{"id":54094,"date":"2022-10-13T18:16:33","date_gmt":"2022-10-13T22:16:33","guid":{"rendered":"https:\/\/www.singlecare.com\/blog\/?p=54094"},"modified":"2025-10-07T14:26:49","modified_gmt":"2025-10-07T18:26:49","slug":"venlafaxine-side-effects","status":"publish","type":"post","link":"https:\/\/www.singlecare.com\/blog\/venlafaxine-side-effects\/","title":{"rendered":"Venlafaxine side effects and how to avoid them"},"content":{"rendered":"<p><a href=\"https:\/\/www.singlecare.com\/prescription\/venlafaxine-hcl-er\"><span style=\"font-weight: 400;\">Venlafaxine<\/span><\/a><span style=\"font-weight: 400;\">, also sold as brand-name <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/effexor-xr\"><span style=\"font-weight: 400;\">Effexor XR<\/span><\/a><span style=\"font-weight: 400;\">, is an antidepressant that is FDA-approved to treat <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/depression-treatment-and-medications\"><span style=\"font-weight: 400;\">major depressive disorder<\/span><\/a><span style=\"font-weight: 400;\"> (MDD), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/anxiety-treatment-and-medications\"><span style=\"font-weight: 400;\">generalized anxiety disorder<\/span><\/a><span style=\"font-weight: 400;\">, social anxiety disorder, and panic disorder. It is also prescribed off-label for post-traumatic stress disorder (PTSD), <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraines<\/span><\/a><span style=\"font-weight: 400;\">, and nerve pain.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Venlafaxine belongs to a family of drugs called serotonin-norepinephrine reuptake inhibitors or <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/snris\"><span style=\"font-weight: 400;\">SNRIs.<\/span><\/a><span style=\"font-weight: 400;\"> These drugs increase the concentration of certain chemicals that pass signals between nerves (called neurotransmitters). This mechanism essentially activates the parts of the brain that help with mood control. Changing the way the nervous system works has benefits for many people, but may also produce a variety of unwanted side effects.\u00a0<\/span><\/p>\n<h2 id=\"common-side-effects-of-venlafaxine\"><span style=\"font-weight: 400;\">Common side effects of venlafaxine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Nausea is the most common side effect of <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/venlafaxine-hcl-er\/what-is\"><span style=\"font-weight: 400;\">venlafaxine<\/span><\/a><span style=\"font-weight: 400;\">. About <\/span><span style=\"font-weight: 400;\">30%<\/span><span style=\"font-weight: 400;\"> to <\/span><span style=\"font-weight: 400;\">60%<\/span><span style=\"font-weight: 400;\"> of people on venlafaxine feel queasy or nauseous, especially when first starting the medication.. <\/span><span style=\"font-weight: 400;\">Common side effects<\/span><span style=\"font-weight: 400;\"> of venlafaxine include:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nausea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Trouble sleeping<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drowsiness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dry mouth<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ejaculation problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weight loss<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Loss of appetite<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Constipation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Elevated blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Impotence<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Yawning<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diarrhea<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Decreased interest in sex<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Indigestion<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Tremor<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Infection<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Orgasm problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vomiting<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flushing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blurred vision<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Strange dreams<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fast or irregular heart beats<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Numbness or tingling<\/span><\/li>\n<\/ul>\n<h2 id=\"serious-side-effects-of-venlafaxine\"><span style=\"font-weight: 400;\">Serious side effects of venlafaxine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">The most serious side effects of venlafaxine are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Suicidal thoughts and behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Worsening of depression<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mania or hypomania<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/serotonin-syndrome-treatment-and-medications\"><span style=\"font-weight: 400;\">Serotonin syndrome<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rhythm abnormalities<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Drug-induced involuntary movement problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/conditions\/pancreatitis-treatment-and-medications\"><span style=\"font-weight: 400;\">Swollen pancreas<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver poisoning<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sodium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Angle-closure glaucoma<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bleeding<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure (hypertension)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Lung disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Withdrawal if stopped suddenly<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Growth suppression (in children)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe allergic or skin reactions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle tremors, movements, or contractions<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart failure<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">\t\t<div class=\"singlecare-dynamic-newsletter-wrapper sin-newsletter-wrapper\">\n\t\t\t<span class=\"heading\">Get our mental health newsletter<\/span>\n\t\t\t<form class=\"form-wrapper\" data-newsletter-form=\"1\" data-subsource=\"Mental Health Newsletter\">\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<label for=\"dynamic-email\">Email<\/label>\n\t\t\t\t\t<input type=\"email\" id=\"dynamic-email\" class=\"email\" required>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"input-wrapper\">\n\t\t\t\t\t<input class=\"submit-form-btn\" type=\"submit\" value=\"Click to sign up\">\n\t\t\t\t<\/div>\n\t\t\t<\/form>\n\t\t\t<p class=\"success-message\" aria-live=\"polite\"><\/p>\n\t\t<\/div>\n\t<\/span><\/p>\n<h3 id=\"sexual-dysfunction\"><span style=\"font-weight: 400;\">Sexual dysfunction<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Sexual problems are commonly experienced by people taking <\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antidepressants\"><span style=\"font-weight: 400;\">antidepressants<\/span><\/a><span style=\"font-weight: 400;\">. Up to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3108697\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">67%<\/span><\/a><span style=\"font-weight: 400;\"> of people taking venlafaxine may experience sexual dysfunction symptoms. These issues may include ejaculation problems, erectile dysfunction, loss of sexual drive, and problems reaching orgasm. Fortunately, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8061302\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">most people<\/span><\/a><span style=\"font-weight: 400;\"> will see a return to normal sexual functioning when the drug is stopped. If sexual function is a problem, talk to the prescribing healthcare provider.<\/span><\/p>\n<h3 id=\"weight-changes\"><span style=\"font-weight: 400;\">Weight changes<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Weight loss is a common problem in children taking venlafaxine. In <\/span><a href=\"https:\/\/labeling.pfizer.com\/showlabeling.aspx?ID=100#section-5.10\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">clinical trials<\/span><\/a><span style=\"font-weight: 400;\">, 18% to 47% of pediatric participants lost weight on venlafaxine <a href=\"https:\/\/www.singlecare.com\/prescription\/venlafaxine-hcl\/dosage\">depending on the dose<\/a> and the condition being treated. Children on venlafaxine also gained less height than those receiving a placebo. Although appetite loss is a common side effect, healthcare professionals do not believe venlafaxine-induced weight loss is related to decreased appetite. Children, particularly those younger than 12, will need to be monitored for both height and weight when taking venlafaxine.<\/span><\/p>\n<h3 id=\"urinary-retention\"><span style=\"font-weight: 400;\">Urinary retention<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Urinary retention is a rare side effect of venlafaxine, occurring in less than one percent of patients. People taking venlafaxine may also urinate more than usual or experience urinary urgency or incontinence. These problems can manifest early on in treatment, so tell the prescribing healthcare provider about the problem.<\/span><\/p>\n<h3 id=\"sleepiness\"><span style=\"font-weight: 400;\">Sleepiness<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">It\u2019s fairly common to feel sleepy when taking certain antidepressants. For venlafaxine, 15% of people taking the drug felt <\/span><a href=\"https:\/\/www.pdr.net\/drug-summary\/Effexor-XR-venlafaxine-619#12\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">drowsy<\/span><\/a><span style=\"font-weight: 400;\">, but the rate could be as high as 23%. If sleepiness, fatigue, or tiredness is interfering with daily functioning, get medical advice from the prescribing healthcare provider.<\/span><\/p>\n<h2 id=\"how-soon-do-venlafaxine-side-effects-start\"><span style=\"font-weight: 400;\">How soon do venlafaxine side effects start?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Some common venlafaxine side effects such as drowsiness, nausea, headache, sleeplessness, and dry mouth can start shortly after starting treatment. Allergic reactions could start within minutes. Side effects such as weight loss, sexual dysfunction, appetite loss, and many of the most serious side effects don\u2019t usually begin until after several weeks of treatment.<\/span><\/p>\n<h2 id=\"how-long-do-venlafaxine-side-effects-last\"><span style=\"font-weight: 400;\">How long do venlafaxine side effects last?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Many of the most common side effects of venlafaxine become milder as the body adapts to the medicine. Some, however, may not get better until the medicine is stopped. Once it\u2019s stopped, most adverse effects should start clearing up by the next day. Some side effects, particularly the more severe ones, may cause long-term problems.\u00a0<\/span><\/p>\n<h2 id=\"what-are-the-long-term-side-effects-of-venlafaxine\"><span style=\"font-weight: 400;\">What are the long-term side effects of venlafaxine?<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">For adults, venlafaxine is safe to take for a long time. Doing so does not produce unique side effects, but it is more likely to cause withdrawal symptoms if discontinued suddenly. Most side effects of venlafaxine do not persist for long after the drug has stopped. However, some serious side effects, such as heart problems, lung disease, or <\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/glaucoma-treatment-and-medications\"><span style=\"font-weight: 400;\">glaucoma<\/span><\/a><span style=\"font-weight: 400;\">, could have long-term consequences.<\/span><\/p>\n<h2 id=\"venlafaxine-contraindications\"><span style=\"font-weight: 400;\">Venlafaxine contraindications<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Venlafaxine is contraindicated in people with a known history of allergic reactions to venlafaxine or a similar drug, <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/pristiq\"><span style=\"font-weight: 400;\">Pristiq<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/desvenlafaxine-succinate-er\"><span style=\"font-weight: 400;\">desvenlafaxine<\/span><\/a><span style=\"font-weight: 400;\">). It should also not be taken by people who have taken a category of antidepressants called MAO inhibitors within the last 14 days.<\/span><\/p>\n<h3 id=\"pregnancy\"><span style=\"font-weight: 400;\">Pregnancy<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The risk of fetal harm is low if taking venlafaxine during pregnancy. If taken in the last three months of pregnancy, a newborn baby may experience withdrawal or serotonin syndrome. There may also be increased bleeding after delivery.<\/span><\/p>\n<h3 id=\"breastfeeding\"><span style=\"font-weight: 400;\">Breastfeeding<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The risk to a nursing infant is low. However, venlafaxine is present in breast milk, so talk with your healthcare provider about risks and benefits if you are breastfeeding.<\/span><\/p>\n<h3 id=\"children\"><span style=\"font-weight: 400;\">Children<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The Food and Drug Administration (FDA) has not approved the use of venlafaxine for anyone younger than the age of 18. It is sometimes used to treat mental health conditions in some children. However, there is a risk of worsening depression, suicidality, weight loss, and growth suppression in children and adolescents given venlafaxine.<\/span><\/p>\n<h2 id=\"venlafaxine-warnings\"><span style=\"font-weight: 400;\">Venlafaxine warnings<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Though only contraindicated for people with hypersensitivity to venlafaxine, that doesn\u2019t mean the drug is completely safe for everyone else. Because of potential problems, some situations may be riskier than others.<\/span><\/p>\n<h3 id=\"black-box-warning\"><span style=\"font-weight: 400;\">Black box warning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Like other antidepressants, venlafaxine contains an FDA-mandated <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/black-box-warning\/\"><span style=\"font-weight: 400;\">black box warning<\/span><\/a><span style=\"font-weight: 400;\"> about the risk of worsening depression and suicidality in children, teens, and young adults given the medicine.\u00a0<\/span><\/p>\n<h3 id=\"cautions\"><span style=\"font-weight: 400;\">Cautions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Existing health conditions may be worsened by venlafaxine, so healthcare professionals are advised to be cautious, monitor for problems, and sometimes adjust doses for people with:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Heart problems: <\/b><span style=\"font-weight: 400;\">People with irregular heartbeats, a personal or family history of some kinds of EKG changes, congestive heart failure, or a recent heart attack may require regular monitoring while taking venlafaxine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bleeding disorders: <\/b><span style=\"font-weight: 400;\">Venlafaxine can slow down blood clotting, a side effect that will worsen pre-existing bleeding problems.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Bipolar disorder: <\/b><span style=\"font-weight: 400;\">Venlafaxine can bring on mania or hypomania.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>History of seizures: <\/b><span style=\"font-weight: 400;\">Venlafaxine can bring on seizures in people who are already at risk for seizures.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Uncorrected narrow angles: <\/b><span style=\"font-weight: 400;\">Angle-closure glaucoma, an eye problem that rapidly progresses to vision loss and blindness, has been reported in people taking venlafaxine. Uncorrected narrow angles are the primary risk factor for angle-closure glaucoma.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>High blood pressure <\/b><span style=\"font-weight: 400;\">can be worsened by venlafaxine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Dehydration <\/b><span style=\"font-weight: 400;\">puts people at risk for low sodium if they\u2019re on venlafaxine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Electrolyte imbalance<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Liver impairment<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Kidney dysfunction<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Overactive thyroid<\/b><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Seniors: <\/b><span style=\"font-weight: 400;\">Older adults have a potentially greater risk of side effects, low sodium, or weight loss.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Young adults:<\/b><span style=\"font-weight: 400;\"> People younger than 25 years of age have a heightened risk of worsening depression and suicidality when taking venlafaxine.<\/span><\/li>\n<\/ul>\n<h3 id=\"abuse-and-dependence\"><span style=\"font-weight: 400;\">Abuse and dependence<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Venlafaxine is not a controlled substance. The FDA does not consider venlafaxine as having a risk for abuse. It does not create physical dependence. However, sudden discontinuation of the drug could result in withdrawal symptoms.<\/span><\/p>\n<h3 id=\"overdose\"><span style=\"font-weight: 400;\">Overdose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">A venlafaxine overdose will require immediate treatment, particularly if the medicine is taken with alcohol or other CNS depressants. For adults, the dose should not exceed 225 mg per day.<\/span><\/p>\n<h2 id=\"venlafaxine-interactions\"><span style=\"font-weight: 400;\">Venlafaxine interactions<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">As a drug that primarily affects the brain, venlafaxine has several potential drug interactions.<\/span><\/p>\n<h3 id=\"contraindications\"><span style=\"font-weight: 400;\">Contraindications<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Venlafaxine can change the way the heart beats. Some drug interactions can amplify this effect, raising the risk of serious heart problems. For this reason, venlafaxine is never combined with:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/antipsychotics\/\"><span style=\"font-weight: 400;\">antipsychotic medications<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/pimozide\"><span style=\"font-weight: 400;\">pimozide<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/thioridazine-hcl\"><span style=\"font-weight: 400;\">thioridazine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The heart rate medication <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/quinidine-sulfate\"><span style=\"font-weight: 400;\">quinidine<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Cerdelga (eliglustat)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">It is also never combined with monoamine oxidase inhibitors (MAOIs) because of the risk of serotonin syndrome or other severe side effects. These drugs must be stopped 14 days before taking venlafaxine:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/marplan\"><span style=\"font-weight: 400;\">Marplan<\/span><\/a><span style=\"font-weight: 400;\"> (isocarboxazid)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/parnate\"><span style=\"font-weight: 400;\">Parnate<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tranylcypromine-sulfate\"><span style=\"font-weight: 400;\">tranylcypromine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/nardil\"><span style=\"font-weight: 400;\">Nardil<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/phenelzine-sulfate\"><span style=\"font-weight: 400;\">phenelzine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/zyvox\"><span style=\"font-weight: 400;\">Zyvox<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/linezolid\"><span style=\"font-weight: 400;\">linezolid<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Safinamide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><a href=\"https:\/\/www.singlecare.com\/prescription\/selegiline-hcl\"><span style=\"font-weight: 400;\">Selegiline<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Methylene blue<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other drug interactions may have other risks, but the combination isn\u2019t prohibited. The combination can raise the risk of several health problems, including:<\/span><\/p>\n<ul>\n<li aria-level=\"1\"><b>Increased risk of heart problems<\/b><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart rate or heart rhythm drugs<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Increased risk of serotonin syndrome<\/b><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Other SNRIs such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cymbalta\"><span style=\"font-weight: 400;\">Cymbalta<\/span><\/a> <a href=\"https:\/\/www.singlecare.com\/prescription\/duloxetine-hcl\"><span style=\"font-weight: 400;\">(duloxetine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">SSRIs such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/prozac\"><span style=\"font-weight: 400;\">Prozac<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fluoxetine-hcl\"><span style=\"font-weight: 400;\">fluoxetine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/blog\/tricyclic-antidepressants\/\"><span style=\"font-weight: 400;\">Tricyclic antidepressants<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Anxiety medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Antipsychotic medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Bipolar disorder medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/lithium\"><span style=\"font-weight: 400;\">lithium<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/blog\/opioids\/\"><span style=\"font-weight: 400;\">Opioids<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Amphetamines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/conditions\/adhd-treatment-and-medications\"><span style=\"font-weight: 400;\">ADHD medications<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/blog\/anticonvulsants\/\"><span style=\"font-weight: 400;\">Anticonvulsants<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Ergot drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/conditions\/migraine-treatment-and-medications\"><span style=\"font-weight: 400;\">migraine drugs<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/blog\/antiemetics\/\"><span style=\"font-weight: 400;\">Anti-nausea medications<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Some over-the-counter supplements such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/l-tryptophan\"><span style=\"font-weight: 400;\">tryptophan<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/st-johns-wort\"><span style=\"font-weight: 400;\">St. John\u2019s wort<\/span><\/a><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Increased risk of bleeding episodes<\/b><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Blood thinners such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/warfarin-sodium\"><span style=\"font-weight: 400;\">warfarin<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Nonsteroidal anti-inflammatory drugs (<\/span><a href=\"https:\/\/www.singlecare.com\/drug-classes\/nsaids\"><span style=\"font-weight: 400;\">NSAIDs<\/span><\/a><span style=\"font-weight: 400;\">)\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Dietary supplements such as garlic and krill oil<\/span><\/li>\n<\/ul>\n<ul>\n<li aria-level=\"1\"><b>Increased risk of side effects in general<\/b><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/macrolides\"><span style=\"font-weight: 400;\">Macrolide antibiotics<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/conditions\/hiv-treatment-and-medications\"><span style=\"font-weight: 400;\">HIV\/AIDS<\/span><\/a><span style=\"font-weight: 400;\"> medications<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/benzodiazepines\"><span style=\"font-weight: 400;\">Benzodiazepines<\/span><\/a><span style=\"font-weight: 400;\">, sedatives, sleep aids and other CNS depressants<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/antifungals\"><span style=\"font-weight: 400;\">Antifungal medications<\/span><\/a><span style=\"font-weight: 400;\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">H2 blockers<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><a href=\"https:\/\/www.singlecare.com\/drug-classes\/calcium-channel-blockers\"><span style=\"font-weight: 400;\">Calcium channel blockers<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Cannabis and cannabinoids<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"2\"><span style=\"font-weight: 400;\">Dietary supplements such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/niacin\"><span style=\"font-weight: 400;\">niacin<\/span><\/a><\/li>\n<\/ul>\n<h2 id=\"how-to-avoid-venlafaxine-side-effects\"><span style=\"font-weight: 400;\">How to avoid venlafaxine side effects<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Even though venlafaxine\u2019s side effects are common, there are ways to minimize the problems.<\/span><\/p>\n<h3 id=\"1-tell-the-prescriber-about-all-medical-conditions\"><span style=\"font-weight: 400;\">1. Tell the prescriber about all medical conditions<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">The prescribing healthcare provider needs to have a complete medical history. In particular, make sure the prescriber knows about:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Heart problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizure problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bipolar disorder<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diabetes<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Liver disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Kidney disease<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Thyroid problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Low sodium<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High cholesterol<\/span><\/li>\n<\/ul>\n<h3 id=\"2-tell-the-prescriber-about-any-drugs-being-taken\"><span style=\"font-weight: 400;\">2. Tell the prescriber about any drugs being taken<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Another source of serious problems is drug interactions. The prescriber needs to know all the drugs being taken regularly. That includes over-the-counter drugs and dietary supplements. These are the most important:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">MAO inhibitors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Antidepressants, anxiety drugs, antipsychotics, bipolar medications, or similar psychiatric drugs<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Amphetamines<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Migraine medications such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/sumatriptan-succinate\"><span style=\"font-weight: 400;\">sumatriptan<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Opioids like <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tramadol-hcl\"><span style=\"font-weight: 400;\">tramadol<\/span><\/a><span style=\"font-weight: 400;\"> or <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/fentanyl\"><span style=\"font-weight: 400;\">fentanyl<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Blood thinners such as warfarin<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Histamine blockers such as <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/tagamet-hb\"><span style=\"font-weight: 400;\">Tagamet<\/span><\/a><span style=\"font-weight: 400;\"> (<\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/cimetidine-hcl\"><span style=\"font-weight: 400;\">cimetidine<\/span><\/a><span style=\"font-weight: 400;\">)<\/span><\/li>\n<\/ul>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Supplements or herbal remedies like St. John\u2019s wort or tryptophan.<\/span><\/li>\n<\/ul>\n<h3 id=\"3-take-venlafaxine-as-directed\"><span style=\"font-weight: 400;\">3. Take venlafaxine as directed<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Follow all the instructions given by the prescribing healthcare provider or printed on the prescription label or medication guide. The dosing schedules will be different depending on the format prescribed: venlafaxine is taken as either an immediate-release tablet or an extended-release capsule.\u00a0<\/span><\/p>\n<h3 id=\"4-don-t-take-extra-doses-to-make-up-for-a-missed-dose\"><span style=\"font-weight: 400;\">4. Don\u2019t take extra doses to make up for a missed dose<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If a dose is missed, take it when remembered. If it\u2019s almost time for the next dose, though, skip the missed dose and take the next dose as scheduled.\u00a0<\/span><\/p>\n<h3 id=\"5-take-the-dose-in-the-morning\"><span style=\"font-weight: 400;\">5. Take the dose in the morning<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To help prevent insomnia, take each day\u2019s dose early in the morning.<\/span><\/p>\n<h3 id=\"6-avoid-alcohol-and-other-depressants\"><span style=\"font-weight: 400;\">6. Avoid alcohol and other depressants<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Alcohol, sedatives, and sleep aids will make some of venlafaxine\u2019s side effects worse including drowsiness and dizziness.<\/span><\/p>\n<h3 id=\"7-avoid-aspirin-and-ibuprofen\"><span style=\"font-weight: 400;\">7. Avoid aspirin and ibuprofen<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">To prevent problems with bleeding, stomach pain, and ulcers, avoid NSAIDs when taking venlafaxine. If possible, use <\/span><a href=\"https:\/\/www.singlecare.com\/prescription\/acetaminophen\"><span style=\"font-weight: 400;\">acetaminophen<\/span><\/a><span style=\"font-weight: 400;\"> instead.<\/span><\/p>\n<h2 id=\"how-to-treat-side-effects-of-venlafaxine\"><span style=\"font-weight: 400;\">How to treat side effects of venlafaxine<\/span><\/h2>\n<p><span style=\"font-weight: 400;\">Here are some tips for handling some of the most common or serious problems.<\/span><\/p>\n<h3 id=\"drowsiness-and-dizziness\"><span style=\"font-weight: 400;\">Drowsiness and dizziness<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">If venlafaxine causes drowsiness or dizziness, the primary goal is to avoid falls and injuries. Stand up slowly, move slowly, and consider removing obstacles on the floor that are dangerous if they\u2019re fallen on.\u00a0<\/span><\/p>\n<h3 id=\"low-sodium\"><span style=\"font-weight: 400;\">Low sodium<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">When mild, low sodium is unpleasant. However, it can evolve into a serious medical condition. The best advice is to call a healthcare professional. The most common symptoms of low sodium are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Headache<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Weakness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coordination problems<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Confusion<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">If seizures are experienced, go to an emergency room.<\/span><\/p>\n<h3 id=\"suicidal-thoughts-and-behaviors\"><span style=\"font-weight: 400;\">Suicidal thoughts and behaviors<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">Young adults and children are vulnerable to suicidal thoughts and behaviors when taking venlafaxine. Medical help is required before that person can harm themselves. The symptoms to watch out for are:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Attempts at suicide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Talking about, thinking about, or planning suicide<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Talking or thinking about death<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or sudden changes in mood or behavior<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">New or worsening depression or anxiety<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Aggressiveness or hostility<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Violent behavior<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Reckless or risky behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Unusual behaviors<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation, restlessness, irritability, or anger<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Panic attacks<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hyperactivity or uncontrolled talking<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Insomnia<\/span><\/li>\n<\/ul>\n<h3 id=\"serotonin-syndrome\"><span style=\"font-weight: 400;\">Serotonin syndrome<\/span><\/h3>\n<p><span style=\"font-weight: 400;\">All antidepressants can cause <\/span><a href=\"https:\/\/www.singlecare.com\/blog\/serotonin-syndrome-symptoms\/\"><span style=\"font-weight: 400;\">serotonin syndrome<\/span><\/a><span style=\"font-weight: 400;\">, but it usually requires that similar serotonin-raising drugs be taken. Serotonin syndrome is usually mild, but could rapidly develop into a medical emergency. Serotonin syndrome requires immediate medical help, so look for symptoms such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Racing heartbeat<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">High or low blood pressure<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Flushing<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Agitation<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Hallucinations<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dizziness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fever<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Sweating<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Muscle stiffness<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Seizures or convulsions<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Venlafaxine, also sold as brand-name Effexor XR, is an antidepressant that is FDA-approved to treat major depressive disorder (MDD), generalized anxiety disorder, social anxiety disorder, and panic disorder. It is also prescribed off-label for post-traumatic stress disorder (PTSD), migraines, and nerve pain.\u00a0 Venlafaxine belongs to a family of drugs called serotonin-norepinephrine reuptake inhibitors or SNRIs. [&hellip;]<\/p>\n","protected":false},"author":15,"featured_media":54099,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4589],"tags":[451,12752,450],"coauthors":[8861],"class_list":["post-54094","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-info","tag-depression","tag-medication-side-effects","tag-mental-health","wpautop"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Venlafaxine side effects and how to avoid them | SingleCare<\/title>\n<meta name=\"description\" content=\"Sexual dysfunction, weight changes, urinary retention and sleepiness are common venlafaxine side effects. 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