{"id":53125,"date":"2022-08-10T09:30:19","date_gmt":"2022-08-10T13:30:19","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53125"},"modified":"2023-08-04T12:28:32","modified_gmt":"2023-08-04T16:28:32","slug":"drugs-affecting-muscle-growth","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/drugs-affecting-muscle-growth\/","title":{"rendered":"4 drugs that affect muscle growth"},"content":{"rendered":"

You\u2019re still sore from your last workout, so you pop an ibuprofen to power through today\u2019s routine. Or maybe you\u2019re training for a marathon, but your knee keeps acting up\u2014instead of throwing in the towel, you\u2019ve been relying on NSAIDs to get you through your grueling training runs. But will taking anti-inflammatories\u2014or other medications\u2014before or after your workout affect those sought-after gains?<\/span><\/p>\n

4 drugs that affect muscle growth<\/span><\/h2>\n

Here\u2019s what you need to know about the substances that might affect muscle growth and physical performance, plus whether they\u2019re safe to take pre- and post-workout.<\/span><\/p>\n

1. Advil (ibuprofen) and other NSAIDs<\/span><\/h3>\n

Whether the goal is pain prevention, enhanced performance, or to push through an injury, athletes take nonsteroidal anti-inflammatory drugs (<\/span>NSAIDs<\/span><\/a>), like <\/span>Advil<\/span><\/a>, <\/span>more than any other medication<\/span><\/a>. But according to <\/span>Robert Glatter, MD<\/span><\/a>, <\/span>an emergency medicine physician at<\/span> Lenox Hill Hospital<\/span><\/a> in New York, multiple studies have found minimal, if any, improvements in performance among those taking <\/span>ibuprofen<\/span><\/a>. What\u2019s more, taking Advil before a workout could potentially mask or hide pain, potentially increasing your risk of injury, Dr. Glatter says.<\/span><\/p>\n

A recent <\/span>study<\/span><\/a> found that NSAIDs can delay the resolution of <\/span>inflammation<\/span><\/a>, potentially leading to chronic pain<\/span>.<\/span> That\u2019s because the body\u2019s acute inflammatory response (via neutrophil activation) protects us against its development, Dr. Glatter explains. <\/span>Neutrophils<\/span><\/a>, a specific type of leukocyte (white blood cells), are sent to areas of inflammation or infection to set the stage for <\/span>macrophages<\/span><\/a>, another type of specialized white blood cells, to repair muscle damage. But according to the study, NSAIDs like ibuprofen may blunt this reparative response, both at the cellular level and genetically, Dr. Glatter says, ultimately contributing to chronic pain.\u00a0<\/span><\/p>\n

D<\/span>oes ibuprofen affect muscle growth?<\/span><\/h4>\n

Ibuprofen and other NSAIDs are commonly used to address pain and soreness from exercise, says <\/span>Brijesh Chandwani, DMD, BDS<\/span><\/a>, <\/span>an orofacial pain specialist at <\/span>Connecticut and NY TMJ<\/span><\/a>. They do this by inhibiting <\/span>cyclooxygenase (COX) activity<\/span><\/a>, a major enzyme involved in several physiological functions including inflammation and pain. \u201cCOX is required by muscles to develop mass (hypertrophy\/strength), which is an adaptive response to exercise,\u201d Dr. Chandwani says. \u201cIf COX is blocked using NSAIDs, theoretically the muscle growth is blocked.\u201d<\/span><\/p>\n

Research<\/span><\/a> indicates that NSAIDs have the potential to impede muscle growth, specifically in otherwise healthy young individuals engaged in resistance training when taken at high doses for an extended period of time, says <\/span>J. Wes Ulm, MD, Ph.D.<\/span><\/a>,<\/span> a physician-researcher and bioinformatics expert at<\/span> Harvard Medical School Hospital System<\/span><\/a>.\u00a0<\/span><\/p>\n

For example, if you\u2019re a bodybuilder, each exercise you do essentially injures the muscle, albeit in a controlled way, to promote growth. And <\/span>inflammation is an important part of this process<\/span><\/a>, says Dr. Ulm. \u201cThrough a series of steps involving growth factors, other regulatory molecules, and cellular signaling pathways, satellite cells surrounding the damaged muscle divide and fuse with the muscle fibers already present, leading to muscle hypertrophy and visible growth of the muscles,\u201d Dr. Ulm says. Preventing the body\u2019s inflammatory process with NSAIDs may inhibit muscle growth.<\/span><\/p>\n

Ibuprofen after exercise<\/span><\/h4>\n

The research is not fully clear on the dosage, timing, or full impact in general of NSAIDs surrounding strength-building and resistance training workouts. \u201cHowever, as a rule, blood plasma levels are highest shortly after ingesting an ibuprofen pill (or a dose of any other NSAID),\u201d Dr. Ulm says. Therefore, to the extent that the research thus far suggests some potential for impeded muscle growth and repair post-workout from ibuprofen in young people, it may be optimal to avoid taking an Advil shortly before or after a workout.<\/span><\/p>\n

In general, it\u2019s advisable to avoid NSAIDs including ibuprofen, naproxen, and aspirin in high doses, Dr. Glatter agrees. \u201cThere is not only no measurable benefit,\u201d he says, \u201cbut the risk of <\/span>kidney injury (including hyponatremia)<\/span><\/a> in light of more intense activity is also a potential concern.\u201d Other risks of NSAIDs include intestinal bleeding, stomach upset, and cardiovascular issues.\u00a0<\/span><\/p>\n

2. Statins<\/span><\/h3>\n

Statins<\/span><\/a> are drugs used to reduce high levels of <\/span>bad cholesterol (LDLs or low-density lipoproteins)<\/span><\/a> in the blood. \u201cStatins impede the activity of a key liver enzyme involved in cholesterol production and packaging\u2014but they, too, may also be associated with diminished muscle gains,\u201d Dr. Ulm says.\u00a0<\/span><\/p>\n

It’s long been known that statins can cause <\/span>side effects<\/span><\/a> including myalgias (muscle pain), cramping, and weakness, especially at high doses. In severe cases, statins may cause <\/span>rhabdomyolysis<\/span><\/a>, a breakdown of muscle tissue that can cause kidney damage. And according to research, they can <\/span>decrease workout performance<\/span><\/a>. <\/span>
\n<\/span>
\n<\/span>RELATED: <\/b>The causes of rhabdo – and how to recover<\/b><\/a><\/p>\n

3. Alcohol<\/span><\/h3>\n

Alcohol has been shown to reduce physical performance and muscle recovery, Dr. Chandwani says. According to <\/span>research<\/span><\/a>, alcohol impairs protein synthesis, the body\u2019s process of building muscle, particularly among those who drink heavily. So if your goal is to gain muscle mass, it\u2019s best to keep your alcohol consumption to a minimum.<\/span>
\n<\/span>
\n<\/span>RELATED: <\/b>Effects of post-workout drinking<\/b><\/a><\/p>\n

4. Metformin<\/span><\/h3>\n

It\u2019s possible that the diabetes drug <\/span>metformin<\/span><\/a> may impair your ability to gain muscle mass. According to a <\/span>small study<\/span><\/a> conducted in 2019, healthy adults over the age of 65 who were taking metformin experienced blunted gains in lean mass after following an exercise regimen that produced measurable increases in muscle mass in those not taking the drug. While more research is needed, it\u2019s a good idea to consult with your healthcare provider if you\u2019re on metformin and looking to put on muscle.<\/span><\/p>\n

How to reach your optimal health<\/span><\/h2>\n

Staying well hydrated<\/span><\/a>, eating a <\/span>balanced and healthy diet<\/span><\/a>, and getting adequate amounts of sleep can help you to live a full and healthy life while taking statins or NSAIDS, Dr. Glatter advises. \u201cModerate amounts of aerobic exercise along with engaging in strength training and conditioning are generally considered to be safe while taking such medications in lower to moderate dosages.\u201d he says.<\/span><\/p>\n

And Dr. Glatter emphasizes that adequate warm-up and stretching, proper nutrition, and adequate hydration play a more important role in reducing your potential for muscle injury and soreness than taking any anti-inflammatory medications.\u00a0<\/span><\/p>\n

Still, it\u2019s important to have a discussion with your healthcare provider if you experience muscle aches, pain, or any perceived decrease in muscle strength or reduced endurance while taking statins and NSAIDS, Dr. Glatter recommends. \u201cThe remote risk of myopathy and rhabdomyolysis leading to kidney failure and more serious effects should be considered in those patients with persistent or worsening muscle pain or tenderness while taking statins,\u201d he says. <\/span>
\n<\/span>
\n<\/span>READ NEXT: <\/b>Creatinine levels<\/b><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

You\u2019re still sore from your last workout, so you pop an ibuprofen to power through today\u2019s routine. Or maybe you\u2019re training for a marathon, but your knee keeps acting up\u2014instead of throwing in the towel, you\u2019ve been relying on NSAIDs to get you through your grueling training runs. But will taking anti-inflammatories\u2014or other medications\u2014before or […]<\/p>\n","protected":false},"author":135,"featured_media":53129,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[788,12752,8905],"coauthors":[20608],"class_list":["post-53125","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-drug-safety","tag-medication-side-effects","tag-seasonal","wpautop"],"acf":[],"yoast_head":"\nDrugs that affect muscle growth<\/title>\n<meta name=\"description\" content=\"The long-term use of NSAIDs in healthy people can inhibit muscle growth during resistance exercise. 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