{"id":54055,"date":"2022-09-30T22:11:48","date_gmt":"2022-10-01T02:11:48","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54055"},"modified":"2024-11-12T19:15:29","modified_gmt":"2024-11-13T00:15:29","slug":"prednisone-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/prednisone-side-effects\/","title":{"rendered":"Prednisone side effects and how to avoid them"},"content":{"rendered":"<p><span style=\"font-weight: 400;\"><a href=\"#common-prednisone-side-effects\">Common prednisone side effects<\/a>\u00a0| <a href=\"#serious-side-effects\">Serious side effects<\/a> | <a href=\"#insomnia\">Insomnia<\/a> | <a href=\"#weight-gain\">Weight gain<\/a> | <a href=\"#hair-loss\">Hair loss<\/a> | <a href=\"#constipation\">Constipation<\/a> | <a href=\"#side-effects-timeline\">Side effects timeline<\/a> | <a href=\"#contraindications\">Contraindications<\/a> | <a href=\"#warnings\">Warnings<\/a> | <a href=\"#interactions\">Interactions<\/a> | <a href=\"#how-to-avoid-side-effects\">How to avoid side effects<\/a> | <a href=\"#how-to-treat-side-effects\">How to treat side effects<\/a><\/span><\/p>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\"><span style=\"font-weight: 400;\">Prednisone<\/span><\/a><span style=\"font-weight: 400;\"> is a generic prescription drug prescribed for <\/span><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=e9d6774e-45f6-419f-b388-8dfb4dd34944\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">many medical conditions<\/span><\/a><span style=\"font-weight: 400;\"> including <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/allergy-treatment-and-medications\"><span style=\"font-weight: 400;\">allergic reactions<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/arthritis-treatment-and-medications\"><span style=\"font-weight: 400;\">inflammatory arthritis<\/span><\/a><span style=\"font-weight: 400;\">, cancer, autoimmune diseases, <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ibs-treatment-and-medications\"><span style=\"font-weight: 400;\">irritable bowel syndrome<\/span><\/a><span style=\"font-weight: 400;\"> (IBS), lung disorders, endocrine disorders, blood disorders, connective tissue disorders, and organ transplants.\u00a0<\/span><\/p>\n<p><span data-sheets-root=\"1\" data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:6849,&quot;3&quot;:{&quot;1&quot;:0},&quot;9&quot;:1,&quot;10&quot;:2,&quot;12&quot;:0,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;}\" data-sheets-formula=\"=CONCATENATE(R[0]C[-2],R[0]C[-3],R[0]C[-1])\"><\/span><\/p>\n<p><span style=\"font-weight: 400;\">As a <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/corticosteroids\/\"><span style=\"font-weight: 400;\">corticosteroid<\/span><\/a><span style=\"font-weight: 400;\">, prednisone primarily affects the immune system to reduce inflammation. Unfortunately, it also has a rich variety of side effects. At a low dose for a short time, prednisone can provide tremendous benefits without serious problems. High-dose or long-term treatment may be needed for certain conditions, but is also associated with more side effects. Not all prednisone side effects are avoidable, but they may be minimized or managed.<\/span><\/p>\n<h2 id=\"common-prednisone-side-effects\"><span style=\"font-weight: 400;\">Common side effects of prednisone<\/span><\/h2>\n<p><a href=\"https:\/\/www.singlecare.com\/prescription\/prednisone\/what-is\"><span style=\"font-weight: 400;\">Prednisone<\/span><\/a><span style=\"font-weight: 400;\"> has a long list of common side effects affecting just about every system in the body. Most people\u2014about 2 in every 3\u2014will experience some side effects when taking prednisone. <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/27305\/prednisone\/Adverse-Reactions\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Common side effects<\/span><\/a><span style=\"font-weight: 400;\"> include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Stomach pain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea and vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Face puffiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Facial redness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unwanted hair growth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Acne<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Changes in appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mood swings<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rash<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hives<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thinning or discoloration of the skin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fluid retention and swelling<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sodium retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Potassium loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated pressure in the eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased blood glucose<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Slow wound healing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Menstrual changes<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects\"><span style=\"font-weight: 400;\">Serious side effects of prednisone<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Serious side effects are more likely when taken in high doses or for a long time. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Steroid psychosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle damage<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Congestive heart failure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peptic ulcer or gastrointestinal perforation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Swelling of the pancreas<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone tissue death<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tendon rupture<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bulging eyes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Increased pressure in the brain<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe or life-threatening allergic reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal or adrenal gland insufficiency<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">When taken over the long term, serious side effects might also involve:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bone loss (osteoporosis)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cataracts<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Serious infections<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Growth suppression in children<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cushing syndrome<\/span><\/li>\n<\/ul>\n<h3 id=\"insomnia\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">While <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Prednisone-Tablets-prednisone-3516.6194\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">the incidence is not known<\/span><\/a><span style=\"font-weight: 400;\">, sleep problems are a common complaint in people taking prednisone. It may <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7357890\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">not always affect total sleep time<\/span><\/a><span style=\"font-weight: 400;\">, but people taking prednisone may wake up during the night more than usual and feel less rested in addition to having problems falling asleep. People can try to take prednisone early in the day and practice good sleep hygiene. If sleep quality becomes a problem, ask for medical advice from a healthcare professional.<\/span><\/p>\n<h3 id=\"weight-gain\"><span style=\"font-weight: 400;\">Weight gain<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When taken continuously for a long enough time, corticosteroids are associated with weight gain. <\/span><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/art.21984\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">In one study<\/span><\/a><span style=\"font-weight: 400;\">, 70% of people taking corticosteroids for 60 days gained some weight. Part of this is due to increased appetite and part is due to a change in the body\u2019s metabolism. Fluid retention also adds weight, but this will go away when steroid treatment is stopped. People taking a short course of prednisone shouldn\u2019t be concerned, but when taken for weeks or months at a time, the best solution is to talk to a nutritionist or other healthcare professional about a fitness and diet program.<\/span><\/p>\n<h3 id=\"hair-loss\"><span style=\"font-weight: 400;\">Hair loss<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">In some people, prednisone and other corticosteroids may accelerate hair thinning, but the incidence is unknown. However, they may also cause unwanted hair growth. Talk to a healthcare provider if hair loss or unwanted growth is becoming problematic.\u00a0<\/span><\/p>\n<h3 id=\"constipation\"><span style=\"font-weight: 400;\">Constipation<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Some people experience constipation when taking prednisone. It\u2019s unclear why systemic corticosteroids may cause constipation, but it seems to be <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3936564\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">dose-related.<\/span><\/a><span style=\"font-weight: 400;\"> Constipation can be managed through fluid intake, fiber intake, and medications, so talk to a healthcare provider if constipation is a problem when taking prednisone.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">Prednisone side effects in women vs. men<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Women may be more vulnerable to prednisone side effects. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6192695\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">In one study<\/span><\/a><span style=\"font-weight: 400;\">, more women experienced side effects than men (95% versus 81%), including intolerable side effects (77% versus 50%). The exact reasons aren\u2019t known. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4207281\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Studies<\/span><\/a><span style=\"font-weight: 400;\"> have shown that men eliminate prednisolone, the active version of prednisone, from the body faster than women, which may be a factor. Age may also be a factor because women past menopause clear prednisolone from the body <\/span><a href=\"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/abs\/10.1016\/S0009-9236%2896%2990112-5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">more slowly<\/span><\/a><span style=\"font-weight: 400;\"> than premenopausal women. No matter the reason, always get medical advice when the problems seem to outweigh the benefits of a drug.<\/span><\/p>\n<h2 id=\"side-effects-timeline\"><span style=\"font-weight: 400;\">How soon do prednisone side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When a prednisone tablet is taken, it is rapidly and almost fully absorbed into the body, and will reach peak concentration in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6073839\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">one or two hours<\/span><\/a><span style=\"font-weight: 400;\">. Some side effects such as headache, insomnia, abdominal pain, and mood problems can come on within that short period. Others such as fluid retention, skin problems, and increased appetite will take a few days or weeks to become a problem. Some side effects are experienced more commonly by people taking prednisone for longer periods of time, including weight gain, facial puffiness, and thinning hair. Many of the most serious side effects occur with long-term use or high doses.<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">How long do prednisone side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The body clears prednisolone, the active version of prednisone, pretty slowly. The half-life ranges anywhere from 18 to 36 hours, so it may take a few days for side effects like headache, mood swings, or irritability to start getting better. Some side effects, such as weight gain, swelling, hair loss, or skin problems may take a few weeks or months to return to normal.\u00a0<\/span><\/p>\n<h2><span style=\"font-weight: 400;\">What are the long-term side effects of prednisone?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Even after prednisone has been stopped, some side effects may have long-term consequences, such as bone loss, muscle damage, glaucoma, cataracts, and heart failure.<\/span><\/p>\n<h2 id=\"contraindications\"><span style=\"font-weight: 400;\">Prednisone contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some medical conditions make taking prednisone too risky. Allergies to the drug top the list, but other people who can\u2019t take prednisone include those with certain types of infections such as body-wide fungal infections or cerebral malaria.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Risks and benefits of prednisone should be discussed with the pregnant person. When possible, long-term treatment and treatment during early pregnancy should be avoided. Corticosteroids like prednisone can harm a fetus by causing adrenal gland problems or cleft palate.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Women who are breastfeeding are given prednisone, but often at the lowest possible dose. Although prednisone is present in the breast milk of mothers on prednisone treatment, the amounts are small, and no adverse effects on nursing babies have yet been reported.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The FDA has determined that prednisone is safe and effective in treating some medical conditions in infants, children, and teens.<\/span><\/p>\n<h2 id=\"warnings\"><span style=\"font-weight: 400;\">Prednisone warnings<\/span><\/h2>\n<h3><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisone has a variety of effects that can worsen some medical conditions. In particular, prednisone suppresses the immune system, so it\u2019s avoided or used with caution in people with active or latent infections. Try to avoid exposure to infections and certain vaccines while taking prednisone.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other problems that require caution include:<\/span><\/p>\n<ul>\n<li><span style=\"font-weight: 400;\">Heart problems and irregular heartbeats<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/blog\/types-of-diabetes\/\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/blood-pressure-treatment-and-medications\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcer-treatment-and-medications\"><span style=\"font-weight: 400;\">Peptic ulcer disease<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400;\">Intestinal problems such as <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/ulcerative-colitis-treatment-and-medications\"><span style=\"font-weight: 400;\">ulcerative colitis<\/span><\/a><span style=\"font-weight: 400;\"> that have a risk of perforation<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/epilepsy-treatment-and-medications\"><span style=\"font-weight: 400;\">A history of seizures<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400;\">Neurological disorders including <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/myasthenia-gravis-treatment-and-medications\"><span style=\"font-weight: 400;\">myasthenia gravis<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400;\">Emotional instability<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Psychosis<\/span><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/osteoporosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/a><\/li>\n<li><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">Glaucoma<\/span><\/a><\/li>\n<li><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li><span style=\"font-weight: 400;\">Eye inflammation and infection<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">In addition, people with reduced thyroid function or cirrhosis of the liver may be more likely to experience prednisone side effects. Prednisone may be less effective when given to people with overactive thyroid.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisone is not used as a recreational drug. It does not cause physical dependence, but it does suppress adrenal gland function, an important source of hormones including cortisol. Its sudden discontinuation can cause withdrawal symptoms. The adrenal gland may not fully function for weeks or months after treatment has ended. Healthcare professionals typically stop prednisone by using a gradually decreasing dose over several weeks to prevent withdrawal symptoms.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">There is no maximum dosage for prednisone, but do not take more than instructed. Prednisone can cause problems in high doses or when taken for a long time. If the prescribed dose is exceeded, call a poison helpline for advice.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our allergies newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Allergies Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h2 id=\"interactions\"><span style=\"font-weight: 400;\">Prednisone interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Because it affects so many systems in the body, prednisone can have a variety of drug interactions. These combinations can affect the safety or effectiveness of prednisone, the other drugs, or both. In particular, live vaccines such as chickenpox vaccine can never be used when a person is taking prednisone or other corticosteroids. Because prednisone suppresses the immune system, it increases the risk of infection by these vaccines.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Because prednisone suppresses the immune system, other drugs that may be a problem include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other corticosteroids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Immune suppressing drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Allergy skin tests<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Some vaccines<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some drugs don\u2019t work as well when combined with prednisone. In essence, prednisone worsens the conditions these drugs treat. These include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/diabetes-treatment-and-medications\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/a><span style=\"font-weight: 400;\"> medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood pressure medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/estrogens\"><span style=\"font-weight: 400;\">Estrogens<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antipsychotics\"><span style=\"font-weight: 400;\">Antipsychotics<\/span><\/a><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Some drugs increase the risk of side effects and may need extra monitoring for problems including:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Other corticosteroids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">): increased risk of gastrointestinal problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">Migraine<\/span><\/a><span style=\"font-weight: 400;\"> medications and stimulants: increased risk of high blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/loop-diuretics\"><span style=\"font-weight: 400;\">Loop<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/thiazide-diuretics\"><span style=\"font-weight: 400;\">thiazide diuretics<\/span><\/a><span style=\"font-weight: 400;\">: increased risk of low potassium\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Testosterone: increased risk of fluid retention<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/quinolones\"><span style=\"font-weight: 400;\">Quinolone antibiotics<\/span><\/a><span style=\"font-weight: 400;\">: increased risk of tendon rupture<\/span><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-side-effects\"><span style=\"font-weight: 400;\">How to avoid prednisone side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Side effects are common when taking corticosteroids like prednisone. A few tips can help keep them at a minimum.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">1. Take prednisone as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Take prednisone tablets as prescribed. The dose can vary widely, from just a few milligrams to more than 1000 for some very serious conditions. Most doses are between 5 and 60 mg per day. Understand the proper dose and follow the dosing schedule rigorously. Use an alarm or app to help remember doses.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">2. Tell the prescriber about all medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">As with all medications, the best way to avoid side effects is to make sure the prescribing healthcare provider knows about all past and present medical conditions, <\/span><a href=\"https:\/\/online.epocrates.com\/drugs\/27308\/prednisone\/Patient-Education\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">especially<\/span><\/a><span style=\"font-weight: 400;\">:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infections, particularly fungal infections, tuberculosis, or herpes infection of the eye<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Electrolyte problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Digestive system problems, especially stomach ulcers, diverticulitis, inflammatory bowel disease (IBD), or past colon surgery<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/multiple-sclerosis-treatment-and-medications\"><span style=\"font-weight: 400;\">Multiple sclerosis<\/span><\/a><span style=\"font-weight: 400;\"> or myasthenia gravis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Osteoporosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mental illness or psychosis<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thyroid problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pregnancy or pregnancy plans<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Breastfeeding or any plans to breastfeed<\/span><\/li>\n<\/ul>\n<h3><span style=\"font-weight: 400;\">3. Tell the prescriber about all medications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another way to avoid side effects is to keep a list of all prescription drugs, over-the-counter medications, and supplements being taken and let the prescriber read it over. In particular, make sure the prescribing healthcare provider is informed about any recent live vaccines or plans for vaccines.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">4. Take prednisone tablets with food<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Taking prednisone with a meal or snack will help prevent or minimize stomach pain and other gastrointestinal side effects.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">5. Avoid NSAIDs and alcohol<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another good way to avoid digestive system problems, particularly ulcers, is to avoid alcohol and NSAIDs like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/aspirin\"><span style=\"font-weight: 400;\">aspirin<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/ibuprofen\"><span style=\"font-weight: 400;\">ibuprofen<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">6. Eat a healthy diet and exercise<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid weight gain from steroid treatment, eat a healthy diet and increase exercise levels. A nutritionist or dietitian can help and they will likely advise a diet high in lean protein. When taking prednisone long-term, weight-bearing exercise can help prevent or minimize bone density loss.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">7. Cut back on salt<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Fluid retention can be minimized by adopting a low-salt diet. By keeping excess fluid from building up, other side effects such as swelling and weight gain can also be minimized.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">8. Add potassium to the diet<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To prevent potassium depletion, eat foods high in potassium or add potassium supplements to the day\u2019s routine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">9. Take calcium and vitamin D supplements<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To avoid bone loss while taking prednisone over a long time, take calcium and vitamin D supplements. Again, a nutritionist or dietitian can help, as well as having a regular exercise routine.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">10. Try not to get sick<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Even low-dose prednisone weakens the immune system, so it\u2019s easier to get infected by something. While taking prednisone, try to stay away from people with infections. Wash your hands regularly. Wearing a mask is always a good idea. Make sure to get medical help at any sign of an infection.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">11. Do not stop taking prednisone<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Corticosteroids like prednisone can cause some unpleasant and even serious withdrawal problems, so follow the tapering dose schedule given by the prescriber. If prednisone is causing problems, talk to a healthcare professional before stopping the drug abruptly.\u00a0<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects\"><span style=\"font-weight: 400;\">How to treat side effects of prednisone<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">When side effects do become a problem, there are ways to either help minimize the problem or prevent further problems.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Infections<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Infections can become serious when taking prednisone. Immediately inform a healthcare professional at any sign of infection.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Mood changes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Make sure to tell family and friends about possible mood changes and irritability before taking prednisone. Seek medical attention if you begin to feel depressed, have too much energy, can\u2019t sleep, or have disturbing thoughts.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Insomnia<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If sleeping is a problem, the prescriber may suggest taking the dose of prednisone earlier in the day. Practice good sleep hygiene by going to bed at the same time each night, turning out the light, and removing any distractions before or after going to bed.<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Gastrointestinal problems<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If stomach pain is a problem, take prednisone with food, preferably food that isn\u2019t spicy or acidic. Antacids can also help. Avoid alcohol and other medications that can bother the stomach. Get medical help if you vomit blood or blood clots, if stools become black and tarry, or if abdominal pain does not go away.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Low potassium<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Talk to a healthcare professional at any sign of low potassium including muscle weakness, cramps, heart flutters, constipation, or increased urinary frequency.\u00a0<\/span><\/p>\n<h3><span style=\"font-weight: 400;\">Withdrawal<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Prednisone affects the hormone system that keeps the adrenal gland functioning at full capacity. This can become a problem when prednisone is stopped after taking it for more than a few days. Prednisone doses are often lowered slowly. Talk to the prescribing healthcare provider if the following symptoms occur: weakness, fatigue, diarrhea, light-headedness, skin color changes, and cravings for salt. If blood pressure drops too low, immediate medical attention may be needed.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Common prednisone side effects\u00a0| Serious side effects | Insomnia | Weight gain | Hair loss | Constipation | Side effects timeline | Contraindications | Warnings | Interactions | How to avoid side effects | How to treat side effects Prednisone is a generic prescription drug prescribed for many medical conditions including allergic reactions, inflammatory arthritis, [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":54059,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[554,12164,10965,12752],"coauthors":[8861],"class_list":["post-54055","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-allergies","tag-arthritis","tag-asthma","tag-medication-side-effects","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Prednisone side effects and how to avoid them<\/title>\n<meta name=\"description\" content=\"Insomnia, weight gain, hair loss, and constipation are common prednisone side effects. 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