{"id":52515,"date":"2022-07-05T10:11:56","date_gmt":"2022-07-05T14:11:56","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=52515"},"modified":"2023-01-03T16:45:29","modified_gmt":"2023-01-03T21:45:29","slug":"movantik-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/movantik-alternatives\/","title":{"rendered":"Movantik alternatives: What can I take instead of Movantik?"},"content":{"rendered":"

Compare Movantik alternatives<\/a>\u00a0| <\/span>Relistor<\/span><\/a> | <\/span>Symproic<\/span><\/a> | Entereg<\/a> | <\/span>Amitiza<\/span><\/a> | Linzess<\/a> | Trulance<\/a> | Natural alternatives<\/a> | How to switch meds<\/a><\/span><\/p>\n

Movantik<\/span> (<\/span>naloxegol<\/span>) is a medication manufactured by <\/span>AstraZeneca<\/span> and used in the <\/span>treatment of opioid<\/span> induced constipation<\/span> (IOC). To better understand how <\/span>Movantik<\/span> works, let\u2019s take a look at how opioid <\/span>pain medications<\/span> cause constipation. <\/span>Opioid <\/span>pain medications<\/span><\/a>, such as oxycodone, oxycontin, morphine, dilaudid (also referred to as narcotic pain meds, exert their pain relieving effects by its actions on 3 specific receptors: mu, delta, and kappa. Think of the receptors as the lock and the opioids as the key that can open the lock.\u00a0<\/span><\/p>\n

The problem is, these receptors are not only located in pain nerves, but also along our <\/span>gastrointestinal<\/span> (GI) tract (specifically the mu receptor). So, when you take an opioid <\/span>pain medication<\/span>, not only do the pain nerve fibers become desensitized, but the motility (movement) of the GI tract also becomes affected. When the mu receptor in the GI tract becomes activated by opioids, three main changes occur: decreased contractions of the GI tract, increased absorption of fluid from the GI tract lumen, and decreased secretion of fluid into the lumen of the GI tract (the last two changes both make it more dry and less lubricated in the GI tract). This results in constipation, which can be severe.\u00a0<\/span><\/p>\n

Constipation<\/span><\/a> is one of the most <\/span>common side effects<\/span> from the <\/span>use of opioid<\/span> pain medications<\/span>. This is where <\/span>Movantik<\/span> comes in. <\/span>Movantik<\/span>, and other <\/span>peripheral<\/span> opioid antagonists, block opioid medications\u2019 effects on the mu receptor in the GI tract.<\/span><\/p>\n

RELATED: <\/b>8 medications that cause constipation<\/b><\/a><\/p>\n

What can I take in place of <\/span>Movantik<\/span>?<\/span><\/h2>\n

For various reasons, a patient may need to switch to a different type of medication to treat <\/span>opioid induced constipation<\/span> and constipation in general. Some patients may not respond to <\/span>Movantik<\/span>. Other patients’ insurance may not cover the <\/span>brand-name<\/span> Movantik<\/span> b. Still others may have side effects to <\/span>naloxegol<\/span>, which may include <\/span>opioid withdrawal symptoms<\/span>. Fortunately, there are several alternative medications for constipation that can be tried.<\/span><\/p>\n

There are also three other <\/span>prescription drugs<\/span> indicated to treat chronic idiopathic constipation (CIC): <\/span>Amitiza<\/span> (<\/span>lubiprostone<\/span>), Linzess (linaclotide), and Trulance (plecanatide). While only one of these medications is also indicated for <\/span>OIC<\/span> (<\/span>Amitiza<\/span>), they can all be used for someone who has chronic constipation from the <\/span>effects of opioids<\/span>.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare Movantik alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nSavings options<\/b><\/td>\n<\/tr>\n
Movantik<\/td>\nOpioid induced constipation<\/td>\n12.5 mg, 25 mg oral tablet<\/td>\nMovantik coupons<\/a><\/td>\n<\/tr>\n
Relistor<\/td>\nOpioid induced constipation<\/td>\n150 mg oral tablet; 8 mg per 0.4 ml, 12 mg per 0.6 ml SC injection<\/td>\nRelistor coupons<\/a><\/td>\n<\/tr>\n
Symproic<\/td>\nOpioid induced constipation<\/td>\n0.2 mg oral tablet<\/td>\nSymproic coupons<\/a><\/td>\n<\/tr>\n
Entereg<\/td>\nPostoperative ileus<\/td>\n12 mg oral capsule<\/td>\nEntereg coupons<\/a><\/td>\n<\/tr>\n
Amitiza<\/td>\nChronic idiopathic constipation (CIC);constipation predominant irritable bowel syndrome (IBS-C); and opioid induced constipation (OIC)<\/td>\n8 mcg, 24 mcg oral capsule<\/td>\nAmitiza coupons<\/a><\/td>\n<\/tr>\n
Linzess<\/td>\nCIC; IBS-C<\/td>\n72 mcg, 145 mcg, and 290 mcg oral capsule<\/td>\nLinzess coupons<\/a><\/td>\n<\/tr>\n
Trulance<\/td>\nCIC; IBS-C<\/td>\n3 mg oral tablet<\/td>\nTrulance coupons<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top <\/span>Movantik<\/span> alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>Movantik<\/span>.<\/span><\/p>\n

Relistor<\/span><\/h3>\n

Relistor<\/span> <\/a>(<\/span>methylnaltrexone bromide<\/span>) is a medication in a class called <\/span>peripheral<\/span> opioid antagonists<\/span><\/a> (blockers), which is the same class as <\/span>Movantik<\/span> and <\/span>Symproic<\/span>. It is indicated for <\/span>opioid induced constipation<\/span> in patients that are taking narcotic <\/span>pain relief<\/span> medications for <\/span>chronic non-cancer pain<\/span>. It comes in one dose oral tablet and two different <\/span>subcutaneous<\/span> injection strengths. The <\/span>standard oral dose<\/span><\/a> is 450mg (which would be 3 tablets) once daily in the morning, at least 30 minutes prior to the first meal. The standard <\/span>subcutaneous<\/span> injection dose is 12mg once daily. Rare but serious side effects include <\/span>intestinal<\/span> perforation and severe diarrhea. <\/span>Common side effects<\/span> include nausea, headache, diarrhea, flatulence, and abdominal cramping.<\/span><\/p>\n

RELATED: <\/b>Opioid antagonists: Uses, common brands, and safety info<\/b><\/a><\/p>\n

Symproic<\/span><\/h3>\n

Symproic<\/span> <\/a>(<\/span>naldemedine<\/span>) is a third <\/span>peripheral<\/span> opioid antagonist, along with <\/span>Movantik<\/span> and <\/span>Relistor<\/span>. It comes in <\/span>one oral 0.2mg dose<\/span><\/a> tablet. Again, it is used for <\/span>opioid induced constipation<\/span> in patients that are taking narcotic <\/span>pain medications<\/span> for non-cancer related pain. <\/span>Symproic<\/span> can be taken with or without food, once daily. Rare but serious side effects include <\/span>intestinal<\/span> perforation, <\/span>opioid withdrawal<\/span>, and severe diarrhea. <\/span>Common side effects<\/span> include nausea, vomiting, headache, diarrhea, flatulence, <\/span>abdominal pain<\/span>.\u00a0<\/span><\/p>\n

Entereg<\/span><\/h3>\n

Entereg <\/span><\/a>(alvimopan) is an oral <\/span>mu-opioid receptor antagonist<\/span> medication approved for postoperative ileus. When you undergo any type of surgery, especially bowel surgery, your <\/span>intestines<\/span> can take a temporary break from contracting. Since contractions are what make your stool move throughout your <\/span>intestines<\/span> and enable you to have a <\/span>bowel movement<\/span>, when they don\u2019t contract, you won\u2019t have a <\/span>bowel movement<\/span>. This is referred to as an ileus. This can <\/span>occur after surgery<\/span><\/a> due to several reasons: the anesthesia given for the surgery, the surgery itself, and the <\/span>pain medications<\/span> given after the surgery is completed. Entereg has one dose only, 12mg. This is taken orally twice daily for up to seven days. It is recommended to start this within 5 hours before the surgery as <\/span>a single dose<\/span><\/a>, and then start it twice daily the day after surgery. A rare complication with long-term use only (which is not recommended), is the possibility of a heart attack. <\/span>Common side effects<\/span> include flatulence, urinary retention, and upset stomach.<\/span><\/p>\n

Amitiza<\/span><\/h3>\n

Amitiza<\/span> <\/a>(<\/span>lubiprostone<\/span>), an oral <\/span>chloride channel activator<\/span>, is a medication approved for three conditions: chronic idiopathic constipation (CIC), irritable <\/span>bowel syndrome<\/span> with constipation (IBS-C), and <\/span>opioid induced constipation<\/span> (<\/span>OIC<\/span>—–just like <\/span>Movantik<\/span>). This medication works by activating chloride channels in the <\/span>intestine<\/span>, promoting fluid secretion into the lumen of the <\/span>intestines<\/span>. This lubricates the <\/span>intestines<\/span> and causes contractions. This comes in two <\/span>doses<\/span><\/a>, an 8 mcg and 24 mcg oral capsule. The 8 mcg dose (twice daily) is indicated for constipation-predominant IBS. The 24 mcg dose twice daily is used for <\/span>OIC<\/span> and CIC. <\/span>Lubiprostone<\/span><\/a> should be taken with food. Rare but serious side effects include allergic reaction and hypotension (low blood pressure). <\/span>Common side effects<\/span> include nausea, bloating, headache, and diarrhea.<\/span><\/p>\n

RELATED: <\/b>Chloride channel activators<\/b>: Uses, common brands, and safety info<\/b><\/a><\/p>\n

Linzess<\/span><\/h3>\n

Linzess <\/span><\/a>(linaclotide), is a medication approved for two conditions: chronic idiopathic constipation (CIC) and irritable <\/span>bowel syndrome<\/span> with constipation (IBS-C). This medication works by activating guanylate cyclase-C, which then stimulates cyclic GMP in the <\/span>intestines<\/span>, promoting fluid secretion into the lumen of the <\/span>intestines<\/span>. This lubricates the <\/span>intestines<\/span> and causes contractions. Linzess comes in <\/span>three different doses<\/span><\/a>, a 72 mcg, 145 mcg, and 290 mcg oral capsule. The 290 mcg dose is indicated for constipation-predominant IBS. The 72 mcg and 145 mcg doses are used for CIC. Linzess is best taken first thing in the morning on an empty stomach. Rare but serious <\/span>side effects<\/span><\/a> include allergic reactions and severe diarrhea. <\/span>Common side effects<\/span> include nausea, flatulence, headache, and mild diarrhea.<\/span><\/p>\n

RELATED: How much is Linzess without insurance?<\/a><\/strong><\/p>\n

Trulance<\/span><\/h3>\n

Trulance<\/span><\/a> (plecanatide), is a medication approved for two conditions: chronic idiopathic constipation (CIC) and irritable <\/span>bowel syndrome<\/span> with constipation (IBS-C). Like Linzess, this medication works by activating guanylate cyclase-C, which then stimulates cyclic GMP in the <\/span>intestines<\/span>, promoting fluid secretion into the lumen of the <\/span>intestines<\/span>. This lubricates the <\/span>intestines<\/span> and causes contractions. Trulance comes in <\/span>only one dose<\/span><\/a>, 3 mg, making it a bit more simple to prescribe compared to say, Linzess. The most <\/span>common side effect<\/span> of Trulance is diarrhea, which can rarely be severe.<\/span><\/p>\n

Related: <\/b>Trulance vs. Llinzess<\/b><\/a><\/p>\n

Natural and OTC alternatives to <\/span>Movantik<\/span><\/h2>\n

The most well known natural <\/span>laxatives<\/span> to help with constipation include high fiber foods such as leafy greens, broccoli, brussel sprouts, and legumes. A high fiber diet, along with drinking plenty of water and regular exercise, is the foundation of treatment for mild constipation.\u00a0<\/span><\/p>\n

Prunes can also be quite helpful with mild forms of constipation. These regimens may not be enough for more significant constipation, including constipation caused or made worse by <\/span>opiates<\/span>. In this case, there are several OTC medications that can help with constipation (whether caused by opioids or not). These would be referred to as <\/span>over-the-counter<\/span> laxatives<\/span><\/a>.\u00a0<\/span><\/p>\n

In fact, in hospitalized patients who are constipated from opioids, we often use an OTC regimen of twice-daily <\/span>colace<\/span><\/a> (<\/span>docusate<\/span> sodium) 100 mg, a <\/span>stool softener<\/span>, along with <\/span>senokot<\/span><\/a> (sennosides) two 8.6 mg tablets in the evening. As sennosides are a derivative of the Senna plant (Senna alexandrina), this would be a natural alternative to <\/span>Movantik<\/span>. Senna acts as a stimulant <\/span>laxative<\/span>, much like <\/span>Dulcolax<\/span><\/a> (<\/span>bisacodyl<\/span>), another OTC <\/span>laxative<\/span>.\u00a0<\/span><\/p>\n

Stimulant <\/span>laxatives<\/span> are meant to be used short-term, unless otherwise directed by your physician or provider. When used long-term (more than approximately 1 month), they can be habit-forming, and result in worsening constipation if stopped.\u00a0<\/span><\/p>\n

Other OTC <\/span>laxatives<\/span> include <\/span>Miralax<\/span><\/a> (polyethylene glycol), <\/span>Citroma<\/span><\/a> (magnesium citrate), and <\/span>milk of magnesia<\/span><\/a>, all of which are considered osmotic <\/span>laxatives<\/span>. When oral <\/span>laxatives<\/span> are not enough or not tolerated, my patients will sometimes resort to using enemas, the most common of which is the <\/span>Fleet enema<\/span><\/a> and mineral oil enema. It is always best to consult with your <\/span>healthcare<\/span> provider before taking herbs or <\/span>supplements<\/span> to treat a medical condition.<\/span><\/p>\n

RELATED: <\/b>20 home remedies for constipation<\/b><\/a><\/p>\n

How to switch to a <\/span>Movantik<\/span> alternative<\/span><\/h2>\n

As mentioned, there are several alternative medications that can be substituted for <\/span>Movantik<\/span>, both in the same class and different classes for constipation. It is not always necessary for a person who is on opioid <\/span>pain medication<\/span> and is experiencing constipation to use a <\/span>peripheral<\/span> opioid antagonist.<\/span><\/p>\n

Other <\/span>laxatives<\/span>, both <\/span>over the counter<\/span> and prescription, should be stopped once you are placed on <\/span>Movantik<\/span>, <\/span>Relistor<\/span>, or <\/span>Symproic<\/span>, unless otherwise advised by your physician. In addition, once the opioid <\/span>pain medication<\/span> itself is stopped, the <\/span>peripheral<\/span> opioid antagonist should also be stopped.\u00a0<\/span><\/p>\n

Remember, if you have any questions about switching medications, if you experience <\/span>adverse effects<\/span> such as <\/span>severe abdominal pain<\/span> despite switching to a <\/span>new drug<\/span>, or have <\/span>risk factors<\/span> that may be of concern, contact your prescribing doctor or <\/span>healthcare professional<\/span> for <\/span>medical advice<\/span>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Compare Movantik alternatives\u00a0| Relistor | Symproic | Entereg | Amitiza | Linzess | Trulance | Natural alternatives | How to switch meds Movantik (naloxegol) is a medication manufactured by AstraZeneca and used in the treatment of opioid induced constipation (IOC). To better understand how Movantik works, let\u2019s take a look at how opioid pain medications […]<\/p>\n","protected":false},"author":133,"featured_media":52548,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[16414,4350],"coauthors":[20033],"class_list":["post-52515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-digestive-health","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop Movantik alternatives and how to switch your Rx<\/title>\n<meta name=\"description\" content=\"Relistor, Symproic, Entereg, Amitiza, Linzessare, and Trulance some Movantik alternatives. 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All of the medications mentioned above can successfully treat <\/span>opioid induced constipation<\/span>. However, insurance may not cover one of the meds approved for CIC or IBS-C (Linzess, Trulance), as they are not approved by the <\/span>Food and Drug Administration<\/span> (<\/span>FDA<\/span>) for <\/span>off-label<\/span><\/a> usage. Using a <\/span>SingleCare discount card<\/span><\/a> at <\/span>participating pharmacies<\/span><\/a> can help reduce the price for many prescription medications.<\/span><\/p>\n

There are three other <\/span>peripheral<\/span> opioid antagonists: <\/span>Relistor<\/span> (<\/span>methylnaltrexone<\/span>), <\/span>Symproic<\/span> (<\/span>naldemedine<\/span>), and Entereg (Alvimopan). These three alternatives work in the same way that <\/span>Movantik<\/span> works, by <\/span>blocking the opioid action<\/span><\/a> at the <\/span>intestinal<\/span> mu receptor. However, it should be noted that Entereg is only indicated to treat postoperative ileus (lack of <\/span>intestinal<\/span> contractions following surgery). This is a slightly different situation than <\/span>OIC<\/span>, however, the two conditions both involve constipation contributed to by <\/span>opiates<\/span>.<\/span><\/p>\n