{"id":50513,"date":"2022-05-15T00:17:35","date_gmt":"2022-05-15T04:17:35","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=50513"},"modified":"2025-10-07T15:03:42","modified_gmt":"2025-10-07T19:03:42","slug":"premarin-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/premarin-alternatives\/","title":{"rendered":"Premarin alternatives: What can I take instead of Premarin?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#compare-premarin-alternatives\">Compare Premarin alternatives<\/a>\u00a0| <a href=\"#estrace\">Estrace<\/a> | <a href=\"#estrogel\">EstroGel<\/a> | <a href=\"#prempro\">Prempro<\/a> | <a href=\"#estring\">Estring<\/a> | <a href=\"#vivelle-dot\">Vivelle-Dot<\/a> | <a href=\"#natural-alternatives\">Natural alternatives<\/a> | <a href=\"#how-to-switch-meds\">How to switch meds<\/a><\/span><\/p>\n<p><span style=\"font-weight: 400;\">Menopause can be a challenging phase of life for some women. Hormonal changes can be uncomfortable and affect mood and quality of life. Hormone replacement therapy (HRT) medicines can be helpful in managing moderate to severe symptoms of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/menopause-questions-and-answers\/\"><span style=\"font-weight: 400;\">menopause<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Premarin <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10862263\/\" target=\"_blank\" rel=\"noopener\">conjugated estrogens<\/a><\/span><span style=\"font-weight: 400;\">\u00a0are isolated from the urine of pregnant mares. Premarin has been approved by the <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/004782s162s164s167lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Food and Drug Administration (FDA)<\/span><\/a><span style=\"font-weight: 400;\"> for the treatment of menopausal symptoms such as hot flashes, vaginal pain, vaginal dryness, palliation for certain types of cancer, and prevention of <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">osteoporosis<\/span><\/a><span style=\"font-weight: 400;\"> in postmenopausal women.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/premarin\/what-is\"><span style=\"font-weight: 400;\">Premarin<\/span><\/a><span style=\"font-weight: 400;\"> may not be the right medication for every woman experiencing symptoms of menopause. There are many alternatives to Premarin and several forms of estrogen therapy available. Some formulations may also include <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/progesterones\"><span style=\"font-weight: 400;\">progesterone<\/span><\/a><span style=\"font-weight: 400;\"> or synthetic progestins. The formulation that\u2019s chosen will depend on which specific symptoms are being experienced and patient tolerance and desire for a certain type of medication. These include: <\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Oral estrogen tablets<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Topical moisturizers, creams, lotions, gels, and sprays\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal creams\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other vaginal estrogen inserts such as vaginal rings and vaginal tablets\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">HRT medications are not available as over-the-counter medicines. They are prescription drugs that are typically prescribed by a gynecologist or healthcare provider with training and interest in women\u2019s health. These medications are all associated with <\/span><a href=\"https:\/\/www.fda.gov\/consumers\/free-publications-women\/menopause-medicines-help-you\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">severe side effects<\/span><\/a><span style=\"font-weight: 400;\"> including an increased risk of blood clots, stroke, heart attack, retinal vein thrombosis, and certain types of estrogen-sensitive tumors including an increased risk of breast cancer, endometrial cancer, and ovarian cancer. It is important to follow medical advice while taking these medications and to use them only as prescribed.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/drug-classes\/estrogens\"><b>Estrogens: Uses, common brands, and safety information<\/b><\/a><b>\u00a0<\/b><\/p>\n<table class=\" singlecare-table\">\n<thead>\n<tr>\n<th>\n<h2 id=\"compare-premarin-alternatives\"><span class=\"title\">Compare Premarin alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr class=\"header-row\">\n<td><b>Drug name<\/b><\/td>\n<td><b>Uses<\/b><\/td>\n<td><b>Dosage<\/b><\/td>\n<td><b>Coupons<\/b><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Premarin<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, osteoporosis prevention, hypoestrogenism, palliative treatment for metastatic breast or advanced prostate cancer, dysfunctional uterine bleeding, uremic bleeding<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cream: 0.625 mg conjugated estrogens applied to vagina daily for 2 weeks then tapered\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Tablet: 0.3-10 mg conjugated estrogens by mouth depending on indication<\/span><br \/>\n<span style=\"font-weight: 400;\">Injection: 0.6mg\/kg OR 25 mg conjugated estrogens bolus depending on indication\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/premarin\"><span style=\"font-weight: 400;\">Premarin coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Estrace<\/span><br \/>\n<span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, osteoporosis prevention, hypoestrogenism, palliative treatment for metastatic breast or advanced prostate cancer<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Cream: 0.01% estradiol applied to vagina 1-3 days per week\u00a0<\/span><br \/>\n<span style=\"font-weight: 400;\">Tablet: 0.5-2 mg estradiol by mouth, cycled 21 days on and 7 days off<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/estrace\"><span style=\"font-weight: 400;\">Estrace coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Delestrogen\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, hypoestrogenism, palliative treatment for advanced prostate cancer<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Injection: 10-30 mg estradiol valerate every 4 weeks\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/delestrogen\"><span style=\"font-weight: 400;\">Delestrogen coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Prempro\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, osteoporosis prevention\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablet: 0.3 mg\/1.5 mg conjugated estrogens\/medroxyprogesterone once per day<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/prempro\"><span style=\"font-weight: 400;\">Prempro coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vivelle-Dot<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, hypoestrogenism, osteoporosis prevention\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Patch: 0.025-0.01 mg estradiol applied twice per week<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/vivelle-dot\"><span style=\"font-weight: 400;\">Vivelle-Dot coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Vagifem\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vulvovaginal atrophy\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablet: 10 mcg estradiol per vagina daily for two weeks, then taper<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/vagifem\"><span style=\"font-weight: 400;\">Vagifem coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Estring\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vulvovaginal atrophy\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Ring: 7.5 mcg estradiol per 24 hours per vagina, change ring every 3 months\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/estring\"><span style=\"font-weight: 400;\">Estring coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Climara\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, hypoestrogenism, osteoporosis prevention, abnormal uterine bleeding\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Patch: 0.025-0.1 mg estradiol applied once per week\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/climara\"><span style=\"font-weight: 400;\">Climara coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Premphase\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, osteoporosis prevention\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Tablet: 0.625 mg estrogens for 14 days followed by 0.625 mg\/5 mg conjugated estrogens\/medroxyprogesterone for 14 days\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/premphase\"><span style=\"font-weight: 400;\">Premphase coupons<\/span><\/a><\/td>\n<\/tr>\n<tr>\n<td><a href=\"https:\/\/www.singlecare.com\/prescription\/combipatch\/what-is\"><span style=\"font-weight: 400;\">Combipatch\u00a0<\/span><\/a><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy, hypoestrogenism<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Patch: 0.05 mg\/0.14 mg &#8211; 0.05mg\/0.25 mg estradiol\/norethindrone acetate applied twice per week<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/combipatch\"><span style=\"font-weight: 400;\">Combipatch coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Climara Pro<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, osteoporosis prevention\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Patch: 0.045 mg\/0.015 mg estradiol\/levonorgestrel applied once per week<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/climara-pro\"><span style=\"font-weight: 400;\">Climara Pro coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Menostar\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Osteoporosis prevention\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Patch: 0.014 mg estradiol applied once per week<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/menostar\"><span style=\"font-weight: 400;\">Menostar coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">EstroGel<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms, vulvovaginal atrophy<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gel: 0.06%, 0.75 mg estradiol per pump applied one pump per day<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/estrogel\"><span style=\"font-weight: 400;\">EstroGel coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Divigel\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Gel: 0.1%, 0.25-1.25 mg estradiol per packet applied once per day\u00a0<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/divigel\"><span style=\"font-weight: 400;\">Divigel coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Imvexxy\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Menopausal dyspareunia\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Insert: 4-10 mcg twice per week<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/imvexxy-starter-pack\"><span style=\"font-weight: 400;\">Imvexxy coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td><span style=\"font-weight: 400;\">Evamist\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Vasomotor symptoms\u00a0<\/span><\/td>\n<td><span style=\"font-weight: 400;\">Spray: 1.53 mg estradiol per spray, use 1-3 sprays per day to inner surface of forearm<\/span><\/td>\n<td><a class=\"cta-button\" href=\"https:\/\/www.singlecare.com\/prescription\/evamist\"><span style=\"font-weight: 400;\">Evamist coupons<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span style=\"font-weight: 400;\">Other alternatives to Premarin<\/span><\/h3>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estrasorb tablet\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/femring\"><span style=\"font-weight: 400;\">Femring vaginal ring\u00a0<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/elestrin\"><span style=\"font-weight: 400;\">Elestrin gel<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/menest\"><span style=\"font-weight: 400;\">Menest oral tablet<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/osphena\"><span style=\"font-weight: 400;\">Osphena oral tablet<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/minivelle\"><span style=\"font-weight: 400;\">Minivelle transdermal patch<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<\/ul>\n<h2><span style=\"font-weight: 400;\">Top 5 Premarin alternatives<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The following are some of the most common alternatives to Premarin.<\/span><\/p>\n<h3 id=\"estrace\"><span style=\"font-weight: 400;\">1. Estrace<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estrace\/what-is\"><span style=\"font-weight: 400;\">Estrace<\/span><\/a><span style=\"font-weight: 400;\"> is one brand name used for estradiol preparations. While Premarin contains conjugated estrogens, which include estrogen and estradiol metabolites, Estrace contains estrogen only. Both are very effective at mitigating symptoms of menopause and have similar side effect profiles.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Premarin vaginal cream has one indication over Estrace, in that it is also used to treat dyspareunia (painful intercourse) that occurs as a result of atrophic vaginitis, or painful thinning and inflammation of the vaginal tissues from lack of estrogen.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both are available as a tablet or cream for at-home use.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/estrace-vs-premarin\/\"><b>Estrace vs. Premarin<\/b><\/a><b>\u00a0<\/b><\/p>\n<h3 id=\"estrogel\"><span style=\"font-weight: 400;\">2. EstroGel<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estrogel\/what-is\"><span style=\"font-weight: 400;\">EstroGel<\/span><\/a><span style=\"font-weight: 400;\"> is a topical gel consisting of 0.06% estradiol.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Premarin cream is applied directly to the vaginal tissues while one pump of EstroGel is to be applied to clean, unbroken skin on the inside and outside of the arm. Many women like the application of gel products as they absorb faster than lotions or creams and can be used as part of their daily bathing or showering routine.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While Premarin has a broad spectrum of uses, EstroGel is primarily used to reduce moderate to severe vasomotor symptoms, which include hot flashes and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/night-sweats\/\"><span style=\"font-weight: 400;\">night sweats<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/estradiol-side-effects\/\"><b>Estradiol side effects<\/b><\/a><\/p>\n<h3 id=\"prempro\"><span style=\"font-weight: 400;\">3. Prempro<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/prempro\/what-is\"><span style=\"font-weight: 400;\">Prempro<\/span><\/a><span style=\"font-weight: 400;\"> is an oral tablet preparation of 0.3 mg\/1.5 mg conjugated estrogens\/medroxyprogesterone. Prempro contains progesterone as well as the same conjugated estrogens found in Premarin.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">While Premarin has more indications for use, Prempro is primarily used for vasomotor symptoms of menopause and vulvovaginal atrophy. However, for women who have not had a hysterectomy (removal of the uterus), the addition of progestins in medications like Prempro may be preferable. Estrogen-only therapy may cause unwanted thickening of the lining of the uterus and lead to vaginal bleeding and endometrial cancer.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/prescription\/prempro\/dosage\">Prempro dosing<\/a><\/strong><\/p>\n<h3 id=\"estring\"><span style=\"font-weight: 400;\">4. Estring<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/estring\/what-is\"><span style=\"font-weight: 400;\">Estring<\/span><\/a><span style=\"font-weight: 400;\"> is an estradiol-releasing vaginal ring. Estring is unique in that the inserted vaginal ring is placed and then changed every three months. It\u2019s a good option for women with busy lifestyles that don\u2019t want to worry about taking a pill or applying a cream every day. Estring is also a great option for women who are primarily only experiencing vaginal pain, dryness, and discomfort as symptoms of menopause.\u00a0<\/span><\/p>\n<h3 id=\"vivelle-dot\"><span style=\"font-weight: 400;\">5. Vivelle-Dot<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/vivelle-dot\/what-is\"><span style=\"font-weight: 400;\">Vivelle-Dot<\/span><\/a><span style=\"font-weight: 400;\"> is an estradiol-releasing transdermal patch. It is applied to the skin of the abdomen twice per week. Vivelle-Dot is used in the management of vasomotor symptoms, vulvovaginal atrophy, and to prevent osteoporosis in postmenopausal women. In some women, <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22325243\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">transdermal HRT<\/span><\/a><span style=\"font-weight: 400;\"> may be preferable as the medications in these preparations bypass liver metabolism and may not have the associated adverse effects.\u00a0<\/span><\/p>\n<h2 id=\"natural-alternatives\"><span style=\"font-weight: 400;\">Natural alternatives to Premarin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many women are interested in non-pharmaceutical options for vasomotor symptom relief. While there are no supplements that are identical replacements of estrogen or progesterone, there are other options available that are considered safe and relatively effective. <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/female-hormones-and-mental-health\/\"><span style=\"font-weight: 400;\">Hormone changes<\/span><\/a><span style=\"font-weight: 400;\"> with age are normal and expected.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Estrogen is a steroid hormone with an important role in lipid metabolism. Dysregulation of lipid metabolism due to alterations in estrogen levels may affect body fat mass and distribution and increase the risk of heart disease and diabetes. It is recommended that postmenopausal women eat <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7019719\/\"><span style=\"font-weight: 400;\">lower-calorie, balanced diets<\/span><\/a><span style=\"font-weight: 400;\"> with adequate protein, vitamin D, vitamin B-12, antioxidants, fiber, fresh fruits, fresh vegetables, and hydrating fluids.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/menopause-diet\/\"><b>The best diet for menopause<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">Vitamins\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vitamins are important cofactors the body needs to function normally. Vitamins do not increase estrogen levels but may need to be supplemented when they are not adequately present in the diet.\u00a0<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">Vitamin D<\/span><\/h4>\n<p><a href=\"https:\/\/www.singlecare.com\/blog\/vitamin-d-prescription\/\"><span style=\"font-weight: 400;\">Vitamin D deficiency<\/span><\/a><span style=\"font-weight: 400;\"> is associated with bone mineral density loss and, inadequate intake is protective for certain types of cancers. Women going through menopause or who are postmenopausal and do not receive adequate sunlight should consider increasing dietary vitamin D or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-d\"><span style=\"font-weight: 400;\">vitamin D<\/span><\/a><span style=\"font-weight: 400;\"> supplementation.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-much-vitamin-d-should-i-take\/\"><b>How much vitamin D should I take?<\/b><\/a><\/p>\n<h4><span style=\"font-weight: 400;\">Omega-3 fatty acids<\/span><\/h4>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/fatty-acids\"><span style=\"font-weight: 400;\">Omega-3 fatty acids<\/span><\/a><span style=\"font-weight: 400;\"> cannot be synthesized by the body and must be obtained by the diet. Omega-3 fatty acids are cardioprotective, anti-inflammatory, insulin-sensitizing, and have been reported to protect against obesity and metabolic syndrome in postmenopausal women. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/omega-3\"><span style=\"font-weight: 400;\">Omega-3 fatty acids<\/span><\/a><span style=\"font-weight: 400;\"> can be found in some nuts and their oils such as flaxseeds, walnuts, and soybeans, as well as wild-caught fish.\u00a0<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">Antioxidants\u00a0<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Lower estrogen states are associated with oxidative stress. Oxidation damages biological tissues, increases inflammation, and is associated with obesity, diabetes, insulin resistance, and cardiovascular disease. Postmenopausal women are recommended to increase their intake of antioxidants which may include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-c\"><span style=\"font-weight: 400;\">vitamin C<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-a\"><span style=\"font-weight: 400;\">vitamin A<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-e\"><span style=\"font-weight: 400;\">vitamin E<\/span><\/a><span style=\"font-weight: 400;\">, plant flavonoids, and soy isoflavones.\u00a0<\/span><\/p>\n<h4><span style=\"font-weight: 400;\">S-equol<\/span><\/h4>\n<p><span style=\"font-weight: 400;\">Most supplements available as alternatives to Premarin contain the ingredient S-equol. S-equol is a <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15883431\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">compound from soy<\/span><\/a><span style=\"font-weight: 400;\"> that can attach to estrogen-receptor beta. It is naturally present in small amounts in individuals with certain bacteria in their gut. Since these compounds bind the estrogen receptor, they can <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25692726\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">alleviate vasomotor symptoms<\/span><\/a><span style=\"font-weight: 400;\"> and reduce bone loss. In the <\/span><a href=\"https:\/\/www.mdpi.com\/resolver?pii=ijms22063212\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">limited studies<\/span><\/a><span style=\"font-weight: 400;\"> available, these isolated compounds have been found to be safe and effective in certain populations of women.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/vitamin-absorption\/\"><b>How to absorb vitamins better<\/b><\/a><\/p>\n<h2 id=\"how-to-switch-meds\"><span style=\"font-weight: 400;\">How to switch to a Premarin alternative<\/span><span style=\"font-weight: 400;\">\u00a0<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Changing prescription medications is usually done with informed decision-making between an individual and their healthcare provider. Depending on which preparation of Premarin you are taking (vaginal cream or tablet), you may need to taper your medication before starting a new one. In most cases, the new medication can be started as soon as Premarin is discontinued. It is important to talk with your healthcare provider about changing medications prior to discontinuing them. Using a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">prescription discount card<\/span><\/a><span style=\"font-weight: 400;\"> from SingleCare may help reduce the cost of Premarin and Premarin alternatives at local pharmacies.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/es\/recursos\/alternativas-a-premarin\"><span style=\"font-weight: 400;\">Lea este art\u00edculo en espa\u00f1ol aqu\u00ed.<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Compare Premarin alternatives\u00a0| Estrace | EstroGel | Prempro | Estring | Vivelle-Dot | Natural alternatives | How to switch meds Menopause can be a challenging phase of life for some women. Hormonal changes can be uncomfortable and affect mood and quality of life. Hormone replacement therapy (HRT) medicines can be helpful in managing moderate to [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":50527,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[8670],"coauthors":[20759],"class_list":["post-50513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Top Premarin alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Estrace, EstroGel, Prempro, Estring, and Vivelle-Dot are some Premarin alternatives. Get the full list here, including natural remedies for menopause.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/premarin-alternatives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What can I take instead of Premarin?\" \/>\n<meta property=\"og:description\" content=\"See what your menopause medication options are\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/premarin-alternatives\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-15T04:17:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-10-07T19:03:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/premarin-alternatives.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Georgia C. 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