-hormones-and-mental-health\/\"><b>The impact of hormones on women\u2019s mental health<\/b><\/a><\/p>\n<h2 id=\"estradiol-contraindications-and-warnings\"><span style=\"font-weight: 400;\">Estradiol contraindications and warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">There are drug warnings you should be aware of when taking estradiol, and certain people should not take it.<\/span><\/p>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If an overdose is suspected, contact your local poison control center or seek emergency medical attention immediately. Taking too much medication, in the wrong way, or by a person it was not prescribed for may be dangerous. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/estradiol\/dosage\"><span style=\"font-weight: 400;\">Maximum dosage<\/span><\/a><span style=\"font-weight: 400;\"> is as follows for menopausal symptoms, but the actual dosage will vary based on the condition being treated:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Oral<\/b><span style=\"font-weight: 400;\">: 2 mg per day, three weeks on and one week off<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Patch:<\/b><span style=\"font-weight: 400;\"> 0.1 mg per day given in a patch that is replaced once or twice a week<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Topical gel:<\/b><span style=\"font-weight: 400;\"> 1.25 grams per day<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vaginal cream: <\/b><span style=\"font-weight: 400;\">4 grams of .01% cream daily for 2 weeks, tapered to 1 gram one to three times a week\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Vaginal ring<\/b><span style=\"font-weight: 400;\">: One ring every 90 days<\/span><\/li>\n<\/ul>\n<h3 id=\"restrictions\"><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">You should not take <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK549797\/\"><span style=\"font-weight: 400;\">estradiol<\/span><\/a><span style=\"font-weight: 400;\"> if you:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are allergic to estradiol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experience unusual vaginal bleeding that doesn\u2019t have a diagnosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a history of blood clots, breast cancer, or any estrogen-dependent cancer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are pregnant or breastfeeding\u00a0\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have a blood condition that puts you at risk for clots<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Certain patients should use caution when taking estradiol. Tell your healthcare provider if\u00a0 you:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Are older than 65<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have heart disease, high blood pressure, elevated cholesterol, or diabetes\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Smoke tobacco<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Have endometriosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experience migraine headaches or seizures<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">This isn\u2019t a complete list of estradiol precautions. Talk with your healthcare provider about all your current and past health conditions, as well as your family health history.<\/span><\/p>\n<h2 id=\"estradiol-interactions\"><span style=\"font-weight: 400;\">Estradiol interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If you are taking a blood thinner, be sure to let your healthcare provider know, as adverse effects may occur. The <\/span><a href=\"https:\/\/www.mayoclinic.org\/drugs-supplements\/estradiol-transdermal-route\/before-using\/drg-20075306\"><span style=\"font-weight: 400;\">following prescription drugs<\/span><\/a><span style=\"font-weight: 400;\"> should be avoided when taking estradiol:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fezolinetant (treats hot flashes)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tranexamic acid (promotes blood clotting)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Many other drugs and supplements can interact with estradiol, so be sure to tell your healthcare provider about all medications you are taking, including over-the-counter and prescribed medications, vitamins, and supplements. You may need to adjust the dose of one or more medications.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you are taking estradiol, it\u2019s important that you do not smoke or use tobacco products. Smoking combined with estradiol can increase your risk of blood clots, stroke, high blood pressure, and heart attack.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Avoid grapefruit<\/span> <span style=\"font-weight: 400;\">and products containing grapefruit because they may raise estradiol levels in the body.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Consult with your healthcare provider about drinking alcohol<\/span><b>.<\/b><span style=\"font-weight: 400;\"> Some studies have shown that alcohol <\/span><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11629438\/\"><span style=\"font-weight: 400;\">increases the risk<\/span><\/a><span style=\"font-weight: 400;\"> of breast cancer and other types of cancer.\u00a0<\/span><\/p>\n<h2 id=\"how-to-avoid-estradiol-side-effects\"><span style=\"font-weight: 400;\">How to avoid estradiol side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The best way to prevent estradiol side effects is to take it as prescribed and according to the drug information contained in the package insert. How often you take estradiol will depend on the form and your individual circumstances. Other ways to avoid side effects include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">To avoid an upset stomach, take the oral form of estradiol with food or shortly after eating, and take it at the same time each day.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you are using the gel form of estradiol, you can apply it at any time of the day, but be sure to do so around the same time each day to minimize side effects.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">If you miss a dose and it\u2019s more than 12 hours before your next dose, take the missed dose right away. Otherwise, skip the dose and wait until it is time to take your next one.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Take the minimum effective dose of estradiol. Your healthcare provider will monitor your symptoms and side effects on a regular basis.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Get regular checkups and routine screening tests as recommended by your healthcare provider.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tell your healthcare provider about any persistent or unusual vaginal bleeding. You may need additional tests to find out the cause. You may also be given an additional hormone called a progestin to take together with estradiol.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Estradiol is available in many forms to treat symptoms associated with menopause. Its benefits outweigh the risks for most people who take it, but it\u2019s not right for everyone. To decrease the risks of common or serious side effects, only take estradiol as prescribed by a qualified healthcare provider.<\/span><\/p>\n<p><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/resources\/estrogen\">Estrogen Costs &amp; Coupons<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Estradiol is a generic prescription medication that is approved by the Food and Drug Administration (FDA) primarily to treat symptoms of menopause, such as hot flashes and vaginal dryness. When taking estradiol or any medication, it\u2019s important to weigh the benefits and risks, including potential side effects. What is estradiol? Estradiol (E2) is the strongest [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":47450,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,8670],"coauthors":[8861],"class_list":["post-47448","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Estradiol side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"Estradiol side effects tend to be mild and improve over time. 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