{"id":53247,"date":"2022-08-16T13:17:04","date_gmt":"2022-08-16T17:17:04","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53247"},"modified":"2026-03-10T09:47:20","modified_gmt":"2026-03-10T13:47:20","slug":"naproxen-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/naproxen-side-effects\/","title":{"rendered":"How to avoid naproxen side effects"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen\"><span style=\"font-weight: 400;\">Naproxen<\/span><\/a><span style=\"font-weight: 400;\"> (brand names Aleve, Naprosyn, Naprelan, Anaprox DS) is a common pain reliever used for arthritis, back pain, gout, menstrual cramps, and everyday aches and fever. It belongs to a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs) &#8211; the same family as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">aspirin<\/span><\/a><span style=\"font-weight: 400;\">.<\/span> <span style=\"font-weight: 400;\">Like other NSAIDs, naproxen works well for pain and inflammation, but it comes with risks, especially if used long-term or at higher doses.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/resources\/nsaids\"><b>NSAID prices &amp; pain management resources<\/b><\/a><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on  Naproxen with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\t Naproxen 500 mg (60 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-kroger.svg\" alt=\"Kroger Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$7.34<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/naproxen#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-harristeeter.svg\" alt=\"Harris Teeter Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$7.34<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/naproxen#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/naproxen#blog-cta\" class=\"coupon-see-all-btn\">See  Naproxen prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2 id=\"common-side-effects-of-naproxen\"><span style=\"font-weight: 400;\">Common side effects of naproxen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Stomach problems and other gastrointestinal complaints are the most common side effects of naproxen. Many mild side effects are possible and listed in order of incidence, they are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gas (flatulence)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flu<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heartburn<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ringing in the ears<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Itching<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin discoloration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Back pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stuffy sinuses<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stuffy nose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sore throat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastritis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anemia<\/span><\/li>\n<\/ul>\n<h3 id=\"side-effects-in-females-vs-males\"><span style=\"font-weight: 400;\">Side effects in females vs. males<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While naproxen affects both sexes similarly, females should be aware of when they take naproxen. It is often used for menstrual cramps, but at higher doses, it may temporarily delay ovulation, which is important for those trying to conceive. During pregnancy, it is generally avoided after 20 weeks due to the risks of kidney issues in the baby.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For males, long-term or heavy use of NSAIDs has been linked in <\/span><a href=\"https:\/\/www.auajournals.org\/doi\/10.1016\/S0022-5347%2805%2901000-1\"><span style=\"font-weight: 400;\">some studies<\/span><\/a> <span style=\"font-weight: 400;\">to an increased <\/span><span style=\"font-weight: 400;\">risk of erectile dysfunction, though the underlying health condition being treated is often the primary cause.<\/span><\/p>\n<h2 id=\"serious-side-effects-of-naproxen\"><span style=\"font-weight: 400;\">Serious side effects of naproxen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Both prescription and nonprescription naproxen (Aleve) can produce serious and even life-threatening side effects, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe gastrointestinal problems such as stomach ulcers, bleeding, and perforation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vision problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood clots<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stroke<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Congestive heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney dysfunction or kidney damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3 id=\"sexual-dysfunction\"><span style=\"font-weight: 400;\">Sexual dysfunction<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Regular use of nonsteroidal anti-inflammatory drugs is associated with erectile dysfunction in older men, but how much is uncertain. <\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022534710052031\"><span style=\"font-weight: 400;\">Initial research<\/span><\/a><span style=\"font-weight: 400;\"> concluded that regular NSAID users were almost 1.4 times more likely to have erectile problems than other men of a similar age and with similar health conditions. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4826049\/\"><span style=\"font-weight: 400;\">Later research<\/span><\/a><span style=\"font-weight: 400;\"> has demonstrated varying associations based on the indication for use of the NSAID. No matter what the incidence, it\u2019s safe to say that using drugs like aspirin, ibuprofen, and naproxen on a regular basis may cause sexual dysfunction in men. Keep in mind, however, that many of the conditions treated by NSAIDs, such as muscle pain, arthritis, sciatica, headache, and atherosclerosis, are far more likely to cause erectile dysfunction. It\u2019s a trade-off, then.<\/span><\/p>\n<h3 id=\"high-blood-pressure\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">All NSAIDs, including naproxen, can cause or worsen high blood pressure. For naproxen, the exact incidence may be as high as 3 out of 100 people taking the drug, but those most at risk are people who already have high blood pressure and are taking blood pressure medications like <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/ace-inhibitors\/\"><span style=\"font-weight: 400;\">ACE inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretics<\/span><\/a><span style=\"font-weight: 400;\">. High blood pressure can lead to serious cardiovascular events, so people with high blood pressure should monitor their blood pressure when taking naproxen or other NSAIDs.<\/span><\/p>\n<h3 id=\"chest-pain\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Chest pain is not one of naproxen\u2019s most common side effects (3% or less), but it is serious. However, because non-aspirin NSAIDs like naproxen can cause heart attack or stroke, if chest pain is experienced when taking naproxen, <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-strengthens-warning-non-aspirin-nonsteroidal-anti-inflammatory\"><span style=\"font-weight: 400;\">get immediate medical care<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3 id=\"weight-gain\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Naproxen is not associated with weight gain. However, the drug can cause fluid retention and swelling, particularly when combined with other drugs that also might cause water retention. Increased fluid retention will, of course, add weight to the body. This is, however, just water weight. Though it\u2019s not good, body weight will return to normal once the offending drugs have been discontinued.<\/span><\/p>\n<h3 id=\"water-retention\"><span style=\"font-weight: 400;\">Water retention<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Speaking of fluid retention, as much as 9% of people taking naproxen will experience some swelling, and another 3% will see their hands, feet, and ankles swell because of water retention. These are delayed side effects that mainly occur in people taking naproxen over several days or longer. For most people, this is inconvenient, but for people with edema or heart failure, it&#8217;s a serious problem. In those cases, discuss the issue with a doctor or other healthcare professional.\u00a0<\/span><\/p>\n<h2 id=\"how-soon-do-naproxen-side-effects-start\"><span style=\"font-weight: 400;\">How soon do naproxen side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/blog\/how-long-does-naproxen-take-to-kick-in\/\">Naproxen usually takes about an hour to start working<\/a> and reaches its peak in two<\/span><a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Naproxen\"><span style=\"font-weight: 400;\"> to four hours<\/span><\/a><span style=\"font-weight: 400;\">. Many side effects, such as headaches and less serious stomach problems, could manifest within that time, even after one dose, though they become more likely as naproxen levels build in the body before hitting a maximum in a few days. Some side effects are delayed and may take a few days or weeks of continuous use to become a problem, including sinus problems, skin discoloration, ringing in the ears, edema, constipation, and serious gastrointestinal problems.\u00a0<\/span><\/p>\n<h3 id=\"how-long-do-naproxen-side-effects-last\"><span style=\"font-weight: 400;\">How long do naproxen side effects last?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Most of naproxen\u2019s side effects only last as long as naproxen is working in the body, about two days based on its half-life of 12 to 17 hours. It may take the body a while to recover from some of the delayed side effects, such as swelling, anemia, and blood problems.<\/span><\/p>\n<h3 id=\"do-higher-dosages-increase-side-effects\"><span style=\"font-weight: 400;\">Do higher dosages increase side effects?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking a higher dose of naproxen significantly increases the risk and potential severity of side effects. For example, higher doses place more strain on the kidneys and increase the likelihood of developing painful stomach ulcers or internal bleeding. Always stick to the lowest dose that manages your pain to keep these risks as low as possible.<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-naproxen\"><span style=\"font-weight: 400;\">What are the long-term side effects of naproxen?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Naproxen and Aleve are risky to take over the long term. Over-the-counter naproxen is only intended for short-term use, while prescription naproxen is only intended for time-limited use (no more than six months). This is because the long-term use of naproxen can produce side effects such as edema, blood disorders, kidney dysfunction, liver problems, blood clots, and serious gastrointestinal injury. The risk of these long-term side effects is proportional to the length of time the drug is taken. In addition, many of these long-term side effects can last for years or a lifetime after the drug has been stopped.<\/span><\/p>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Naproxen is contraindicated for anyone with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Known allergies to naproxen or other NSAIDs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of aspirin-induced or NSAID-induced asthma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A history of aspirin-induced or NSAID-induced hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aspirin-exacerbated respiratory disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe kidney disease<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Naproxen and other NSAIDs should never be taken in the days before or after coronary artery bypass graft (CABG) surgery.<\/span><\/p>\n<h3 id=\"pregnancy\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Naproxen use should be avoided by pregnant women starting at the 30<\/span><span style=\"font-weight: 400;\">th<\/span><span style=\"font-weight: 400;\"> week because it could cause a heart defect in the newborn. Beyond that, healthcare professionals are not certain if naproxen is safe to use during pregnancy, but there is no evidence that it causes birth defects when taken early in pregnancy. However, naproxen could cause problems with amniotic fluid when taken beyond week 20.\u00a0<\/span><\/p>\n<h3 id=\"breastfeeding\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Naproxen is considered compatible with breastfeeding, though it is present in breast milk in small amounts.<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Over-the-counter naproxen should not be given to children younger than 12 years of age. There are no OTC naproxen products that allow for pediatric dosing. However, prescription naproxen is FDA-approved for use in children as young as 2 years old for juvenile idiopathic arthritis or other pain. In those cases, the treatment is supervised by a healthcare professional, and the doses are determined by the child\u2019s weight.\u00a0<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Don\u2019t be fooled by how easily naproxen can be purchased at a drug or grocery store. Naproxen and Aleve should be used with care. The first step is to learn all the possible pitfalls and factor those in when deciding to take this drug.\u00a0<\/span><\/p>\n<h3 id=\"black-box-warning\"><span style=\"font-weight: 400;\">Black box warning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The FDA includes a cautionary warning that naproxen could cause gastrointestinal bleeding, ulcers, perforation, blood clots, stroke, and heart attack. These serious and even life-threatening adverse effects can happen within the first few weeks of use, without warning, and are more likely to occur the longer the drug is taken.<\/span><\/p>\n<h3 id=\"cautions\"><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some health conditions can be worsened by naproxen, or they increase the risks of side effects, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cardiovascular diseases, including heart attack and heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risk factors for heart disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hypertension<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Gastrointestinal disorders such as <\/span><span style=\"font-weight: 400;\">peptic ulcer disease<\/span><span style=\"font-weight: 400;\"> (PUD) and bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Water retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dehydration<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Asthma<\/span><\/li>\n<\/ul>\n<h3 id=\"fertility\"><span style=\"font-weight: 400;\">Fertility<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Naproxen can delay ovulation. Women trying to conceive should consider avoiding NSAIDs, particularly if they have problems conceiving or are undergoing infertility treatment.<\/span><\/p>\n<h3 id=\"seniors\"><span style=\"font-weight: 400;\">Seniors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">People older than 65 or who are debilitated should exercise greater caution with NSAIDs like naproxen. They are more vulnerable to some of the more serious side effects, including kidney problems, gastrointestinal bleeding, ulcer, and perforation.\u00a0<\/span><\/p>\n<h2 id=\"overuse-overdose\"><span style=\"font-weight: 400;\">Overuse &amp; overdose<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Although naproxen and other NSAIDs are not associated with abuse or physical dependence, they can be overused. Naproxen should not be taken continuously except under the care of a doctor or healthcare professional. Chronic use of naproxen increases the risks of serious side effects such as bleeding, blood clots, heart attack, stroke, and death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Call a poison helpline or get medical attention if too much naproxen is taken. Most people who overdose will experience stomach pain, nausea, and feel tired, but a large overdose can produce seizures, slowed breathing, high blood pressure, kidney failure, and coma.\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People taking non-prescription naproxen should not exceed 440 mg per day, but the maximum daily dose for prescription naproxen is 1650 mg per day for a limited time and 1500 mg per day over the long term.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Do not take prescription-strength doses with over-the-counter naproxen or Aleve. Although these doses of naproxen are considered safe for people under the care of a healthcare professional, they are not safe when self-medicating.<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Naproxen\u2019s side effects, particularly the serious ones, could be worsened when naproxen is combined with other drugs. In some cases, though, naproxen could increase the effects and side effects of other drugs. Naproxen\u2019s most significant drug interactions are as follows:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ketorolac, a prescription NSAID that is never combined with naproxen<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other NSAIDs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Salicylates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood thinners<\/span><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">warfarin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood pressure medications<\/span><span style=\"font-weight: 400;\">, particularly <\/span><span style=\"font-weight: 400;\">ACE inhibitors<\/span><span style=\"font-weight: 400;\">, angiotensin receptor blockers (<\/span><span style=\"font-weight: 400;\">ARBs<\/span><span style=\"font-weight: 400;\">), and <\/span><span style=\"font-weight: 400;\">beta blockers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thiazide diuretics<\/span><span style=\"font-weight: 400;\"> and <\/span><span style=\"font-weight: 400;\">loop diuretics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Corticosteroids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aminoglycoside antibiotics<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">SSRIs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">SNRIs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alcohol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Smoking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dietary supplements such as <\/span><span style=\"font-weight: 400;\">omega-3<\/span><span style=\"font-weight: 400;\"> fatty acids<\/span><\/li>\n<\/ul>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/blog\/naproxen-interactions\/\">Learn more about naproxen interactions<\/a><\/strong><\/p>\n<h2 id=\"how-to-avoid-naproxen-side-effects\"><span style=\"font-weight: 400;\">How to avoid naproxen side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As an over-the-counter medicine, ibuprofen is generally safe for people to take as directed. Still, side effects can be a problem, so here are a few ways to avoid them:<\/span><\/p>\n<h3 id=\"1-take-naproxen-as-directed\"><span style=\"font-weight: 400;\">1. Take naproxen as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">With OTC naproxen, please read and follow the instructions on the package, included in the drug information. For prescription naproxen, follow the instructions given by the prescriber or written on the prescription label. If a dose of prescription naproxen is missed, take it when remembered unless it\u2019s almost time for the next dose. In that case, skip the missed dose and take the next dose on time.\u00a0<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/prescription\/naproxen\/dosage\">Naproxen dosage guide<\/a><\/strong><\/p>\n<h3 id=\"2-take-naproxen-only-as-needed\"><span style=\"font-weight: 400;\">2. Take naproxen only as needed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Take the smallest possible dose for the shortest period possible when taking OTC naproxen. Once pain or fever has faded, stop taking the drug.\u00a0<\/span><\/p>\n<h3 id=\"3-do-not-take-other-nsaids-with-naproxen\"><span style=\"font-weight: 400;\">3. Do not take other NSAIDs with naproxen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Whether taking prescription or nonprescription naproxen\/Aleve, don\u2019t add similar drugs to the mix like <\/span><span style=\"font-weight: 400;\">aspirin<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">ibuprofen<\/span><span style=\"font-weight: 400;\">. Many cold and flu combination drugs also contain NSAIDs. The more NSAIDs taken, the greater the chance of side effects.<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\">List of NSAIDs<\/a><\/strong><\/p>\n<h3 id=\"4-avoid-smoking-and-alcohol\"><span style=\"font-weight: 400;\">4. Avoid smoking and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid stomach or bleeding problems, don\u2019t drink or smoke when taking NSAIDs.\u00a0<\/span><\/p>\n<p><strong>RELATED: <a href=\"https:\/\/www.singlecare.com\/blog\/naproxen-and-alcohol\/\">Learn more about alcohol and naproxen<\/a><\/strong><\/p>\n<h3 id=\"5-eat-before-taking-naproxen\"><span style=\"font-weight: 400;\">5. Eat before taking naproxen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another way to prevent stomach problems is to have a snack or a meal right before taking the medicine.<\/span><\/p>\n<h3 id=\"6-always-tell-healthcare-providers-about-naproxen\"><span style=\"font-weight: 400;\">6. Always tell healthcare providers about naproxen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Make sure that healthcare providers know naproxen is being taken every once in a while. In this way, side effects due to drug interactions can be avoided.\u00a0<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects-of-naproxen\"><span style=\"font-weight: 400;\">How to treat side effects of naproxen<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects are commonly experienced when using naproxen\/Aleve, particularly in people with pre-existing medical conditions or those taking prescription naproxen. When problems happen, there are solutions.<\/span><\/p>\n<h3 id=\"stomach-pain\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For stomach pain, upset stomach, or heartburn, use antacids. The best time to take them is right before a dose. If there\u2019s bleeding, then medical attention is needed. Watch for symptoms such as vomiting blood, blood clots (\u201ccoffee grounds vomit\u201d), fainting, or black, tarry stools.<\/span><\/p>\n<h3 id=\"kidney-problems\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Kidney problems due to naproxen will require medical attention. The most obvious symptoms are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Problems urinating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hand, ankle, and foot swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble breathing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<\/ul>\n<h3 id=\"heart-problems-or-blood-clots\"><span style=\"font-weight: 400;\">Heart problems or blood clots<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Get emergency medical attention if you experience chest pain, shortness of breath, weakness on one side of the body, or rapid swelling in the legs.<\/span><\/p>\n<h2 id=\"expert-takeaway\"><span style=\"font-weight: 400;\">Expert takeaway<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">\u201cDon\u2019t let naproxen\u2019s over-the-counter status fool you into thinking it\u2019s totally safe. While it effectively treats pain and inflammation, it also carries serious risks to your heart, kidneys, and stomach. Protect yourself by using the lowest effective dose for the shortest time possible, and always verify potential drug interactions with your pharmacist,\u201d says <\/span><a href=\"https:\/\/www.pacificu.edu\/about\/directory\/people\/jeff-fortner-pharmd-rph\"><span style=\"font-weight: 400;\">Jeff Fortner, Pharm.D.<\/span><\/a><span style=\"font-weight: 400;\">, a member of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/author\/jeff-fortner\/\"><span style=\"font-weight: 400;\">SingleCare\u2019s Medical Review Board<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Naproxen (brand names Aleve, Naprosyn, Naprelan, Anaprox DS) is a common pain reliever used for arthritis, back pain, gout, menstrual cramps, and everyday aches and fever. It belongs to a group of drugs called NSAIDs (nonsteroidal anti-inflammatory drugs) &#8211; the same family as ibuprofen and aspirin. Like other NSAIDs, naproxen works well for pain and [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":53248,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,808],"coauthors":[8861],"class_list":["post-53247","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-pain-management","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How to avoid naproxen side effects<\/title>\n<meta name=\"description\" content=\"Naproxen is an effective pain reliever, but it can cause side effects, especially if used long-term or at high doses.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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