{"id":52075,"date":"2022-06-16T16:22:59","date_gmt":"2022-06-16T20:22:59","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=52075"},"modified":"2022-06-20T14:29:48","modified_gmt":"2022-06-20T18:29:48","slug":"tamoxifen-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/tamoxifen-alternatives\/","title":{"rendered":"Tamoxifen alternatives: What can I take instead of tamoxifen?"},"content":{"rendered":"

Compare tamoxifen alternatives<\/a>\u00a0| Other SERMs<\/a>\u00a0| Faslodex<\/a> \u00a0| Aromatase inhibitors<\/a> \u00a0| Natural alternatives<\/a> | How to switch meds<\/a><\/span><\/p>\n

Most <\/span>breast cancers<\/span> (<\/span>almost 70%<\/span><\/a>) are hormone receptor-positive; in other words, the tumors contain <\/span>estrogen<\/span> or <\/span>progesterone<\/span> receptors. <\/span>Estrogen<\/span> or <\/span>progesterone<\/span> hormones can promote the growth and spread of <\/span>breast cancer cells<\/span> if left unchecked. Blocking hormone receptors or decreasing the amount of <\/span>estrogen<\/span> produced in the body is the standard way to treat <\/span>hormone receptor-positive breast cancer<\/span>.\u00a0<\/span><\/p>\n

Tamoxifen<\/span>, known by the brand names Nolvadex and Soltamox, is a commonly prescribed prescription drug used to treat <\/span>hormone receptor-positive breast cancer<\/span>. It is classified as a <\/span>selective <\/span>estrogen receptor<\/span> modulator<\/span> (SERM)<\/span><\/a> that can treat all stages of <\/span>breast cancer<\/span> in men and premenopausal or <\/span>postmenopausal women<\/span>. <\/span>Tamoxifen<\/span> has been shown to reduce the risk of dying from <\/span>breast cancer<\/span> by <\/span>27%<\/span><\/a>. However, serious <\/span>side effects of tamoxifen<\/span> include <\/span>uterine<\/span> cancer and <\/span>blood clots<\/span>.<\/span><\/p>\n

Other hormone or <\/span>endocrine therapies<\/span>, such as <\/span>aromatase inhibitors<\/span>, are available to help treat or prevent <\/span>breast cancer<\/span>. Continue reading to learn more about <\/span>tamoxifen<\/span> alternatives and how they work.\u00a0<\/span><\/p>\n

What can I take in place of <\/span>tamoxifen<\/span>?<\/span><\/h2>\n

Other options to treat <\/span>hormone receptor-positive breast cancer<\/span> are available. The most popular alternative to <\/span>tamoxifen<\/span> is an <\/span>aromatase inhibitor<\/span>, such as <\/span>Arimidex<\/span> (<\/span>anastrozole<\/span>) and <\/span>Aromasin<\/span> (<\/span>exemestane<\/span>)<\/span><\/a>. Other SERMs, such as Evista (raloxifene), and <\/span>estrogen-receptor<\/span> antagonists, such as Faslodex (fulvestrant), may also be prescribed instead of <\/span>tamoxifen<\/span>. These treatment options may be preferred because they are effective and tend to carry a lower risk of severe <\/span>side effects<\/span> associated with <\/span>tamoxifen<\/span>. Most <\/span>breast cancer<\/span> drugs are used as <\/span>adjuvant therapy<\/span> or treatments that are given after surgery.\u00a0<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare tamoxifen alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nCoupons<\/b><\/td>\n<\/tr>\n
Tamoxifen<\/td>\n\n
    \n
  • Treatment of estrogen receptor-positive metastatic breast cancer<\/li>\n
  • Adjuvant treatment of early-stage estrogen receptor-positive breast cancer<\/li>\n
  • Reduction in risk of breast cancer<\/li>\n<\/ul>\n

     <\/td>\n

20-40 mg by mouth once daily<\/td>\nTamoxifen coupons<\/a><\/td>\n<\/tr>\n
Evista (raloxifene)<\/td>\n\n
    \n
  • Treatment and prevention of osteoporosis in postmenopausal women<\/li>\n
  • Reduction in risk of breast cancer in postmenopausal women<\/li>\n<\/ul>\n<\/td>\n
60 mg by mouth once daily<\/td>\nEvista coupons<\/a><\/td>\n<\/tr>\n
Fareston (toremifene)<\/td>\n\n
    \n
  • Treatment of metastatic breast cancer in postmenopausal women with hormone receptor-positive or unknown receptor status in postmenopausal women<\/li>\n<\/ul>\n<\/td>\n
60 mg by mouth once daily<\/td>\nFareston coupons<\/a><\/td>\n<\/tr>\n
Faslodex (fulvestrant)<\/td>\n\n
    \n
  • Treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in postmenopausal women<\/li>\n<\/ul>\n<\/td>\n
500 mg administered intramuscularly (IM) on Days 1, 15, 29, and then once per month<\/td>\nFaslodex coupons<\/a><\/td>\n<\/tr>\n
Arimidex (anastrozole)<\/td>\n\n
    \n
  • Treatment of hormone receptor-positive early-stage breast cancer in postmenopausal women<\/li>\n
  • Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women<\/li>\n<\/ul>\n<\/td>\n
1 mg by mouth once daily<\/td>\nArimidex coupons<\/a><\/td>\n<\/tr>\n
Femara (letrozole)<\/td>\n\n
    \n
  • Treatment for hormone receptor-positive early breast cancer in postmenopausal women<\/li>\n
  • Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women<\/li>\n
  • Treatment of hormone receptor-positive or unknown advanced breast cancer in postmenopausal women<\/li>\n<\/ul>\n<\/td>\n
2.5 mg by mouth once daily<\/td>\nFemara coupons<\/a><\/td>\n<\/tr>\n
Aromasin (exemestane)<\/td>\n\n
    \n
  • Treatment of advanced breast cancer that has progressed after tamoxifen therapy in postmenopausal women<\/li>\n
  • Adjuvant treatment of hormone receptor-positive early breast cancer in postmenopausal women who have received 2-3 years of treatment with tamoxifen<\/li>\n<\/ul>\n<\/td>\n
25 mg by mouth once daily<\/td>\nAromasin coupons<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 3 <\/span>tamoxifen<\/span> alternatives<\/span><\/h2>\n

1. Other SERMs, such as Evista (raloxifene) and Fareston (toremifene)<\/span><\/h3>\n

Raloxifene and toremifene are other SERMs that act similarly to <\/span>tamoxifen<\/span>. They stop cancer growth by binding to <\/span>estrogen receptors<\/span> and blocking the ability of <\/span>estrogen<\/span> to bind to these receptors. However, SERMs can also mimic the effects of <\/span>estrogen<\/span> in other parts of the body, such as the uterus, which can increase the risk of certain cancers. These drugs are not usually recommended if previous treatment with <\/span>tamoxifen<\/span> has not been successful. Toremifene is only approved for the treatment of <\/span>metastatic breast cancer<\/span> in <\/span>postmenopausal women<\/span>, so its uses are more limited than those of <\/span>tamoxifen<\/span>.\u00a0<\/span><\/p>\n

Some <\/span>healthcare providers<\/span> may prescribe raloxifene over <\/span>tamoxifen<\/span> due to its lower risk of serious <\/span>side effects<\/span>, such as <\/span>uterine<\/span> cancer. Raloxifene may be prescribed to <\/span>postmenopausal women<\/span> with <\/span>osteoporosis<\/span> who are at a <\/span>high risk<\/span> of <\/span>invasive breast cancer<\/span>. However, raloxifene may be less effective at preventing <\/span>breast cancer<\/span> than <\/span>tamoxifen<\/span> and has only been tested in <\/span>postmenopausal women<\/span>. On the other hand, <\/span>tamoxifen<\/span> is an option to prevent <\/span>breast cancer<\/span> in <\/span>premenopausal women<\/span>.\u00a0<\/span><\/p>\n

SERMs are generally taken by mouth. <\/span>Side effects<\/span> may include <\/span>hot flashes<\/span>, muscle or <\/span>joint pain<\/span>, and leg cramps. Serious <\/span>side effects<\/span> may include an <\/span>increased risk<\/span> of <\/span>uterine<\/span> or <\/span>endometrial cancer<\/span> and <\/span>blood clots<\/span><\/a> in the legs or lungs.\u00a0<\/span><\/p>\n

2. Antiestrogens or <\/span>estrogen receptor<\/span> antagonists, such as Faslodex (fulvestrant)<\/span><\/h3>\n

Antiestrogens, such as fulvestrant, bind to <\/span>estrogen receptors<\/span> and cause the receptors to break down. These drugs are effective when used alone or in combination with other <\/span>hormone therapy<\/span> drugs to treat advanced <\/span>breast cancer<\/span>. A <\/span>healthcare provider<\/span> may prescribe fulvestrant if SERMs, such as <\/span>tamoxifen<\/span>, or <\/span>aromatase inhibitors<\/span>, such as <\/span>letrozole<\/span>, have stopped working.<\/span><\/p>\n

Unlike <\/span>tamoxifen<\/span>, fulvestrant is administered as an intramuscular injection. Fulvestrant needs to be given along with a luteinizing hormone-releasing hormone (LHRH), such as Lupron (leuprolide) or Zoladex (goserelin), in <\/span>premenopausal women<\/span>. Common <\/span>side effects<\/span> of fulvestrant include pain at the site of injection, nausea, headache, and fatigue.\u00a0<\/span><\/p>\n

3. <\/span>Aromatase inhibitors<\/span>, such as <\/span>Arimidex<\/span> (<\/span>anastrozole<\/span>), <\/span>Femara<\/span> (<\/span>letrozole<\/span>), and <\/span>Aromasin<\/span> (<\/span>exemestane<\/span>)<\/span><\/h3>\n

Aromatase inhibitors<\/span><\/a> work by blocking the production of <\/span>estrogen<\/span> in the body. They are generally reserved for <\/span>postmenopausal women<\/span> with <\/span>breast cancer<\/span> whose <\/span>estrogen<\/span> is primarily produced by the aromatase enzyme. <\/span>Aromatase inhibitors<\/span> may be used in <\/span>premenopausal women<\/span> if ovarian suppression treatments are also used.\u00a0<\/span><\/p>\n

Unlike <\/span>tamoxifen<\/span>, <\/span>aromatase inhibitors<\/span> have a low risk of causing <\/span>uterine<\/span> cancer or <\/span>blood clots<\/span>. However, <\/span>aromatase inhibitors<\/span> can cause muscle and <\/span>joint pain<\/span>, which can lead to some women discontinuing treatment. Because they block the production of <\/span>estrogen<\/span>, <\/span>aromatase inhibitors<\/span> can cause bone loss in women after menopause.\u00a0<\/span><\/p>\n

Common <\/span>side effects<\/span> of <\/span>aromatase inhibitors<\/span> include <\/span>vaginal dryness<\/span>, muscle pain, joint aches, and <\/span>hot flashes<\/span> or night <\/span>sweats<\/span>.\u00a0<\/span><\/p>\n

Natural alternatives to <\/span>tamoxifen<\/span><\/h2>\n

Healthcare providers<\/span> do not recommend replacing <\/span>tamoxifen<\/span> and conventional treatments with natural therapies. No natural alternatives to <\/span>tamoxifen<\/span> have been proven to help treat <\/span>breast cancer<\/span>, and they may even cause harm in some <\/span>breast cancer patients<\/span>. Certain supplements or herbal treatments may lead to an <\/span>increased risk<\/span> of drug interactions or adverse effects if used without the guidance of a <\/span>healthcare provider<\/span>.<\/span><\/p>\n

Some natural therapies may be helpful to support the body and mind while battling <\/span>breast cancer<\/span>. <\/span>Healthcare providers<\/span> may recommend natural therapies in addition to standard <\/span>breast cancer treatments<\/span>. These therapies may include:<\/span><\/p>\n

Acupuncture<\/span><\/h3>\n

Acupuncture involves placing thin, tiny needles into certain points of the skin. This type of treatment is believed to stimulate the central nervous system and support the body\u2019s natural healing abilities. The foundation of acupuncture lies in the belief in chi or qi, the body\u2019s source of energy, according to traditional Chinese medicine.\u00a0<\/span><\/p>\n

Massage<\/span><\/h3>\n

Massage may be beneficial for relieving stress and fatigue in <\/span>breast cancer patients<\/span>. An experienced massage therapist can apply the appropriate amount of pressure to release muscle tension.\u00a0<\/span><\/p>\n

Meditation<\/span><\/h3>\n

Meditation is the practice of deep focus, mindfulness, and relaxation, and it may help lower anxiety and stress in people with cancer. Some people find that meditation also helps improve sleep and pain. Setting aside one or two parts of the day to meditate, either alone or with guidance from a group or sole practitioner, may help improve the quality of life in people with cancer.\u00a0<\/span><\/p>\n

Aromatherapy<\/span><\/h3>\n

Aromatherapy involves the use of fragrant oils that release scents into the air. Inhaling the aroma of these oils is considered safe and may help relieve stress, pain, and nausea. It\u2019s important to always test the oils before using them to avoid any allergic or hypersensitivity reactions. Applying lavender or tea tree oil on the skin should be avoided in women with <\/span>breast cancer<\/span> since these oils may affect <\/span>breast tissue growth<\/span><\/a>.\u00a0<\/span><\/p>\n

Diet<\/span><\/h3>\n

A healthy diet is always recommended to support general overall health. Eating a balanced diet can help support the body\u2019s natural functions while being treated for <\/span>breast cancer<\/span>. It\u2019s best to stick with nutrient-rich foods, such as fruits and vegetables, as well as lean meats and whole grains. Avoid foods high in fat, sugars, and processed ingredients.\u00a0<\/span><\/p>\n

How to switch to a <\/span>tamoxifen<\/span> alternative<\/span><\/h2>\n

Hormone therapy<\/span> for <\/span>breast cancer<\/span> is typically started after surgery. Switching to a <\/span>tamoxifen<\/span> alternative may depend on the response to treatment. The timeline for <\/span>hormone therapy<\/span> may look like one of the following:<\/span><\/p>\n

    \n
  • Start an <\/span>aromatase inhibitor<\/span> two to three years after treatment with <\/span>tamoxifen<\/span>. Continue taking the <\/span>aromatase inhibitor<\/span> for two to three years for a total of five years of treatment with <\/span>tamoxifen<\/span> and the <\/span>aromatase inhibitor<\/span>. This treatment timeline is appropriate for <\/span>postmenopausal women<\/span>.\u00a0<\/span><\/li>\n
  • Start an <\/span>aromatase inhibitor<\/span> two to three years after treatment with <\/span>tamoxifen<\/span>. Continue taking the <\/span>aromatase inhibitor<\/span> for five years for a total of seven to eight years of treatment with <\/span>tamoxifen<\/span> and the <\/span>aromatase inhibitor<\/span>. This treatment timeline is appropriate for <\/span>postmenopausal women<\/span>.\u00a0<\/span><\/li>\n
  • Start an <\/span>aromatase inhibitor<\/span> five years after treatment with <\/span>tamoxifen<\/span> and ovarian suppression therapy. Continue taking the <\/span>aromatase inhibitor<\/span> for five years for a total of 10 years of treatment with <\/span>tamoxifen<\/span> and the <\/span>aromatase inhibitor<\/span>. This treatment timeline is appropriate for women who are premenopausal at the time of diagnosis.\u00a0<\/span><\/li>\n<\/ul>\n

    \u00a0<\/span>An <\/span>oncologist<\/span> will recommend <\/span>follow-up<\/span> care every few months to assess the effects after treatment with <\/span>hormone therapy<\/span>. They will also assess the <\/span>risk of recurrence<\/span> of cancer and determine the next steps for treatment as needed.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

    Compare tamoxifen alternatives\u00a0| Other SERMs\u00a0| Faslodex \u00a0| Aromatase inhibitors \u00a0| Natural alternatives | How to switch meds Most breast cancers (almost 70%) are hormone receptor-positive; in other words, the tumors contain estrogen or progesterone receptors. Estrogen or progesterone hormones can promote the growth and spread of breast cancer cells if left unchecked. Blocking hormone receptors […]<\/p>\n","protected":false},"author":133,"featured_media":52120,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[794,4350,8670],"coauthors":[8669],"class_list":["post-52075","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-cancer","tag-prescription-savings","tag-womens-health","wpautop"],"acf":[],"yoast_head":"\nTop tamoxifen alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Evista, Fareston, Faslodex, Arimidex, and Femara are some tamoxifen alternatives. 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