{"id":53574,"date":"2022-09-07T11:34:59","date_gmt":"2022-09-07T15:34:59","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53574"},"modified":"2022-09-07T11:34:59","modified_gmt":"2022-09-07T15:34:59","slug":"letrozole-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/letrozole-side-effects\/","title":{"rendered":"Letrozole side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#common-letrozole-side-effects\">Common letrozole side effects<\/a>\u00a0| <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#nausea\">Nausea<\/a> | <a href=\"#difficulty-sleeping\">Difficulty sleeping<\/a> | <a href=\"#cough\">Cough<\/a> | <a href=\"#side-effects-timeline\">Side effects timeline<\/a> | <a href=\"#contraindications\">Contraindications<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-treat-side-effects\">How to avoid side effects<\/a> | <a href=\"#how-to-treat-side-effects\">How to treat side effects<\/a><\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/letrozole\"><span style=\"font-weight: 400;\">Letrozole<\/span><\/a><span style=\"font-weight: 400;\"> is a generic prescription drug used to treat postmenopausal women with hormone receptor-positive <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/breast-cancer-treatment-and-medications\"><span style=\"font-weight: 400;\">breast cancer<\/span><\/a><span style=\"font-weight: 400;\">. Hormone receptor-positive breast cancers encompass those cancers which express either estrogen or progestin receptors on cells, and when the hormones attach to such available receptors, this stimulates the cancer to grow and spread. Hormone-receptor breast cancers are further defined as estrogen receptor-positive or negative, and progestin receptor positive or negative. . As a breast cancer treatment, letrozole is intended to be taken for years to prevent cancer from returning. It is typically prescribed after surgery and with other drugs\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Letrozole, its brand-name version, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/femara\"><span style=\"font-weight: 400;\">Femara<\/span><\/a><span style=\"font-weight: 400;\">, and another drug, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/arimidex\"><span style=\"font-weight: 400;\">Arimidex<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/anastrozole\"><span style=\"font-weight: 400;\">anastrozole<\/span><\/a><span style=\"font-weight: 400;\">), belong to a family of drugs called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/aromatase-inhibitors\"><span style=\"font-weight: 400;\">aromatase inhibitors<\/span><\/a><span style=\"font-weight: 400;\">. These drugs block the enzyme that synthesizes estrogen. Shutting down estrogen production stops the growth of hormone receptor-positive breast cancer tumors. As a hormone-blocking drug, letrozole\u2019s side effects are commonly experienced. It is, however, a life-saving drug, so it\u2019s important to learn about, prepare for, and manage side effects.<\/span><\/p>\n<h2 id=\"common-letrozole-side-effects\"><span style=\"font-weight: 400;\">Common side effects of letrozole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many of the most commonly-experienced side effects of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/letrozole\/what-is\"><span style=\"font-weight: 400;\">letrozole<\/span><\/a><span style=\"font-weight: 400;\"> are serious side effects such as bone fractures and chest pain. <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=fa2d40a5-3504-44ef-8f5c-aa4c06308074\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">In order of incidence<\/span><\/a><span style=\"font-weight: 400;\">, the most common side effects of letrozole include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated cholesterol levels<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hot flashes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone fractures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Night sweats<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Edema<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight decrease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal dryness or irritation<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of letrozole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most serious <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/74205\/letrozole\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">side effects of letrozole<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone fractures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New tumors or malignancies including ovarian cancer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood clots including pulmonary embolism<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stroke<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3 id=\"nausea\"><span style=\"font-weight: 400;\">Nausea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Nausea is a common side effect of letrozole treatment, but it tends to be mild. In clinical trials, about 6% to 11% of participants complained of nausea, but severe nausea was rare. If nausea becomes severe or debilitating, get medical attention.<\/span><\/p>\n<h3 id=\"difficulty-sleeping\"><span style=\"font-weight: 400;\">Difficulty sleeping<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In clinical trials, trouble sleeping was reported in close to 8% of participants, but most of these problems were mild to moderate in severity. Since letrozole is intended for years of daily dosing, even mild sleeplessness can interfere with daily life. When trouble falling asleep or staying asleep becomes a problem, report the problem to the prescribing healthcare provider.<\/span><\/p>\n<h3 id=\"cough\"><span style=\"font-weight: 400;\">Cough<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Coughing is a very common side effect of letrozole. About 6% to 13% of participants in clinical trials complained about coughing while taking the drug. Even mild coughing can be bothersome, but there are effective treatment options, so report any unwanted coughing to the prescribing healthcare provider.<\/span><\/p>\n<h2 id=\"side-effects-timeline\"><span style=\"font-weight: 400;\">How soon do letrozole side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some of letrozole\u2019s side effects appear <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Femara-letrozole-430.10\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">early in treatment<\/span><\/a><span style=\"font-weight: 400;\">. These include weakness, drowsiness, and some other mild side effects. Most adverse effects of letrozole, however, are delayed side effects due to the accumulating effects of reduced estrogen production. They could take weeks or months before becoming a problem. However, letrozole therapy continues for several years, so delayed side effects are possible.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do letrozole side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some of letrozole\u2019s mild side effects could resolve as the body adapts to the medicine. Delayed side effects, however, could persist as long as the drug is taken. These include coughing, hair thinning, swelling, and bone loss. Some of these longer-term side effects should resolve when treatment is discontinued. Some very serious side effects such as blood clots, stroke, or serious heart problems may have long-term or lifelong consequences.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What are the long-term side effects of letrozole?<\/span><\/h2>\n<p><a href=\"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.18.01160\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Guidelines<\/span><\/a><span style=\"font-weight: 400;\"> call for letrozole to be taken daily for five, seven, or 10 years to significantly reduce the risk of recurrence. Many of letrozole\u2019s adverse effects occur because the drug is used for so long. Long-term side effects are primarily due to a prolonged drop in estrogen and mimic the symptoms of menopause. These long-term effects\u2014hair thinning, bone loss, increased risk for bone fractures, and increased risk for cardiovascular disease\u2014are possible consequences of long-term hormone suppression treatment.<\/span><\/p>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Letrozole contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Letrozole is never prescribed to:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnant women<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Women who have a known allergy to the drug<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Letrozole is contraindicated in pregnant women. Letrozole can harm or kill a fetus or cause spontaneous abortion. It is never used in pregnant women. However, women of reproductive age <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8245002\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">are often prescribed letrozole off-label<\/span><\/a><span style=\"font-weight: 400;\"> as part of fertility treatment. The drug is only used for a short time and will not be reused if the woman becomes pregnant.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Although there is no research on whether letrozole is present in human breast milk or can harm a nursing infant, healthcare providers will advise women to stop breastfeeding while taking letrozole. They may also advise women not to begin breastfeeding until three weeks after the last dose of letrozole has been taken.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The Food and Drug Administration (FDA) has not approved the use of letrozole in children or teens. However, letrozole is sometimes prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> to increase the height of boys with short stature or whose puberty is delayed or in young females experiencing <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/precocious-puberty\/symptoms-causes\/syc-20351811\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">precocious puberty<\/span><\/a><span style=\"font-weight: 400;\">. This treatment may affect fertility later in life.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Seniors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Healthcare professionals consider letrozole to be safe and effective in older women. Because letrozole is intended for postmenopausal women, clinical trials focused mainly on older women. A substantial percentage were older than 65 and many were older than 70. <\/span><a href=\"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2007.12.6334\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Women older than 70 had more side effects<\/span><\/a><span style=\"font-weight: 400;\"> in comparison to younger women in clinical trials but overall responded well to this treatment.\u00a0<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Letrozole warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">All prescription drugs may cause problems either because of pre-existing conditions or other issues. Letrozole is no exception.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some pre-existing medical conditions can be worsened by the side effects of letrozole. These include:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-treatment-and-medications\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/a><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Letrozole is not a drug that is used recreationally or abused. It is not associated with physical dependence or withdrawal.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Call a poison control center or get medical attention if too much letrozole is taken. There are no known symptoms of a letrozole overdose. The maximum approved dosage is a single 2.5 mg tablet taken once per day, but fertility treatment doses can be as high as 20 mg per day. The best advice is to never take more than the prescribed dose.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Recalls<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Letrozole has never been taken off the market entirely. However, individual batches from individual manufacturers have been recalled because of manufacturing irregularities.\u00a0<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Letrozole interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Letrozole does not have many significant drug interactions. Because letrozole is used to suppress estrogen, estrogen-containing medicines are avoided. These include birth control pills and female hormone therapies containing estrogens or ethinyl estradiol.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tamoxifen, a drug used to block the effects of estrogen in women with certain types of breast cancer, is not used at the same time as letrozole. However, it is usually taken for several years before letrozole treatment.<\/span><\/p>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid letrozole side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Letrozole is a long-term treatment, so managing possible side effects contributes a lot to the drug\u2019s success.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Make sure the prescriber has a complete medical history<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Realistically speaking, the cancer doctor, called an oncologist, will have a complete medical history and a great deal of information from medical tests before any drugs are prescribed. Anything you can do to fill out that history will help. The oncologist will be most concerned about a few particular medical conditions or drugs, including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Problems with osteoporosis\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Any female hormone replacement treatments<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tamoxifen treatment<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">2. Take letrozole as instructed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Follow all the instructions given by the prescriber or written on the prescription label when taking letrozole. Don\u2019t miss doses, and don\u2019t take extra medicine. If a dose is missed, take that dose when remembered. If it\u2019s almost time for the next dose, though, skip the missed dose and take the next dose as scheduled. Do not take extra medicine to make up for a missed dose.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Cut back on smoking, alcohol, and hot drinks<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Avoiding nicotine, alcohol, and hot drinks can help reduce the severity of hot flashes. Stopping smoking can <\/span><a href=\"https:\/\/www.bones.nih.gov\/health-info\/bone\/osteoporosis\/conditions-behaviors\/bone-smoking\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">help prevent<\/span><\/a><span style=\"font-weight: 400;\"> bone loss and bone fractures.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Take letrozole with food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Letrozole can be taken with a meal or on an empty stomach. Taking it with or after eating can help prevent nausea and vomiting.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Get more calcium and vitamin D<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To prevent bone loss, take daily calcium and vitamin D supplements. It also helps to add more calcium-rich and vitamin D-rich foods to the diet, foods like milk, cheese, eggs, and fatty fish.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Exercise<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another way to stave off bone loss is exercise and stretching. The best are exercises that involve staying on your feet, such as walking, jogging, dancing, or stair-climbing. Exercise can also help improve any tiredness or fatigue experienced during letrozole treatment.<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects\"><span style=\"font-weight: 400;\">How to treat side effects of letrozole<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">It is highly probable that you will experience at least some side effects when taking letrozole. Remember that letrozole is a life-saving cancer treatment. It reduces the probability that certain types of breast cancer will return in the same breast or other parts of the body. Managing side effects, then, can have a payoff that lasts a lifetime.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some of letrozole\u2019s most common side effects\u2014especially early in the treatment\u2014are menopausal symptoms. Women past menopause already have reduced estrogen because of changes to the ovaries. However, other tissues in the body still produce a little estrogen. Letrozole shuts that down, so estrogen levels fall even further, causing menopausal symptoms like hot flashes, vaginal dryness, and night sweats.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Hot flashes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To manage hot flashes, dress in layers\u2014cotton clothing is best\u2014and remove clothes when feeling too hot. Cooling pads, cold drinks, and spraying the face with cool water can also help. Report serious problems with hot flashes to the prescriber. Some drugs may help reduce the incidence and severity of hot flashes, particularly types of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5482277\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\"> called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/ssris\"><span style=\"font-weight: 400;\">SSRIs<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><span style=\"font-weight: 400;\">SNRIs<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Vaginal irritation<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Vaginal dryness and irritation is another menopausal symptom associated with letrozole treatment. Over-the-counter lubricants and moisturizers can help.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Joint and muscle pain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Joint and muscle pain is a very common side effect of letrozole. It is also one of the most<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4861358\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\"> frequent reasons people stop taking letrozole<\/span><\/a><span style=\"font-weight: 400;\">. There are a few things that can help. Talk to the prescriber about over-the-counter pain relievers. Exercise and stretching can also help. If pain is severe, the prescriber could refer you to a joint specialist or a pain management specialist.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Headaches<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Headaches are not that common a side effect, but when they do happen, try using over-the-counter pain relievers. If the pain is too debilitating, ask the prescribing healthcare provider for medical advice or treatment options.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">An over-the-counter <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiemetics\"><span style=\"font-weight: 400;\">antiemetic<\/span><\/a><span style=\"font-weight: 400;\"> (antinausea) medicine such as an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antihistamines\"><span style=\"font-weight: 400;\">antihistamine<\/span><\/a><span style=\"font-weight: 400;\"> might help. If vomiting is severe or persistent, talk to a healthcare professional.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Vaginal bleeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There may be some vaginal bleeding or spotting early in letrozole treatment. If, however, bleeding continues, contact the prescribing healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Bone loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There are ways to help prevent bone loss, but healthcare professionals will regularly test patients for bone mineral density using a scanner or blood tests. There are no symptoms of bone loss, but fractures are more likely as bones get thinner. Healthcare providers will treat bone loss with medicines called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/bisphosphonates\"><span style=\"font-weight: 400;\">bisphosphonates<\/span><\/a><span style=\"font-weight: 400;\"> to help increase bone density.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Allergic reactions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Allergic reactions to letrozole require immediate medical attention and that the medicine be immediately discontinued. Symptoms include <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hives-treatment-and-medications\"><span style=\"font-weight: 400;\">hives<\/span><\/a><span style=\"font-weight: 400;\">, trouble breathing, shortness of breath, and swelling of the face, mouth, or neck.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Sources<\/span><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.18.01160\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: ASCO clinical practice guideline focused update<\/span><\/a><span style=\"font-weight: 400;\">, American Society of Clinical Oncology<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/online.epocrates.com\/drugs\/74201\/letrozole\/Adult-Dosing\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Letrozole<\/span><\/a><span style=\"font-weight: 400;\">, Epocrates<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.pdr.net\/drug-summary\/Femara-letrozole-430.10\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Letrozole drug summary<\/span><\/a><span style=\"font-weight: 400;\">, Prescriber\u2019s Digital Reference<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8245002\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Letrozole for female infertility<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">Frontiers in Endocrinology<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=fa2d40a5-3504-44ef-8f5c-aa4c06308074\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Letrozole tablets prescribing information<\/span><\/a><span style=\"font-weight: 400;\">, U.S. National Library of Medicine<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4861358\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Patient-reported outcomes and early discontinuation in aromatase inhibitor-treated postmenopausal women with early-stage breast cancer<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><i><span style=\"font-weight: 400;\">The Oncologist<\/span><\/i><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.bones.nih.gov\/health-info\/bone\/osteoporosis\/conditions-behaviors\/bone-smoking\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Smoking and bone health<\/span><\/a><span style=\"font-weight: 400;\">, NIH Osteoporosis and Related Bone Diseases National Resources Center<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Common letrozole side effects\u00a0| Serious side effects | Nausea | Difficulty sleeping | Cough | Side effects timeline | Contraindications | Warnings | Interactions | How to avoid side effects | How to treat side effects Letrozole is a generic prescription drug used to treat postmenopausal women with hormone receptor-positive breast cancer. Hormone receptor-positive breast [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":53596,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[12752,8670],"coauthors":[8861],"class_list":["post-53574","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-medication-side-effects","tag-womens-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Letrozole side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Nausea, trouble sleeping, and cough are common letrozole side effects. 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