{"id":53260,"date":"2022-08-17T14:24:28","date_gmt":"2022-08-17T18:24:28","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53260"},"modified":"2024-05-28T13:22:03","modified_gmt":"2024-05-28T17:22:03","slug":"fluconazole-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/fluconazole-side-effects\/","title":{"rendered":"Fluconazole side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#common-fluconazole-side-effects\">Common fluconazole side effects<\/a>\u00a0| <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#stomach-pain\">Stomach pain<\/a> | <a href=\"#nausea\">Nausea<\/a> | <a href=\"#rash\">Rash<\/a> | <a href=\"#headache\">Headache<\/a> | <a href=\"#side-effects-timeline\">Side effects timeline<\/a> | <a href=\"#contraindications\">Contraindications<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a> | <a href=\"#how-to-treat-side-effects\">How to treat side effects<\/a><\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\"><span style=\"font-weight: 400;\">Fluconazole<\/span><\/a><span style=\"font-weight: 400;\">, also prescribed as brand-name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/diflucan\"><span style=\"font-weight: 400;\">Diflucan<\/span><\/a><span style=\"font-weight: 400;\">, is a generic prescription drug used to treat fungal infections. Specifically, the FDA has approved fluconazole to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/yeast-infection-treatment-and-medications\"><span style=\"font-weight: 400;\">yeast infections<\/span><\/a><span style=\"font-weight: 400;\">\u2014<\/span><i><span style=\"font-weight: 400;\">Candida<\/span><\/i><span style=\"font-weight: 400;\"> infections of the <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/oral-thrush-treatment-and-medications\"><span style=\"font-weight: 400;\">mouth<\/span><\/a><span style=\"font-weight: 400;\">, esophagus, and vagina\u2014as well as cryptococcal meningitis, a yeast infection of the membranes that surround and protect the brain and spinal cord. While many common <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antifungals\"><span style=\"font-weight: 400;\">antifungal medications<\/span><\/a><span style=\"font-weight: 400;\"> are topical, and only applied to the skin, fluconazole is used systemically; that is, it is taken as an oral tablet or suspension, or given as an injection, so that the whole body is affected. That means side effects are more likely than when using <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/topical-antifungals\"><span style=\"font-weight: 400;\">topical antifungals<\/span><\/a><span style=\"font-weight: 400;\">. Even so, many people on fluconazole won\u2019t experience side effects. Those who do will generally have only mild or moderate issues.\u00a0<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:6849,&quot;3&quot;:{&quot;1&quot;:0},&quot;9&quot;:1,&quot;10&quot;:2,&quot;12&quot;:0,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;}\" data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<h2 id=\"common-fluconazole-side-effects\"><span style=\"font-weight: 400;\">Common side effects of fluconazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The types and severity of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\/what-is\"><span style=\"font-weight: 400;\">fluconazole<\/span><\/a><span style=\"font-weight: 400;\"> side effects will depend on whether the drug is administered as a single large one-day dose (for vaginal candidiasis), a double dose (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d3ca59bd-ae00-48ab-89aa-87c7f56e9989\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">for initial injections<\/span><\/a><span style=\"font-weight: 400;\">), or multiple doses spread out over several days. As can be expected, a single large dose is more likely to cause side effects. Headache is the most common side effect in people receiving a single large dose (<\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=0adb2f88-8a6f-4f33-9e2d-73f537e05313\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">13% incidence<\/span><\/a><span style=\"font-weight: 400;\">), while nausea is the most common side effect in people taking multiple smaller doses (3.7% incidence). Immune-compromised or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hiv-treatment-and-medications\"><span style=\"font-weight: 400;\">HIV\/AIDS<\/span><\/a><span style=\"font-weight: 400;\"> patients are more likely to experience fluconazole side effects.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/63505\/Diflucan\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common side effects<\/span><\/a><span style=\"font-weight: 400;\"> of fluconazole are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Abdominal pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acid indigestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in how things taste<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of fluconazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though rare, the most serious side effects of fluconazole include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased white blood cell or platelet counts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rhythm changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased adrenal gland function<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic or skin reactions<\/span><\/li>\n<\/ul>\n<h3 id=\"stomach-pain\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Abdominal pain is a common side effect of fluconazole, but it\u2019s more likely if the drug is administered as a single large dose. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=0adb2f88-8a6f-4f33-9e2d-73f537e05313\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">In clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, approximately 6% of people getting one large dose complained of stomach pain. When given smaller doses over several days, only 2% of participants complained of abdominal pain. Unless it\u2019s too hard to take, stomach pain is not health-threatening. If it\u2019s too debilitating, talk to the prescribing healthcare provider.\u00a0<\/span><\/p>\n<h3 id=\"nausea\"><span style=\"font-weight: 400;\">Nausea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Again, nausea is more likely to happen when given a single large dose of fluconazole. In clinical trials, the incidence was 7%. For people receiving multiple small doses, nausea affected only about 4% of participants. Nausea is a common problem with prescription drugs, but it is usually not health-threatening.<\/span><\/p>\n<h3 id=\"rash\"><span style=\"font-weight: 400;\">Rash<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Skin rash is an uncommon side effect of fluconazole and mainly occurs in people taking fluconazole over several days. About 2% of people taking multiple doses in the clinical trials experienced skin rash. By itself, a skin rash is not a medical emergency, but it could be an initial sign of a serious and even life-threatening skin reaction to the drug. Immediately contact the prescribing healthcare provider or another healthcare professional if a rash appears when taking fluconazole.<\/span><\/p>\n<h3 id=\"headache\"><span style=\"font-weight: 400;\">Headache<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Headache is the most common side effect in people given a single large dose of fluconazole. About 13% of people given a large dose will have problems with headache, while the incidence drops to 1.9% of people taking multiple small doses. Fluconazole-induced headaches are not by themselves a medical emergency and can be treated with over-the-counter pain relievers. Patients who experience headaches can consult their pharmacist or doctor if they need help selecting a pain reliever.\u00a0<\/span><\/p>\n<h2 id=\"side-effects-timeline\"><span style=\"font-weight: 400;\">How soon do fluconazole side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fluconazole side effects such as headache, nausea, and stomach pain can start quickly when given an injection. When fluconazole is taken by mouth, minor side effects could appear within an hour or two, the amount of time it normally takes an oral dose of fluconazole to hit its peak in the bloodstream.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do fluconazole side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fluconazole is a short-term, time-limited treatment. It can be given as a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluconazole\/dosage\"><span style=\"font-weight: 400;\">single large dose or as multiple daily doses<\/span><\/a><span style=\"font-weight: 400;\"> for one to three weeks. Most people, then, can expect side effects to resolve when treatment stops. However, it takes some time for the body to clear a dose. Healthy people clear fluconazole in about five days, but it may take two to three weeks in people with kidney disease. Serious but rare adverse effects like lowered white blood cell counts or adrenal insufficiency may take several weeks to recover from.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What are the long-term side effects of fluconazole?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fluconazole is a time-limited treatment for most people. However, in some cases, fluconazole is used over the long term to prevent a recurrence of certain fungal infections. Most chronic users will experience side effects <\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30535104\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">due to long-term use<\/span><\/a><span style=\"font-weight: 400;\">; the most common are dry skin, dry eyes, dry mouth, hair loss, and fatigue. Healthcare providers may need to reduce the dose or switch to another antifungal.<\/span><\/p>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Fluconazole contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Fluconazole is never prescribed to people who are allergic to the drug. Fluconazole should not be taken with certain medications like erythromycin, pimozide, or quinidine. This is because heart rhythm problems can occur when they are taken together.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">People with various sugar problems, like fructose intolerance, are never given fluconazole oral suspension because of the sugars mixed in with it. However, they can safely take tablets or get injections.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Healthcare professionals avoid giving fluconazole to women in the first trimester of pregnancy because of the risk of birth defects. Because of this risk, women of reproductive age should use contraception during fluconazole treatment to avoid getting pregnant. Though occasionally prescribed to mothers, if needed, later in a pregnancy, there\u2019s still a risk of spontaneous abortion up to week 22. In general, pregnant women and their healthcare providers have to weigh the pros and cons of fluconazole treatment before making a decision.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Healthcare providers are cautious about administering fluconazole to breastfeeding mothers. Fluconazole is present in breast milk but at levels below the FDA-approved dose for infants. Women who are breastfeeding should consult their healthcare provider for guidance.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Older adults<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Healthcare professionals are urged to use caution using azole antifungal medications like fluconazole in people ages 65 years and older. Guidelines call for seniors to receive the lowest possible dose for the shortest period. Several issues may cause problems, including kidney problems\/poor clearance of the drug, drug interactions, and changes in the heart\u2019s rhythm.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The Food and Drug Administration (FDA) has approved fluconazole for children of all ages including newborns.<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Fluconazole warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though problems are uncommon with fluconazole, they are possible. Some situations, though, make problems more likely.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some medical conditions may worsen during fluconazole therapy. Others may increase the chance of side effects. The greatest hazard involves changes to the heart\u2019s rhythm, particularly a lengthening of the time it takes for the heart to relax after it starts contracting, called QT prolongation. This prolongation can be hazardous and even life-threatening, so fluconazole is used cautiously in anyone with a heart rhythm problem (or a family history of heart rhythm problems). Electrolyte imbalance, particularly low potassium, also increases the risk of throwing off the natural rhythm of the heart when fluconazole is taken.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Kidney disease and liver disease can slow the body\u2019s ability to eliminate fluconazole from the body. As a result, fluconazole levels can build up in the body, increasing the risk of side effects. Doses may need to be adjusted.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluconazole is not a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/controlled-substances-act\/\"><span style=\"font-weight: 400;\">controlled substance<\/span><\/a><span style=\"font-weight: 400;\">. It is not a medication that risks abuse or physical dependence (or withdrawal when discontinued).\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Call the prescriber or go to an emergency room if too much fluconazole is taken. Some people have experienced hallucinations and paranoia after a fluconazole overdose.<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Fluconazole interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As with all prescription drugs, fluconazole may cause side effects or worse when combined with other drugs. The most concerning are drugs that build up in the body because fluconazole is a moderate inhibitor of the enzyme that breaks down these drugs. Some of these drugs can cause serious side effects when they\u2019re not properly broken down. A number of these drugs are contraindicated for use with fluconazole because the combination is just too dangerous. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiarrhythmics\"><span style=\"font-weight: 400;\">heart rhythm drugs<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/quinidine-sulfate\"><span style=\"font-weight: 400;\">quinidine<\/span><\/a><span style=\"font-weight: 400;\"> and dronedarone<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/how-do-antibiotics-work\/\"><span style=\"font-weight: 400;\">antibiotic<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/erythromycin\"><span style=\"font-weight: 400;\">erythromycin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">antipsychotic<\/span><\/a><span style=\"font-weight: 400;\"> medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pimozide\"><span style=\"font-weight: 400;\">pimozide<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/tramadol-hcl\"><span style=\"font-weight: 400;\">Tramadol<\/span><\/a><span style=\"font-weight: 400;\">, an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">opioid<\/span><\/a><span style=\"font-weight: 400;\"> pain reliever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">And several others<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other drugs can also build up in the body when fluconazole is being taken. These are less hazardous than contraindicated drugs, but doses may need to be adjusted. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Certain oral <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\"> drugs that lower blood sugar such as glimepiride, glipizide, and glyburide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-pressure-treatment-and-medications\"><span style=\"font-weight: 400;\">blood pressure medications<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/losartan-potassium\"><span style=\"font-weight: 400;\">losartan<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/statins\"><span style=\"font-weight: 400;\">Statins<\/span><\/a><span style=\"font-weight: 400;\"> such as atorvastatin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some immune system suppressants such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tacrolimus\"><span style=\"font-weight: 400;\">tacrolimus<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticonvulsants\"><span style=\"font-weight: 400;\">Anticonvulsants<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/phenytoin-sodium\"><span style=\"font-weight: 400;\">phenytoin<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/carbamazepine\"><span style=\"font-weight: 400;\">carbamazepine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioids such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\"><span style=\"font-weight: 400;\">fentanyl<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/methadone-hcl\"><span style=\"font-weight: 400;\">methadone<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/amitriptyline-hcl\"><span style=\"font-weight: 400;\">amitriptyline<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/anticoagulants\"><span style=\"font-weight: 400;\">blood thinner<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\"><span style=\"font-weight: 400;\">warfarin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/asthma-treatment-and-medications\"><span style=\"font-weight: 400;\">asthma<\/span><\/a><span style=\"font-weight: 400;\"> medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/theophylline\"><span style=\"font-weight: 400;\">theophylline<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chemotherapy drugs known as alkaloids such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vincristine-sulfate\"><span style=\"font-weight: 400;\">vincristine<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/vinblastine-sulfate\"><span style=\"font-weight: 400;\">vinblastine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/vitamin-a\"><span style=\"font-weight: 400;\">Vitamin A<\/span><\/a><span style=\"font-weight: 400;\"> supplements and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/retinoids\"><span style=\"font-weight: 400;\">retinoids<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Caffeine is another substance that can build up in the body during fluconazole treatment. It\u2019s not a health threat, but drinking coffee and other caffeinated drinks will have slightly more pronounced and longer-lasting effects when combined with fluconazole.<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/tuberculosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Tuberculosis<\/span><\/a><span style=\"font-weight: 400;\"> antibiotics such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/rifampin\"><span style=\"font-weight: 400;\">rifampin<\/span><\/a><span style=\"font-weight: 400;\"> could reduce fluconazole\u2019s effectiveness, so the dose of fluconazole may need to be increased.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Finally, healthcare professionals are discouraged from using more than one azole antifungal at a time. These include <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ketoconazole\"><span style=\"font-weight: 400;\">ketoconazole<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/voriconazole\"><span style=\"font-weight: 400;\">voriconazole<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/itraconazole\"><span style=\"font-weight: 400;\">itraconazole<\/span><\/a><span style=\"font-weight: 400;\">. They all work more or less the same way, so combining them is like doubling or tripling the dose of one.<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid fluconazole side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many people will experience mild side effects, or none at all, when taking fluconazole. When there are side effects, they\u2019re usually manageable. Here are some useful ways to minimize the possibility:<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Follow the directions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Follow all the instructions for taking fluconazole given by the prescriber or written on the prescription label. Above all, don\u2019t take more than instructed. Sometimes, a dose will be missed. It can be taken when remembered, but not if it\u2019s almost time for the next dose. In that case, skip the missed dose. Take the next dose as scheduled.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Make sure the prescriber has a complete medical history<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Medical conditions, both current and past, may affect whether fluconazole causes problems, so make sure the prescriber is aware of these conditions, particularly:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rhythm problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low potassium or other electrolyte imbalances<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy or pregnancy plans<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding or breastfeeding plans<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">3. Make sure the prescriber is aware of all medications being taken<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluconazole has many possible drug interactions. Most increase the likelihood of side effects from the other drugs being taken. For this reason, the prescriber needs to know all the prescription drugs, over-the-counter medications, and vitamins or dietary supplements being taken. The list of problem drugs is long, so the best advice is to leave nothing out.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Check with the prescriber before starting other medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Because fluconazole can cause problems with so many other drugs and supplements (see #3), don\u2019t start anything new until getting medical advice from the prescribing healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Take fluconazole with food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluconazole tablets or oral solution can be taken with or without food. If nausea is a problem, try taking each dose with a snack or meal.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Avoid some pain relievers<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluconazole could increase side effects like stomach pain caused by NSAIDs like ibuprofen and naproxen. This is not a serious drug interaction, but using <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\"><span style=\"font-weight: 400;\">acetaminophen<\/span><\/a><span style=\"font-weight: 400;\"> for pain or fever instead may help prevent stomach pain.<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects\"><span style=\"font-weight: 400;\">How to treat side effects of fluconazole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many people will avoid fluconazole&#8217;s side effects. When they do happen, there are ways to manage them.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Headache<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking an over-the-counter pain reliever such as acetaminophen is okay. Some people cannot take certain medications, so check with your healthcare provider or pharmacist if you\u2019re not sure what you can take. Drinking plenty of fluids and resting in a cool, dark, quiet room can also help.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Stomach pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">For stomach pain, a heating pad may help relieve the problem. If the pain is too debilitating, talk to a healthcare professional.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Liver problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluconazole can cause serious liver problems, so contact a healthcare professional if any symptoms of liver dysfunction are noticed such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Foul-smelling or dark urine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pale\/clay-colored stools<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yellowing of the skin or whites of the eyes<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Severe allergic or skin reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While rare, severe, life-threatening allergic or skin reactions may occur. Patients taking fluconazole should be alert to symptoms of an allergic reaction such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hives-treatment-and-medications\"><span style=\"font-weight: 400;\">hives<\/span><\/a><span style=\"font-weight: 400;\">, difficulty breathing, or swelling of the face, lips, tongue, or throat. Patients should also be alert to symptoms of a serious skin reaction such as fever, burning eyes, sore throat, red or purple rash, or blistering or peeling skin. Emergency medical attention is required for patients experiencing an allergic or skin reaction.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Sources<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/63501\/Diflucan\/Adult-Dosing\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fluconazole<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/Diflucan-fluconazole-1847\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fluconazole drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=d3ca59bd-ae00-48ab-89aa-87c7f56e9989\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fluconazole injection prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=0adb2f88-8a6f-4f33-9e2d-73f537e05313\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fluconazole tablet prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30535104\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Tolerability of long-term fluconazole therapy<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">The Journal of Antimicrobial Chemotherapy<\/span><\/i><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Common fluconazole side effects\u00a0| Serious side effects | Stomach pain | Nausea | Rash | Headache | Side effects timeline | Contraindications | Warnings | Interactions | How to avoid side effects | How to treat side effects Fluconazole, also prescribed as brand-name Diflucan, is a generic prescription drug used to treat fungal infections. Specifically, [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":53262,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752],"coauthors":[8861],"class_list":["post-53260","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Fluconazole side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Stomach pain, nausea, rash, and headache are common fluconazole side effects. 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