{"id":48022,"date":"2022-01-12T16:20:33","date_gmt":"2022-01-12T21:20:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=48022"},"modified":"2022-01-12T16:43:48","modified_gmt":"2022-01-12T21:43:48","slug":"novolog-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/novolog-side-effects\/","title":{"rendered":"Novolog side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"#common-side-effects\">Novolog side effects<\/a> | <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#hypoglycemia\">Hypoglycemia<\/a> | <a href=\"#weight-gain\">Weight gain<\/a> | <a href=\"#how-long-do-side-effects-last\">How long do side effects last?<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a> | <a href=\"#resources\">Resources<\/a><\/p>\n<p><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> is a <\/span><span style=\"font-weight: 400;\">brand-name,<\/span> <span style=\"font-weight: 400;\">fast-acting <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/insulins\"><span style=\"font-weight: 400;\">insulin<\/span><\/a><span style=\"font-weight: 400;\"> that helps reduce mealtime blood sugar spikes in people with <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes mellitus<\/span><\/a><span style=\"font-weight: 400;\">. The active ingredient in <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">insulin aspart<\/span><span style=\"font-weight: 400;\">, is a manmade insulin analog that works faster and for a shorter duration than regular human insulin. Most people taking <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> may also be prescribed a <\/span><span style=\"font-weight: 400;\">long-acting<\/span><span style=\"font-weight: 400;\"> insulin to maintain fasting <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-blood-glucose-levels\/\"><span style=\"font-weight: 400;\">blood sugar levels<\/span><\/a><span style=\"font-weight: 400;\"> throughout the day.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">All insulins, from <\/span><span style=\"font-weight: 400;\">rapid-acting<\/span><span style=\"font-weight: 400;\"> to <\/span><span style=\"font-weight: 400;\">long-acting<\/span><span style=\"font-weight: 400;\"> insulins, have <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\">. Some side effects, like <\/span><span style=\"font-weight: 400;\">low blood sugar (hypoglycemia)<\/span><span style=\"font-weight: 400;\">, are common in people who are taking insulin. Knowing what <\/span><span style=\"font-weight: 400;\">side effects<\/span><span style=\"font-weight: 400;\"> to expect, what pre-existing conditions might cause problems, and potential <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> can help people avoid problems during insulin treatment.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/prescription\/novolog\/what-is\">Learn more about Novolog<\/a><\/strong><\/p>\n<h2 id=\"common-side-effects\">Common side effects of Novolog<\/h2>\n<p><span style=\"font-weight: 400;\">The most <\/span><span style=\"font-weight: 400;\">common side effects of Novolog<\/span><span style=\"font-weight: 400;\"> are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">H<\/span><span style=\"font-weight: 400;\">ypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Injection site<\/span><span style=\"font-weight: 400;\"> reactions, such as redness or swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Urinary tract infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sinusitis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sensory disturbances<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slowed reflexes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling in the arms or legs (peripheral edema)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Source: <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">DailyMed<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/244005\/NovoLog\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Epocrates<\/span><\/a><\/p>\n<h2 id=\"serious-side-effects\">Serious side effects of Novolog<\/h2>\n<p><span style=\"font-weight: 400;\">The most <\/span><span style=\"font-weight: 400;\">serious side effects<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> are<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe hypoglycemia<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low potassium levels<\/span><span style=\"font-weight: 400;\"> (<\/span><span style=\"font-weight: 400;\">hypokalemia<\/span><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe <\/span><span style=\"font-weight: 400;\">allergic reactions,<\/span><span style=\"font-weight: 400;\"> including anaphylaxis<\/span><\/li>\n<\/ul>\n<h3 id=\"hypoglycemia\">Novolog and hypoglycemia<\/h3>\n<p><span style=\"font-weight: 400;\">Hypoglycemia<\/span><span style=\"font-weight: 400;\"> (defined as <\/span><a href=\"https:\/\/www.diabetes.org\/healthy-living\/medication-treatments\/blood-glucose-testing-and-control\/hypoglycemia\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">less than 70<\/span><\/a><span style=\"font-weight: 400;\"> milligrams of <\/span><span style=\"font-weight: 400;\">glucose<\/span><span style=\"font-weight: 400;\"> per deciliter of blood) is the most common <\/span><span style=\"font-weight: 400;\">side effect of insulin<\/span><span style=\"font-weight: 400;\"> treatment. Most people taking insulin products like <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> can reasonably expect to experience <\/span><span style=\"font-weight: 400;\">low blood sugar<\/span><span style=\"font-weight: 400;\"> at some point during treatment, even if it is a mild case. <\/span><a href=\"https:\/\/drc.bmj.com\/content\/6\/1\/e000503\"><span style=\"font-weight: 400;\">Studies<\/span><\/a><span style=\"font-weight: 400;\"> show that around 75% of people taking insulin for <\/span><span style=\"font-weight: 400;\">Type 1 diabetes<\/span><span style=\"font-weight: 400;\"> and over 50% of people taking insulin for <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\"> may experience at least one incident of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> in a given year.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Severe hypoglycemia<\/span><span style=\"font-weight: 400;\"> is a serious and potentially <\/span><span style=\"font-weight: 400;\">life-threatening<\/span><span style=\"font-weight: 400;\"> complication of insulin therapy that will require immediate medical attention. Even mild <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> can have serious consequences if ignored. <\/span><span style=\"font-weight: 400;\">Low blood sugar levels can<\/span><span style=\"font-weight: 400;\"> impair concentration and reduce reaction time, putting people at risk for accidental injury, particularly if they\u2019re driving or operating machinery.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A number of factors can raise the risk of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\">: the <\/span><span style=\"font-weight: 400;\">type of insulin used<\/span><span style=\"font-weight: 400;\">, the timing of injections, the use of antidiabetic medications, and changes in physical activity, diet, or <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2190773\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">injection sites<\/span><\/a><span style=\"font-weight: 400;\">. The first way to manage hypoglycemia is to be aware of the <\/span><a href=\"https:\/\/www.mynovoinsulin.com\/insulin-products\/novolog\/side-effects.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">signs of <\/span><span style=\"font-weight: 400;\">low blood sugar<\/span><\/a><span style=\"font-weight: 400;\">. People who are prescribed Novolog should recognize hypoglycemia symptoms, test their <\/span><span style=\"font-weight: 400;\">blood sugar regularly<\/span><span style=\"font-weight: 400;\">, and understand how to fix <\/span><span style=\"font-weight: 400;\">low blood sugar<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3 id=\"weight-gain\">Novolog and weight gain<\/h3>\n<p><span style=\"font-weight: 400;\">Weight gain<\/span><span style=\"font-weight: 400;\"> is a possible <\/span><span style=\"font-weight: 400;\">side effect of insulin<\/span><span style=\"font-weight: 400;\"> treatment, and there may be a number of <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17924864\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">reasons<\/span><\/a><span style=\"font-weight: 400;\"> why this may happen. People taking insulin may experience increased appetite, for example. Insulin normally transports <\/span><span style=\"font-weight: 400;\">glucose from food<\/span><span style=\"font-weight: 400;\"> into the body\u2019s cells to be used for energy. However, if more calories are eaten than burned off, there may be excess <\/span><span style=\"font-weight: 400;\">glucose for the cells to use. This excess glucose<\/span><span style=\"font-weight: 400;\"> may be converted into fat.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are ways to control <\/span><span style=\"font-weight: 400;\">weight gain<\/span><span style=\"font-weight: 400;\"> while on insulin. The most practical way to manage weight is to eat an appropriate diet and stay consistent with physical activity. Your healthcare provider or nutritionist can help design a dietary plan for you to follow while taking insulin. The American Diabetes Association recommends <\/span><a href=\"https:\/\/www.diabetes.org\/healthy-living\/fitness\/weekly-exercise-targets\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">150 minutes<\/span><\/a><span style=\"font-weight: 400;\"> of moderate-intensity exercise each week, and these minutes can be split up across different days. For example, you might choose to go for a brisk walk for 30 minutes during the workweek. In order to manage weight, a doctor may also prescribe appetite-suppressing drugs, such as Victoza (liraglutide), or oral antidiabetic medications, such as Glucophage (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin-hcl\"><span style=\"font-weight: 400;\">metformin<\/span><\/a><span style=\"font-weight: 400;\">).\u00a0<\/span><\/p>\n<h2 id=\"how-long-do-side-effects-last\">How long do side effects last?<\/h2>\n<p><span style=\"font-weight: 400;\">Side effects are generally mild and temporary when using Novolog as prescribed. Novolog provides peak blood sugar-lowering effects within one to three hours, and the blood sugar-lowering effects generally last for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">three to five<\/span><\/a><span style=\"font-weight: 400;\"> hours. The duration of side effects associated with hypoglycemia will depend on the amount of insulin taken, blood sugar levels, and the severity of symptoms. The use of other insulins or antidiabetic medications can also affect the incidence and severity of hypoglycemia. Some <\/span><span style=\"font-weight: 400;\">side effects,<\/span><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">weight gain<\/span><span style=\"font-weight: 400;\">, severe <\/span><span style=\"font-weight: 400;\">hypersensitivity<\/span><span style=\"font-weight: 400;\"> reactions, and skin changes, may take days to months to resolve.\u00a0<\/span><\/p>\n<h2 id=\"warnings\">Novolog contraindications &amp; warnings<\/h2>\n<p><span style=\"font-weight: 400;\">Insulin is a life-saving medication that may cause problems in certain people. Some people may be at a higher risk of complications and side effects than others.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Insulin products, such as <\/span><span style=\"font-weight: 400;\">Novolog,<\/span><span style=\"font-weight: 400;\"> do not cause physical dependence or withdrawal symptoms. Insulin is not abused as a recreational drug.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">An overdose of <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> could lead to <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">hypokalemia<\/span><span style=\"font-weight: 400;\">. Depending on the dose of insulin given, the effects of an overdose could be minor and readily corrected. However, if the dose is large enough, <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> could cause potentially <\/span><span style=\"font-weight: 400;\">life-threatening<\/span> <span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> that will require immediate treatment. People who are taking <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> may be prescribed a <\/span><span style=\"font-weight: 400;\">glucagon<\/span><span style=\"font-weight: 400;\"> kit to administer if blood sugar levels get too low. If not, emergency medical treatment may be warranted.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Restrictions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hypoglycemia<\/span><span style=\"font-weight: 400;\">, hypokalemia, and severe <\/span><span style=\"font-weight: 400;\">allergic reactions<\/span><span style=\"font-weight: 400;\"> are the most serious side effects when taking <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\">. People with allergies to <\/span><span style=\"font-weight: 400;\">insulin aspart<\/span><span style=\"font-weight: 400;\"> should not use Novolog. In addition, <\/span><span style=\"font-weight: 400;\">people who are experiencing<\/span> <span style=\"font-weight: 400;\">hypoglycemia or hypokalemia<\/span><span style=\"font-weight: 400;\"> should avoid the use of Novolog.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some pre-existing conditions increase the risk of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> when taking insulin. These conditions include kidney or liver problems. Illness, infection, or high stress levels can also alter <\/span><span style=\"font-weight: 400;\">blood sugar levels<\/span><span style=\"font-weight: 400;\">. Increased <\/span><span style=\"font-weight: 400;\">glucose<\/span><span style=\"font-weight: 400;\"> monitoring and more frequent <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> dose adjustments may be required in people at risk of hypoglycemia.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People with vision problems who are taking insulin may be at an increased <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/NovoLog-insulin-aspart--rDNA-origin--456.3612\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">risk of medication errors<\/span><\/a><span style=\"font-weight: 400;\">, such as injecting the wrong insulin or getting the dose wrong. If visual impairment is severe enough, it may be safer for insulin injections to be administered by a caregiver.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Pregnancy and nursing<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The <\/span><span style=\"font-weight: 400;\">FDA<\/span><span style=\"font-weight: 400;\"> has approved <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> to treat gestational diabetes, so <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> may prescribe <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> to pregnant women. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Clinical studies<\/span><\/a><span style=\"font-weight: 400;\"> on the safety of <\/span><span style=\"font-weight: 400;\">insulin aspart<\/span><span style=\"font-weight: 400;\"> have only focused on the second trimester, but both clinical experience and animal studies have shown no evidence that <\/span><span style=\"font-weight: 400;\">insulin aspart<\/span><span style=\"font-weight: 400;\"> harms the fetus, causes birth defects, or affects pregnancy.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> is prescribed to women who are <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\">. Because there are no studies on the presence of <\/span><span style=\"font-weight: 400;\">insulin aspart<\/span><span style=\"font-weight: 400;\"> in human milk or its effects on a nursing infant, women should get <\/span><span style=\"font-weight: 400;\">medical advice<\/span><span style=\"font-weight: 400;\"> from a <\/span><span style=\"font-weight: 400;\">healthcare professional<\/span><span style=\"font-weight: 400;\"> before taking <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> while <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> is <\/span><span style=\"font-weight: 400;\">FDA-<\/span><span style=\"font-weight: 400;\">approved to treat children as young as 2 years of age for <\/span><span style=\"font-weight: 400;\">Type 1 diabetes<\/span><span style=\"font-weight: 400;\">. Although some <\/span><span style=\"font-weight: 400;\">healthcare providers<\/span><span style=\"font-weight: 400;\"> may prescribe <\/span><span style=\"font-weight: 400;\">Novolog<\/span> <a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> to children with <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\">, Novolog has not been determined as safe and effective for treating <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\"> in children.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Seniors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> was effective in adults of all ages. Adults older than 65 may be more likely to experience <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> while taking insulin, so frequent <\/span><span style=\"font-weight: 400;\">blood sugar<\/span><span style=\"font-weight: 400;\"> monitoring and dose adjustments may be necessary.<\/span><\/p>\n<h2 id=\"interactions\">Novolog interactions<\/h2>\n<p><span style=\"font-weight: 400;\">As an insulin product, <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\">\u2019s most significant <\/span><span style=\"font-weight: 400;\">drug interactions<\/span><span style=\"font-weight: 400;\"> involve drugs that affect blood sugar. In some cases, patients will have to closely monitor their <\/span><span style=\"font-weight: 400;\">blood glucose<\/span><span style=\"font-weight: 400;\"> when taking other antidiabetic drugs while on insulin.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Oral antidiabetic medications are frequently combined with insulin therapy, but the addition of antidiabetic medications may increase the risk of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/thiazolidinediones\"><span style=\"font-weight: 400;\">Thiazolidinediones<\/span><\/a><span style=\"font-weight: 400;\"> (TZDs) are antidiabetic drugs that are used cautiously with insulin treatment. Also called glitazones, TZDs may cause <\/span><span style=\"font-weight: 400;\">fluid retention<\/span><span style=\"font-weight: 400;\">, especially when combined with insulin. Fluid retention could worsen <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/congestive-heart-failure-treatment-and-medications\"><span style=\"font-weight: 400;\">heart failure<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some types of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-pressure-treatment-and-medications\"><span style=\"font-weight: 400;\">blood pressure medications<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ace-inhibitors\/\"><span style=\"font-weight: 400;\">ACE inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/angiotensin-ii-receptor-blockers\"><span style=\"font-weight: 400;\">ARBs<\/span><\/a><span style=\"font-weight: 400;\">), salicylates (aspirin and related drugs), fluoroquinolone antibiotics, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/sulfonamides\/\"><span style=\"font-weight: 400;\">sulfonamide antibiotics<\/span><\/a><span style=\"font-weight: 400;\"> can increase insulin sensitivity, enhancing the <\/span><span style=\"font-weight: 400;\">effects of insulin<\/span><span style=\"font-weight: 400;\"> therapy. Aspirin and salicylates increase insulin secretion. People taking these medications while using insulin may need to be monitored for hypoglycemia.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some drugs such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">beta-blockers<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">reserpine<\/span><span style=\"font-weight: 400;\"> can mask the <\/span><span style=\"font-weight: 400;\">symptoms of low blood sugar<\/span><span style=\"font-weight: 400;\">, increasing the risk of <\/span><span style=\"font-weight: 400;\">severe hypoglycemia<\/span><span style=\"font-weight: 400;\">. People taking these drugs with insulin may require <\/span><span style=\"font-weight: 400;\">blood glucose<\/span><span style=\"font-weight: 400;\"> monitoring.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some drugs can elevate blood sugar levels, canceling out the benefits of insulin. These include <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\"><span style=\"font-weight: 400;\">corticosteroids<\/span><\/a><span style=\"font-weight: 400;\">, diuretics, <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">atypical antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">, birth control pills, sympathomimetic medications (such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/epinephrine\"><span style=\"font-weight: 400;\">epinephrine<\/span><\/a><span style=\"font-weight: 400;\">), female hormone therapies, and <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypothyroidism-treatment-and-medications\"><span style=\"font-weight: 400;\">thyroid hormones<\/span><\/a><span style=\"font-weight: 400;\">. Dose adjustments may be needed to ensure that the insulin is working as it should.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some drugs, such as alcohol, beta-blockers, clonidine, and lithium salts, can cause increased or decreased blood sugar levels.<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\">How to avoid Novolog side effects<\/h2>\n<p><span style=\"font-weight: 400;\">Insulin treatment is a life-saver for millions of people, but it may require patients to learn how to administer injections safely, monitor <\/span><span style=\"font-weight: 400;\">glucose levels<\/span><span style=\"font-weight: 400;\">, and know when to get medical help. Here are a few general tips for maximizing the benefits of <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> insulin while avoiding problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Tell the prescribing <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> about all <\/span><span style=\"font-weight: 400;\">medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The prescribing <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\"> will need a complete medical history and be updated when anything changes. In particular, make sure the prescriber knows if you have a history of:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver or kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy or pregnancy plans<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">breastfeeding<\/span><span style=\"font-weight: 400;\"> plans<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">They will also need to know about other drugs and <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\"> you may be taking. As a general rule, keep a written list of any prescription drugs, <\/span><span style=\"font-weight: 400;\">over-the-counter<\/span><span style=\"font-weight: 400;\"> medications, dietary <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\">, or herbal <\/span><span style=\"font-weight: 400;\">supplements<\/span><span style=\"font-weight: 400;\"> you are taking. If a new drug or <\/span><span style=\"font-weight: 400;\">supplement<\/span><span style=\"font-weight: 400;\"> is started, make sure both the prescriber and the pharmacist know about it.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Take <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">You should only use insulin as prescribed by your healthcare provider. Follow the directions given by the prescriber and those written on the prescription label. It may also be helpful to read the <\/span><span style=\"font-weight: 400;\">patient information<\/span><span style=\"font-weight: 400;\"> sheet packaged with the prescription.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Read the instructions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The <\/span><span style=\"font-weight: 400;\">Novolog<\/span> <span style=\"font-weight: 400;\">patient information<\/span><span style=\"font-weight: 400;\"> sheet contains illustrated step-by-step instructions for giving injections using a standard <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/insulin-syringe\"><span style=\"font-weight: 400;\">insulin syringe<\/span><\/a><span style=\"font-weight: 400;\">, reusable <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/novolog-penfill\"><span style=\"font-weight: 400;\">PenFill<\/span><span style=\"font-weight: 400;\"> injector<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/novolog-flexpen\"><span style=\"font-weight: 400;\">Novolog FlexPen<\/span><\/a><span style=\"font-weight: 400;\">, or <\/span><span style=\"font-weight: 400;\">Novolog<\/span> <span style=\"font-weight: 400;\">FlexTouch<\/span> <span style=\"font-weight: 400;\">insulin pen<\/span><span style=\"font-weight: 400;\">. Read these instructions before each injection to ensure that injections are given properly, safely, and with the appropriate dose. People who are using <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> in an <\/span><span style=\"font-weight: 400;\">insulin pump<\/span><span style=\"font-weight: 400;\"> can follow illustrated instructions for filling the pump reservoir from the pump manufacturer.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Always check the medicine before giving an injection<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Side effects<\/span><span style=\"font-weight: 400;\">, especially <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\">, are frequently the result of medication errors. Always check the insulin product before giving an injection. Make sure it is the right type of insulin, whether it be a fast-acting or long-acting insulin. Check the <\/span><span style=\"font-weight: 400;\">expiration date<\/span><span style=\"font-weight: 400;\">. If it\u2019s expired, don\u2019t use it.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Choose a different <\/span><span style=\"font-weight: 400;\">injection site<\/span><span style=\"font-weight: 400;\"> for each injection<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Insulin users will give themselves several injections per day on their <\/span><span style=\"font-weight: 400;\">upper arms<\/span><span style=\"font-weight: 400;\">, stomach area, thighs, or buttocks. It is important to choose different areas for injections regularly. Giving injections repeatedly in one spot increases the risk of <\/span><span style=\"font-weight: 400;\">lipodystrophy<\/span><span style=\"font-weight: 400;\"> (pitting or thickening of the skin) or local <\/span><span style=\"font-weight: 400;\">cutaneous amyloidosis<\/span><span style=\"font-weight: 400;\"> (skin with lumps). In addition, injecting insulin into areas of the skin with lipodystrophy may increase the risk of <\/span><span style=\"font-weight: 400;\">side effects,<\/span><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Eat a meal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Eat a meal within five to 10 minutes of a <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> injection. <\/span><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> is fast-acting, so waiting too long to eat after an injection could increase the risk of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Check <\/span><span style=\"font-weight: 400;\">blood sugar levels<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Monitor <\/span><span style=\"font-weight: 400;\">blood glucose<\/span><span style=\"font-weight: 400;\"> levels as instructed by a <\/span><span style=\"font-weight: 400;\">healthcare provider<\/span><span style=\"font-weight: 400;\">. A fingerstick test with a glucose meter can be used. Some people may decide to use a continuous <\/span><span style=\"font-weight: 400;\">blood glucose<\/span><span style=\"font-weight: 400;\"> meter, especially if they are at an increased risk of insulin complications.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Avoid alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol lowers blood sugar, raising the risk of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> when taking insulin. If you drink alcohol, make sure to eat a small snack with it.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">9. Know the <\/span><span style=\"font-weight: 400;\">symptoms of low blood sugar<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hypoglycemia<\/span><span style=\"font-weight: 400;\"> is a common <\/span><span style=\"font-weight: 400;\">side effect of insulin<\/span><span style=\"font-weight: 400;\"> therapy. If ignored, it could turn into a medical emergency. Be vigilant for <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3784865\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">signs of <\/span><span style=\"font-weight: 400;\">low blood sugar<\/span><\/a><span style=\"font-weight: 400;\">, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hunger<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shakiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pale skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chills<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Problems with coordination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irregular or fast heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slurred speech<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">10. Know when to get help<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Get emergency help if you experience:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shortness of breath<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the face, mouth, or throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe drowsiness, dizziness, or confusion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fainting<\/span><\/li>\n<\/ul>\n<h2 id=\"resources\">Resources<\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3784865\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Hypoglycemia<\/span><span style=\"font-weight: 400;\">: The neglected complication<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Indian Journal of Endocrinology and Metabolism<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/NovoLog-insulin-aspart--rDNA-origin--456.3612\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Insulin aspart<\/span><span style=\"font-weight: 400;\"> rDNA origin drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17924864\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Insulin-associated <\/span><span style=\"font-weight: 400;\">weight gain<\/span><span style=\"font-weight: 400;\"> in diabetes\u2014causes, effects and coping strategies<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Diabetes, Obesity, &amp; Metabolism<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.dvm360.com\/view\/insulin-therapy-dogs-and-cats-proceedings-0\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Insulin therapy in dogs and cats<\/span><\/a><span style=\"font-weight: 400;\">, DVM360<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/244001\/NovoLog\/Adult-Dosing\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Novolog<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=3a1e73a2-3009-40d0-876c-b4cb2be56fc5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Novolog<\/span><span style=\"font-weight: 400;\"> prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27161418\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Rates and predictors of hypoglycaemia in 27 585 people from 24 countries with insulin-treated Type 1 and <\/span><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><span style=\"font-weight: 400;\">: the global HAT study<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Diabetes, Obesity, &amp; Metabolism<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/drc.bmj.com\/content\/6\/1\/e000503\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Real-world crude incidence of <\/span><span style=\"font-weight: 400;\">hypoglycemia<\/span><span style=\"font-weight: 400;\"> in adults with diabetes: Results of the InHypo-DM Study, Canada<\/span><\/a><span style=\"font-weight: 400;\">, BMJ Open Diabetes Research &amp; Care<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Novolog side effects | Serious side effects | Hypoglycemia | Weight gain | How long do side effects last? | Warnings | Interactions | How to avoid side effects | Resources Novolog is a brand-name, fast-acting insulin that helps reduce mealtime blood sugar spikes in people with diabetes mellitus. The active ingredient in Novolog, insulin [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":48024,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,10298,788,12752],"coauthors":[8861],"class_list":["post-48022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-diabetes","tag-drug-safety","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Novolog side effects, warning, interactions, and how to avoid them<\/title>\n<meta name=\"description\" content=\"Headache, nausea, and diarrhea are common Novolog side effects. 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