{"id":50284,"date":"2022-03-31T14:55:33","date_gmt":"2022-03-31T18:55:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=50284"},"modified":"2025-10-02T17:26:44","modified_gmt":"2025-10-02T21:26:44","slug":"lisinopril-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/lisinopril-alternatives\/","title":{"rendered":"Lisinopril alternatives: What can I take instead of lisinopril?"},"content":{"rendered":"

Lisinopril<\/span><\/a> is one of the most prescribed medications for <\/span>hypertension<\/span><\/a> (high blood pressure) and is often known by the brand names <\/span>Prinivil<\/span><\/a> (discontinued) and <\/span>Zestril<\/span><\/a>. Besides being an antihypertensive, lisinopril is also approved by the Food and Drug Administration (FDA) for treating heart failure and improving survival after a heart attack. Althoughde its use is widespread, lisinopril is not irreplaceable. Several lisinopril alternatives exist, providing options for times when lisinopril is contraindicated or its <\/span>side effects<\/span><\/a> are intolerable.<\/span><\/p>\n

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Save up to 80% on Lisinopril with SingleCare<\/p>\n\t\t\t

Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t

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\n\t\t\t\t\tLisinopril 10 mg (90 Tablets)\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\"Kroger\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$6.76\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\"Harris\t\t\t<\/div>\n\t\t\t
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\n\t\t\t\t\t$6.76\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\ti<\/span>\n\t\t\t\t\tPrice with signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t
\n\t\t\t\tGet free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\tSee Lisinopril prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t<\/span><\/p>\n

What can I take in place of lisinopril?<\/span><\/h2>\n

There are many other options available to treat high blood pressure. These alternative prescription medications include other types of <\/span>angiotensin-converting enzyme inhibitors (ACE inhibitors)<\/span><\/a> or other classes of blood pressure medications such as <\/span>angiotensin II receptor blockers (ARBs)<\/span><\/a>, <\/span>calcium channel blockers<\/span><\/a>, and <\/span>diuretics<\/span><\/a>. These options may be more suitable for certain people due to their different uses, side effects, and dosages.<\/span><\/p>\n

For children and those who have trouble swallowing, <\/span>Qbrelis<\/span><\/a> is the oral liquid version of lisinopril. It can be a good alternative in cases when it\u2019s not feasible to switch to a completely new drug.<\/span><\/p>\n

Top 5 lisinopril alternatives<\/span><\/h2>\n

1. Lotensin (benazepril)<\/span><\/h3>\n

Benazepril<\/span><\/a> is an ACE inhibitor in the same class as lisinopril and <\/span>works just as well<\/span><\/a> to lower blood pressure. Both drugs share similar side effects, with cough, dizziness, and headache among the most common. Although benazepril doesn\u2019t carry FDA approval for heart failure or use after a heart attack, it is available in more combination products than lisinopril. Benazepril can be found as a combination drug with hydrochlorothiazide (<\/span>Lotensin HCT<\/span><\/a>) and amlodipine (<\/span>Lotrel<\/span><\/a>), while lisinopril is only paired with hydrochlorothiazide (Prinzide, Zestoretic).<\/span><\/p>\n

Related:<\/b> Benazepril dosage<\/b><\/a><\/p>\n

2. Diovan (valsartan)<\/span><\/h3>\n

A dry, tickling cough is a side effect that affects many people taking ACE inhibitors, often resulting in a search for alternatives. That search might land on valsartan, part of the ARB drug class that includes <\/span>Cozaar<\/span><\/a> (losartan), <\/span>Benicar<\/span><\/a> (olmesartan), and <\/span>Atacand<\/span><\/a> (candesartan).\u00a0<\/span><\/p>\n

ARBs work through a slightly different pathway but provide similar cardiovascular and kidney protection. Like lisinopril, valsartan is approved for high blood pressure, heart failure, and post\u2013heart attack treatment, which makes it a versatile substitute.<\/span><\/p>\n

Another advantage of valsartan is the availability of combination drugs. Valsartan is often paired with HCTZ <\/span>(Diovan HCT)<\/span><\/a>, amlodipine <\/span>(Exforge)<\/span><\/a>, and both HCTZ and amlodipine <\/span>(Exforge HCT)<\/span><\/a>.<\/span><\/p>\n

3. Hydrochlorothiazide (HCTZ)<\/span><\/h3>\n

Hydrochlorothiazide is a <\/span>thiazide diuretic<\/span><\/a> that lowers blood pressure by helping the kidneys remove excess salt and water. Unlike lisinopril, which can raise potassium, HCTZ may lower potassium levels. For those with high potassium levels on lisinopril, HCTZ may be a viable alternative.\u00a0<\/span><\/p>\n

HCTZ is widely available as a low-cost generic and is often used in combination with other blood pressure drugs for added effect. Pairing it with an ACE inhibitor such as lisinopril has a proven <\/span>synergistic effect<\/span><\/a>, but it can also be prescribed alone or in other fixed-dose combinations.<\/span><\/p>\n

4. Norvasc (amlodipine)<\/span><\/h3>\n

Amlodipine is a calcium channel blocker that relaxes blood vessels to lower blood pressure. Unlike lisinopril, it does not affect potassium levels or kidney function, making it a valuable alternative for patients with electrolyte imbalances. <\/span>Common side effects<\/span><\/a> include ankle swelling, flushing, and headache.<\/span><\/p>\n

While amlodipine is a <\/span>first-line option<\/span><\/a> for hypertension, it is not approved for heart failure with reduced ejection fraction and may worsen edema in some patients. Still, its once-daily dosing, good tolerability, and availability in combination pills (such as with valsartan in Exforge) make it a practical substitute or add-on therapy.<\/span><\/p>\n

RELATED: <\/b>How does lisinopril affect your kidneys?<\/b><\/a><\/p>\n

5. Toprol XL (metoprolol succinate)<\/span><\/h3>\n

Metoprolol succinate is a <\/span>beta blocker<\/span><\/a> that can lower blood pressure and decrease stress on the heart. Unlike lisinopril, it does not affect potassium levels or cause cough, but side effects can include fatigue, dizziness, and low heart rate.\u00a0<\/span><\/p>\n

Beta blockers are not usually the first choice for uncomplicated hypertension. However, metoprolol succinate is approved for hypertension, chest pain, and heart failure, which makes it a potential lisinopril alternative. Toprol XL\u2019s once-daily dosing is also convenient for many when a beta blocker is needed.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Compare Lisinopril alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Zestril (lisinopril)<\/span><\/td>\n$1,434 per 90, 10 mg tablets<\/span><\/td>\n$7 per 90, 10 mg tablets of generic Zestril<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Vasotec (enalapril)<\/span><\/td>\n$1,003 per 30, 20 mg tablets<\/span><\/td>\n$9 per 30, 20 mg tablets of generic Vasotec<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Lotensin (benazepril)<\/span><\/td>\n$75 per 30, 10 mg tablets<\/span><\/td>\n$8 per 30, 10 mg tablets of generic Lotensin<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Microzide (HCTZ)<\/span><\/td>\n$19 per 30, 25 mg tablets<\/span><\/td>\n$4 per 30, 25 mg tablets of generic Microzide<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Zestoretic (combination lisinopril\/hydrochlorothiazide)<\/span><\/td>\n$483 per 30, 20-12.5 mg tablets<\/span><\/td>\n$3 per 30, 20-12.5 mg tablets of generic Zestoretic<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cozaar (losartan)<\/span><\/td>\n$682 per 90, 100 mg tablets<\/span><\/td>\n$11 per 90, 100 mg tablets of generic Cozaar<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Diovan (valsartan)<\/span><\/td>\n$1,135 per 90, 160 mg tablets<\/span><\/td>\n$29 per 90, 160 mg tablets of generic Diovan<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Norvasc (amlodipine)<\/span><\/td>\n$419 per 30, 10 mg tablets<\/span><\/td>\n$4 per 30, 10 mg tablets of generic Norvasc<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cardizem CD (diltiazem extended release)<\/span><\/td>\n$3,128 per 90, 120 mg capsules<\/span><\/td>\n$6 per 30, 120 mg capsules of generic Cardizem CD<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Toprol XL (metoprolol extended release)<\/span><\/td>\n$160 per 90, 25 mg tablet<\/span><\/td>\n$9 per 90, 25 mg tablet of generic Toprol XL<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cardura (doxazosin)<\/span><\/td>\n$674 per 90, 4 mg tablets<\/span><\/td>\n$16 per 90, 4 mg tablets of generic Cardura<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
Drug prices fluctuate and vary by pharmacy and location. These are the most current prices as of the time of publication.\u00a0<\/span><\/i><\/h5>\n

Natural alternatives to lisinopril<\/span><\/h2>\n

Before resorting to lisinopril or other prescription drugs for hypertension, a healthcare provider may recommend lifestyle changes, which can be used alone or combined with drug therapy:\u00a0<\/span><\/p>\n