{"id":53734,"date":"2022-09-06T09:50:05","date_gmt":"2022-09-06T13:50:05","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53734"},"modified":"2025-10-20T15:13:30","modified_gmt":"2025-10-20T19:13:30","slug":"hydralazine-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/hydralazine-side-effects\/","title":{"rendered":"Hydralazine side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#common-hydralazine-side-effects\"> Common hydralazine side effects<\/a> | <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#tachycardia\">Tachycardia<\/a> | <a href=\"#lupus-like-symptoms\">Lupus-like symptoms<\/a> | <a href=\"#frequent-urination\">Frequent urination<\/a> | <a href=\"#fatigue\">Fatigue<\/a> | <a href=\"#hair-loss\">Hair loss<\/a> | <a href=\"#side-effects-timeline\">Side effects timeline<\/a> | <a href=\"#contraindications\">Contraindications<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a> | <a href=\"#how-to-treat-side-effects\">How to treat side effects<\/a><\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/hydralazine-hcl\"><span style=\"font-weight: 400;\">Hydralazine<\/span><\/a><span style=\"font-weight: 400;\"> is a generic prescription drug FDA-approved for the treatment of <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/blood-pressure-levels\/\"><span style=\"font-weight: 400;\">high blood pressure (hypertension)<\/span><\/a><span style=\"font-weight: 400;\">. However, it may be used off-label to treat congestive heart failure or, as an IV injection, to manage dangerously high blood pressure in an emergency. As a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/vasodilators\"><span style=\"font-weight: 400;\">vasodilator<\/span><\/a><span style=\"font-weight: 400;\">, hydralazine widens peripheral blood vessels, reducing blood pressure. Outside of emergency situations, hydralazine is not the most commonly used blood pressure drug. It\u2019s usually prescribed as an <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470296\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">add-on drug<\/span><\/a><span style=\"font-weight: 400;\"> when other drugs don\u2019t work. That\u2019s because there are <\/span><a href=\"https:\/\/www.cochranelibrary.com\/cdsr\/doi\/10.1002\/14651858.CD004934.pub4\/full\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">concerns about its effectiveness<\/span><\/a><span style=\"font-weight: 400;\"> and its side effects. Many of these adverse effects involve the heart.<\/span><\/p>\n<h2 id=\"common-hydralazine-side-effects\"><span style=\"font-weight: 400;\">Common side effects of hydralazine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/22105\/hydralazine\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">common side effects<\/span><\/a><span style=\"font-weight: 400;\"> of hydralazine have an incidence rate that may be as high as <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Hydralazine-Hydrochloride-Tablets-hydralazine-hydrochloride-738.119\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">1 in 10<\/span><\/a><span style=\"font-weight: 400;\"> people:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite (anorexia)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain (angina)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Palpitations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of hydralazine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most serious side effects of <a href=\"https:\/\/www.singlecare.com\/prescription\/hydralazine-hcl\/what-is\">hydralazine<\/a> are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart attack<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dangerously low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood disorders<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lupus-like symptoms<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic reactions<\/span><\/li>\n<\/ul>\n<h3 id=\"tachycardia\"><span style=\"font-weight: 400;\">Tachycardia<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Rapid heartbeat, or tachycardia, is <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Hydralazine-Hydrochloride-Tablets-hydralazine-hydrochloride-738.119\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">estimated to occur in 10% of people taking hydralazine<\/span><\/a><span style=\"font-weight: 400;\">. That\u2019s because hydralazine causes the body to stimulate the heart through <\/span><a href=\"https:\/\/cvpharmacology.com\/vasodilator\/direct\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">the blood pressure reflex<\/span><\/a><span style=\"font-weight: 400;\">; the body releases substances to make the heart beat faster because peripheral blood pressure is low. If your heart rate increases when taking hydralazine, talk to your prescribing healthcare provider. A <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/beta-blockers\"><span style=\"font-weight: 400;\">beta blocker<\/span><\/a><span style=\"font-weight: 400;\"> or a <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/diuretics\"><span style=\"font-weight: 400;\">diuretic<\/span><\/a> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470296\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">may be prescribed<\/span><\/a><span style=\"font-weight: 400;\"> to resolve this side effect.<\/span><\/p>\n<h3 id=\"lupus-like-symptoms\"><span style=\"font-weight: 400;\">Lupus-like symptoms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drug-induced lupus-like symptoms <\/span><a href=\"https:\/\/www.hindawi.com\/journals\/crirh\/2017\/5245904\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">occur in 5\u201310% of patients<\/span><\/a><span style=\"font-weight: 400;\"> taking hydralazine. Symptoms include joint pain (arthralgia), muscle pain (myalgia), and fever. Other organs normally affected by lupus, such as lungs and kidneys, are usually spared and heart involvement is rare. Stopping hydralazine typically resolves the symptoms. If symptoms continue after discontinuing hydralazine then therapy with <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/corticosteroids\"><span style=\"font-weight: 400;\">corticosteroids<\/span><\/a><span style=\"font-weight: 400;\"> or other immunosuppressant medications may be started.<\/span><\/p>\n<h3 id=\"frequent-urination\"><span style=\"font-weight: 400;\">Frequent urination<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Frequent urination is not a listed side effect of hydralazine, but difficulty with urination is. However, hydralazine is frequently prescribed with other blood pressure medications called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/thiazide-diuretics\"><span style=\"font-weight: 400;\">thiazide diuretics<\/span><\/a><span style=\"font-weight: 400;\">, popularly known as \u201cwater pills.\u201d Diuretics do significantly increase urination because they increase the amount of water and salts eliminated through the kidneys. Frequent urination is the intended and beneficial effect of diuretic treatment, and it can have dramatic effects on blood pressure.<\/span><\/p>\n<h3 id=\"fatigue\"><span style=\"font-weight: 400;\">Fatigue<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine is not associated with fatigue as a side effect. However, it is commonly used with other blood pressure drugs that may cause fatigue, such as beta blockers. Fatigue is also a symptom of a rare side effect of hydralazine: drug-induced systemic <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/lupus-treatment-and-medications\"><span style=\"font-weight: 400;\">lupus <\/span><\/a><span style=\"font-weight: 400;\">erythematosus (SLE), a condition in which the body\u2019s immune system attacks healthy cells and tissues. However, drug-induced SLE has other symptoms, including skin rash, fever, and weight loss. If fatigue is a problem or accompanied by other symptoms, talk to the prescriber.<\/span><\/p>\n<h3 id=\"hair-loss\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine is not associated with hair loss. On the contrary, drugs like hydralazine that widen peripheral blood vessels usually promote hair growth. The hair growth drug minoxidil, for instance, is a vasodilator like hydralazine and was originally used to treat high blood pressure. Remember: hydralazine is often prescribed with other blood pressure drugs. Some, like beta blockers, may cause hair to thin.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Hydralazine side effects in elderly patients<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine has been used since 1949. There is <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Hydralazine-Hydrochloride-Tablets-hydralazine-hydrochloride-738.119#11\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">no clinical evidence<\/span><\/a><span style=\"font-weight: 400;\"> that hydralazine is less effective or less safe in elderly people than in younger adults. Because older adults may clear the drug more slowly than younger adults, healthcare providers usually start the drug at a lower dose.<\/span><\/p>\n<h2 id=\"side-effects-timeline\"><span style=\"font-weight: 400;\">How soon do hydralazine side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine begins working on the first dose, so some side effects, such as headache, palpitations, or rapid\u00a0 heartbeat, may begin one or two hours after taking a dose as a direct response to the drug\u2019s vasodilating effects. Other side effects such as diarrhea or vomiting may appear in a few days. The more serious problems caused by hydralazine are generally delayed side effects that occur after long-term use.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do hydralazine side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some of hydralazine\u2019s minor side effects may get better as the body adapts to the drug or the side effect. Most side effects will reverse when the drug is stopped, typically in a day or two. Some side effects, such as heart attack or stroke, may have long-term consequences.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What are the long-term side effects of hydralazine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine is intended for long-term treatment, often in combination with other drugs. There are no side effects due to the long-term use of hydralazine, but delayed side effects may include heart problems and drug-induced lupus.\u00a0<\/span><\/p>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Hydralazine contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine should not be taken by people with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">A known allergic reaction to the drug<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coronary artery disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mitral valve disease caused by rheumatic heart disease<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The safety of hydralazine taken during pregnancy has not been studied. Healthcare professionals are cautious in prescribing the drug to pregnant women for high blood pressure, particularly in the third trimester. However, hydralazine IV injections may be used <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> for hypertensive emergencies in pregnant women, but their use is intended to save the life of the mother and the baby.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine is present in human breast milk and is considered an acceptable drug to be used in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK500954\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">women who are breastfeeding<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine is not approved for use in children or adolescents, though some healthcare providers may prescribe it off-label to treat hypertension or chronic hypertension in pediatric patients.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our heart health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Heart Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Hydralazine warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine is not considered a first-line blood pressure treatment because of its reflex effects on the heart. These and other issues are concerning enough to give prescribers pause when considering using this drug.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine could worsen some medical conditions, particularly heart or blood vessel conditions. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Congestive heart failure (unless combined with <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/isosorbide-dinitrate\"><span style=\"font-weight: 400;\">isosorbide dinitrate<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aortic aneurysm<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">History of stroke<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased intracranial pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood pressure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, people with kidney disease eliminate hydralazine from the body more slowly than others, so hydralazine doses may need to be reduced.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine is not associated with drug abuse and is not known to cause physical dependence or withdrawal symptoms.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If too much hydralazine is taken, get medical attention or call a <\/span><a href=\"https:\/\/www.poison.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">poison control center<\/span><\/a><span style=\"font-weight: 400;\">. Although there are no known fatalities, an overdose can cause shock or serious heart problems such as heart attack. <\/span><a href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/1996\/008303s068lbl.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Symptoms of an overdose<\/span><\/a><span style=\"font-weight: 400;\"> include flushing, headache, low blood pressure, and rapid heartbeat. The maximum daily hydralazine dose for high blood pressure is 300 mg but may be higher when prescribed off-label. The best rule to avoid an overdose is to never exceed the prescribed dose.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Recalls<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine itself has never been recalled, but individual batches from individual manufacturers have been periodically recalled because of manufacturing or impurity concerns.\u00a0<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Hydralazine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Hydralazine has some drug interactions. Most concern lowering blood pressure or affecting the way other drugs work. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>MAO inhibitors (<\/b><a href=\"https:\/\/www.singlecare.com\/drug-classes\/maois\"><b>MAOIs<\/b><\/a><b>)<\/b><span style=\"font-weight: 400;\">. This small family of drugs can either increase the blood pressure lowering effects of hydralazine or, in some cases, hydralazine can increase the side effects of these drugs. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/marplan\"><span style=\"font-weight: 400;\">Marplan<\/span><\/a><span style=\"font-weight: 400;\"> (isocarboxazid), an MAO inhibitor prescribed as an <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressant<\/span><\/a><span style=\"font-weight: 400;\">, is never used with blood pressure-reducing drugs.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drugs that affect heart rhythm or heart rate.<\/b><span style=\"font-weight: 400;\"> Hydralazine can speed up the heart, so it\u2019s used cautiously with drugs that can change the heart\u2019s rhythm, such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antiarrhythmics\"><span style=\"font-weight: 400;\">antiarrhythmics<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">antipsychotics<\/span><\/a><span style=\"font-weight: 400;\">. Because of the risk of irregular heartbeats, it is never prescribed with the antipsychotic <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/thioridazine-hcl\"><span style=\"font-weight: 400;\">thioridazine.<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drugs that lower blood pressure.<\/b><span style=\"font-weight: 400;\"> Hydralazine is usually prescribed with other antihypertensives. However, some of these combinations can result in blood pressure dropping too low. Other drugs such as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/opioids\"><span style=\"font-weight: 400;\">opioids<\/span><\/a><span style=\"font-weight: 400;\">, sleeping aids, and alcohol also lower blood pressure, but the effects aren\u2019t a cause for concern unless blood pressure is not being regularly monitored.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Drugs that raise blood pressure.<\/b><span style=\"font-weight: 400;\"> Many drugs will push blood pressure up, including stimulants, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine<\/span><\/a><span style=\"font-weight: 400;\"> drugs, attention-deficit hyperactivity disorder (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/adhd-treatment-and-medications\"><span style=\"font-weight: 400;\">ADHD<\/span><\/a><span style=\"font-weight: 400;\">) medications, over-the-counter decongestants, nonsteroidal anti-inflammatory drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">), and caffeine. These aren\u2019t dangerous drug interactions, but taking these drugs will compromise the therapeutic benefits of taking blood pressure medications like hydralazine.<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid hydralazine side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects are fairly common in people taking hydralazine. The most worrisome side effects involve the heart, so there are a few things everyone should do to minimize the possibility of side effects.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Give the prescriber a complete medical history<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Avoiding serious side effects is most effectively accomplished by giving the prescribing healthcare provider a complete medical history. For hydralazine, the prescriber especially needs to know about:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lupus<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">2. Give the prescriber a complete rundown on drugs being taken<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another way to avoid side effects is to avoid drug interactions. Start by giving the prescribing healthcare provider a complete picture of all the prescription drugs, over-the-counter medications, or dietary supplements being used. The prescriber may make adjustments or advise on what to avoid. When getting a new prescription, make sure the prescriber or pharmacist knows that you\u2019re taking hydralazine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Take hydralazine as prescribed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another tried and true way of avoiding a prescription drug\u2019s side effects is to follow the instructions. Take the dose as instructed. Take each dose when it\u2019s scheduled. Do not skip doses. Use a smartphone app or alarm to help remember when to take a dose. This is especially important for a drug like hydralazine that needs to be taken four times a day.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Do not take extra doses<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Do not exceed the prescribed dose. The risk of side effects, especially drug-induced lupus, goes up when higher doses are taken. If a dose is missed, take it when remembered. If it\u2019s almost time for the next dose, skip the missed dose and take the next dose as scheduled. Remember: hydralazine is typically taken four times a day. That\u2019s once every four hours. On such a tight timeline, chances are that most missed doses will have to be skipped.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Be consistent in how hydralazine is taken<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine can be taken with a meal or on an empty stomach. To prevent side effects, be consistent in how it\u2019s taken. Either always take the dose with food or always take it without food.<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects\"><span style=\"font-weight: 400;\">How to treat side effects of hydralazine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some of hydralazine\u2019s side effects can be managed at home, but others will require professional medical advice or medical attention.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Headache<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drinking fluids and rest can help. It\u2019s safe to take a pain reliever such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\/what-is\"><span style=\"font-weight: 400;\">acetaminophen<\/span><\/a><span style=\"font-weight: 400;\">, but NSAIDs like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">aspirin<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\"> can raise blood pressure a bit. If headaches persist or get worse, talk to the prescribing healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Nausea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Eat smaller meals and stick to bland foods. Avoid greasy and heavy foods.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Vomiting<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drink fluids to avoid dehydration and avoid solid foods until vomiting stops. If vomiting persists or gets worse, contact a healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Diarrhea<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Drink fluids to avoid dehydration. If diarrhea persists or gets worse, contact a healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Swelling<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluid retention is commonly caused by vasodilators like hydralazine and typically involves swelling in the feet and lower legs. If this happens, elevate the feet and rest. If swelling persists or gets worse, talk to the prescribing healthcare provider.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Nerve problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine can cause problems with peripheral nerves, so contact the prescribing healthcare provider if there are any unexplained or bizarre sensations in the hands or feet such as tingling, burning, or pain.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Chest pain or rapid heartbeat<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If palpitations, rapid heartbeat, or chest pain is experienced, immediately call the prescribing healthcare provider or get medical attention.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Low blood pressure<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Unless regularly checking blood pressure, the only way to spot low blood pressure are the symptoms: lightheadedness, dizziness, and feeling like you\u2019re going to pass out. Get medical attention if any of these symptoms are experienced.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Lupus-like symptoms<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Hydralazine can cause a lupus-like reaction a few weeks or months into treatment. In fact, hydralazine is one of the drugs most commonly associated <\/span><a href=\"https:\/\/www.lupus.org\/resources\/about-drug-induced-lupus\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">with drug-induced lupus<\/span><\/a><span style=\"font-weight: 400;\">, and it is more likely if the doses are large. Drug-induced lupus is a serious side effect and requires that the drug be stopped and that immediate medical attention be sought out. Watch for symptoms such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Chest pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tiredness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joint pain and swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle pain<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Common hydralazine side effects | Serious side effects | Tachycardia | Lupus-like symptoms | Frequent urination | Fatigue | Hair loss | Side effects timeline | Contraindications | Warnings | Interactions | How to avoid side effects | How to treat side effects Hydralazine is a generic prescription drug FDA-approved for the treatment of high [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":53739,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[737,12752],"coauthors":[8861],"class_list":["post-53734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-heart-health","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Hydralazine side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Tachycardia, Lupus-like symptoms, and frequent urination are common hydralazine side effects. 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