{"id":50863,"date":"2022-04-18T08:44:49","date_gmt":"2022-04-18T12:44:49","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=50863"},"modified":"2026-05-14T12:04:31","modified_gmt":"2026-05-14T16:04:31","slug":"humira-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/","title":{"rendered":"What can I take instead of Humira?"},"content":{"rendered":"

Humira<\/span><\/a> (adalimumab) is a brand-name prescription biologic drug that is administered by an under-the-skin injection. A type of lab-made protein that targets specific parts of the immune system, used to treat several autoimmune conditions, including rheumatoid arthritis, Crohn’s disease, and plaque psoriasis. It is typically self-administered at home once every two weeks or once weekly. When cost, effectiveness, or side effects become a concern, several alternatives to Humira are available.\u00a0<\/span><\/p>\n

What can I take in place of Humira?<\/b><\/h2>\n

Humira was the first human monoclonal antibody FDA approved for rheumatoid arthritis in 2003 and has since received approval for several additional conditions. Other tumor necrosis factor (TNF) inhibitors (drugs that reduce inflammation by blocking a protein called TNF) that work similarly include<\/span> Remicade<\/span><\/a> (infliximab),<\/span> Simponi<\/span><\/a> (golimumab),<\/span> Cimzia<\/span><\/a> (certolizumab), and<\/span> Enbrel<\/span><\/a> (etanercept).\u00a0<\/span><\/p>\n

Humira biosimilars<\/span><\/a> can also serve as an alternative. Biosimilars are drugs that are highly similar to a brand-name biologic but not identical. They work the same way and are generally less expensive. Ten Humira biosimilars are currently FDA approved, some of which have their own lower-priced generic versions.<\/span><\/p>\n

Other biologic medications that work differently from TNF inhibitors may also serve as alternatives. Traditional disease-modifying antirheumatic drugs (<\/span>DMARDs<\/span><\/a>) are another option, often prescribed early in the treatment of conditions like rheumatoid arthritis.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u00a0 \u00a0 Humira alternatives cost comparison<\/b><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Humira (adalimumab)<\/b><\/td>\n$8,839 for 2, 1 auto-injector kits<\/span><\/td>\n$6,042 for 2, 1 auto-injector kits of brand-name Humira at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cyltezo (adalimumab-ryvk)<\/b><\/td>\n$7,812 for 2, 1 auto-injector boxes\u00a0<\/span><\/td>\n$1,288 for 2, 1 auto-injector boxes of generic Cyltezo at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Methotrexate<\/b><\/td>\n$104 for 24, 2.5 mg tablets<\/span><\/td>\n$12 for 24, 2.5 mg tablets of generic methotrexate at Food Lion<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Simponi (golimumab)<\/b><\/td>\n$8,132 for 1, 0.5 mL of 50 mg\/0.5 mL pen<\/span><\/td>\n$6,519 for 1, 0.5 mL of 50 mg\/0.5 mL brand-name Simponi pen at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Orencia (abatacept)<\/b><\/td>\n$6,241 per 3, 250 mg solution<\/span><\/td>\n$4,709 per 3, 250 mg solution of brand-name Orencia at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Xeljanz (tofacitinib)<\/b><\/td>\n$7,672 for 60, 5 mg tablets<\/span><\/td>\n$3,970 for 60, 5 mg tablets of brand-name Xeljanz at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 Humira alternatives<\/span><\/h2>\n

Cyltezo and other Humira biosimilars<\/b><\/h3>\n

Of the 10 FDA-approved Humira biosimilars, only three have been approved as fully interchangeable products: Cyltezo (adalimumab-adbm), <\/span>Abrilada<\/span><\/a> (adalimumab-afzb), and<\/span> Simlandi<\/span><\/a> (adalimumab-ryvk). A fully interchangeable biosimilar can be substituted for Humira without requiring a new prescription, using the same dosage and carrying the same warnings. Both Cyltezo and Simlandi have lower-priced generic versions available.<\/span><\/p>\n

Even among the three interchangeable biosimilars, there are important differences that pharmacists and prescribers should be aware of, including whether the product contains latex, a concern for people with latex allergies. Biosimilars that are not fully interchangeable may also differ in administration technique, concentration, and dosage.<\/span><\/p>\n

The remaining Humira biosimilars include<\/span> Amjevita<\/span><\/a> (adalimumab-atto),<\/span> Hadlima<\/span><\/a> (adalimumab-bwwd),<\/span> Hulio<\/span><\/a> (adalimumab-fkjp),<\/span> Hyrimoz<\/span><\/a> (adalimumab-adaz),<\/span> Idacio<\/span><\/a> (adalimumab-aacf), <\/span>Yuflyma<\/span><\/a> (adalimumab-aaty), and<\/span> Yusimry<\/span><\/a> (adalimumab-aqvb).<\/span><\/p>\n

Methotrexate<\/b><\/h3>\n

Oral<\/span> methotrexate<\/span><\/a> is traditionally the first-line <\/span>DMARD<\/span><\/a> for rheumatoid arthritis. If there is an inadequate response after three to four months of optimized<\/span> dosing<\/span><\/a>, a different DMARD or biologic agent may be added or substituted.\u00a0<\/span><\/p>\n

Methotrexate costs around $100 per month, making it significantly more affordable than biologic medications like Humira. However, it can cause<\/span> side effects<\/span><\/a> that some people find intolerable, including liver, kidney, and lung toxicity, as well as immunosuppression. Close laboratory monitoring is required when starting treatment, typically every <\/span>two months<\/span><\/a>.<\/span><\/p>\n

Methotrexate can also cause gastrointestinal side effects such as nausea, vomiting, and diarrhea. <\/span>Splitting the once-weekly dose into two or three doses<\/span><\/a> given 12 hours apart may help reduce these effects. Methotrexate is not recommended for people with poor kidney function.\u00a0<\/span><\/p>\n

Simponi (golimumab)<\/b><\/h3>\n

Like Humira, <\/span>Simponi <\/span><\/a>(golimumab) is a TNF inhibitor. It is typically used alongside methotrexate for rheumatoid arthritis but can serve as a standalone alternative to Humira for psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Simponi is given as a once-monthly injection under the skin, or as an intravenous infusion administered by a healthcare professional in a monitored setting. Side effects are similar to those of Humira.\u00a0<\/span><\/p>\n

Orencia (abatacept)<\/b><\/h3>\n

Orencia<\/span><\/a> (abatacept) belongs to a different drug class from Humira, known as T-cell costimulation modulators, drugs that work by blocking the activation of T-cells (immune cells that drive inflammation) in the joints. It is approved for rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, and psoriatic arthritis.<\/span><\/p>\n

Orencia can be given as a flat-dose injection under the skin or as a weight-based intravenous infusion. Because it interacts with many other medications, a full medication review is recommended before starting treatment. Orencia can be added to traditional DMARDs for rheumatoid arthritis, but<\/span> should not be combined with a TNF inhibitor<\/span><\/a> like Humira, as doing so significantly increases the risk of serious and potentially fatal infections.<\/span><\/p>\n

Xeljanz (tofacitinib)<\/b><\/h3>\n

Xeljanz<\/span><\/a> (tofacitinib) belongs to a class of drugs called Janus kinase (JAK) inhibitors, which work by blocking the JAK enzyme, a protein involved in signaling that drives joint and tissue inflammation. Xeljanz is<\/span> FDA approved<\/span><\/a> to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, and ulcerative colitis.<\/span><\/p>\n

It is available as an oral tablet taken twice daily (immediate-release) or once daily (extended-release). Regular monitoring is required throughout treatment, including blood cholesterol levels, white blood cell counts (lymphocytes and neutrophils), liver function, and kidney function.<\/span> Dose<\/span><\/a> adjustments or discontinuation may be recommended based on lab results.<\/span><\/p>\n

Xeljanz carries the risk of<\/span> serious side effects<\/span><\/a>. Clinical trials found that the higher dose of 10 mg twice daily was associated with a<\/span> higher risk of death<\/span><\/a> (including sudden cardiovascular death) and<\/span> blood clots<\/span><\/a> in people with rheumatoid arthritis ages 50 and older with at least one cardiovascular risk factor, compared to the 5 mg dose or a TNF inhibitor like Humira. As an immunosuppressant, appropriate screening is required before starting treatment.<\/span><\/p>\n

Natural alternatives to Humira<\/b><\/h2>\n

For moderate to severe inflammatory conditions, there are no true natural alternatives to Humira or other prescription medications. However, some complementary approaches may help manage symptoms alongside prescribed treatment.<\/span><\/p>\n

Probiotics<\/span><\/a> and prebiotics may support the management of Crohn’s disease and ulcerative colitis.<\/span> Certain micronutrient deficiencies<\/span><\/a> are also common in inflammatory bowel diseases, including iron, B12, vitamin D, vitamin K, folic acid, selenium, zinc, and vitamins B1 and B6. Anti-inflammatory supplements such as<\/span> fish oil<\/span><\/a>,<\/span> cayenne pepper<\/span><\/a>, and<\/span> turmeric<\/span><\/a> may also be helpful. <\/span>Aloe vera gel<\/span><\/a> has also shown promising results in small studies for managing ulcerative colitis, though larger trials are needed to confirm its effectiveness. People taking immunosuppressing medications should adopt<\/span> healthy lifestyle practices<\/span><\/a> to reduce the risk of infection.<\/span><\/p>\n

RELATED: <\/b>The best natural remedies for arthritis<\/b><\/a> | <\/span>The 6 best exercises for arthritis<\/b><\/a><\/p>\n

How to switch to a Humira alternative<\/b><\/h2>\n

With biosimilars now widely available, insurance formularies may be changed to prefer an interchangeable biosimilar over brand-name Humira. State laws on substitution vary, and prescriber notification is not always required. People switching to a biosimilar should be aware that<\/span> differences in administration, dosing, storage, and indications can exist between products<\/span><\/a>, even among interchangeable ones. If your insurance company switches your medication at the pharmacy, ask the pharmacist or your healthcare provider about the change and whether it is appropriate for you.\u00a0<\/span><\/p>\n

Never stop taking Humira abruptly without medical guidance. Stopping a biologic can cause the body to develop antibodies against it, meaning<\/span> if the drug is restarted<\/span><\/a>, it may no longer be effective. <\/span>Withdrawal effects<\/span><\/a> have also been reported with abrupt discontinuation. Most conditions treated by Humira and its alternatives are chronic and will require lifelong treatment. Always consult a healthcare provider before making any changes to your treatment plan.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Humira (adalimumab) is a brand-name prescription biologic drug that is administered by an under-the-skin injection. A type of lab-made protein that targets specific parts of the immune system, used to treat several autoimmune conditions, including rheumatoid arthritis, Crohn’s disease, and plaque psoriasis. It is typically self-administered at home once every two weeks or once weekly. […]<\/p>\n","protected":false},"author":133,"featured_media":50867,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12164,790],"coauthors":[10869],"class_list":["post-50863","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-arthritis","tag-chronic-disease","wpautop"],"acf":[],"yoast_head":"\nHumira alternatives: What can I take instead of Humira?<\/title>\n<meta name=\"description\" content=\"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What can I take instead of Humira?\" \/>\n<meta property=\"og:description\" content=\"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/\" \/>\n<meta property=\"og:site_name\" content=\"The Checkup\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/singlecare\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-18T12:44:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-14T16:04:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Marissa Walsh, Pharm.D., BCPS-AQ ID\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:site\" content=\"@SingleCare\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Marissa Walsh, Pharm.D., BCPS-AQ ID\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/\"},\"author\":{\"name\":\"Christie Falzone\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\"},\"headline\":\"What can I take instead of Humira?\",\"datePublished\":\"2022-04-18T12:44:49+00:00\",\"dateModified\":\"2026-05-14T16:04:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/\"},\"wordCount\":1230,\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Humira-alternatives.png\",\"keywords\":[\"Arthritis\",\"Chronic disease\"],\"articleSection\":[\"Drug Info\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/\",\"name\":\"Humira alternatives: What can I take instead of Humira?\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Humira-alternatives.png\",\"datePublished\":\"2022-04-18T12:44:49+00:00\",\"dateModified\":\"2026-05-14T16:04:31+00:00\",\"description\":\"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Humira-alternatives.png\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/04\\\/Humira-alternatives.png\",\"width\":1920,\"height\":1080,\"caption\":\"Rx pill bottles: Humira alternatives\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/humira-alternatives\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What can I take instead of Humira?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"name\":\"The Checkup, a health blog by SingleCare\",\"description\":\"Read the latest in prescription, wellness, and healthcare news\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#organization\",\"name\":\"SingleCare\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/01\\\/placeholderimage-1.jpg\",\"width\":1200,\"height\":630,\"caption\":\"SingleCare\"},\"image\":{\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/singlecare\",\"https:\\\/\\\/x.com\\\/SingleCare\",\"https:\\\/\\\/www.instagram.com\\\/singlecare\\\/?hl=en\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/singlecare\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCd9kiPIjCQw95-2BHCYePKA\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/#\\\/schema\\\/person\\\/5ff7c7bb5ce0c66a6962ecf7c8d7941e\",\"name\":\"Christie Falzone\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g\",\"caption\":\"Christie Falzone\"},\"description\":\"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.\",\"url\":\"https:\\\/\\\/www.singlecare.com\\\/blog\\\/author\\\/cfalzone\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Humira alternatives: What can I take instead of Humira?","description":"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/","og_locale":"en_US","og_type":"article","og_title":"What can I take instead of Humira?","og_description":"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.","og_url":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/","og_site_name":"The Checkup","article_publisher":"https:\/\/www.facebook.com\/singlecare","article_published_time":"2022-04-18T12:44:49+00:00","article_modified_time":"2026-05-14T16:04:31+00:00","og_image":[{"width":1920,"height":1080,"url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png","type":"image\/png"}],"author":"Marissa Walsh, Pharm.D., BCPS-AQ ID","twitter_card":"summary_large_image","twitter_creator":"@SingleCare","twitter_site":"@SingleCare","twitter_misc":{"Written by":"Marissa Walsh, Pharm.D., BCPS-AQ ID","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#article","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/"},"author":{"name":"Christie Falzone","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e"},"headline":"What can I take instead of Humira?","datePublished":"2022-04-18T12:44:49+00:00","dateModified":"2026-05-14T16:04:31+00:00","mainEntityOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/"},"wordCount":1230,"publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png","keywords":["Arthritis","Chronic disease"],"articleSection":["Drug Info"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/","url":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/","name":"Humira alternatives: What can I take instead of Humira?","isPartOf":{"@id":"https:\/\/www.singlecare.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#primaryimage"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#primaryimage"},"thumbnailUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png","datePublished":"2022-04-18T12:44:49+00:00","dateModified":"2026-05-14T16:04:31+00:00","description":"Cyltezo, methotrexate, Simponi, Orencia, and Xeljanz are some Humira alternatives. Get the full list here, including natural alternatives.","breadcrumb":{"@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.singlecare.com\/blog\/humira-alternatives\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#primaryimage","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2022\/04\/Humira-alternatives.png","width":1920,"height":1080,"caption":"Rx pill bottles: Humira alternatives"},{"@type":"BreadcrumbList","@id":"https:\/\/www.singlecare.com\/blog\/humira-alternatives\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.singlecare.com\/blog\/"},{"@type":"ListItem","position":2,"name":"What can I take instead of Humira?"}]},{"@type":"WebSite","@id":"https:\/\/www.singlecare.com\/blog\/#website","url":"https:\/\/www.singlecare.com\/blog\/","name":"The Checkup, a health blog by SingleCare","description":"Read the latest in prescription, wellness, and healthcare news","publisher":{"@id":"https:\/\/www.singlecare.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.singlecare.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.singlecare.com\/blog\/#organization","name":"SingleCare","url":"https:\/\/www.singlecare.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","contentUrl":"https:\/\/www.singlecare.com\/blog\/wp-content\/uploads\/2020\/01\/placeholderimage-1.jpg","width":1200,"height":630,"caption":"SingleCare"},"image":{"@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/singlecare","https:\/\/x.com\/SingleCare","https:\/\/www.instagram.com\/singlecare\/?hl=en","https:\/\/www.linkedin.com\/company\/singlecare\/","https:\/\/www.youtube.com\/channel\/UCd9kiPIjCQw95-2BHCYePKA"]},{"@type":"Person","@id":"https:\/\/www.singlecare.com\/blog\/#\/schema\/person\/5ff7c7bb5ce0c66a6962ecf7c8d7941e","name":"Christie Falzone","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=gf47683752158743086d9c95bc1ebdaa7","url":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2e99585820d49affcf442acba86e464b68d836bf071db26829d667da12209555?s=96&d=mm&r=g","caption":"Christie Falzone"},"description":"Christie Falzone recently graduated summa cum laude from Old Dominion University in Norfolk, Virginia, with a bachelor\u2019s degree in professional writing. During her time in college, she developed a passion for helping children and volunteers as a Court Appointed Special Advocate on behalf of foster youth.","url":"https:\/\/www.singlecare.com\/blog\/author\/cfalzone\/"}]}},"_links":{"self":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/50863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/users\/133"}],"replies":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/comments?post=50863"}],"version-history":[{"count":0,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/posts\/50863\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media\/50867"}],"wp:attachment":[{"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/media?parent=50863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/categories?post=50863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/tags?post=50863"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.singlecare.com\/blog\/wp-json\/wp\/v2\/coauthors?post=50863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}