{"id":52826,"date":"2022-08-04T09:49:17","date_gmt":"2022-08-04T13:49:17","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=52826"},"modified":"2022-08-04T09:49:17","modified_gmt":"2022-08-04T13:49:17","slug":"ropinirole-alternatives","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/ropinirole-alternatives\/","title":{"rendered":"Ropinirole alternatives: What can I take instead of ropinirole?"},"content":{"rendered":"

Compare ropinirole alternatives<\/a>\u00a0| Neurontin<\/a> | Neupro<\/a> | Sinemet<\/a> | Azilect<\/a> | Trihexyphenidyl<\/a> | Natural alternatives<\/a> | How to switch meds<\/a><\/span><\/p>\n

Whether you are using it for the <\/span>treatment of restless legs syndrome<\/span> or for <\/span>treatment of Parkinson disease<\/span>, <\/span>ropinirole<\/span><\/a> is likely a crucial component of your therapeutic regimen. You may recognize it by its former <\/span>brand names<\/span>, <\/span>Requip<\/span> and the <\/span>extended-release<\/span> form <\/span>Requip XL<\/span>. <\/span>Ropinirole<\/span> is a <\/span>dopamine agonist<\/span><\/a>. Stimulating dopamine <\/span>receptors<\/span> in the brain makes perfect sense in combating the dopamine deficiency of <\/span>Parkinson disease<\/span> (PD) and its resultant <\/span>dyskinesia<\/span> (abnormal movements such as tremor) and general slowing. The mechanism for effectiveness against leg discomfort and the urge to move one\u2019s legs in <\/span>restless leg syndrome<\/span> (<\/span>RLS<\/span>)<\/span><\/a> is not well established, likely because the underlying basis for <\/span>RLS<\/span> itself has not been defined yet. As beneficial as <\/span>ropinirole<\/span> may be for these two conditions, it may have significant negative aspects for you as well. Adverse effects are a common reason why one may be searching for an alternative to <\/span>ropinirole<\/span>. If so, and you\u2019d like to improve your <\/span>quality of life<\/span>, your search can start right here.<\/span><\/p>\n

What can I take in place of <\/span>ropinirole<\/span>?<\/span><\/h2>\n

Ropinirole<\/span> is often a first or second-line medication for <\/span>RLS<\/span> and <\/span>Parkinson disease<\/span>. These types of decisions are usually based on effectiveness, safety, and cost, all in comparison to other <\/span>treatment options<\/span>. While these comparisons may oftentimes support trying <\/span>ropinirole<\/span>, it simply may not work out due to <\/span>common side effects<\/span> . If this is the case, your other options for <\/span>RLS<\/span> include gabapentinoids, other <\/span>dopamine agonists<\/span>, and dopamine precursors. For <\/span>Parkinson disease<\/span>, you may want to consider other <\/span>dopamine agonists<\/span><\/a>, dopamine precursors, <\/span>monoamine oxidase inhibitors<\/span><\/a> (MAOIs), anticholinergics, and <\/span>amantadine<\/span><\/a>. We will cover these agents, so you can be well prepared to engage in a discussion with your <\/span>healthcare provider<\/span> and get their <\/span>medical advice<\/span> on the matter.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Compare ropinirole alternatives<\/span><\/h2>\n<\/th>\n<\/tr>\n<\/thead>\n

Drug name<\/b><\/td>\nUses<\/b><\/td>\nDosage<\/b><\/td>\nCoupons<\/b><\/td>\n<\/tr>\n
Ropinirole<\/span><\/td>\nRestless leg syndrome<\/b>, <\/b>Parkinson disease<\/b><\/td>\n0.25 to 4 mg once daily in the evening for <\/b>RLS<\/b>, 0.25 to 8 mg three times daily for PD<\/b><\/td>\nRopinirole<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Ropinirole<\/span> XR (<\/span>ropinirole<\/span> extended release<\/span><\/td>\nParkinson disease<\/b><\/td>\n2 to 24 mg once daily<\/b><\/td>\nRopinirole<\/span> XR coupons<\/span><\/a><\/td>\n<\/tr>\n
Neurontin (gabapentin)<\/span><\/td>\nRestless leg syndrome<\/b> (<\/b>off-label<\/b><\/a>), seizure, post-herpetic neuralgia<\/b><\/td>\n100 to 300 mg two hours before bedtime or as directed for <\/b>RLS<\/b><\/td>\nNeurontin coupons<\/span><\/a><\/td>\n<\/tr>\n
Horizant (<\/span>gabapentin enacarbil<\/span>)<\/span><\/td>\nRestless leg syndrome<\/b>, post-herpetic neuralgia<\/b><\/td>\n600 mg once daily<\/b><\/td>\nHorizant coupons<\/span><\/a><\/td>\n<\/tr>\n
Lyrica (pregabalin)<\/span><\/td>\nRestless leg syndrome<\/b> (off-label), diabetic neuropathic pain, post-herpetic neuralgia, fibromyalgia, partial seizures, spinal cord injury-associated neuropathic pain<\/b><\/td>\n50 to 75 mg two hours before bedtime or as directed for <\/b>RLS<\/b><\/td>\nLyrica coupons<\/span><\/a><\/td>\n<\/tr>\n
Pramipexole<\/span><\/td>\nRestless leg syndrome<\/b>, <\/b>Parkinson disease<\/b><\/td>\n0.125 to 0.5 mg once daily in the evening for <\/b>RLS<\/b>, 0.25 to 1.5 mg three times daily for PD<\/b><\/td>\nPramipexole<\/span> coupons<\/span><\/a><\/td>\n<\/tr>\n
Mirapex<\/span> ER (<\/span>pramipexole<\/span> extended release<\/span>)<\/span><\/td>\nParkinson disease<\/b><\/td>\n0.375 to 4.5 mg once daily<\/b><\/td>\nMirapex<\/span> ER coupons<\/span><\/a><\/td>\n<\/tr>\n
Neupro (<\/span>rotigotine<\/span>)<\/span><\/td>\nRestless leg syndrome<\/b>, <\/b>Parkinson disease<\/b><\/td>\n1 to 3 mg patch applied once daily for <\/b>RLS<\/b>, 2 to 8 mg patch applied once daily for PD<\/b><\/td>\nNeupro coupons<\/span><\/a><\/td>\n<\/tr>\n
Sinemet (<\/span>carbidopa<\/span>\/<\/span>levodopa<\/span>)<\/span><\/td>\nParkinsonism, <\/b>restless leg syndrome<\/b> (off-label)<\/b><\/td>\n10 mg\/100 mg three to four times daily for PD and increased as directed, 25 mg\/100 mg at bedtime for <\/b>RLS<\/b><\/td>\nSinemet coupons<\/span><\/a><\/td>\n<\/tr>\n
Carbidopa<\/span>\/<\/span>levodopa<\/span> ER (<\/span>extended release<\/span>)<\/span><\/td>\nParkinson disease<\/b><\/td>\n50 mg\/200 mg two to three times daily and increased as directed<\/b><\/td>\nCarbidopa<\/span>\/<\/span>levodopa<\/span> ER coupons<\/span><\/a><\/td>\n<\/tr>\n
Azilect (rasagiline)<\/span><\/td>\nParkinson disease<\/b><\/td>\n0.5 to 1 mg once daily<\/b><\/td>\nAzilect coupons<\/span><\/a><\/td>\n<\/tr>\n
Zelapar (selegiline)<\/span><\/td>\nParkinson disease<\/b><\/td>\n1.25 to 2.5 mg once daily<\/b><\/td>\nZelapar coupons<\/span><\/a><\/td>\n<\/tr>\n
Xadago (safinamide)<\/span><\/td>\nParkinson disease<\/b><\/td>\n50 to 100 mg once daily<\/b><\/td>\nXadago coupons<\/span><\/a><\/td>\n<\/tr>\n
Amantadine<\/span><\/td>\nParkinsonism, influenza A treatment and prophylaxis<\/b><\/td>\n100 mg twice daily<\/b><\/td>\nAmantadine coupons<\/span><\/a><\/td>\n<\/tr>\n
Trihexyphenidyl<\/span><\/td>\nParkinson disease<\/b><\/td>\n6 to 10 mg divided into three daily doses<\/b><\/td>\nTrihexyphenidyl coupons<\/span><\/a><\/td>\n<\/tr>\n
Benztropine<\/span><\/td>\nParkinson disease<\/b><\/td>\n1 to 2 mg once daily at bedtime<\/b><\/td>\nBenztropine coupons<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Top 5 alternatives<\/span><\/h2>\n

The following are some of the most common alternatives to <\/span>ropinirole<\/span>.<\/span><\/p>\n

1. Neurontin<\/span><\/h3>\n

Neurontin<\/span><\/a> may be better known by its generic name, <\/span>gabapentin<\/span><\/a>, since it has been available in generic form for a number of years. The drug has <\/span>Food and Drug Administration<\/span> (<\/span>FDA<\/span>) indications for seizures and nerve pain after shingles, and widespread off-label use is seen for conditions such as <\/span>restless leg syndrome<\/span> and fibromyalgia. An evening dose of Neurontin could be recommended by your <\/span>healthcare provider<\/span> to treat <\/span>RLS<\/span>.<\/span><\/p>\n

Neurontin is a member of the gabapentinoid class of drugs, a category that also includes <\/span>Lyrica<\/span><\/a> and the longer-lasting <\/span>Horizant<\/span><\/a>. Horizant is the only gabapentinoid with an actual <\/span>FDA<\/span> indication for <\/span>RLS<\/span>, and its long duration of action permits once daily dosing, a desirable feature for those with symptoms throughout the day. Lyrica has also been studied more than Neurontin for <\/span>RLS<\/span> treatment. Although the Horizant and Lyrica may seem more appealing, they are usually more expensive. Generic Neurontin, gabapentin, can often be obtained at a reasonable cost, or a <\/span>SingleCare discount card<\/span><\/a> may help with the pricing of any drug at <\/span>participating pharmacies<\/span><\/a>.\u00a0<\/span><\/p>\n

Gabapentinoids like Neurontin are <\/span>first-line medications for <\/span>RLS<\/span><\/a>. Choosing them over <\/span>ropinirole<\/span> is typically a matter of wanting to avoid <\/span>possible side effects<\/span>. Notable, potential adverse <\/span>effects of ropinirole<\/span> include dizziness, orthostatic <\/span>hypotension<\/span> (<\/span>low blood pressure<\/span> upon standing up), anxiety, impulse control problems, compulsions, rebound symptoms when the medication wears off, and a withdrawal syndrome that can be severe if the medication is stopped without tapering off. <\/span>Ropinirole<\/span> can also be associated with an <\/span>augmentation syndrome<\/span><\/a> in which <\/span>RLS symptoms<\/span> worsen as treatment proceeds. Although Neurontin may avoid some of these issues, it can be associated with other <\/span>serious side effects<\/span> like dizziness, <\/span>sleepiness<\/span>, respiratory depression (reduced breathing), suicidality, drug dependency, and depression. Thus, Neurontin could be a reasonable alternative to <\/span>ropinirole<\/span>, but it may not be recommended by your <\/span>healthcare provider<\/span> if you have a history of <\/span>drowsiness<\/span>, obesity, depression, or substance abuse. It is also not a treatment for <\/span>Parkinson disease<\/span>.<\/span><\/p>\n

RELATED: <\/b>Lyrica vs. gabapentin: Differences, similarities, and which is better for you<\/b><\/a><\/p>\n

2. Neupro<\/span><\/h3>\n

All of the <\/span>dopamine agonists<\/span>, <\/span>ropinirole<\/span>, <\/span>pramipexole<\/span><\/a>, and <\/span>Neupro<\/span><\/a>, share many of the same risks, so choosing one over another may not avoid a <\/span>side effect<\/span>. <\/span>Pramipexole<\/span> is also taken in a manner similar to <\/span>ropinirole<\/span> for both <\/span>RLS<\/span> and PD, and <\/span>Mirapex<\/span> ER<\/span><\/a> and <\/span>ropinirole<\/span> XR<\/span><\/a> are both taken once daily for PD. You can surmise that if <\/span>ropinirole<\/span> is not working out for you, there is not much of an argument for changing to <\/span>pramipexole<\/span>.\u00a0<\/span><\/p>\n

On the other hand, you may be interested in the advantages of Neupro, as it is a patch. The convenience of use and its daylong effectiveness could be enticing for either <\/span>RLS<\/span> or PD. Unlike the other once-daily <\/span>dopamine agonists<\/span>, <\/span>Mirapex<\/span> ER and <\/span>ropinirole<\/span> XR, Neupro has an <\/span>FDA<\/span> indication for <\/span>RLS<\/span>. Before you jump at this option for <\/span>RLS<\/span>, you should recognize that most people with <\/span>RLS<\/span> only have symptoms in the evenings and do not need medication all day. The <\/span>RLS<\/span> indication is limited to those with moderate to severe disease with persistent symptoms. Another reason to potentially keep looking for other alternatives for <\/span>RLS<\/span> or PD symptoms is that Neupro is more expensive than <\/span>ropinirole<\/span> and other options.\u00a0<\/span><\/p>\n

3. Sinemet<\/span><\/h3>\n

Sinemet<\/span><\/a> has two components, <\/span>levodopa<\/span> to work as a dopamine precursor and <\/span>carbidopa<\/span> to inhibit peripheral decarboxylase in order for <\/span>levodopa<\/span> to not be broken down before it gets to the brain. By enhancing dopamine effects, Sinimet can have similar benefits and risks compared to dopamine <\/span>receptor<\/span> agonists like <\/span>ropinirole<\/span>. The risk of an augmentation phenomenon with Sinemet is particularly concerning. In these cases, continued <\/span>worsening<\/span> of Parkinson or <\/span>RLS symptoms<\/span> can be experienced as dosages are increased. Nonetheless, the effectiveness of Sinemet keeps it as a mainstay for <\/span>Parkinson disease<\/span>. For <\/span>RLS<\/span> treatment, it is used off-label and on an as-needed basis for those suffering symptoms only intermittently rather than daily.<\/span><\/p>\n

4. Azilect<\/span><\/h3>\n

Azilect<\/span><\/a> could be chosen over <\/span>ropinirole<\/span> for mild cases of <\/span>Parkinson disease<\/span>. It avoids some of the <\/span>dopamine agonist<\/span> side effects<\/span> and offers the conveniences of once daily dosing. Through inhibition of monoamine oxidase type B, Azilect helps to prevent the breakdown of dopamine. <\/span>Xadago<\/span><\/a> and <\/span>Zelapar<\/span><\/a> are also monoamine oxidase inhibitors (MAOIs). Azilect and its fellow type B MAOIs are not potent, so the drugs are typically chosen for individuals with mild PD symptoms. Its <\/span>dopaminergic<\/span> effect results in it having some adverse effects that are similar to <\/span>ropinirole<\/span>, such as potential depression and compulsive behaviors. Due to a lengthy list of drug interactions, you should also review your list of prescription drugs, over-the-counter medications, and <\/span>supplements<\/span> with the <\/span>prescribing<\/span> provider before starting and while taking Azilect.<\/span><\/p>\n

5. Trihexyphenidyl<\/span><\/h3>\n

Another option for those in the early stages of <\/span>Parkinson disease<\/span>, <\/span>trihexyphenidyl<\/span><\/a> may be worth considering if you are younger and troubled predominantly by tremor. Interested individuals would likely include those fearing the possibility of impulse control problems or augmentation phenomenon with <\/span>ropinirole<\/span> and Sinemet. An older age could be a reason for hesitation about trihexyphenidyl. It is an anticholinergic drug, meaning it blocks the action of acetylcholine. The effectiveness in PD is based on better balancing acetylcholine and dopamine activity in the brain. Seniors are more susceptible to anticholinergic <\/span>side effects<\/span> such as confusion, hallucinations, <\/span>constipation<\/span>, and urinary retention.<\/span><\/p>\n

Natural alternatives to <\/span>ropinirole<\/span><\/h2>\n

Regarding <\/span>Parkinson disease<\/span>, nonpharmacologic interventions are a common area of interest for both the treating providers and patients. Avoiding medication <\/span>side effects<\/span> is attractive to all parties. Based on proven benefits in <\/span>clinical trials<\/span>, <\/span>exercise is often used<\/span><\/a> early and throughout the course of treatment if possible. <\/span>Mindfulness yoga<\/span><\/a> also has evidence to support its use. Adding in a type of Mediterranean-style diet, term <\/span>the MIND diet<\/span><\/a>, could help slow the progression of PD.<\/span><\/p>\n

Restless leg syndrome<\/span> has viable natural alternatives too. If your iron stores are tested and found to be low, <\/span>iron replacement therapy<\/span><\/a> could help to ameliorate <\/span>symptoms of restless legs syndrome<\/span>. Studies also support <\/span>exercise regimens<\/span><\/a> as an option for <\/span>RLS<\/span>. In fact, studies have looked at a number of <\/span>complementary strategies for <\/span>RLS<\/span> treatment<\/span><\/a>, but the volume of evidence is low. <\/span>Magnesium <\/span>supplementation<\/span><\/a> has generated interest but remains unproven.<\/span><\/p>\n

How to switch to a <\/span>ropinirole<\/span> alternative<\/span><\/h2>\n

The opportunity to try a new medicine may be enticing if you are not getting the results that you had hoped for out of <\/span>ropinirole<\/span>, but changing drugs should not be undertaken brazenly. You should review your reasoning and alternatives with the treating <\/span>healthcare<\/span> professional. If you both agree on switching your therapy, ask for directions on how to gradually taper off <\/span>ropinirole<\/span> and how to start a new medication, since some require a slow titration due to the possibility of <\/span>withdrawal symptoms<\/span>. Fortunately, you now know that alternatives exist and what factors to consider when deciding on a drug change.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Compare ropinirole alternatives\u00a0| Neurontin | Neupro | Sinemet | Azilect | Trihexyphenidyl | Natural alternatives | How to switch meds Whether you are using it for the treatment of restless legs syndrome or for treatment of Parkinson disease, ropinirole is likely a crucial component of your therapeutic regimen. You may recognize it by its former […]<\/p>\n","protected":false},"author":133,"featured_media":52828,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[790,808,4350],"coauthors":[20732],"class_list":["post-52826","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-chronic-disease","tag-pain-management","tag-prescription-savings","wpautop"],"acf":[],"yoast_head":"\nTop ropinirole alternatives and how to switch your Rx | SingleCare<\/title>\n<meta name=\"description\" content=\"Neurontin, Neupro, Sinemet, Azilect, and trihexyphenidyl are some ropinirole alternatives. 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