{"id":52466,"date":"2022-07-08T09:19:30","date_gmt":"2022-07-08T13:19:30","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=52466"},"modified":"2026-03-03T17:08:32","modified_gmt":"2026-03-03T22:08:32","slug":"combigan-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/combigan-alternatives\/","title":{"rendered":"Combigan alternatives: What can I take instead of Combigan?"},"content":{"rendered":"

Combigan<\/span><\/a> (<\/span>brimonidine tartrate<\/span>–<\/span>timolol maleate<\/span>) is a <\/span>brand-name<\/span> prescription <\/span>eye drop<\/span> medication that combines two drugs that work in different ways to <\/span>lower eye pressure<\/span>. Eye doctors use <\/span>Combigan<\/span> in people diagnosed with high <\/span>eye pressure<\/span> or <\/span>glaucoma<\/span><\/a>, a condition in which elevated <\/span>eye pressure<\/span> damages the <\/span>optic nerve<\/span>. While eye doctors consider a variety of issues when prescribing <\/span>eye pressure<\/span> drugs, the initial choice may not be the right one. It may not be powerful enough, or <\/span>side effects<\/span> may be a problem. In those cases, they have a variety of alternative drug types to relieve <\/span>ocular hypertension<\/span>.\u00a0<\/span><\/p>\n

What can I take instead of <\/span>Combigan<\/span>?<\/span><\/h2>\n

While an effective treatment for some people, <\/span>Combigan<\/span> may not be the best and safest option. First of all, not everyone with elevated <\/span>eye pressure<\/span> needs two medications. Most cases of elevated <\/span>eye pressure<\/span> due to the most common form of <\/span>glaucoma<\/span>\u2013<\/span>open-angle glaucoma<\/span>\u2013can be treated with just one drug. First-line agents are typically <\/span>prostaglandin<\/span> analogs, such as <\/span>Xalatan<\/span> (<\/span>latanoprost<\/span>)<\/span><\/a> or <\/span>Travatan Z<\/span> (<\/span>travoprost<\/span>)<\/span><\/a>, which may be more effective at decreasing <\/span>intraocular pressure<\/span> (<\/span>IOP<\/span>) than the components of <\/span>Combigan<\/span>. If patients do not achieve a goal decrease in <\/span>IOP<\/span>, ophthalmologists may need to add a second or third drug for severe or more stubborn cases.<\/span><\/p>\n

Some people <\/span>can never take <\/span>Combigan<\/span> safely<\/span><\/a> because of <\/span>asthma<\/span><\/a>, <\/span>chronic obstructive pulmonary disease (COPD)<\/span><\/a>, or serious heart problems. They will need a different drug than one that contains <\/span>timolol<\/span>.<\/span><\/p>\n

Ophthalmologists<\/span> have a wide variety of drugs they can use. For <\/span>fixed combination<\/span> eye drops<\/span>, they can use <\/span>Combigan<\/span>, generic <\/span>Combigan<\/span>, <\/span>Cosopt<\/span><\/a>, generic <\/span>Cosopt<\/span>, <\/span>Rocklatan<\/span><\/a>, or <\/span>Simbrinza<\/span><\/a>.\u00a0<\/span><\/p>\n

There are also a variety of single-medication <\/span>eye drops<\/span> and oral medications available that may work better than <\/span>Combigan<\/span>, including carbonic anhydrase inhibitors like <\/span>Azopt<\/span>, <\/span>prostaglandin<\/span> analogs like <\/span>Xalatan<\/span><\/a> (<\/span>latanoprost<\/span><\/a>), and a new type of drug called a rho-kinase inhibitor like <\/span>Rhopressa<\/span><\/a> (<\/span>netarsudil<\/span>).\u00a0<\/span><\/p>\n

Before switching, get <\/span>medical advice<\/span> from the eye doctor. While many <\/span>glaucoma medications<\/span><\/a> have <\/span>common side effects<\/span>, some alternatives have distinct adverse effects that should be considered before switching to a different medication.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Combigan<\/span> alternatives cost comparison<\/span><\/h3>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nPrice without insurance<\/b><\/td>\nSingleCare price<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Combigan<\/span> (<\/span>brimonidine<\/span>\/<\/span>timolol<\/span>)<\/span><\/td>\n$278 for 5 mL of 0.2-0.5% solution<\/span><\/td>\n$24 for 5 mL of 0.2-0.5% solution of generic <\/span>Combigan<\/span> at CVS Pharmacy<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Generic <\/span>Combigan<\/span> (<\/span>brimonidine<\/span>\/<\/span>timolol<\/span>)<\/span><\/td>\n$245 for 5 mL of 0.2-0.5% solution<\/span><\/td>\n$24 for 5 mL of 0.2-0.5% solution of generic <\/span>Combigan<\/span> at CVS Pharmacy<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Cosopt<\/span> (<\/span>dorzolamide<\/span>\/<\/span>timolol<\/span>)<\/span><\/td>\n$265 for 10 mL of 2-0.5% solution<\/span><\/td>\n$15 for 10 mL of 2-0.5% solution of generic <\/span>Cosopt<\/span> at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Xalatan<\/span> (<\/span>latanoprost<\/span>)<\/span><\/td>\n$345 per 2.5 mL of 0.005% solution\u00a0<\/span><\/td>\n$9 per 2.5 mL of 0.005% solution of generic <\/span>Xalatan<\/span> at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Azopt<\/span> (<\/span>brinzolamide<\/span>)<\/span><\/td>\n$464 per 10 mL of 1% solution<\/span><\/td>\n$59 per 10 mL of 1% solution of generic <\/span>Azopt<\/span> at CVS Pharmacy<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Rhopressa<\/span> (<\/span>netarsudil<\/span>)<\/span><\/td>\n$431 per 2.5 mL of 0.02% solution<\/span><\/td>\n$339 per 2.5 mL of 0.02% solution of <\/span>brand-name<\/span> Rhopressa at Kroger<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n
Simbrinza<\/span> (<\/span>brinzolamide<\/span>\/<\/span>brimonidine tartrate<\/span>)<\/span><\/td>\n$360 for 1, 8 mL of 1-0.2% solution<\/span><\/td>\n$193 for 1, 8 mL of 1-0.2% solution of <\/span>brand-name<\/span> Simbrinza<\/span> at Walmart<\/span><\/td>\nSee latest prices<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Prescription drug<\/span><\/i> prices often change. These are the most accurate medication prices at the time of publishing in ZIP code 23666 as of 02\/01\/26. Click the link under \u201cSee our lowest price\u201d to see the latest drug prices.<\/span><\/i><\/small><\/p>\n

Top 5 <\/span>Combigan<\/span> alternatives<\/span><\/h2>\n

2. \u200b\u200b<\/span>Xalatan<\/span>, Xelpros (<\/span>latanoprost<\/span>)<\/span><\/h3>\n

Latanoprost<\/span><\/a> is a <\/span>prostaglandin<\/span> analogue, a highly potent treatment for high <\/span>eye pressure<\/span> and <\/span>open-angle glaucoma<\/span>. Unlike <\/span>Combigan<\/span> or <\/span>Cosopt<\/span>, <\/span>latanoprost<\/span> doses are administered once daily, usually in the evening. <\/span>Brand-name<\/span> versions include <\/span>Xalatan<\/span><\/a> and <\/span>Xelpros<\/span><\/a>, but the <\/span>generic version<\/span> is a more affordable option.\u00a0<\/span><\/p>\n

Latanoprost<\/span> has similar <\/span>side effects<\/span> as <\/span>Combigan<\/span>, but also has reports of foreign body sensation (gritty sensation in the eye), upper respiratory infection, increased pigmentation or darkening of the iris, and <\/span>eyelash<\/span> changes, including increased length and thickness.<\/span><\/p>\n

RELATED: <\/b>What are <\/b>prostaglandins<\/b>?<\/b><\/a><\/p>\n

3. <\/span>Azopt<\/span> (<\/span>brinzolamide<\/span>)<\/span><\/h3>\n

Azopt<\/span> has <\/span>similar <\/span>side effects<\/span><\/a> as <\/span>Combigan<\/span>, but also has reports of inflammation of the eyelids, foreign body sensation (gritty sensation in the eye), stuffy nose, and bitter, sour, or unusual taste. Unlike <\/span>Combigan<\/span>, <\/span>Azopt<\/span> can be prescribed to people with asthma, COPD, or serious heart problems.<\/span><\/p>\n

RELATED: <\/b>Carbonic anhydrase inhibitors: Uses, common brands, and safety information<\/b><\/a><\/p>\n

4. Rhopressa (<\/span>netarsudil<\/span> ophthalmic solution<\/span>)<\/span><\/h3>\n

Rhopressa<\/span><\/a> has reports of <\/span>side effects<\/span> that <\/span>Combigan<\/span> does not have, including eye pain when administering, corneal verticillata (deposits in the cornea), and broken blood vessels in the eye.<\/span><\/p>\n

5. <\/span>Simbrinza<\/span> (<\/span>brinzolamide<\/span> and <\/span>brimonidine tartrate<\/span>)<\/span><\/h3>\n

Simbrinza<\/span><\/a> is a combination <\/span>eye drop<\/span> that can be used to manage <\/span>open-angle glaucoma<\/span> and <\/span>ocular hypertension<\/span>. There is no <\/span>generic version<\/span>. <\/span>Simbrinza<\/span> contains a carbonic anhydrase inhibitor (<\/span>brinzolamide<\/span>) and an alpha blocker (<\/span>brimonidine tartrate<\/span>). Unlike <\/span>Combigan<\/span>, <\/span>Simbrinza<\/span> is dosed three times daily.\u00a0<\/span><\/p>\n

Simbrinza<\/span><\/a> has reports of <\/span>side effects<\/span> that <\/span>Combigan<\/span> does not have, including a bad taste in the mouth and dry mouth. Unlike <\/span>Combigan<\/span>, <\/span>Simbrinza<\/span> can be prescribed to people with asthma, COPD, or serious heart problems.<\/span><\/p>\n

Natural alternatives to <\/span>Combigan<\/span>\u00a0<\/span><\/h2>\n

Natural alternatives to <\/span>Combigan<\/span> can help eye health, but they are no substitute for medical attention and drugs that <\/span>lower eye pressure<\/span>. Relying solely on natural treatments may be risky. Elevated intraocular pressure steadily damages the <\/span>optic nerve<\/span> and can lead to permanent vision loss or blindness. If the pressure is high enough, <\/span>optic nerve<\/span> damage can happen quickly.<\/span><\/p>\n

That being said, certain supplements, lifestyle changes, and diet modifications can help keep the eyes healthy. According to the <\/span>American Optometric Association<\/span><\/a>, proper nutrition for eye health includes a diet that has zinc, copper, essential fatty acids, lutein, vitamin C, vitamin E, and vitamin A. The supplement <\/span>PreserVision<\/span><\/a> includes many of these nutrients and is available over the counter.<\/span><\/p>\n

Physical exercise and weight loss can have a positive impact on reducing some <\/span>glaucoma<\/span> risk factors, including high <\/span>blood pressure<\/span> and diabetes. Since caffeine can increase <\/span>eye pressure<\/span>, it may help to limit caffeine intake.\u00a0<\/span><\/p>\n

How to switch to a <\/span>Combigan<\/span> alternative<\/span><\/h2>\n

1. Discuss all health conditions with a <\/span>healthcare provider<\/span><\/h3>\n

Before switching from <\/span>Combigan<\/span> to an alternative, it\u2019s important that the prescribing doctor has reviewed all health conditions and potential <\/span>drug interactions<\/span>. Get <\/span>medical advice<\/span> from an <\/span>ophthalmologist<\/span> prior to changing medication therapy.<\/span><\/p>\n

2. Do not suddenly stop taking <\/span>Combigan<\/span><\/h3>\n

Before stopping <\/span>Combigan<\/span>, make a <\/span>glaucoma<\/span> or <\/span>ocular hypertension<\/span> care plan with the prescribing doctor to avoid increases in <\/span>intraocular pressure<\/span>. Once a plan has been established, <\/span>Combigan<\/span> can be safely discontinued and replaced with the new treatment.<\/span><\/p>\n

3. Continue proper <\/span>eye drop<\/span> administration<\/span><\/h3>\n

Using <\/span>eye drops<\/span> correctly<\/span><\/a> ensures proper drug administration and absorption into the eye. It\u2019s important to make sure <\/span>contact lenses<\/span> are removed from the eye before using <\/span>eye drops<\/span>, unless the eye doctor has instructed the patient to keep them in. Make sure hands are washed, tilt head backward while sitting, standing, or lying down, place the index finger below the lower lid to gently pull down and form a pocket, look up, and squeeze the drop into the pocket. It\u2019s important to keep the eye closed after the drop has been administered. Try to keep your eye closed for 1 to 3 minutes without blinking.<\/span><\/p>\n

If using more than one drop or more than one type of <\/span>eye drop<\/span>, wait five minutes before putting the next drop in. This will keep the first drop from being washed out by the second before it has had time to work.<\/span><\/p>\n

4. Keep and maintain eye doctor appointments<\/span><\/h3>\n

People with <\/span>glaucoma<\/span> and <\/span>ocular hypertension<\/span> should be regularly checked by their eye doctor. At these appointments, intraocular <\/span>pressure<\/span> (<\/span>IOP<\/span>) can be measured to assess the effectiveness of their medication regimen. People managing their IOP need to be aware of the normal <\/span>eye pressure<\/span> range (<\/span>12-21 mm Hg<\/span><\/a>) and the <\/span>high pressure<\/span> range (greater than 21 mm Hg). Vision tests may also be performed to detect any loss of vision or <\/span>optic nerve<\/span> damage.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Combigan (brimonidine tartrate–timolol maleate) is a brand-name prescription eye drop medication that combines two drugs that work in different ways to lower eye pressure. Eye doctors use Combigan in people diagnosed with high eye pressure or glaucoma, a condition in which elevated eye pressure damages the optic nerve. While eye doctors consider a variety of […]<\/p>\n","protected":false},"author":133,"featured_media":52626,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,4350],"coauthors":[20740],"class_list":["post-52466","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop Combigan alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Cosopt, Xalatan, Azopt, Rhopressa, and Simbrinza are some Combigan alternatives. 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Rhopressa<\/span><\/a> is a new type of <\/span>open-angle glaucoma<\/span> and <\/span>eye pressure<\/span> drug called a rho-kinase inhibitor. It\u2019s slightly less potent than <\/span>latanoprost<\/span>, but it may be the right medication for certain situations. Unfortunately, there is no <\/span>generic version<\/span>. Doses are administered once daily in the evening.\u00a0<\/span><\/p>\n

Brinzolamide<\/span><\/a> is a carbonic anhydrase inhibitor and a potent treatment for <\/span>open-angle glaucoma<\/span> and <\/span>ocular hypertension<\/span>. As a carbonic anhydrase inhibitor, it\u2019s not as powerful as <\/span>latanoprost<\/span>, but it should be strong enough for many cases of high <\/span>eye pressure<\/span>. Unlike <\/span>Combigan<\/span>, <\/span>brinzolamide<\/span> is dosed three times daily.\u00a0<\/span><\/p>\n

1. <\/span>Cosopt<\/span> (<\/span>dorzolamide<\/span>\/<\/span>timolol<\/span>)<\/span><\/h3>\n

Cosopt<\/span><\/a> is a combination <\/span>eye drop<\/span> that can be used to manage <\/span>open-angle glaucoma<\/span> and <\/span>ocular hypertension<\/span>. <\/span>Cosopt<\/span> contains a carbonic anhydrase inhibitor (<\/span>dorzolamide<\/span>) and a <\/span>beta blocker<\/span> (<\/span>timolol<\/span>). Like <\/span>Combigan<\/span>, <\/span>Cosopt<\/span> is dosed twice daily into the <\/span>affected eyes<\/span>.\u00a0<\/span><\/p>\n

Cosopt<\/span> also has a lower-priced generic option available called <\/span>dorzolamide<\/span> hydrochloride and <\/span>timolol maleate<\/span><\/a>. <\/span>Cosopt<\/span> is available in a <\/span>preservative-free<\/span> formulation (<\/span>Cosopt<\/span> PF) that can help reduce eye inflammation and be beneficial for those who experience <\/span>dry eyes<\/span>.\u00a0<\/span><\/p>\n

Cosopt<\/span> has <\/span>side effects<\/span><\/a> similar to those of <\/span>Combigan<\/span>, but there are also reports of a bitter, sour, or unusual taste. Like <\/span>Combigan<\/span>, <\/span>Cosopt<\/span> should not be used in people who have asthma, COPD, sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, or cardiogenic shock.<\/span><\/p>\n