{"id":53824,"date":"2022-09-08T13:34:15","date_gmt":"2022-09-08T17:34:15","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=53824"},"modified":"2025-10-24T13:31:44","modified_gmt":"2025-10-24T17:31:44","slug":"signs-metformin-is-not-working","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/signs-metformin-is-not-working\/","title":{"rendered":"Signs metformin is not working"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin\"><span style=\"font-weight: 400;\">Metformin<\/span><\/a><span style=\"font-weight: 400;\"> is a generic <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">diabetes medication<\/span><\/a><span style=\"font-weight: 400;\"> frequently prescribed as a first-line drug (along with diet and exercise) to help control blood sugar in patients with Type 2 diabetes. You may also recognize metformin by its brand name, Glucophage. Although the brand-name drug is no longer available in the United States, generic versions are commonly used.\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/conditions\/type-2-diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Type 2 diabetes<\/span><\/a><span style=\"font-weight: 400;\"> occurs when the body is unable to produce or use insulin properly, which results in high glucose (sugar) levels. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/metformin\/what-is\"><span style=\"font-weight: 400;\">Metformin<\/span><\/a><span style=\"font-weight: 400;\">, which comes in immediate and extended-release forms, is generally effective as a diabetes medication in controlling blood glucose levels, especially when combined with lifestyle changes. However, not everyone\u2019s body responds the same to drug treatments.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Unexplained increases in blood sugar may be the first indication that metformin is not working. Knowing what additional symptoms may point to metformin&#8217;s potential ineffectiveness is crucial for seeking alternate therapies.<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Metformin with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. 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However, over time, the effectiveness of metformin may decrease and no longer work for its prescribed use. The following signs can be indications that metformin is no longer working.\u00a0<\/span><\/p>\n<h3 id=\"type-2-diabetes-and-prediabetes\"><span style=\"font-weight: 400;\">Type 2 diabetes and prediabetes\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A rise in blood sugar levels (hyperglycemia) is typically the first sign that metformin is no longer working for those with Type 2 diabetes or its precursor, prediabetes. Symptoms of hyperglycemia include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood sugar<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased thirst and\/or hunger<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Frequent urination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fatigue (feeling weak, tired)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vaginal and skin infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow-healing cuts and sores<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If any of these signs are present, a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/normal-a1c-levels\/\"><span style=\"font-weight: 400;\">hemoglobin A1C<\/span><\/a><span style=\"font-weight: 400;\"> (HbA1c) blood test requested by a healthcare professional can determine if there has been a rise in previous blood sugar levels over the last few months. If metformin is not working to lower a person\u2019s blood glucose, a dosage adjustment, an alternative or additional medication, or an insulin regimen may be recommended.\u00a0<\/span><\/p>\n<h3 id=\"pcos\"><span style=\"font-weight: 400;\">PCOS<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When prescribed for PCOS, metformin treatment may take <\/span><a href=\"https:\/\/www.womenshealth.gov\/a-z-topics\/polycystic-ovary-syndrome\"><span style=\"font-weight: 400;\">several months<\/span><\/a><span style=\"font-weight: 400;\"> to improve menstrual function and increase fertility. If a decrease in excessive hair growth, acne, and weight gain, as well as improved ovulation and menstrual regulation, is not noticed in this time frame, it may be beneficial to contact your healthcare provider to discuss whether or not a metformin prescription is providing the benefits to aid in managing PCOS.\u00a0<\/span><\/p>\n<h3 id=\"weight-loss\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Metformin is sometimes prescribed <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/off-label-prescription-drugs\/\"><span style=\"font-weight: 400;\">off-label<\/span><\/a><span style=\"font-weight: 400;\"> (for a non-FDA-approved use) for weight loss. If you are adhering to your medication regimen, following the lifestyle changes recommended by your healthcare provider, and do not see a slight weight loss after a few months, contact your healthcare provider. They may make some changes to your regimen, or, if you have elevated blood sugar, they may recommend that you keep taking metformin even if you do not lose weight, for its benefits on blood sugar control.\u00a0<\/span><\/p>\n<h2 id=\"what-to-do-if-metformin-is-not-working\"><span style=\"font-weight: 400;\">What to do if metformin is not working<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">If a person suspects that metformin is not working, contacting a healthcare provider for medical advice should be the first step. It is important to understand that metformin may take some time to work, and desired results may not be noticeable right away. Some adverse effects, such as chest pain or rash, may be severe. Call a healthcare provider right away or seek emergency care if any of these signs are encountered. A new medication regimen may be initiated if a doctor determines that metformin is not working. Many prescription medications can replace or work alongside metformin\u2014many people need to take more than one medicine for blood sugar control.<\/span><\/p>\n<h2 id=\"alternatives-to-metformin\"><span style=\"font-weight: 400;\">Alternatives to metformin<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metformin is in a drug class called <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/biguanides\"><span style=\"font-weight: 400;\">biguanides<\/span><\/a><span style=\"font-weight: 400;\">. Biguanides help reduce the amount of sugar the liver makes while improving insulin sensitivity, which helps reduce high blood sugar. <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/synjardy\"><span style=\"font-weight: 400;\">Synjardy<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/invokamet\"><span style=\"font-weight: 400;\">Invokamet<\/span><\/a><span style=\"font-weight: 400;\">, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/trijardy-xr\"><span style=\"font-weight: 400;\">Trijardy XR<\/span><\/a><span style=\"font-weight: 400;\"> are common combination drugs that contain metformin as an ingredient (along with other drugs from different classes) and are also used for treating Type 2 diabetes. Medication for Type 2 diabetes is usually accompanied by dietary and lifestyle\/exercise changes, which you can discuss with your healthcare provider. Other drug classes have proven beneficial, including:<\/span><\/p>\n<h3 id=\"1-sglt2-inhibitors\"><span style=\"font-weight: 400;\">1. SGLT2 inhibitors<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/sglt2-inhibitors\"><span style=\"font-weight: 400;\">SGLT2 inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> help block glucose (sugar) from being reabsorbed by helping the kidneys to eliminate sugar in the urine, which aids in the lowering of glucose levels. Drugs in the SGLT2 inhibitor class include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Invokana (canagliflozin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/farxiga\"><span style=\"font-weight: 400;\">Farxiga<\/span><\/a><span style=\"font-weight: 400;\"> (dapagliflozin)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/jardiance\"><span style=\"font-weight: 400;\">Jardiance<\/span><\/a><span style=\"font-weight: 400;\"> (empagliflozin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/steglatro\"><span style=\"font-weight: 400;\">Steglatro<\/span><\/a><span style=\"font-weight: 400;\"> (ertugliflozin)<\/span><\/li>\n<\/ul>\n<h3 id=\"2-glp-1-receptor-agonists\"><span style=\"font-weight: 400;\">2. GLP-1 receptor agonists\u00a0<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/glp-1-agonists\"><span style=\"font-weight: 400;\">GLP-1 receptor agonists<\/span><\/a><span style=\"font-weight: 400;\"> are commonly used for Type 2 diabetes, weight loss, and cardiovascular risk reduction\u2014the FDA-approved uses depend on the specific drug. Common side effects are mostly gastrointestinal, including nausea, vomiting, diarrhea, constipation, and stomach pain. GLP-1 drugs, as well as similar drugs known as dual GIP\/GLP-1 receptor agonists, are available in both injectable and oral formulations and include drugs such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/ozempic-weight-loss\/\"><span style=\"font-weight: 400;\">Ozempic<\/span><\/a><span style=\"font-weight: 400;\">, Wegovy (semaglutide injectable)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rybelsus (semaglutide oral)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/mounjaro-generic-availability-cost-and-more\/\"><span style=\"font-weight: 400;\">Mounjaro<\/span><\/a><span style=\"font-weight: 400;\">, Zepbound (tirzepatide injectable)<\/span><\/li>\n<\/ul>\n<h3 id=\"3-thiazolidinediones\"><span style=\"font-weight: 400;\">3. Thiazolidinediones<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Also known as <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/glitazones\"><span style=\"font-weight: 400;\">glitazones<\/span><\/a><span style=\"font-weight: 400;\">, thiazolidinediones are oral insulin-sensitizing drugs used to treat Type 2 diabetes mellitus. They <\/span><a href=\"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCHEARTFAILURE.118.005855\"><span style=\"font-weight: 400;\">lower blood sugar<\/span><\/a><span style=\"font-weight: 400;\"> with little chance of hypoglycemia (low blood sugar) and may have advantages against <\/span><a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/arteriosclerosis-atherosclerosis\/symptoms-causes\/syc-20350569\"><span style=\"font-weight: 400;\">atherosclerosis<\/span><\/a><span style=\"font-weight: 400;\">. Thiazolidinediones may also be used to treat <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551656\/\"><span style=\"font-weight: 400;\">polycystic ovarian syndrome<\/span><\/a><span style=\"font-weight: 400;\"> due to their potential to enhance ovulation, lower insulin resistance, and enhance endothelial function. Commonly prescribed thiazolidinediones include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/actos\"><span style=\"font-weight: 400;\">Actos<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pioglitazone-hcl\"><span style=\"font-weight: 400;\">pioglitazone<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/actoplus-met\"><span style=\"font-weight: 400;\">Actoplus Met<\/span><\/a><span style=\"font-weight: 400;\"> (pioglitazone and metformin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/duetact\"><span style=\"font-weight: 400;\">Duetact<\/span><\/a><span style=\"font-weight: 400;\"> (contains glimepiride, a sulfonylurea, along with pioglitazone)<\/span><\/li>\n<\/ul>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/drug-classes\/thiazolidinediones\"><b>Thiazolidinediones: Uses, common brands, and safety info<\/b><\/a><\/p>\n<h3 id=\"4-dipeptidyl-peptidase-4-dpp-4-inhibitors\"><span style=\"font-weight: 400;\">4. Dipeptidyl peptidase-4 (DPP-4) inhibitors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Used with diet and exercise, <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/information-drug-class\/information-dipeptidyl-peptidase-4-dpp-4-inhibitors\"><span style=\"font-weight: 400;\">DPP-4 inhibitors<\/span><\/a><span style=\"font-weight: 400;\"> reduce blood sugar by assisting the body in raising its post-meal insulin levels. Also known as gliptins, DPP-4 inhibitors are <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6593043\/\"><span style=\"font-weight: 400;\">typically prescribed<\/span><\/a><span style=\"font-weight: 400;\"> to patients with Type 2 diabetes who do not respond favorably to conventional diabetes medications such as metformin. DPP-4 inhibitors include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/januvia\"><span style=\"font-weight: 400;\">Januvia<\/span><\/a><span style=\"font-weight: 400;\"> (sitagliptin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/saxagliptin-hcl\"><span style=\"font-weight: 400;\">Saxagliptin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/tradjenta\"><span style=\"font-weight: 400;\">Tradjenta<\/span><\/a><span style=\"font-weight: 400;\"> (linagliptin)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/nesina\"><span style=\"font-weight: 400;\">Nesina<\/span><\/a><span style=\"font-weight: 400;\"> (alogliptin)<\/span><\/li>\n<\/ul>\n<h3 id=\"5-sulfonylureas\"><span style=\"font-weight: 400;\">5. Sulfonylureas<\/span><\/h3>\n<p><a href=\"https:\/\/www.singlecare.com\/drug-classes\/sulfonylureas\"><span style=\"font-weight: 400;\">Sulfonylureas<\/span><\/a><span style=\"font-weight: 400;\"> are a class of drug used for Type 2 diabetes. These are some of the older drugs developed for diabetes. They work by stimulating the pancreas to make insulin. Side effects include hypoglycemia, weight gain, dizziness, headache, nausea, and diarrhea. Examples of sulfonylureas include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabeta (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/glyburide\"><span style=\"font-weight: 400;\">glyburide<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/glimepiride-side-effects\/\"><span style=\"font-weight: 400;\">Glimepiride<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glucotrol XL (<\/span><a href=\"https:\/\/www.singlecare.com\/blog\/glipizide-vs-metformin\/\"><span style=\"font-weight: 400;\">glipizide<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<h2 id=\"what-s-next-when-metformin-isn-t-enough-for-type-2-diabetes\"><span style=\"font-weight: 400;\">What\u2019s next when metformin isn\u2019t enough for Type 2 diabetes?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Metformin is used as first-line therapy because it is both extremely effective and reasonably priced. If you are not seeing desired results, talk to your healthcare provider. Sometimes, an additional drug may be needed, which can be effective when used in combination with metformin. This can be done with single-ingredient drugs or combination drugs.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If cost is a concern, using a <\/span><a href=\"https:\/\/www.singlecare.com\/prescription-discount-card\"><span style=\"font-weight: 400;\">SingleCare discount card<\/span><\/a><span style=\"font-weight: 400;\"> can help with additional savings at local pharmacies. Stop taking metformin only after consulting a healthcare professional for medical advice. Hyperglycemia may result if metformin is abruptly stopped. Metformin should only be stopped abruptly in the case of a severe allergic reaction or other emergency situation.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/metformin-without-insurance\/\"><b>How much is metformin without insurance?<\/b><\/a><\/p>\n<h3 id=\"when-to-switch-from-metformin-to-insulin\"><span style=\"font-weight: 400;\">When to switch from metformin to insulin?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Many Type 2 diabetes patients require treatment with insulin, either as a stand-alone medication or as an addition to an oral regimen, because they are unable to achieve adequate glycemic control with oral medications (or injectable non-insulin medications like Ozempic). The start of insulin may be recommended if there is evidence of long-term and chronic hyperglycemia, given how quickly and effectively insulin lowers blood sugar levels. A medical team may recommend using insulin if glucose targets are unable to be made after being diagnosed (whether this is due to a condition that has worsened over time, the ineffectiveness of present treatments to lower your glucose, or the development of problems occurring).<\/span><\/p>\n<h3 id=\"what-are-the-steps-you-should-take-if-metformin-stops-working\"><span style=\"font-weight: 400;\">What are the steps you should take if metformin stops working?<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Your diabetes care team must reevaluate your plan (including lifestyle changes and medications) if metformin no longer keeps blood sugar levels within the desired range. Talking to a healthcare provider about concerns should always be the first step in seeking alternative treatments.<\/span><\/p>\n<h2 id=\"how-to-take-metformin-to-maximize-benefits\"><span style=\"font-weight: 400;\">How to take metformin to maximize benefits<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Lifestyle changes, such as <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/diabetes-and-exercise\/\"><span style=\"font-weight: 400;\">exercise<\/span><\/a><span style=\"font-weight: 400;\"> and a healthy <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/diabetes-diet\/\"><span style=\"font-weight: 400;\">diet<\/span><\/a><span style=\"font-weight: 400;\">, are effective for improving diabetes management and cardiovascular health while taking metformin. Both of these lifestyle modifications can help to maximize the benefits of metformin.<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/how-to-lower-blood-sugar\/\"><b>How to lower blood sugar naturally<\/b><\/a><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5439361\/\"><span style=\"font-weight: 400;\">DASH<\/span><\/a><span style=\"font-weight: 400;\"> (Dietary Approaches to Stop Hypertension) plan is a wholesome, well-balanced, and long-lasting eating regimen that can help with a variety of health issues, such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/hypertension-treatments-and-medications\"><span style=\"font-weight: 400;\">hypertension<\/span><\/a><span style=\"font-weight: 400;\"> (high blood pressure), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/high-cholesterol-causes\"><span style=\"font-weight: 400;\">high cholesterol<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/insulin-resistance\/\"><span style=\"font-weight: 400;\">insulin resistance<\/span><\/a><span style=\"font-weight: 400;\">, and obesity. Some of the most beneficial foods to eat (along with taking metformin) to help blood sugar control include non-starchy vegetables such as asparagus, broccoli, cauliflower, leafy greens, salad greens, squash, and green beans, to name a few. Avoiding saturated fats and consuming lean meats and plant-based proteins are also beneficial. It is suggested that sugary drinks and foods high in carbohydrates (such as cookies and chips) be avoided to help prevent excessive blood sugar spikes after meals.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Metformin may contribute to a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6867725\/\"><span style=\"font-weight: 400;\">vitamin B12 deficiency<\/span><\/a><span style=\"font-weight: 400;\">. A healthcare provider may recommend <\/span><a href=\"https:\/\/diabetes.org\/healthy-living\/recipes-nutrition\/vitamins-diabetes\"><span style=\"font-weight: 400;\">B12 testing<\/span><\/a><span style=\"font-weight: 400;\"> be done while taking metformin.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Exercise encourages muscle cells to take in and use more sugar, lowering blood sugar levels. It can also lower the chance of developing diabetes and make it simpler to manage a current diagnosis. Make it a point to get some exercise for at least 30 minutes a day, five days a week (or as directed by your doctor). A simple <\/span><a href=\"https:\/\/www.cdc.gov\/diabetes\/caring\/steps-to-help-you-stay-healthy-with-diabetes.html\"><span style=\"font-weight: 400;\">10-minute walk three times a day<\/span><\/a><span style=\"font-weight: 400;\"> is an effective way to accomplish this goal.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metformin is a generic diabetes medication frequently prescribed as a first-line drug (along with diet and exercise) to help control blood sugar in patients with Type 2 diabetes. You may also recognize metformin by its brand name, Glucophage. Although the brand-name drug is no longer available in the United States, generic versions are commonly used.\u00a0 [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":53832,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[10298],"coauthors":[20902],"class_list":["post-53824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-diabetes","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Signs metformin is not working | SingleCare<\/title>\n<meta name=\"description\" content=\"Metformin doesn&#039;t work for everyone, or it can have serious side effects. 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