{"id":54032,"date":"2022-09-20T09:30:44","date_gmt":"2022-09-20T13:30:44","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54032"},"modified":"2025-10-21T16:47:32","modified_gmt":"2025-10-21T20:47:32","slug":"prednisone-side-effects-in-dogs","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/prednisone-side-effects-in-dogs\/","title":{"rendered":"What are the side effects of prednisone in dogs?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Dogs, like humans, are prescribed various medications over their lifespans for a myriad of health issues. One medication your furry best friend might need is <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\/what-is\"><span style=\"font-weight: 400;\">prednisone<\/span><\/a><span style=\"font-weight: 400;\">, a commonly prescribed steroid.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You may have been <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\"><span style=\"font-weight: 400;\">prescribed prednisone<\/span><\/a><span style=\"font-weight: 400;\"> after an allergic reaction, before surgery, or because of several different health conditions. Similarly,\u00a0 your veterinarian may recommend prednisone for your dog for many reasons. Here, pet owners will learn some of the uses and how to minimize side effects so your dog is comfortable and healthy while taking this medication.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What is prednisone used for in dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Prednisone is a synthetic corticosteroid used to treat inflammation and immune system conditions in dogs and humans. It is an anti-inflammatory and immunosuppressive agent that mimics cortisol, a glucocorticoid hormone. Some dogs need steroid hormones as a replacement, such as pets with Addison\u2019s disease. \u201cSome dogs do not produce a normal amount of steroids needed for the body to function and will need to take this medication to help,\u201d says <\/span><a href=\"https:\/\/seniortailwaggers.com\/team\/dr-sara-ochoa\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sara Ochoa, DVM<\/span><\/a><span style=\"font-weight: 400;\">, a veterinarian at <\/span><a href=\"https:\/\/seniortailwaggers.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seniortailwaggers.com<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some medical conditions dogs may be prescribed prednisone for include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inflammation following injury<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Skin conditions or skin diseases<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/blog\/allergy-medicine-for-dogs-cats\/\"><span style=\"font-weight: 400;\">Allergies<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cancer<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Autoimmune disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inflammatory bowel disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Endocrine disease<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">While prednisone is used for a variety of health conditions and purposes, \u201c<\/span><span style=\"font-weight: 400;\">Its main function is to reduce inflammation,\u201d<\/span><span style=\"font-weight: 400;\">says <\/span><a href=\"https:\/\/www.linkedin.com\/in\/megan-conrad-a84514171\"><span style=\"font-weight: 400;\">Megan Conrad, BVMS<\/span><\/a><span style=\"font-weight: 400;\">, a veterinarian in Oregon<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Prednisone dosage for dogs<\/span><\/h2>\n<p><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.singlecare.com\/blog\/prednisone-dosage-for-dogs\">Dosage for prednisone varies<\/a> based on a variety of factors, including weight and the condition being treated. Dr. Ochoa says the dose usually ranges from 0.5 mg\/kg to 2 mg\/kg once or twice daily. \u201c<\/span><span style=\"font-weight: 400;\">Your vet will try to keep the dose as low as possible to treat the condition but to also reduce side effects as much as possible,\u201d adds Dr. Conrad. You may have a dose ramp up and down as you treat your pet\u2019s health condition and then wean them off the drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you think your pet is not at the right dose of prednisone, do not adjust it on your own. \u201c<\/span><span style=\"font-weight: 400;\">Prednisone should also never be given in larger doses, at a different frequency, or stopped without veterinarian approval as any of these changes can have severe side effects,\u201d says <\/span><a href=\"https:\/\/seniortailwaggers.com\/team\/dr-jamie-whittenburg\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Jamie Whittenburg, DVM<\/span><\/a><i><span style=\"font-weight: 400;\">, <\/span><\/i><span style=\"font-weight: 400;\">a veterinarian at <\/span><a href=\"https:\/\/seniortailwaggers.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">seniortailwaggers.com<\/span><\/a><span style=\"font-weight: 400;\">. \u201cThis medication can have severe, even life-threatening side effects if used incorrectly.\u201d<\/span> <span style=\"font-weight: 400;\">Check and double-check that you\u2019re administering it properly and keep the prescription out of reach of your pet and children to avoid accidental overdose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Always give your pet\u2019s full health and medication history to your vet. \u201cPrednisone should never be given along with other medications unless directed by a veterinarian, as there are many serious drug interactions,\u201d says Dr. Whittenburg. Depending on the length of time your pet has been taking prednisone and the strength of the dose, you may need to wean off the medication instead of stopping it suddenly. Sudden withdrawal from a high dose can be fatal. Make sure to ask about this when at your office visit.\u00a0\u00a0\u00a0<\/span><\/p>\n\t\t<div id=\"coupon-cta\" class=\"coupon-cta master-template\">\n\t\t\t<p id=\"headline\">Save up to 80% on Prednisone with SingleCare<\/p>\n\t\t\t<p id=\"subheadline\">Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.<\/p>\n\t\t\t<div class=\"details-wrap\">\n\t\t\t\t<div class=\"details\">\n\t\t\t\t\tPrednisone 20 mg (10 Tablets)\t\t\t\t<\/div>\n\t\t\t\t<div class=\"address\">\n\t\t\t\t\t23666 - Hampton, VA\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"api-response\">\n\t\t\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart-nbh-market.svg\" alt=\"Walmart Neighborhood Market\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.15<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"coupon\">\n\t\t\t<div class=\"logo\">\n\t\t\t<img decoding=\"async\" src=\"https:\/\/images.singlecare.com\/content\/images\/pharmacy\/logo-color-walmart.svg\" alt=\"Walmart Pharmacy\" \/>\t\t\t<\/div>\n\t\t\t<div class=\"price\">\n\t\t\t\t<div class=\"price-number\">\n\t\t\t\t\t$3.15<br\/>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"price-signup\">\n\t\t\t\t\t<span class=\"info-icon\">i<\/span>\n\t\t\t\t\tPrice with <a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">signup<\/a>\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<div class=\"couponbtn\">\n\t\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\">Get free coupon<\/a>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t<a target=\"_blank\" href=\"https:\/\/www.singlecare.com\/prescription\/prednisone#blog-cta\" class=\"coupon-see-all-btn\">See Prednisone prices at all pharmacies<\/a>\n\t\t<\/div>\n\n\t\t\n<h2><span style=\"font-weight: 400;\">What are the side effects of prednisone in dogs?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">All drugs can have side effects, and, unfortunately, use of prednisone is known to have several short- and long-term effects that can impact your dog\u2019s day-to-day life.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some most common side effects of prednisone include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased drinking and urination\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Irritability<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lethargy or behavior changes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Panting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Water retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lowered ability to fight infection\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slowed wound healing<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Higher doses of prednisone in dogs can lead to a higher incidence of serious side effects such as ulcers.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long can a dog stay on prednisone?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Most dogs only need prednisone for a few weeks. Depending on the size of your dog, if they are on prednisone for more than a month or two, it is considered a long-term use of the drug.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Some dogs do need prednisone for life. \u201cIdeally, no dog or human would require lifelong medication, but there are circumstances where this is necessary. Long-term steroid use, especially in high doses, can cause issues and is best avoided if possible,\u201d says Dr. Whittenbug. In this case, vets recommend regular blood work as recommended by your doctor to check their liver enzymes and kidneys for normal functioning. In most cases, this is done yearly.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Long term side effects of prednisone in dogs<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If your dog is on prednisone for a long time and sustains liver or kidney disease, it can shorten their life. However, usually prednisone is treating a condition that would otherwise shorten their life, such as cancer, so the side effect of the drug versus the condition it is treating needs to be a consideration you and your vet make when discussing treatment.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Long-term steroid use can cause a condition called <\/span><a href=\"https:\/\/vcahospitals.com\/know-your-pet\/steroid-treatment-long-term-effects-in-dogs\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Cushing\u2019s disease<\/span><\/a><span style=\"font-weight: 400;\">. Cushing\u2019s disease causes the adrenal glands to overproduce certain hormones. Look out for the following signs:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased thirst and urination<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased urinary tract infections (UTIs), skin, and <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/dog-ear-infection\/\"><span style=\"font-weight: 400;\">ear infections<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pot-bellied appearance<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Obesity<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If you suspect Cushing\u2019s disease, ask your vet if you can taper off prednisone or try another drug. You may or may not be able to depending on your pet\u2019s health condition.\u00a0<\/span><\/p>\n<p><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/high-blood-pressure-in-dogs\/\"><b>Managing high blood pressure in dogs<\/b><\/a><\/p>\n<h2><span style=\"font-weight: 400;\">Tips for dogs on prednisone<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Reducing the side effects is all about balance: does the reduction in the side effect outweigh the cost to the health issue being addressed? You and your vet will have to look at the factors at play to determine the best course of treatment for your pet but there are some ways to minimize your pet\u2019s discomfort.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Lower the dose if possible or switch drugs\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201c<\/span><span style=\"font-weight: 400;\">There are other synthetic corticosteroids, but each medication has unique indications, and they are not interchangeable,\u201d Dr. Whittenburg says. \u201cAll steroids are not the same and you should give the medication that your veterinarian has prescribed. There is no over-the-counter equivalent of prednisone.\u201d Some common alternatives to prednisone are <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisolone\"><span style=\"font-weight: 400;\">prednisolone<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cyclosporine\"><span style=\"font-weight: 400;\">cyclosporine<\/span><\/a><span style=\"font-weight: 400;\">, budesonide, and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/dexamethasone\"><span style=\"font-weight: 400;\">dexamethasone<\/span><\/a><span style=\"font-weight: 400;\">. Work with your vet to make prednisone or one of the alternatives work for your dog. <\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><span style=\"font-weight: 400;\"><br \/>\n<\/span><b>RELATED: <\/b><a href=\"https:\/\/www.singlecare.com\/blog\/where-to-fill-pet-prescriptions\/\"><b>Where to fill your pet\u2019s prescriptions<\/b><\/a><\/p>\n<h3><span style=\"font-weight: 400;\">2. Administer the medication in the morning\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">\u201cSo if the dog is experiencing more drinking and urination then their owner is awake and able to accommodate their needs,\u201d says Dr. Conrad. However, some dosages require taking prednisone twice a day, so you may need to anticipate your pet\u2019s nighttime potty breaks. Doctors of veterinary medicine do not recommend limiting fluids if your pet is showing signs of excessive thirst.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">3. Monitor your pet\u2019s appetite\u00a0<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While vets say you do not need to alter your pet\u2019s diet while on steroids, an increase in appetite may cause unhealthy weight gain. The increased appetite can also cause your pet to beg or search for additional food. If you are noticing your pet gaining weight, or if they are experiencing behavior changes due to the increased appetite, talk to your vet about diet changes that can help satiate their increased appetite.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is important, with all health conditions, but especially when you have a dog on prednisone, to maintain good communication with your veterinarian to ensure the health and well-being of your dog.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dogs, like humans, are prescribed various medications over their lifespans for a myriad of health issues. One medication your furry best friend might need is prednisone, a commonly prescribed steroid.\u00a0 You may have been prescribed prednisone after an allergic reaction, before surgery, or because of several different health conditions. Similarly,\u00a0 your veterinarian may recommend prednisone [&hellip;]<\/p>\n","protected":false},"author":135,"featured_media":53819,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7956],"tags":[7969],"coauthors":[20599],"class_list":["post-54032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pets","tag-dogs","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prednisone side effects in dogs: Dosage, duration and tips<\/title>\n<meta name=\"description\" content=\"Prednisone side effects in dogs include increased thirst, panting, and lethargy. 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